SG10201706045RA - Pertuzumab variants and evaluation thereof - Google Patents
Pertuzumab variants and evaluation thereofInfo
- Publication number
- SG10201706045RA SG10201706045RA SG10201706045RA SG10201706045RA SG10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA
- Authority
- SG
- Singapore
- Prior art keywords
- evaluation
- pertuzumab variants
- pertuzumab
- variants
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dispersion Chemistry (AREA)
- Electrochemistry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361812603P | 2013-04-16 | 2013-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201706045RA true SG10201706045RA (en) | 2017-08-30 |
Family
ID=50694078
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201706045RA SG10201706045RA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
| SG10201911353WA SG10201911353WA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
| SG11201508536PA SG11201508536PA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201911353WA SG10201911353WA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
| SG11201508536PA SG11201508536PA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US9815904B2 (enExample) |
| EP (3) | EP4483964A3 (enExample) |
| JP (2) | JP2016522176A (enExample) |
| KR (2) | KR20200085942A (enExample) |
| CN (1) | CN105121471A (enExample) |
| AR (1) | AR095863A1 (enExample) |
| AU (3) | AU2014254086B2 (enExample) |
| BR (1) | BR112015024926A2 (enExample) |
| CA (2) | CA2907776C (enExample) |
| CL (3) | CL2015003049A1 (enExample) |
| CR (1) | CR20150576A (enExample) |
| EA (1) | EA201591643A1 (enExample) |
| HK (1) | HK1211948A1 (enExample) |
| IL (2) | IL241103B (enExample) |
| MA (1) | MA38567A1 (enExample) |
| MX (2) | MX368259B (enExample) |
| MY (1) | MY173295A (enExample) |
| NZ (2) | NZ712012A (enExample) |
| PE (2) | PE20211214A1 (enExample) |
| PH (1) | PH12015502382A1 (enExample) |
| RU (2) | RU2737727C2 (enExample) |
| SG (3) | SG10201706045RA (enExample) |
| TW (1) | TWI554284B (enExample) |
| WO (1) | WO2014172371A2 (enExample) |
| ZA (1) | ZA201506594B (enExample) |
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|---|---|---|---|---|
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| TWI472339B (zh) * | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| EP4406615A3 (en) | 2009-10-26 | 2024-12-11 | F. Hoffmann-La Roche AG | Method for the production of a glycosylated immunoglobulin |
| MY194408A (en) | 2011-10-14 | 2022-11-30 | Genentech Inc | Uses for and Article of Manufacture Including Her2 Dimerization Inhibitor Pertuzumab |
| TWI554284B (zh) | 2013-04-16 | 2016-10-21 | 建南德克公司 | 帕妥珠單抗（ｐｅｒｔｕｚｕｍａｂ）變體及其評估 |
| JP6914336B2 (ja) * | 2016-12-28 | 2021-08-04 | ジェネンテック， インコーポレイテッド | 進行したｈｅｒ２発現がんの治療 |
| CN117752782A (zh) | 2017-01-17 | 2024-03-26 | 豪夫迈·罗氏有限公司 | 皮下her2抗体配制剂 |
| CN116531511A (zh) | 2017-03-02 | 2023-08-04 | 豪夫迈·罗氏有限公司 | Her2阳性乳腺癌的辅助治疗 |
| CN110536969A (zh) * | 2017-04-24 | 2019-12-03 | 豪夫迈·罗氏有限公司 | 跨膜或近膜域中的erbb2/her2突变 |
| EP3682249A4 (en) * | 2017-09-13 | 2021-08-25 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF ACID HYDROLYSIS PRODUCTS FROM IMMUNOGLOBULIN HEAVY CHAINS |
| JP7259778B2 (ja) | 2020-01-31 | 2023-04-18 | トヨタ自動車株式会社 | 車両、及び自動運転システム |
| EP3892989A1 (en) * | 2020-04-07 | 2021-10-13 | Ares Trading S.A. | Capillary gel electrophoresis and its use with complex biological molecules |
| KR20250151568A (ko) | 2020-06-29 | 2025-10-21 | 제넨테크, 인크. | 퍼투주맙 + 트라스투주맙 고정 용량 조합 |
| CN113999313A (zh) * | 2020-07-28 | 2022-02-01 | 百奥泰生物制药股份有限公司 | 抗her2抗体及其应用 |
| CN113189184B (zh) * | 2021-04-28 | 2022-09-09 | 浙江大学 | 含有半胱氨酸的毛细管凝胶电泳样品缓冲液 |
| CN117337195A (zh) | 2021-04-29 | 2024-01-02 | 上海汇连生物医药有限公司 | 抗体偶联药物的制备方法及应用 |
| KR102511384B1 (ko) | 2022-04-14 | 2023-03-16 | 지용환 | 곡물의 손상을 줄일 수 있는 도정기 |
| WO2025021118A1 (zh) * | 2023-07-25 | 2025-01-30 | 海南先声再明医药股份有限公司 | 配体-药物偶联物及其偶联连接子 |
| GB202313175D0 (en) | 2023-08-30 | 2023-10-11 | Univ Oxford Innovation Ltd | A bivalent polypeptide scaffold and uses thereof |
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