SG10201809901SA - Generating Pluripotent Cells De Novo - Google Patents

Generating Pluripotent Cells De Novo

Info

Publication number
SG10201809901SA
SG10201809901SA SG10201809901SA SG10201809901SA SG10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA
Authority
SG
Singapore
Prior art keywords
novo
pluripotent cells
generating pluripotent
generating
assays
Prior art date
Application number
SG10201809901SA
Other languages
English (en)
Inventor
Charles A Vacanti
Martin P Vacanti
Koji Kojima
Haruko Obokata
Teruhiko Wakayama
Yoshiki Sasai
Masayuki Yamato
Original Assignee
Vcell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vcell Therapeutics Inc filed Critical Vcell Therapeutics Inc
Publication of SG10201809901SA publication Critical patent/SG10201809901SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature
SG10201809901SA 2012-04-24 2013-04-24 Generating Pluripotent Cells De Novo SG10201809901SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261637631P 2012-04-24 2012-04-24
US201361779533P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
SG10201809901SA true SG10201809901SA (en) 2018-12-28

Family

ID=49483852

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201809901SA SG10201809901SA (en) 2012-04-24 2013-04-24 Generating Pluripotent Cells De Novo
SG11201407768QA SG11201407768QA (en) 2012-04-24 2013-04-24 Generating pluripotent cells de novo

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201407768QA SG11201407768QA (en) 2012-04-24 2013-04-24 Generating pluripotent cells de novo

Country Status (10)

Country Link
US (1) US11963977B2 (zh)
EP (2) EP3483261B1 (zh)
JP (4) JP2015516812A (zh)
KR (2) KR20150045935A (zh)
CN (2) CN112048466A (zh)
AU (2) AU2013251649B2 (zh)
CA (1) CA2885576A1 (zh)
RU (1) RU2696071C2 (zh)
SG (2) SG10201809901SA (zh)
WO (1) WO2013163296A1 (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3260140T3 (da) 2011-12-05 2021-04-19 Factor Bioscience Inc Fremgangsmåder og produkter til transficering af celler
RU2711249C2 (ru) 2012-11-01 2020-01-15 Фэктор Байосайенс Инк. Способы и продукты для экспрессии белков в клетках
AU2014209218B2 (en) 2013-01-25 2018-06-07 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
WO2014123242A1 (ja) 2013-02-08 2014-08-14 国立大学法人京都大学 巨核球及び血小板の製造方法
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US9624471B2 (en) 2013-06-12 2017-04-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
KR20220100078A (ko) 2014-01-31 2022-07-14 팩터 바이오사이언스 인크. 핵산 제조 및 송달을 위한 방법 및 산물
CN106459897A (zh) 2014-03-19 2017-02-22 V 细胞治疗公司 与多能细胞有关的方法
KR101798726B1 (ko) * 2014-12-04 2017-11-16 가톨릭관동대학교기술지주 주식회사 에너지를 이용한 다능성 세포 유도 장치 및 방법
WO2016089178A1 (ko) * 2014-12-04 2016-06-09 가톨릭관동대학교산학협력단 에너지를 이용한 다능성 세포 유도 장치 및 방법
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
KR102050852B1 (ko) * 2016-03-11 2019-12-03 주식회사 스템온 세포 리프로그래밍 장치
KR101855967B1 (ko) * 2016-03-11 2018-05-10 가톨릭관동대학교산학협력단 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
WO2017155166A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교기술지주 주식회사 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
WO2017155167A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교산학협력단 세포 리프로그래밍 장치
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CA3033788A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CA3043166A1 (en) * 2016-11-07 2018-05-11 K2 Research Holdings, Llc Production and therapeutic uses of epinul pluripotent cells and differentiated cells derived therefrom
US20200131473A1 (en) * 2017-03-20 2020-04-30 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generating 2 cell-like stem cells
WO2018226435A1 (en) * 2017-06-10 2018-12-13 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CN107729932B (zh) * 2017-10-10 2019-07-26 杭州智微信息科技有限公司 骨髓细胞标记方法和系统
KR102416171B1 (ko) 2018-10-02 2022-07-06 주식회사 스템온 세포의 리프로그래밍을 유도하는 리프로좀 및 그 제조 방법
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
JP2023513632A (ja) * 2020-02-14 2023-03-31 ハッケンサック メリディアン ヘルス インコーポレイテッド 血小板由来ミトコンドリア治療及び多能性細胞の生成方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
FR2687404B1 (fr) 1992-02-19 1994-05-20 Centre Nal Recherc Scientifique Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques.
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5672346A (en) 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
WO1994008598A1 (en) 1992-10-09 1994-04-28 Advanced Tissue Sciences, Inc. Liver reserve cells
US5753431A (en) * 1993-10-13 1998-05-19 Northeastern Ohio University Cholesterol 7 α-hydroxdylase gene regulatory elements and transcription factors
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US20020151050A1 (en) 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
GB0113118D0 (en) 2001-05-31 2001-07-18 Intercytex Ltd Stem Cells
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
US7632681B2 (en) * 2003-12-02 2009-12-15 Celavie Biosciences, Llc Compositions and methods for propagation of neural progenitor cells
EP1789540B9 (en) * 2004-09-03 2012-02-22 Moraga Biotechnology Inc. Non-embryonic totipotent blastomer-like stem cells and methods therefor
US20060084167A1 (en) 2004-10-16 2006-04-20 Cohenford Menashi A Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells
US20090298095A1 (en) * 2005-04-15 2009-12-03 The John Hopkins University Immortalization of cells including neuronal cells
FR2885368A1 (fr) * 2005-05-04 2006-11-10 Fred Zacouto Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees
WO2007030693A2 (en) * 2005-09-08 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for promoting stem cell proliferation and survival
US20070087437A1 (en) 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20070190646A1 (en) * 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
WO2008038148A2 (en) * 2006-05-11 2008-04-03 Andrew Craig Boquest Stem cells and methods of making and using stem cells
US20100135970A1 (en) 2006-10-27 2010-06-03 Caritas St. Elizabeth Medical Center Of Boston, In Methods for Reprogramming Adult Somatic Cells and Uses Thereof
MX348010B (es) 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
WO2009058884A1 (en) * 2007-10-30 2009-05-07 Le Centre Nationale De La Recherche Scientifique Method for conducting an assay for neutralizing antibodies
EP2096169B1 (en) 2007-10-31 2020-11-18 Kyoto University Nuclear reprogramming method
US20090280518A1 (en) * 2008-05-12 2009-11-12 Massachusetts Institute Of Technology System for high throughput measurement of mechanical properties of cells
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
EP2492715B1 (en) * 2009-10-06 2019-01-09 Canon Kabushiki Kaisha Rear attachment lens, imaging optical system, and image pickup apparatus
JPWO2011125948A1 (ja) 2010-04-02 2013-07-11 独立行政法人理化学研究所 Ｅｓ細胞の製造方法
KR20120002134A (ko) 2010-06-30 2012-01-05 서울대학교산학협력단 지방 기질 세포의 역분화를 유도하는 방법
EP3366327B1 (en) 2010-07-09 2022-09-21 GID BIO, Inc. Apparatus and methods relating to collecting and processing human biological material containing adipose

