SG10201707632PA - Purification of rapamycin derivatives - Google Patents
Purification of rapamycin derivativesInfo
- Publication number
- SG10201707632PA SG10201707632PA SG10201707632PA SG10201707632PA SG10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA SG 10201707632P A SG10201707632P A SG 10201707632PA
- Authority
- SG
- Singapore
- Prior art keywords
- purification
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361799857P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201707632PA true SG10201707632PA (en) | 2017-11-29 |
Family
ID=51538094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507406YA SG11201507406YA (en) | 2013-03-15 | 2014-03-17 | Purification of rapamycin derivatives |
| SG10201707632PA SG10201707632PA (en) | 2013-03-15 | 2014-03-17 | Purification of rapamycin derivatives |
| SG10202112135VA SG10202112135VA (en) | 2013-03-15 | 2014-03-17 | Purification of rapamycin derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507406YA SG11201507406YA (en) | 2013-03-15 | 2014-03-17 | Purification of rapamycin derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202112135VA SG10202112135VA (en) | 2013-03-15 | 2014-03-17 | Purification of rapamycin derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9598439B2 (ja) |
| EP (1) | EP2972258B1 (ja) |
| JP (4) | JP2016519086A (ja) |
| CN (2) | CN108864149B (ja) |
| CA (1) | CA2901162C (ja) |
| ES (1) | ES2897473T3 (ja) |
| HK (1) | HK1218959A1 (ja) |
| SG (3) | SG11201507406YA (ja) |
| WO (1) | WO2014145780A1 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010313105B2 (en) | 2009-11-02 | 2015-02-26 | Pulse Therapeutics, Inc. | Magnetomotive stator system and methods for wireless control of magnetic rotors |
| ES2897473T3 (es) | 2013-03-15 | 2022-03-01 | Biosensors Int Group Ltd | Purificación de derivados de la rapamicina |
| CN109851626B (zh) * | 2019-01-08 | 2021-11-02 | 扬子江药业集团四川海蓉药业有限公司 | 一种替西罗莫司的分离纯化方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| US20060198867A1 (en) * | 1997-09-25 | 2006-09-07 | Abbott Laboratories, Inc. | Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy |
| US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
| TR200500302T3 (tr) * | 2003-03-31 | 2005-04-21 | Biogal Gyogyszergyar Rt. | Makrolidlerin kristalizasyonu ve saflaştırılması. |
| US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| WO2005054253A1 (en) * | 2003-12-05 | 2005-06-16 | Biocon Limited | Process for the purification of macrolides |
| JP4716280B2 (ja) * | 2004-03-01 | 2011-07-06 | テルモ株式会社 | Ｏ−アルキル化ラパマイシン誘導体の製造法 |
| WO2005105811A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Regiospecific synthesis of rapamycin 42-ester derivatives |
| WO2006060614A1 (en) | 2004-12-01 | 2006-06-08 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Methods for preparing pimecrolimus |
| CN101133065A (zh) * | 2005-03-02 | 2008-02-27 | 惠氏公司 | 雷帕霉素的纯化 |
| US20060222627A1 (en) * | 2005-03-30 | 2006-10-05 | Andrew Carter | Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue |
| AR058283A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido |
| US7700614B2 (en) * | 2005-12-14 | 2010-04-20 | Abbott Laboratories | One pot synthesis of tetrazole derivatives of rapamycin |
| GB0601406D0 (en) * | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
| BRPI0708562A2 (pt) | 2006-03-07 | 2011-06-07 | Wyeth Corp | processos para preparar conjugados de polietileno glicor de macrolìdeos imunossupressores, um macrolìdeo imunossupressor peguilado, uma rapamicina peguilada, um everolimus peguilado, um cci-779 peguilado e um tacrolimus peguilado, e, produto |
| US7820812B2 (en) * | 2006-07-25 | 2010-10-26 | Abbott Laboratories | Methods of manufacturing crystalline forms of rapamycin analogs |
