SG10201804124XA - Recombinant cell surface capture proteins - Google Patents

Recombinant cell surface capture proteins

Info

Publication number
SG10201804124XA
SG10201804124XA SG10201804124XA SG10201804124XA SG10201804124XA SG 10201804124X A SG10201804124X A SG 10201804124XA SG 10201804124X A SG10201804124X A SG 10201804124XA SG 10201804124X A SG10201804124X A SG 10201804124XA SG 10201804124X A SG10201804124X A SG 10201804124XA
Authority
SG
Singapore
Prior art keywords
cell surface
domain
recombinant cell
surface capture
proteins
Prior art date
Application number
SG10201804124XA
Other languages
English (en)
Inventor
Dipali Deshpande
Gang Chen
Darya Burakov
James Fandl
Thomas Aldrich
Vishal Kamat
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201804124XA publication Critical patent/SG10201804124XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SG10201804124XA 2012-11-14 2013-11-14 Recombinant cell surface capture proteins SG10201804124XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261726040P 2012-11-14 2012-11-14

Publications (1)

Publication Number Publication Date
SG10201804124XA true SG10201804124XA (en) 2018-07-30

Family

ID=49679651

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502629TA SG11201502629TA (en) 2012-11-14 2013-11-14 Recombinant cell surface capture proteins
SG10201804124XA SG10201804124XA (en) 2012-11-14 2013-11-14 Recombinant cell surface capture proteins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201502629TA SG11201502629TA (en) 2012-11-14 2013-11-14 Recombinant cell surface capture proteins

Country Status (20)

