SG10201807524YA - A multi-index detection microfluidic chip and methods of use - Google Patents

A multi-index detection microfluidic chip and methods of use

Info

Publication number
SG10201807524YA
SG10201807524YA SG10201807524YA SG10201807524YA SG10201807524YA SG 10201807524Y A SG10201807524Y A SG 10201807524YA SG 10201807524Y A SG10201807524Y A SG 10201807524YA SG 10201807524Y A SG10201807524Y A SG 10201807524YA SG 10201807524Y A SG10201807524Y A SG 10201807524YA
Authority
SG
Singapore
Prior art keywords
bottom plate
hole
microfluidic chip
detection
main channel
Prior art date
Application number
SG10201807524YA
Other languages
English (en)
Inventor
Lei Wang
Guohao Zhang
Xinying Zhou
Juan Xin
Yao Zhang
Mingxian Lin
Guoliang Huang
Can Wang
Wanli Xing
Jing Cheng
Original Assignee
Capitalbio Corp
Univ Tsinghua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capitalbio Corp, Univ Tsinghua filed Critical Capitalbio Corp
Publication of SG10201807524YA publication Critical patent/SG10201807524YA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
SG10201807524YA 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use SG10201807524YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410082166.2A CN103831140B (zh) 2014-03-07 2014-03-07 一种多指标检测的微流控芯片

Publications (1)

Publication Number Publication Date
SG10201807524YA true SG10201807524YA (en) 2018-09-27

Family

ID=50795220

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201607270PA SG11201607270PA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use
SG10201807524YA SG10201807524YA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201607270PA SG11201607270PA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use

Country Status (6)

