SG10201500404QA - Methods of Treating Diabetes with DLL4 Antagonists - Google Patents

Methods of Treating Diabetes with DLL4 Antagonists

Info

Publication number
SG10201500404QA
SG10201500404QA SG10201500404QA SG10201500404QA SG10201500404QA SG 10201500404Q A SG10201500404Q A SG 10201500404QA SG 10201500404Q A SG10201500404Q A SG 10201500404QA SG 10201500404Q A SG10201500404Q A SG 10201500404QA SG 10201500404Q A SG10201500404Q A SG 10201500404QA
Authority
SG
Singapore
Prior art keywords
methods
treating diabetes
dll4 antagonists
dll4
antagonists
Prior art date
Application number
SG10201500404QA
Other languages
English (en)
Inventor
Dimitris Skokos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201500404QA publication Critical patent/SG10201500404QA/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201500404QA 2010-01-29 2011-01-28 Methods of Treating Diabetes with DLL4 Antagonists SG10201500404QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29980110P 2010-01-29 2010-01-29
US36168710P 2010-07-06 2010-07-06
US38869710P 2010-10-01 2010-10-01

Publications (1)

Publication Number Publication Date
SG10201500404QA true SG10201500404QA (en) 2015-03-30

Family

ID=43925413

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201500416RA SG10201500416RA (en) 2010-01-29 2011-01-28 Methods of Treating Autoimmune Diseases with DLL4 Antagonists
SG10201500404QA SG10201500404QA (en) 2010-01-29 2011-01-28 Methods of Treating Diabetes with DLL4 Antagonists
SG2012052056A SG182528A1 (en) 2010-01-29 2011-01-28 Methods of treating autoimmune diseases with dll4 antagonists
SG2012052049A SG182527A1 (en) 2010-01-29 2011-01-28 Methods of treating diabetes with dll4 antagonists

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201500416RA SG10201500416RA (en) 2010-01-29 2011-01-28 Methods of Treating Autoimmune Diseases with DLL4 Antagonists

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG2012052056A SG182528A1 (en) 2010-01-29 2011-01-28 Methods of treating autoimmune diseases with dll4 antagonists
SG2012052049A SG182527A1 (en) 2010-01-29 2011-01-28 Methods of treating diabetes with dll4 antagonists

Country Status (29)

Country Link
US (3) US8765125B2 (fr)
EP (2) EP2528946B1 (fr)
JP (2) JP5997613B2 (fr)
KR (2) KR101832118B1 (fr)
CN (2) CN102884081A (fr)
AR (1) AR080026A1 (fr)
AU (2) AU2011210773B2 (fr)
BR (2) BR112012018766A2 (fr)
CA (2) CA2787615C (fr)
CY (2) CY1118223T1 (fr)
DK (2) DK2528945T3 (fr)
ES (2) ES2605430T3 (fr)
HR (2) HRP20170130T1 (fr)
HU (2) HUE032985T2 (fr)
IL (2) IL220887A (fr)
JO (2) JO3183B1 (fr)
LT (2) LT2528945T (fr)
MX (2) MX343553B (fr)
MY (2) MY156538A (fr)
PL (2) PL2528946T3 (fr)
PT (2) PT2528945T (fr)
RS (2) RS55595B1 (fr)
RU (2) RU2587620C2 (fr)
SG (4) SG10201500416RA (fr)
SI (2) SI2528945T1 (fr)
SM (2) SMT201600412B (fr)
TW (2) TWI564019B (fr)
UY (1) UY33206A (fr)
WO (2) WO2011094465A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
EP3029070A1 (fr) 2009-08-29 2016-06-08 AbbVie Inc. Protéines de liaison dll4 thérapeutiques
ES2895226T3 (es) 2009-10-16 2022-02-18 Mereo Biopharma 5 Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos
JO3183B1 (ar) 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
MY160628A (en) 2010-03-02 2017-03-15 Abbvie Inc Therapeutic DLL4 Binding Proteins
BR112014007035B1 (pt) 2011-09-23 2021-05-04 Oncomed Pharmaceuticals, Inc anticorpos biespecíficos que se ligam a vegf/dll4, composição farmacêutica e célula procariótica, fúngica ou de levedura que compreende os mesmos, moléculas de polinucleotídeo, vetor, usos terapêuticos e método para a produção de um anticorpo
KR101535341B1 (ko) * 2012-07-02 2015-07-13 한화케미칼 주식회사 Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
KR20210111353A (ko) 2012-11-01 2021-09-10 애브비 인코포레이티드 항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도
TW201438736A (zh) * 2012-11-14 2014-10-16 Regeneron Pharma 以dll4拮抗劑治療卵巢癌之方法
EP3020731B1 (fr) 2013-07-09 2019-06-12 ABLBio Nouvelles protéines à double cible se liant spécifiquement à dll4 et vegf et leur utilisation
CN111239415B (zh) * 2013-10-17 2024-03-26 综合医院公司 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物
WO2015154795A1 (fr) * 2014-04-08 2015-10-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Polythérapie pour le traitement de maladies auto-immunes
DK3212233T3 (da) 2014-10-31 2020-07-27 Oncomed Pharm Inc Kombinationsterapi til behandling af sygdom
AU2016326609B2 (en) 2015-09-23 2023-03-09 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer
EP3886856A4 (fr) * 2018-11-29 2022-01-19 Zucco Sassi Yonezawa Siviglia, Debora Procédé de traitement ou de prévention de crises associées à un trouble épileptique
US11446262B2 (en) 2018-11-29 2022-09-20 Debora Zucco Sassi Yonezawa Siviglia Neuroquiescence—a treatment for neurodevelopmental and neurodegenerative bioelectrical dysregulation and demyelination
WO2022210802A1 (fr) * 2021-03-30 2022-10-06 国立大学法人熊本大学 Agent thérapeutique pour l'atrophie musculaire
WO2023159166A1 (fr) * 2022-02-18 2023-08-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Anticorps à domaine unique (nanocorps) ciblant le ligand notch dll4 et leurs méthodes d'utilisation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
BR0311161A (pt) * 2002-05-21 2005-03-29 Cv Therapeutics Inc Método de tratamento de diabetes
WO2005103081A2 (fr) 2004-04-20 2005-11-03 Genmab A/S Anticorps monoclonaux humains diriges contre cd20
US20060134121A1 (en) 2004-10-29 2006-06-22 Gavin Thurston DII4 antagonists, assays, and therapeutic methods thereof
AU2006326417B2 (en) * 2005-12-16 2012-05-24 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with Dll4 antagonists
CN102585002A (zh) 2006-06-02 2012-07-18 瑞泽恩制药公司 人il-6受体的高亲和力抗体
KR20090027227A (ko) * 2006-06-06 2009-03-16 제넨테크, 인크. 항-dll4 항체 및 이의 사용 방법
WO2007143689A2 (fr) 2006-06-06 2007-12-13 Genentech, Inc. Compositions et procédés destinés à moduler le développement vasculaire
WO2008019144A2 (fr) 2006-08-07 2008-02-14 Regeneron Pharmaceuticals, Inc. Procédés thérapeuthiques pour traiter des troubles vasculaires de l'oeil par des antagonistes de dll4
MX2009003229A (es) 2006-09-29 2009-06-18 Oncomed Pharm Inc Composiciones y metodos para diagnosticar y tratar cancer.
NO347649B1 (no) * 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
EP3029070A1 (fr) 2009-08-29 2016-06-08 AbbVie Inc. Protéines de liaison dll4 thérapeutiques
JO3183B1 (ar) * 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4