Country Link
US (3) US9758592B2 (xx)
EP (2) EP2949667B1 (xx)
JP (2) JP6668074B2 (xx)
KR (4) KR20230119245A (xx)
CN (2) CN109485728A (xx)
AR (2) AR093491A1 (xx)
AU (3) AU2013344769B2 (xx)
BR (1) BR112015010758A2 (xx)
CA (2) CA2889541C (xx)
DK (2) DK2949667T3 (xx)
EA (2) EA037546B1 (xx)
ES (2) ES2817373T3 (xx)
HK (2) HK1211036A1 (xx)
IL (3) IL238176B (xx)
MX (2) MX2015006112A (xx)
PL (2) PL2949667T3 (xx)
SG (2) SG11201502629TA (xx)
TW (3) TW202206465A (xx)
WO (1) WO2014078475A2 (xx)
ZA (1) ZA201502538B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
US9242014B2 (en) 2010-06-15 2016-01-26 The Regents Of The University Of California Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
DK2663579T3 (en) 2011-01-14 2017-07-31 Univ California THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF
EP3838923B1 (en) 2012-08-24 2024-05-01 The Regents of The University of California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
TW202206465A (zh) 2012-11-14 2022-02-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
EA038931B9 (ru) * 2014-11-20 2022-02-18 Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений
AU2016261854B2 (en) 2015-05-12 2022-05-26 Regeneron Pharmaceuticals, Inc. Multimeric protein purity determination
IL258009B2 (en) 2015-09-15 2024-03-01 Univ Texas Antibodies that bind receptors on T cells (TCR) and their use
TW201803981A (zh) 2016-04-20 2018-02-01 再生元醫藥公司 用於以使用增強表現基因座爲基礎製造抗體之組成物及方法
MX2018012868A (es) 2016-04-20 2019-03-11 Regeneron Pharma Composiciones y metodos para generar anticuerpos basado en el uso de loci potenciadores de expresion.
SG11201811559WA (en) 2016-06-27 2019-01-30 Univ California Cancer treatment combinations
CA3056249A1 (en) 2017-03-24 2018-09-27 Lankenau Institute For Medical Research Methods and compositions for inducible extracellular membrane capture of monoclonal immunoglobulins secreted by hybridomas
CN107177613A (zh) * 2017-07-18 2017-09-19 哈尔滨紫霞生物科技有限公司 一种提高重组猪干扰素‑γ融合蛋白抗病毒活性的方法
TW201925233A (zh) * 2017-12-07 2019-07-01 日商中外製藥股份有限公司 抗體、用於在樣品中偵測或捕捉多肽的組成物以及在樣品中偵測或捕捉多肽的方法
EP3856910A4 (en) * 2018-09-24 2022-09-28 Merck Sharp & Dohme Corp. EXPRESSION VECTORS FOR EUKARYOT EXPRESSION SYSTEMS
US20220144916A1 (en) * 2019-02-12 2022-05-12 Board Of Regents, The University Of Texas System High affinity engineered t-cell receptors targeting cmv infected cells
CN114874333A (zh) * 2021-10-18 2022-08-09 深圳科兴药业有限公司 一种生长激素融合蛋白及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151350A (en) * 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
US5635354A (en) 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system
US6399368B1 (en) 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
US6080840A (en) 1992-01-17 2000-06-27 Slanetz; Alfred E. Soluble T cell receptors
AU679949B2 (en) 1992-10-21 1997-07-17 Stefan Miltenyi Direct selection of cells by secretion product
US6482655B1 (en) 1993-07-23 2002-11-19 University Of Utah Research Foundation Immunoassay procedure utilizing fluorogenic tracer antigens
US6287784B1 (en) 1993-11-23 2001-09-11 Genentech, Inc. Kinase receptor activation assay
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
BRPI9715219B8 (pt) 1996-02-09 2015-07-07 Abbvie Biotechnology Ltd Vetor recombinante de expressão, e célula hospedeira procariótica.
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
WO1999058977A1 (en) 1998-05-11 1999-11-18 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific t cells
DE69931776T2 (de) 1998-05-20 2007-05-16 Chugai Seiyaku K.K. Verfahren zur klonierung von genen
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
DE19900635A1 (de) 1999-01-11 2000-07-13 Deutsches Krebsforsch Selektion von monoklonalen Antikörpern
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7138496B2 (en) 2002-02-08 2006-11-21 Genetastix Corporation Human monoclonal antibodies against human CXCR4
EP1392859B1 (en) 2001-01-16 2006-05-10 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20140072980A1 (en) 2001-01-16 2014-03-13 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20140072979A1 (en) 2001-01-16 2014-03-13 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
ES2309167T3 (es) 2001-02-19 2008-12-16 Merck Patent Gmbh Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida.
PL208712B1 (pl) 2001-08-31 2011-05-31 Avidex Ltd Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd
EP2093286B1 (en) 2001-10-01 2013-02-27 Dyax Corporation Multi-chain eukaryotic display vectors and uses thereof
EP1888649A2 (en) * 2005-05-09 2008-02-20 GlycArt Biotechnology AG Antigen binding molecules having modified fc regions and altered binding to fc receptors
ES2527297T3 (es) * 2007-07-31 2015-01-22 Regeneron Pharmaceuticals, Inc. Anticuerpos humanos para CD20 humano y método para utilizar los mismos
CN103833855A (zh) * 2009-06-26 2014-06-04 瑞泽恩制药公司 容易地分离的具有天然免疫球蛋白形式的双特异性抗体
CA2785414C (en) 2009-12-25 2019-01-22 Tomoyuki Igawa Polypeptide modification method for purifying polypeptide multimers
TW202206465A (zh) 2012-11-14 2022-02-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質