| US7812032B2 (en) * | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
| KR20090080110A (ko) * | 2006-11-10 | 2009-07-23 | 바이오콘 리미티드 | 순수형태의 라파마이신 그리고 그의 회수 및 정제 방법 |
| CN101522691B (zh) * | 2006-11-27 | 2012-08-22 | 泰尔茂株式会社 | O-烷基化雷帕霉素衍生物的制备方法及o-烷基化雷帕霉素衍生物 |
| US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
| CN101077334A (zh) * | 2007-06-29 | 2007-11-28 | 济南康泉医药科技有限公司 | 含酪氨酸激酶抑制剂的抗癌组合物 |
| TW200948361A (en) | 2008-05-26 | 2009-12-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Method for synthesizing Biolimus A9 and the like and method for improving stability of the same |
| US20100055145A1 (en) * | 2008-08-29 | 2010-03-04 | Biosensors International Group | Stent coatings for reducing late stent thrombosis |
| WO2010124098A2 (en) | 2009-04-24 | 2010-10-28 | Boston Scientific Scimed, Inc. | Use of drug polymorphs to achieve controlled drug delivery from a coated medical device |
| CN102464669B (zh) * | 2010-11-17 | 2014-04-16 | 浙江海正药业股份有限公司 | 无定形依维莫司及其制备方法 |
| WO2013022458A1 (en) * | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| CN102786534A (zh) * | 2012-05-25 | 2012-11-21 | 上海现代制药股份有限公司 | 一种依维莫司的制备方法 |
| ES2897473T3 (es) | 2013-03-15 | 2022-03-01 | Biosensors Int Group Ltd | Purificación de derivados de la rapamicina |
-
2014
- 2014-03-17 ES ES14763326T patent/ES2897473T3/es active Active
- 2014-03-17 CN CN201811056060.XA patent/CN108864149B/zh active Active
- 2014-03-17 WO PCT/US2014/030602 patent/WO2014145780A1/en active Application Filing
- 2014-03-17 SG SG11201507406YA patent/SG11201507406YA/en unknown
- 2014-03-17 EP EP14763326.7A patent/EP2972258B1/en active Active
- 2014-03-17 CN CN201480013252.6A patent/CN105102967B/zh active Active
- 2014-03-17 JP JP2016503426A patent/JP2016519086A/ja not_active Withdrawn
- 2014-03-17 CA CA2901162A patent/CA2901162C/en active Active
- 2014-03-17 SG SG10201707632PA patent/SG10201707632PA/en unknown
- 2014-03-17 SG SG10202112135VA patent/SG10202112135VA/en unknown
-
2015
- 2015-09-14 US US14/853,711 patent/US9598439B2/en active Active
-
2016
- 2016-06-17 HK HK16107001.4A patent/HK1218959A1/zh unknown
-
2017
- 2017-02-02 US US15/422,593 patent/US10202402B2/en active Active
-
2018
- 2018-12-18 US US16/224,140 patent/US10597406B2/en active Active
-
2019
- 2019-03-07 JP JP2019041615A patent/JP2019089848A/ja active Pending
-
2020
- 2020-03-02 US US16/806,770 patent/US11046711B2/en active Active
-
2021
- 2021-05-06 JP JP2021078418A patent/JP2021121601A/ja active Pending
- 2021-06-28 US US17/360,973 patent/US11780850B2/en active Active
-
2023
- 2023-08-25 JP JP2023136964A patent/JP2023164476A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202112135VA (en) | 2021-12-30 |
| CN105102967A (zh) | 2015-11-25 |
| US11780850B2 (en) | 2023-10-10 |
| JP2023164476A (ja) | 2023-11-10 |
| EP2972258A4 (en) | 2016-12-21 |
| ES2897473T3 (es) | 2022-03-01 |
| EP2972258B1 (en) | 2021-08-04 |
| EP2972258A1 (en) | 2016-01-20 |
| JP2019089848A (ja) | 2019-06-13 |
| SG11201507406YA (en) | 2015-10-29 |
| JP2021121601A (ja) | 2021-08-26 |
| US20160002262A1 (en) | 2016-01-07 |
| US10202402B2 (en) | 2019-02-12 |
| US11046711B2 (en) | 2021-06-29 |
| CN108864149A (zh) | 2018-11-23 |
| US20220024947A1 (en) | 2022-01-27 |
| HK1218959A1 (zh) | 2017-03-17 |
| JP2016519086A (ja) | 2016-06-30 |
| CN108864149B (zh) | 2022-04-05 |
| US9598439B2 (en) | 2017-03-21 |
| US20170334928A1 (en) | 2017-11-23 |
| CA2901162C (en) | 2021-06-01 |
| US20200270272A1 (en) | 2020-08-27 |
| WO2014145780A4 (en) | 2014-11-20 |
| CN105102967B (zh) | 2018-10-12 |
| CA2901162A1 (en) | 2014-09-18 |
| WO2014145780A1 (en) | 2014-09-18 |
| US10597406B2 (en) | 2020-03-24 |
| US20190256527A1 (en) | 2019-08-22 |
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