SG11201607270PA - A multi-index detection microfluidic chip and methods of use - Google Patents

A multi-index detection microfluidic chip and methods of use

Info

Publication number
SG11201607270PA
SG11201607270PA SG11201607270PA SG11201607270PA SG11201607270PA SG 11201607270P A SG11201607270P A SG 11201607270PA SG 11201607270P A SG11201607270P A SG 11201607270PA SG 11201607270P A SG11201607270P A SG 11201607270PA SG 11201607270P A SG11201607270P A SG 11201607270PA
Authority
SG
Singapore
Prior art keywords
methods
microfluidic chip
index detection
detection microfluidic
index
Prior art date
Application number
SG11201607270PA
Inventor
Lei Wang
Guohao Zhang
Xinying Zhou
Juan Xin
Yao Zhang
Mingxian Lin
Guoliang Huang
Can Wang
Wanli Xing
Jing Cheng
Original Assignee
Capitalbio Corp
Univ Tsinghua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capitalbio Corp, Univ Tsinghua filed Critical Capitalbio Corp
Publication of SG11201607270PA publication Critical patent/SG11201607270PA/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/025Align devices or objects to ensure defined positions relative to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0851Bottom walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0893Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
SG11201607270PA 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use SG11201607270PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410082166.2A CN103831140B (en) 2014-03-07 2014-03-07 A kind of micro-fluidic chip of multiple determination
PCT/CN2015/000141 WO2015131662A1 (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use

Publications (1)

Publication Number Publication Date
SG11201607270PA true SG11201607270PA (en) 2016-09-29

Family

ID=50795220

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201607270PA SG11201607270PA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use
SG10201807524YA SG10201807524YA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201807524YA SG10201807524YA (en) 2014-03-07 2015-03-06 A multi-index detection microfluidic chip and methods of use

Country Status (6)