Country Link
US (1) US10300483B2 (zh)
EP (1) EP3113886B1 (zh)
JP (1) JP6754701B2 (zh)
CN (1) CN103831140B (zh)
SG (2) SG11201607270PA (zh)
WO (1) WO2015131662A1 (zh)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103831140B (zh) 2014-03-07 2015-12-30 博奥生物集团有限公司 一种多指标检测的微流控芯片
CN104668005B (zh) * 2015-01-23 2017-01-04 北京百康芯生物科技有限公司 一种家用微流控芯片及其使用方法
CN105039597B (zh) * 2015-08-03 2017-11-10 博奥生物集团有限公司 一种用于检测流感病毒的试剂盒及其应用
CN105112559B (zh) * 2015-08-03 2017-12-08 博奥生物集团有限公司 一种用于检测冠状病毒的试剂盒及其应用
CN105039596B (zh) * 2015-08-03 2017-11-10 博奥生物集团有限公司 一种用于检测副流感病毒的试剂盒及其应用
US11331665B2 (en) * 2016-01-18 2022-05-17 The Board Of Trustees Of The Leland Stanford Junior University Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics
CN105483293B (zh) * 2016-01-29 2019-07-16 中国人民解放军疾病预防控制所 烈性传染病病原体检测引物组及试剂盒
CN107398307B (zh) 2016-05-18 2023-07-25 博奥生物集团有限公司 一种集成化微流控芯片
CN106018718A (zh) * 2016-07-21 2016-10-12 武汉市农业科学技术研究院农业环境安全检测研究所 一种多成分食品安全检测微流控芯片
CN106238112B (zh) * 2016-08-27 2019-01-25 宋波 一种微流控芯片及其在病原体的鉴定与药敏实验中的应用
US11478791B2 (en) 2016-09-12 2022-10-25 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US10654038B2 (en) 2016-09-12 2020-05-19 Delta Electronics Int'l (Singapore) Pte Ltd Nucleic acid analysis apparatus
US11376581B2 (en) 2016-09-12 2022-07-05 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
CN106622409B (zh) * 2016-11-07 2019-03-08 北京博奥晶典生物技术有限公司 一种多指标试样分析芯片及其使用方法
CN108212228B (zh) * 2016-12-12 2023-10-17 东莞东阳光科研发有限公司 全血分离微流控芯片、检测装置及全血检测方法
CN107367605A (zh) * 2017-08-17 2017-11-21 武汉璟泓万方堂医药科技股份有限公司 胶体金/荧光试纸芯片
CN107541452B (zh) * 2017-09-20 2023-12-15 杭州梓晶生物有限公司 一种微流控芯片及芯片组件
CN109772480B (zh) * 2017-11-15 2020-11-10 中国科学院青岛生物能源与过程研究所 单个微粒包裹液滴在微流控芯片中形成并分别导出的方法
CN108732370B (zh) * 2018-03-28 2021-07-09 无锡科智达科技有限公司 一种试剂的均分方法
CN110470600B (zh) * 2018-05-11 2024-02-27 中国石油化工股份有限公司 便携式水质多参量检测设备和检测方法
IT201800006083A1 (it) * 2018-06-06 2019-12-06 Dispositivo microfluidico per la concentrazione di particelle tramite centrifugazione, e relativo dispositivo di centrifugazione e/o rilevazione
CN108913563A (zh) * 2018-07-05 2018-11-30 宁夏大学 一种碟式微流控基因芯片及相关试剂盒与用途
CN109030813A (zh) * 2018-07-19 2018-12-18 东莞东阳光科研发有限公司 一种化学发光免疫检测微流控芯片、检测仪及检测方法
CN108760686B (zh) * 2018-08-07 2024-05-14 天津诺迈科技有限公司 散射比浊法检测微流控芯片及使用该芯片的生化免疫机
CN109806920A (zh) * 2019-01-28 2019-05-28 湘潭大学 一种用于自动定量分配、收集和检测的微流控装置及使用方法
CN109894165B (zh) * 2019-03-14 2021-05-18 杭州霆科生物科技有限公司 一种瘦肉精三联检测微流控芯片
CN109894166B (zh) * 2019-03-14 2021-06-22 杭州霆科生物科技有限公司 一种真菌毒素多指标检测微流控芯片
CN109810875A (zh) * 2019-03-28 2019-05-28 苏州点晶生物科技有限公司 一种扇形核酸多联检装置
CN110055354B (zh) * 2019-04-23 2023-11-03 深圳市亚辉龙生物科技股份有限公司 核酸组合物、检测单元、微流控芯片及检测装置
CN110075935B (zh) * 2019-04-23 2020-06-19 清华大学 多指标检测微流控卡盒及应用方法
CN110452802B (zh) * 2019-08-07 2023-09-01 深圳市呈晖医疗科技有限公司 全提取分子诊断微流控芯片及微流控系统
CN110518989B (zh) * 2019-09-10 2022-03-29 深圳市共进电子股份有限公司 校准无线保真模块射频功率的方法、装置、设备及介质
CN110777060A (zh) * 2019-11-14 2020-02-11 北京酷搏科技有限公司 反应管、反应管阵列、控制参与反应的样品体积的方法及其应用
EP3865588A3 (de) * 2020-02-14 2021-09-08 Testo bioAnalytics GmbH Verfahren zum nachweis von mikroorganismen und ein fluidisches kanalsystem
CN111558402B (zh) * 2020-03-10 2021-05-11 青岛英赛特生物科技有限公司 一种气压驱动的离心式微流控检测芯片
CN111218395B (zh) 2020-04-18 2020-08-07 博奥生物集团有限公司 一种全流程生物检测装置
CN111545257B (zh) * 2020-04-23 2021-11-12 成都博奥独立医学实验室有限公司 一种多功能微流控芯片及其制备和应用
CN113009136B (zh) * 2020-08-21 2024-04-05 东莞东阳光医疗智能器件研发有限公司 小型多指标检测样本分析装置
CN112387317B (zh) * 2020-10-15 2023-07-07 上海市第五人民医院 一种快速检测血清Septin 9甲基化的微流控液滴芯片
CN112300940B (zh) * 2020-10-30 2023-06-16 大连医科大学 一种基于微流控技术构建的牙周软组织仿生芯片及其应用
CN112604320B (zh) * 2020-11-30 2022-03-01 青岛理工大学 一种预分散微纳气泡支撑液膜发生器
CN113234570B (zh) * 2021-03-31 2023-01-10 广东产品质量监督检验研究院（国家质量技术监督局广州电气安全检验所、广东省试验认证研究院、华安实验室） 一种检测食品动物源性成分的高通量碟式芯片及检测方法
CN113203723B (zh) * 2021-04-08 2023-01-24 复旦大学 纳米金芯片及其制备方法和应用
CN113862112B (zh) * 2021-09-03 2023-08-15 南昌大学 微流控离心式挤压的细胞转染系统及细胞转染方法
CN114225979B (zh) * 2021-12-06 2023-02-21 天津大学 微流控装置和微流控工作系统
CN114453037B (zh) * 2021-12-24 2023-08-29 广州万孚生物技术股份有限公司 均相测试微流控芯片及检测系统
CN115155678B (zh) * 2022-06-09 2024-02-09 安图实验仪器(郑州)有限公司 一种离心式微流控分析芯片
CN117511721B (zh) * 2024-01-08 2024-03-19 英诺维尔智能科技（苏州）有限公司 一种基于高通量微流控芯片的实时荧光定量pcr仪
CN117884203B (zh) * 2024-03-14 2024-06-07 长春理工大学 一种碟式微流控芯片加样移液装置及方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
JP2004529333A (ja) * 2001-03-19 2004-09-24 ユィロス・アクチボラグ 流体機能を規定する構造ユニット
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US7429354B2 (en) * 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
WO2008106719A1 (en) 2007-03-02 2008-09-12 Corbett Research Pty Ltd Apparatus and method for nucleic acid amplification
US7925647B2 (en) * 2007-07-27 2011-04-12 Oracle International Corporation Techniques for optimizing SQL statements using user-defined indexes with auxiliary properties
KR101335727B1 (ko) * 2007-08-22 2013-12-04 삼성전자주식회사 원심력 기반의 혈액 검사용 디스크형 미세유동장치
KR101416694B1 (ko) * 2008-06-11 2014-07-09 삼성전자 주식회사 회전 가능한 미세유동 디스크를 이용한 시료 분석 장치
JP4572973B2 (ja) 2008-06-16 2010-11-04 ソニー株式会社 マイクロチップ及びマイクロチップにおける送流方法
WO2010113959A1 (ja) * 2009-03-31 2010-10-07 凸版印刷株式会社 試料分析チップ、これを用いた試料分析装置及び試料分析方法並びに試料分析チップの製造方法
TWI523950B (zh) * 2009-09-30 2016-03-01 凸版印刷股份有限公司 核酸分析裝置
US8427093B2 (en) * 2010-07-02 2013-04-23 Woodward Hrt, Inc. Controller for actuation system employing Kalman estimator incorporating effect of system structural stiffness
JP2012185000A (ja) * 2011-03-04 2012-09-27 Toppan Printing Co Ltd 試料分析チップ及びこれを用いた試料分析方法
WO2013077391A1 (ja) * 2011-11-25 2013-05-30 凸版印刷株式会社 試料分析チップ並びに試料分析方法及び遺伝子解析方法
CN102886280B (zh) * 2012-08-28 2014-06-11 博奥生物有限公司 一种微流控芯片及其应用
CN103055973A (zh) 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 一种新型微流控分离芯片及其制备方法
CN103831140B (zh) 2014-03-07 2015-12-30 博奥生物集团有限公司 一种多指标检测的微流控芯片

