HK1218118A1 - 雷帕霉素衍生物的低温合成 - Google Patents
雷帕霉素衍生物的低温合成Info
- Publication number
- HK1218118A1 HK1218118A1 HK16106105.1A HK16106105A HK1218118A1 HK 1218118 A1 HK1218118 A1 HK 1218118A1 HK 16106105 A HK16106105 A HK 16106105A HK 1218118 A1 HK1218118 A1 HK 1218118A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- low temperature
- temperature synthesis
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361755388P | 2013-01-22 | 2013-01-22 | |
| PCT/US2014/012398 WO2014116611A1 (en) | 2013-01-22 | 2014-01-21 | Low temperature synthesis of rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1218118A1 true HK1218118A1 (zh) | 2017-02-03 |
Family
ID=51227971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16106105.1A HK1218118A1 (zh) | 2013-01-22 | 2016-05-30 | 雷帕霉素衍生物的低温合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9434744B2 (zh) |
| EP (1) | EP2948460B1 (zh) |
| JP (1) | JP6401713B2 (zh) |
| CN (1) | CN105102463B (zh) |
| CA (1) | CA2898723C (zh) |
| ES (1) | ES2645951T3 (zh) |
| HK (1) | HK1218118A1 (zh) |
| SG (1) | SG11201505719TA (zh) |
| WO (1) | WO2014116611A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153756B (zh) * | 2015-04-25 | 2020-04-28 | 山东新时代药业有限公司 | 一种检测依维莫司中雷帕霉素的高效液相色谱法 |
| CN106146535B (zh) * | 2015-04-25 | 2019-07-26 | 山东新时代药业有限公司 | 一种依维莫司的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| ES2315745T3 (es) * | 2004-03-01 | 2009-04-01 | Terumo Kabushiki Kaisha | Procedimiento para la fabricacion de derivados o-alquilados de rapamicina. |
| JP4716280B2 (ja) * | 2004-03-01 | 2011-07-06 | テルモ株式会社 | Ｏ−アルキル化ラパマイシン誘導体の製造法 |
| JP5456321B2 (ja) * | 2006-11-27 | 2014-03-26 | テルモ株式会社 | Ｏ−アルキル化ラパマイシン誘導体の製造方法およびｏ−アルキル化ラパマイシン誘導体 |
| US20110098241A1 (en) | 2008-04-14 | 2011-04-28 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| TW200948361A (en) | 2008-05-26 | 2009-12-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Method for synthesizing Biolimus A9 and the like and method for improving stability of the same |
| US9321782B2 (en) * | 2010-08-04 | 2016-04-26 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties |
| WO2012066502A1 (en) * | 2010-11-19 | 2012-05-24 | Biocon Limited | Processes for preparation of everolimus and intermediates thereof |
-
2014
- 2014-01-21 CN CN201480005663.0A patent/CN105102463B/zh active Active
- 2014-01-21 SG SG11201505719TA patent/SG11201505719TA/en unknown
- 2014-01-21 EP EP14743372.6A patent/EP2948460B1/en active Active
- 2014-01-21 WO PCT/US2014/012398 patent/WO2014116611A1/en active Application Filing
- 2014-01-21 ES ES14743372.6T patent/ES2645951T3/es active Active
- 2014-01-21 JP JP2015553903A patent/JP6401713B2/ja not_active Expired - Fee Related
- 2014-01-21 CA CA2898723A patent/CA2898723C/en active Active
-
2015
- 2015-07-21 US US14/804,714 patent/US9434744B2/en active Active
-
2016
- 2016-05-30 HK HK16106105.1A patent/HK1218118A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6401713B2 (ja) | 2018-10-10 |
| EP2948460A4 (en) | 2016-06-08 |
| CA2898723A1 (en) | 2014-07-31 |
| CN105102463B (zh) | 2017-05-31 |
| SG11201505719TA (en) | 2015-09-29 |
| US9434744B2 (en) | 2016-09-06 |
| CN105102463A (zh) | 2015-11-25 |
| CA2898723C (en) | 2021-09-14 |
| JP2016505048A (ja) | 2016-02-18 |
| EP2948460A1 (en) | 2015-12-02 |
| US20150322086A1 (en) | 2015-11-12 |
| ES2645951T3 (es) | 2017-12-11 |
| WO2014116611A1 (en) | 2014-07-31 |
| EP2948460B1 (en) | 2017-07-19 |
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