SG10201809146QA - Recombinant host cell engineered to overexpress helper proteins - Google Patents

Recombinant host cell engineered to overexpress helper proteins

Info

Publication number
SG10201809146QA
SG10201809146QA SG10201809146QA SG10201809146QA SG10201809146QA SG 10201809146Q A SG10201809146Q A SG 10201809146QA SG 10201809146Q A SG10201809146Q A SG 10201809146QA SG 10201809146Q A SG10201809146Q A SG 10201809146QA SG 10201809146Q A SG10201809146Q A SG 10201809146QA
Authority
SG
Singapore
Prior art keywords
host cell
recombinant host
helper proteins
cell engineered
protein
Prior art date
Application number
SG10201809146QA
Other languages
English (en)
Inventor
Brigitte Gasser
Diethard Mattanovich
Markus Buchetics
Original Assignee
Boehringer Ingelheim Rcv Gmbh
Sandoz Ag
Vtu Tech Gmbh
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Rcv Gmbh, Sandoz Ag, Vtu Tech Gmbh, Lonza Ag filed Critical Boehringer Ingelheim Rcv Gmbh
Publication of SG10201809146QA publication Critical patent/SG10201809146QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201809146QA 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins SG10201809146QA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14165186 2014-04-17

Publications (1)

Publication Number Publication Date
SG10201809146QA true SG10201809146QA (en) 2018-11-29

Family

ID=50513080

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201809146QA SG10201809146QA (en) 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins
SG11201608084TA SG11201608084TA (en) 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201608084TA SG11201608084TA (en) 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins

Country Status (11)

Country Link
US (1) US10865416B2 (cg-RX-API-DMAC7.html)
EP (2) EP3132028B1 (cg-RX-API-DMAC7.html)
JP (2) JP2017511148A (cg-RX-API-DMAC7.html)
KR (1) KR102373954B1 (cg-RX-API-DMAC7.html)
CN (1) CN106661541B (cg-RX-API-DMAC7.html)
AU (1) AU2015248815B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016023304A2 (cg-RX-API-DMAC7.html)
CA (1) CA2948369C (cg-RX-API-DMAC7.html)
IL (1) IL248376B (cg-RX-API-DMAC7.html)
SG (2) SG10201809146QA (cg-RX-API-DMAC7.html)
WO (1) WO2015158808A2 (cg-RX-API-DMAC7.html)

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BR112016023769A2 (pt) 2014-04-17 2017-10-17 Boehringer Ingelheim Rcv Gmbh célula hospedeira recombinante para a expressão de proteínas de interesse
WO2016077457A1 (en) 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
US11479798B2 (en) * 2017-03-29 2022-10-25 Boehringer Ingelheim Rcv Gmbh & Co Kg Recombinant host cell with altered membrane lipid composition
CN109722445A (zh) * 2017-10-27 2019-05-07 成都必高生物科技有限公司 提升溶菌酶产量及活性的方法
SG11202004412RA (en) * 2017-11-20 2020-06-29 Axxence Holding B V Production of a flavour compound in a host cell
MX2020012243A (es) * 2018-05-17 2021-01-29 Bolt Threads Inc Cepas modificadas con sec para una mejor secrecion de proteinas recombinantes.
SG11202012529VA (en) * 2018-06-27 2021-01-28 Boehringer Ingelheim Rcv Gmbh Means and methods for increased protein expression by use of transcription factors
US12091658B2 (en) 2018-09-24 2024-09-17 Orta Dogu Teknik Universitesi Alcohol dehydrogenase 2 (ADH2) promoter variants by promoter engineering
CN109439640B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDSB及其基因和应用
CN109439639B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDPS及其基因和应用
CN111378585B (zh) * 2018-12-28 2023-06-16 丰益(上海)生物技术研发中心有限公司 用于表达外源基因的毕赤酵母突变株
ES2921137T5 (en) * 2019-01-11 2025-05-06 Lonza Ag Carbon-source regulated protein production in a recombinant host cell
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
FI13395Y1 (fi) 2019-07-11 2023-06-06 Clara Foods Co Koostumuksia, jotka käsittävät rekombinanttia ovomukoidiproteiinia
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
WO2021158817A1 (en) * 2020-02-04 2021-08-12 Clara Foods Co. Systems and methods for high yielding recombinant microorganisms and uses thereof
CN111349177B (zh) * 2020-03-13 2022-04-22 西北农林科技大学 一种融合抗菌肽cat的制备方法和应用
CN111607575B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶phta、制备方法和应用
CN111549007B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶tsta、制备方法和应用
KR20230075436A (ko) * 2020-09-30 2023-05-31 론자 리미티드 번역 인자를 과발현하는 숙주 세포
CN113088533B (zh) * 2021-04-15 2023-03-24 华中科技大学 一种高效表达藤壶粘胶蛋白的酵母工程菌及其制备方法
CN113801801B (zh) * 2021-10-08 2023-03-07 枣庄市杰诺生物酶有限公司 一株高效生产碱性果胶酶的重组菌及其应用
CN118147180A (zh) * 2024-05-09 2024-06-07 芝诺(苏州)生物科技有限公司 一种代谢工程改造毕赤酵母合成人乳铁蛋白的方法

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Also Published As

Publication number Publication date
CA2948369A1 (en) 2015-10-22
EP4311857A2 (en) 2024-01-31
KR20170002453A (ko) 2017-01-06
AU2015248815B2 (en) 2021-07-08
EP3132028B1 (en) 2023-10-25
US10865416B2 (en) 2020-12-15
CN106661541B (zh) 2021-09-03
AU2015248815A1 (en) 2016-11-03
IL248376A0 (en) 2016-11-30
JP2017511148A (ja) 2017-04-20
JP7062633B2 (ja) 2022-05-06
EP3132028A2 (en) 2017-02-22
SG11201608084TA (en) 2016-10-28
WO2015158808A2 (en) 2015-10-22
WO2015158808A3 (en) 2016-01-28
IL248376B (en) 2021-04-29
JP2020072696A (ja) 2020-05-14
US20170029827A1 (en) 2017-02-02
KR102373954B1 (ko) 2022-03-14
CA2948369C (en) 2023-09-26
CN106661541A (zh) 2017-05-10
EP4311857A3 (en) 2024-07-31
BR112016023304A2 (pt) 2017-10-17

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