Also Published As

Publication number Publication date
EP2949667B1 (en) 2020-05-13
TW201439121A (zh) 2014-10-16
KR20210014766A (ko) 2021-02-09
HK1214612A1 (zh) 2016-07-29
EP2949667A2 (en) 2015-12-02
AU2021202371A1 (en) 2021-05-13
AU2018253474A1 (en) 2018-11-15
JP6668074B2 (ja) 2020-03-18
KR20150084028A (ko) 2015-07-21
BR112015010758A2 (pt) 2017-08-22
DK2920208T3 (da) 2020-09-14
IL238176B (en) 2020-06-30
EA201590928A1 (ru) 2015-09-30
IL275270A (en) 2020-07-30
KR20230119245A (ko) 2023-08-16
PL2949667T3 (pl) 2020-11-16
KR102563030B1 (ko) 2023-08-03
IL238176A0 (en) 2015-05-31
WO2014078475A2 (en) 2014-05-22
DK2949667T3 (da) 2020-07-20
TWI675044B (zh) 2019-10-21
CN104797598A (zh) 2015-07-22
US20140134719A1 (en) 2014-05-15
EP2949667A3 (en) 2016-02-24
CN104797598B (zh) 2018-12-11
MX2019015887A (es) 2020-02-07
CN109485728A (zh) 2019-03-19
TWI745610B (zh) 2021-11-11
ES2805526T3 (es) 2021-02-12
MX2015006112A (es) 2015-08-06
CA3204343A1 (en) 2014-05-22
JP2015536345A (ja) 2015-12-21
KR20220025902A (ko) 2022-03-03
JP2019023199A (ja) 2019-02-14
US20180118852A1 (en) 2018-05-03
JP6856593B2 (ja) 2021-04-07
CA2889541C (en) 2023-07-04
AR121002A2 (es) 2022-04-06
EA037546B1 (ru) 2021-04-12
IL285015A (en) 2021-08-31
WO2014078475A3 (en) 2014-11-20
EP2920208B1 (en) 2020-08-19
HK1211036A1 (en) 2016-05-13
CA2889541A1 (en) 2014-05-22
US20210009714A1 (en) 2021-01-14
AR093491A1 (es) 2015-06-10
TW201920289A (zh) 2019-06-01
EP2920208A2 (en) 2015-09-23
AU2013344769A1 (en) 2015-05-21
ES2817373T3 (es) 2021-04-07
PL2920208T3 (pl) 2021-02-08
US9758592B2 (en) 2017-09-12
TW202206465A (zh) 2022-02-16
EA202190266A1 (ru) 2021-07-30
SG11201502629TA (en) 2015-05-28
IL275270B (en) 2021-08-31
AU2018253474B2 (en) 2021-01-21
ZA201502538B (en) 2017-09-27
AU2013344769B2 (en) 2018-11-15

Similar Documents

Publication Publication Date Title
SG10201804124XA (en) Recombinant cell surface capture proteins
IL222507A0 (en) Heterodimeric antibody fc-containing proteins and methods for production thereof
WO2013142859A3 (en) Fusion proteins of superfolder green fluorescent protein and use thereof
WO2013040142A3 (en) Bioinformatic processes for determination of peptide binding
WO2011100566A3 (en) Methods for identifying and isolating cells expressing a polypeptide
WO2015038884A3 (en) Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
WO2014200910A3 (en) Bioinformatic processes for determination of peptide binding
WO2012064836A9 (en) Methods and compositions for neural disease immunotherapy
WO2013136186A3 (en) Readily isolated bispecific antibodies with native immunoglobulin format
EA201171148A1 (ru) Антитело-антагонист, специфичное для гетеродимера альфа-4-бета-7
GB201108236D0 (en) Method
PH12017500489A1 (en) Human-derived anti-dipeptide repeats (dprs) antibody
MX336109B (es) Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo.
MX2015003150A (es) Anticuerpos específicos de polipeptido amiloide de islote humano (hiapp) y sus usos.
WO2012009704A3 (en) Novel peptides and uses thereof
MX353464B (es) Antigenos tpn47 de treponema pallidum, inmunoreactivos, solubles.
WO2011127001A3 (en) Quantum dot-based optical sensors for rapid detection and quantitative analysis of biomolecules and biological materials
WO2011050985A8 (en) Clonal expansion of b cells
WO2011137389A3 (en) Compositions and methods for reliably detecting and/or measuring the amount of a modified target protein in a sample
WO2011055897A3 (en) Fusion protein binding specifically to constant region of antibody, preparation thereof and method for isolating antibody using the same
WO2011116209A3 (en) Using phage epitopes to profile the immune response
PT2284188E (pt) Detecção de anticorpos anti-proteína p ribossómica por meio de péptidos sintéticos
WO2012121911A3 (en) Cd16a reporter assay for evaluation of adcc potential of biologics
WO2012170078A3 (en) Peptide capture and characterization
MX2013014008A (es) Anticuerpo que se aglutina a un polipeptido del transportador a1 del casete de aglutinacion a adenosin trifosfato (atp) (abca 1).