Country Link
US (1) US10300483B2 (en)
EP (1) EP3113886B1 (en)
JP (1) JP6754701B2 (en)
CN (1) CN103831140B (en)
SG (2) SG11201607270PA (en)
WO (1) WO2015131662A1 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103831140B (en) 2014-03-07 2015-12-30 博奥生物集团有限公司 A kind of micro-fluidic chip of multiple determination
CN104668005B (en) * 2015-01-23 2017-01-04 北京百康芯生物科技有限公司 A kind of domestic micro-fluidic chip and using method thereof
CN105039597B (en) * 2015-08-03 2017-11-10 博奥生物集团有限公司 A kind of kit and its application for being used to detect influenza virus
CN105112559B (en) * 2015-08-03 2017-12-08 博奥生物集团有限公司 A kind of kit and its application for being used to detect coronavirus
CN105039596B (en) * 2015-08-03 2017-11-10 博奥生物集团有限公司 A kind of kit and its application for being used to detect parainfluenza virus
US11331665B2 (en) * 2016-01-18 2022-05-17 The Board Of Trustees Of The Leland Stanford Junior University Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics
CN105483293B (en) * 2016-01-29 2019-07-16 中国人民解放军疾病预防控制所 Deadly infectious disease pathogen detection primer sets and kit
CN107398307B (en) 2016-05-18 2023-07-25 博奥生物集团有限公司 Integrated micro-fluidic chip
CN106018718A (en) * 2016-07-21 2016-10-12 武汉市农业科学技术研究院农业环境安全检测研究所 Multi-component food safety detection microfluidic chip
CN106238112B (en) * 2016-08-27 2019-01-25 宋波 A kind of micro-fluidic chip and its application in the identification and drug sensitive experiment of pathogen
US11478791B2 (en) 2016-09-12 2022-10-25 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US10654038B2 (en) 2016-09-12 2020-05-19 Delta Electronics Int'l (Singapore) Pte Ltd Nucleic acid analysis apparatus
US11376581B2 (en) 2016-09-12 2022-07-05 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
CN106622409B (en) * 2016-11-07 2019-03-08 北京博奥晶典生物技术有限公司 A kind of multi objective sample analysis chip and its application method
CN108212228B (en) * 2016-12-12 2023-10-17 东莞东阳光科研发有限公司 Whole blood separation micro-fluidic chip, detection device and whole blood detection method
CN107367605A (en) * 2017-08-17 2017-11-21 武汉璟泓万方堂医药科技股份有限公司 Collaurum/fluorescent test paper chip
CN107541452B (en) * 2017-09-20 2023-12-15 杭州梓晶生物有限公司 Microfluidic chip and chip assembly
CN109772480B (en) * 2017-11-15 2020-11-10 中国科学院青岛生物能源与过程研究所 Method for forming and respectively guiding single particle-wrapped liquid drops in microfluidic chip
CN108732370B (en) * 2018-03-28 2021-07-09 无锡科智达科技有限公司 Reagent averaging method
CN110470600B (en) * 2018-05-11 2024-02-27 中国石油化工股份有限公司 Portable water quality multi-parameter detection equipment and detection method
IT201800006083A1 (en) * 2018-06-06 2019-12-06 MICROFLUIDIC DEVICE FOR THE CONCENTRATION OF PARTICLES THROUGH CENTRIFUGATION, AND RELATED CENTRIFUGATION AND / OR DETECTION DEVICE
CN108913563A (en) * 2018-07-05 2018-11-30 宁夏大学 A kind of micro-fluidic genetic chip of dish-style and related kit and purposes
CN109030813A (en) * 2018-07-19 2018-12-18 东莞东阳光科研发有限公司 A kind of chemiluminescence immunoassay detection micro-fluidic chip, detector and detection method
CN108760686B (en) * 2018-08-07 2024-05-14 天津诺迈科技有限公司 Micro-fluidic chip for detecting turbidimetry and biochemical immunity machine using same
CN109806920A (en) * 2019-01-28 2019-05-28 湘潭大学 A kind of micro fluidic device and application method for automatic ration distribution, collection and detection
CN109894165B (en) * 2019-03-14 2021-05-18 杭州霆科生物科技有限公司 Clenbuterol triple detection micro-fluidic chip
CN109894166B (en) * 2019-03-14 2021-06-22 杭州霆科生物科技有限公司 Mycotoxin multi-index detection micro-fluidic chip
CN109810875A (en) * 2019-03-28 2019-05-28 苏州点晶生物科技有限公司 A kind of multi-joint checking device of sector nucleic acid
CN110055354B (en) * 2019-04-23 2023-11-03 深圳市亚辉龙生物科技股份有限公司 Nucleic acid composition, detection unit, microfluidic chip and detection device
CN110075935B (en) * 2019-04-23 2020-06-19 清华大学 Multi-index detection microfluidic card box and application method
CN110452802B (en) * 2019-08-07 2023-09-01 深圳市呈晖医疗科技有限公司 Full-extraction molecular diagnosis microfluidic chip and microfluidic system
CN110518989B (en) * 2019-09-10 2022-03-29 深圳市共进电子股份有限公司 Method, apparatus, device and medium for calibrating radio frequency power of wireless fidelity module
CN110777060A (en) * 2019-11-14 2020-02-11 北京酷搏科技有限公司 Reaction tube, reaction tube array, method for controlling volume of sample participating in reaction and application of method
EP3865588A3 (en) * 2020-02-14 2021-09-08 Testo bioAnalytics GmbH Method for detecting microorganisms and a fluidic channel system
CN111558402B (en) * 2020-03-10 2021-05-11 青岛英赛特生物科技有限公司 Air pressure driven centrifugal micro-fluidic detection chip
CN111218395B (en) 2020-04-18 2020-08-07 博奥生物集团有限公司 Full-flow biological detection device
CN111545257B (en) * 2020-04-23 2021-11-12 成都博奥独立医学实验室有限公司 Multifunctional micro-fluidic chip and preparation and application thereof
CN113009136B (en) * 2020-08-21 2024-04-05 东莞东阳光医疗智能器件研发有限公司 Small multi-index detection sample analysis device
CN112387317B (en) * 2020-10-15 2023-07-07 上海市第五人民医院 Microfluidic liquid drop chip for rapidly detecting serum Septin9 methylation
CN112300940B (en) * 2020-10-30 2023-06-16 大连医科大学 Periodontal soft tissue bionic chip constructed based on microfluidic technology and application thereof
CN112604320B (en) * 2020-11-30 2022-03-01 青岛理工大学 Pre-dispersion micro-nano bubble supported liquid film generator
CN113234570B (en) * 2021-03-31 2023-01-10 广东产品质量监督检验研究院(国家质量技术监督局广州电气安全检验所、广东省试验认证研究院、华安实验室) High-flux disc type chip for detecting animal-derived ingredients of food and detection method
CN113203723B (en) * 2021-04-08 2023-01-24 复旦大学 Nano gold chip and preparation method and application thereof
CN113862112B (en) * 2021-09-03 2023-08-15 南昌大学 Microfluidic centrifugal extrusion cell transfection system and cell transfection method
CN114225979B (en) * 2021-12-06 2023-02-21 天津大学 Microfluidic device and microfluidic working system
CN114453037B (en) * 2021-12-24 2023-08-29 广州万孚生物技术股份有限公司 Homogeneous phase test micro-fluidic chip and detection system
CN115155678B (en) * 2022-06-09 2024-02-09 安图实验仪器(郑州)有限公司 Centrifugal microfluidic analysis chip
CN117511721B (en) * 2024-01-08 2024-03-19 英诺维尔智能科技(苏州)有限公司 Real-time fluorescence quantitative PCR instrument based on high-flux microfluidic chip
CN117884203B (en) * 2024-03-14 2024-06-07 长春理工大学 Dish-type microfluidic chip sample adding and pipetting device and method