Also Published As

Publication number Publication date
KR20200084916A (ko) 2020-07-13
CN104718283A (zh) 2015-06-17
JP2023002805A (ja) 2023-01-10
US20150110749A1 (en) 2015-04-23
EP3483261A1 (en) 2019-05-15
CN112048466A (zh) 2020-12-08
EP2844738A1 (en) 2015-03-11
KR20150045935A (ko) 2015-04-29
JP2020182480A (ja) 2020-11-12
JP2015516812A (ja) 2015-06-18
SG11201407768QA (en) 2015-01-29
AU2019203943A1 (en) 2019-06-27
AU2013251649B2 (en) 2019-04-04
US11963977B2 (en) 2024-04-23
JP2018183145A (ja) 2018-11-22
EP3483261B1 (en) 2023-11-29
WO2013163296A1 (en) 2013-10-31
AU2013251649A1 (en) 2014-11-06
RU2696071C2 (ru) 2019-07-30
EP2844738A4 (en) 2015-12-23
AU2019203943B2 (en) 2021-10-07
RU2014147093A (ru) 2016-06-10
CA2885576A1 (en) 2013-10-31

Similar Documents

Publication Publication Date Title
SG10201809901SA (en) Generating Pluripotent Cells De Novo
EP2633036A4 (en) METHODS OF DIFFERENTIATION FOR THE PRODUCTION OF GLIAL CELL POPULATIONS
WO2012087965A3 (en) Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
MX2010000348A (es) Cultivo de celulas madre pluripotentes individuales.
WO2010120785A3 (en) Methods and compositions for stem cell cultures
WO2015073683A3 (en) Nuclease-mediated regulation of gene expression
MX353579B (es) Organoide hepatico, sus usos y metodo de cultivo para obtenerlos.
MY183741A (en) Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
MY159971A (en) Multipotent/pluripotent cells and methods
MX2009009371A (es) Produccion mejorada de derivados de acidos grasos.
WO2010111422A3 (en) Induced pluripotent stem cell generation using two factors and p53 inactivation
WO2011130624A3 (en) Sustained polypeptide expression from synthetic, modified rnas and uses thereof
WO2010088633A3 (en) Novel cell lines and methods
WO2012056109A3 (en) Plant derived cell culture material
MX2015005797A (es) Produccion de vacuna recombinante en e.coli mediante conjugacion enzimatica.
SG10201901417UA (en) Production of proteins in glutamine-free cell culture media
SG196784A1 (en) Stem cell cultures
GB2449772A (en) Large scale production of stem cells
RS54073B1 (en) STROMAL MATERIAL CELLS
EP2588594A4 (en) METHODS FOR CULTURING INDIFFERENCED CELLS USING EXTENDED RELEASE COMPOSITIONS
SG10201810830UA (en) Cell culture compositions and methods for polypeptide production
MX2018014043A (es) Composiciones de cultivo celular con antioxidantes y metodos para la produccion de polipeptidos.
MX2012002019A (es) Sistema de placa de pozos profundos con tapa.
EP2582792A4 (en) HEART OF CARDIOMYOCYTES WITH DIALYSATED SERUM
MX366112B (es) Medio de cultivo celular y metodos de produccion de anticuerpos.