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MX343555B (es) 2016-11-10
JO3242B1 (ar) 2018-03-08
RS55715B1 (sr) 2017-07-31
DK2528946T3 (en) 2017-02-20
US20110189176A1 (en) 2011-08-04
PL2528946T3 (pl) 2017-04-28
ES2605430T3 (es) 2017-03-14
AU2011210773A1 (en) 2012-08-23
JP2013518123A (ja) 2013-05-20
WO2011094467A3 (fr) 2011-12-22
EP2528945B1 (fr) 2016-10-26
SI2528946T1 (sl) 2017-01-31
US8889133B2 (en) 2014-11-18
CN102884081A (zh) 2013-01-16
HRP20170130T1 (hr) 2017-03-24
SI2528945T1 (sl) 2017-01-31
AU2011210771A1 (en) 2012-08-23
MX343553B (es) 2016-11-10
IL220889A (en) 2017-07-31
RS55595B1 (sr) 2017-06-30
US20140255429A1 (en) 2014-09-11
CA2787615C (fr) 2019-01-15
MX2012008638A (es) 2012-12-05
TW201615207A (zh) 2016-05-01
ES2609663T3 (es) 2017-04-21
KR101797918B1 (ko) 2017-11-15
CY1118551T1 (el) 2017-07-12
RU2587624C2 (ru) 2016-06-20
MX2012008740A (es) 2012-08-31
KR101832118B1 (ko) 2018-02-26
TWI564019B (zh) 2017-01-01
EP2528945A2 (fr) 2012-12-05
PL2528945T3 (pl) 2017-02-28
EP2528946B1 (fr) 2016-11-16
CN102947336B (zh) 2015-12-02
AU2011210773B2 (en) 2015-11-19
UY33206A (es) 2011-08-31
SG10201500416RA (en) 2015-04-29
WO2011094465A1 (fr) 2011-08-04
LT2528946T (lt) 2017-01-25
IL220889A0 (en) 2012-09-24
KR20130008017A (ko) 2013-01-21
PT2528946T (pt) 2016-12-14
EP2528946A1 (fr) 2012-12-05
MY156353A (en) 2016-02-15
SMT201700021B (it) 2017-03-08
TW201136601A (en) 2011-11-01
HRP20170249T1 (hr) 2017-04-07
SG182528A1 (en) 2012-08-30
HUE032985T2 (en) 2017-11-28
CN102947336A (zh) 2013-02-27
CA2787394C (fr) 2019-01-08
IL220887A (en) 2017-07-31
RU2012136816A (ru) 2014-03-10
JP2013518122A (ja) 2013-05-20
SMT201600412B (it) 2017-01-10
DK2528945T3 (en) 2017-02-06
KR20120123745A (ko) 2012-11-09
SG182527A1 (en) 2012-08-30
CY1118223T1 (el) 2017-06-28
CA2787615A1 (fr) 2011-08-04
RU2587620C2 (ru) 2016-06-20
BR112012018820A2 (pt) 2017-01-10
CA2787394A1 (fr) 2011-08-04
US20110189200A1 (en) 2011-08-04
LT2528945T (lt) 2017-01-25
JP5883801B2 (ja) 2016-03-15
AU2011210771B2 (en) 2015-12-10
MY156538A (en) 2016-02-26
JP5997613B2 (ja) 2016-09-28
BR112012018766A2 (pt) 2017-01-10
TWI600433B (zh) 2017-10-01
BR112012018820A8 (pt) 2018-03-13
PT2528945T (pt) 2016-12-14
US8765125B2 (en) 2014-07-01
JO3183B1 (ar) 2018-03-08
RU2012136817A (ru) 2014-03-10
WO2011094467A2 (fr) 2011-08-04
AR080026A1 (es) 2012-03-07
WO2011094465A4 (fr) 2011-09-22
HUE031432T2 (en) 2017-07-28

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