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
JP2004529333A (en) * 2001-03-19 2004-09-24 ユィロス・アクチボラグ Structural unit that defines fluid function
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US7429354B2 (en) * 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
WO2008106719A1 (en) 2007-03-02 2008-09-12 Corbett Research Pty Ltd Apparatus and method for nucleic acid amplification
US7925647B2 (en) * 2007-07-27 2011-04-12 Oracle International Corporation Techniques for optimizing SQL statements using user-defined indexes with auxiliary properties
KR101335727B1 (en) * 2007-08-22 2013-12-04 삼성전자주식회사 Centrifugal force-based disk type microfluidic device for blood chemistry analysis
KR101416694B1 (en) * 2008-06-11 2014-07-09 삼성전자 주식회사 Analysing apparatus using rotatable microfluidic disk
JP4572973B2 (en) 2008-06-16 2010-11-04 ソニー株式会社 Microchip and flow-feeding method in microchip
WO2010113959A1 (en) * 2009-03-31 2010-10-07 凸版印刷株式会社 Sample analysis chip, sample analyzer using sample analysis chip, sample analysis method, and method of producing sample analysis chip
TWI523950B (en) * 2009-09-30 2016-03-01 凸版印刷股份有限公司 Nucleic acid analysis apparatus
US8427093B2 (en) * 2010-07-02 2013-04-23 Woodward Hrt, Inc. Controller for actuation system employing Kalman estimator incorporating effect of system structural stiffness
JP2012185000A (en) * 2011-03-04 2012-09-27 Toppan Printing Co Ltd Sample analysis chip and sample analysis method using the same
WO2013077391A1 (en) * 2011-11-25 2013-05-30 凸版印刷株式会社 Sample analysis chip, sample analysis method, and gene analysis method
CN102886280B (en) * 2012-08-28 2014-06-11 博奥生物有限公司 Microfluidic chip and application thereof
CN103055973A (en) 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 Novel micro-fluidic separating chip and preparation method thereof
CN103831140B (en) 2014-03-07 2015-12-30 博奥生物集团有限公司 A kind of micro-fluidic chip of multiple determination

Also Published As

Publication number Publication date
CN103831140B (en) 2015-12-30
EP3113886B1 (en) 2019-10-23
US20170014818A1 (en) 2017-01-19
US10300483B2 (en) 2019-05-28
JP6754701B2 (en) 2020-09-16
WO2015131662A1 (en) 2015-09-11
EP3113886A1 (en) 2017-01-11
EP3113886A4 (en) 2017-10-25
CN103831140A (en) 2014-06-04
SG10201807524YA (en) 2018-09-27
JP2017514686A (en) 2017-06-08

Similar Documents

Publication Publication Date Title
SG11201607270PA (en) A multi-index detection microfluidic chip and methods of use
IL293715A (en) Automated detection and repositioning of microobjects in microfluidic devices
IL279606A (en) Anti-trem2 antibodies and methods of use thereof
HK1244465A1 (en) Automated detection of assay-positive areas in microfluidic devices
HK1244874A1 (en) Automated detection and repositioning of micro-objects in microfluidic devices
HK1243102A1 (en) Anti-cd79b antibodies and methods of use
IL250415B (en) Anti-pdl- antibodies and methods of use thereof
HRP20181359T1 (en) Anti-jagged1 antibodies and methods of use
IL251868B (en) Anti-tim3 antibodies and methods of use
GB201802050D0 (en) Microfluidic devices and methods of use thereof
HK1243072A1 (en) Bromodomain inhibitors and uses thereof
HK1258244A1 (en) Fluidic analysis and separation
SG11201608425RA (en) Separation and storage of fluids using itq-55
IL251165A0 (en) Anti-il-1beta antibodies and methods of use
IL253234B (en) Methods of transdifferentiation and methods of use thereof
GB201417048D0 (en) Occupancy-control device and methods of use
IL251286A0 (en) Anti-pdgf-b antibodies and methods of use
IL247919A0 (en) Device for detection of disease states and applications of same
GB201401219D0 (en) Detection device and assay
GB201416797D0 (en) Contianer and method of use thereof