SG10201810087QA - Modified t lymphocytes having improved specificity - Google Patents
Modified t lymphocytes having improved specificityInfo
- Publication number
- SG10201810087QA SG10201810087QA SG10201810087QA SG10201810087QA SG10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA
- Authority
- SG
- Singapore
- Prior art keywords
- lymphocytes
- modified
- improved specificity
- improved
- specificity
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 3
- 108700010039 chimeric receptor Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
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- Toxicology (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361761548P | 2013-02-06 | 2013-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201810087QA true SG10201810087QA (en) | 2018-12-28 |
Family
ID=51300133
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507026WA SG11201507026WA (en) | 2013-02-06 | 2014-02-06 | Modified t lymphocytes having improved specificity |
SG10201810087QA SG10201810087QA (en) | 2013-02-06 | 2014-02-06 | Modified t lymphocytes having improved specificity |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507026WA SG11201507026WA (en) | 2013-02-06 | 2014-02-06 | Modified t lymphocytes having improved specificity |
Country Status (12)
Country | Link |
---|---|
US (2) | US20150368360A1 (ja) |
EP (3) | EP3604500B1 (ja) |
JP (3) | JP6467661B2 (ja) |
KR (2) | KR102417657B1 (ja) |
CN (3) | CN113005091A (ja) |
AU (3) | AU2014214850C1 (ja) |
CA (2) | CA3115383A1 (ja) |
ES (2) | ES2898270T3 (ja) |
HK (2) | HK1218049A1 (ja) |
NZ (2) | NZ750426A (ja) |
SG (2) | SG11201507026WA (ja) |
WO (1) | WO2014124143A1 (ja) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2020124583A (ru) | 2012-10-02 | 2020-08-03 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
CA3115383A1 (en) * | 2013-02-06 | 2014-08-14 | Celgene Corporation | Modified t lymphocytes having improved specificity |
PL2958943T3 (pl) | 2013-02-20 | 2020-04-30 | The Trustees Of The University Of Pennsylvania | Leczenie nowotworu złośliwego za pomocą humanizowanego chimerycznego receptora antygenowego anty-egfrviii |
US9944898B2 (en) * | 2013-03-11 | 2018-04-17 | Case Western Reserve University | Method of generating tumor-specific T cells |
US11071754B2 (en) | 2013-03-11 | 2021-07-27 | Case Western Reserve University | Method of generating tumor-specific T cells |
IL300508A (en) | 2013-03-15 | 2023-04-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
CN111643663A (zh) | 2013-03-15 | 2020-09-11 | 细胞基因公司 | 修饰的t淋巴细胞 |
GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
JP7054622B2 (ja) | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
SG11201700418VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using a cll-1 chimeric antigen receptor |
EP2990416B1 (en) * | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
RU2768019C2 (ru) * | 2014-12-24 | 2022-03-23 | Отолус Лимитед | Клетка |
MA41433A (fr) | 2015-01-26 | 2017-12-05 | Baylor College Medicine | Cellules immunitaires universelles pour l'immunothérapie anticancéreuse |
SG11201706236SA (en) | 2015-02-06 | 2017-08-30 | Nat Univ Singapore | Methods for enhancing efficacy of therapeutic immune cells |
US10647778B2 (en) | 2015-02-09 | 2020-05-12 | University Of Florida Research Foundation, Incorporated | Bi-specific chimeric antigen receptor and uses thereof |
EP3259352A4 (en) * | 2015-02-19 | 2018-12-05 | University of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
JP2018510652A (ja) * | 2015-03-18 | 2018-04-19 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | Her2/erbb2キメラ抗原受容体 |
CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
TWI833684B (zh) * | 2015-06-25 | 2024-03-01 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體(car)、組合物及其使用方法 |
WO2017222593A1 (en) * | 2016-06-24 | 2017-12-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
CA2999037A1 (en) | 2015-09-23 | 2017-03-30 | Cytoimmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
US20190255107A1 (en) | 2015-10-09 | 2019-08-22 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
GB201518816D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
AU2016355178B9 (en) | 2015-11-19 | 2019-05-30 | Massachusetts Institute Of Technology | Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity |
SG10202112024PA (en) * | 2016-01-11 | 2021-12-30 | Univ Leland Stanford Junior | Chimeric proteins and methods of immunotherapy |
PT3436030T (pt) | 2016-04-01 | 2022-11-18 | Amgen Inc | Recetores quiméricos e métodos para a sua utilização |
EP3436036A4 (en) * | 2016-04-01 | 2020-03-18 | Kite Pharma, Inc. | BCMA-BINDING MOLECULES AND METHOD FOR USE THEREOF |
EA201891965A1 (ru) | 2016-04-01 | 2019-04-30 | Кайт Фарма, Инк. | Химерные рецепторы антигенов и т-клеточные рецепторы и способы их применения |
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