Also Published As

Publication number Publication date
CN103831140B (zh) 2015-12-30
EP3113886B1 (en) 2019-10-23
US20170014818A1 (en) 2017-01-19
SG11201607270PA (en) 2016-09-29
US10300483B2 (en) 2019-05-28
JP6754701B2 (ja) 2020-09-16
WO2015131662A1 (en) 2015-09-11
EP3113886A1 (en) 2017-01-11
EP3113886A4 (en) 2017-10-25
CN103831140A (zh) 2014-06-04
JP2017514686A (ja) 2017-06-08

Similar Documents

Publication Publication Date Title
SG10201807524YA (en) A multi-index detection microfluidic chip and methods of use
WO2015195949A3 (en) Methods, compositions, and devices for rapid analysis of biological markers
MY190947A (en) Fluid control
PH12019500706A1 (en) Cyclic dinucleotide compounds
MX2018011216A (es) Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t.
WO2015196128A3 (en) Alternative nucleic acid molecules and uses thereof
WO2015196130A3 (en) Alternative nucleic acid molecules and uses thereof
WO2015063552A3 (en) Microfluidic system and method with focused energy apparatus
MX2021003761A (es) Centrifuga compacta de alta velocidad para utilizarse con peque?os volumenes de muestra.
AR087419A1 (es) Metodos para el monitoreo y la modificacion de una corriente de fluido usando dispositivo opticoanaliticos
PH12016501985A1 (en) Rapid set aqueous coatings
WO2016079731A3 (en) Method of analyzing microbiome
EA201791300A1 (ru) Флюидные системы, содержащие канал инкубации, включающие в себя флюидные системы, образованные литьевым формованием
EA201891667A1 (ru) Сепаратор низкого давления, имеющий внутренний разделитель, и его применение
WO2014171947A3 (en) Device and method for parallel microfluidic pressure-volume-temperature analysis
EP4357753A3 (en) Sample isolation kit, sample isolation device
TW201614209A (en) Collection component and sample processing kit having the same
EP2656762A3 (de) Trockner, insbesondere Handtrockner
EP3029012A3 (de) Vorrichtung zur gesteuerten initiierung der deflagration einer sprengladung
CA3026561C (en) Injectable compositions
EP2942540A3 (en) Piston housing system and apparatus
WO2016075534A3 (en) Gas/liquid mixing apparatus
IT201700030715A1 (it) Procedimento per determinare la capacità antiossidante di un campione biologico e relativo kit.
CL2016002391A1 (es) Ensamble de filtro.
EP3461279A4 (en) FLUID ANALYSIS TOOL AND METHOD OF USING THE SAME