MX343553B - Métodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4. - Google Patents

Métodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4.

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Publication number
MX343553B
MX343553B MX2012008740A MX2012008740A MX343553B MX 343553 B MX343553 B MX 343553B MX 2012008740 A MX2012008740 A MX 2012008740A MX 2012008740 A MX2012008740 A MX 2012008740A MX 343553 B MX343553 B MX 343553B
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Mexico
Prior art keywords
dii4
methods
disorders
diseases
disease
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MX2012008740A
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English (en)
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MX2012008740A (es
Inventor
Skokos Dimitris
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Regeneron Pharma
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Publication date
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Publication of MX2012008740A publication Critical patent/MX2012008740A/es
Publication of MX343553B publication Critical patent/MX343553B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Life Sciences & Earth Sciences (AREA)
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  • Diabetes (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a métodos de tratamiento de una enfermedad o trastorno, en los cuales el incremento en el número de células T reguladoras (Tregs) es benéfico, administrando a un sujeto que padece dicha enfermedad o trastorno una cantidad terapéuticamente efectiva de antagonistas de D114 que bloquean las vías de señal de D114-Notch, incrementando así el número de Treg. Las enfermedades o trastornos tratables por los métodos de la invención incluyen enfermedades o trastornos autoinmunes, tales como esclerosis múltiple (MS), diabetes y similares. Los antagonistas de D114 adecuados para la invención incluyen anticuerpos o fragmentos de anticuerpo que se unen específicamente a D114 y bloquean las interacciones D114-Notch, el dominio extracelular de D114 y similares. La invención también provee métodos para prevenir la ocurrencia o recurrencia de dichas enfermedades o trastornos en un sujeto predispuesto o susceptible a desarrollar dichas enfermedades o trastornos. Además, los métodos de la invención son útiles para prevenir o tratar rechazos de trasplante de órganos o enfermedad de injerto versus hospedero.
MX2012008740A 2010-01-29 2011-01-28 Métodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4. MX343553B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29980110P 2010-01-29 2010-01-29
US36168710P 2010-07-06 2010-07-06
US38869710P 2010-10-01 2010-10-01
PCT/US2011/022810 WO2011094465A1 (en) 2010-01-29 2011-01-28 Methods of treating autoimmune diseases with dll4 antagonists

Publications (2)

Publication Number Publication Date
MX2012008740A MX2012008740A (es) 2012-08-31
MX343553B true MX343553B (es) 2016-11-10

Family

ID=43925413

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Application Number Title Priority Date Filing Date
MX2012008638A MX343555B (es) 2010-01-29 2011-01-28 Métodos de tratamiento de diabetes con antagonistas de ligando tipo delta 4.
MX2012008740A MX343553B (es) 2010-01-29 2011-01-28 Métodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012008638A MX343555B (es) 2010-01-29 2011-01-28 Métodos de tratamiento de diabetes con antagonistas de ligando tipo delta 4.

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US (3) US8889133B2 (es)
EP (2) EP2528945B1 (es)
JP (2) JP5883801B2 (es)
KR (2) KR101797918B1 (es)
CN (2) CN102884081A (es)
AR (1) AR080026A1 (es)
AU (2) AU2011210773B2 (es)
BR (2) BR112012018820A8 (es)
CA (2) CA2787394C (es)
CY (2) CY1118223T1 (es)
DK (2) DK2528946T3 (es)
ES (2) ES2609663T3 (es)
HR (2) HRP20170130T1 (es)
HU (2) HUE031432T2 (es)
IL (2) IL220889A (es)
JO (2) JO3183B1 (es)
LT (2) LT2528946T (es)
MX (2) MX343555B (es)
MY (2) MY156538A (es)
PL (2) PL2528945T3 (es)
PT (2) PT2528945T (es)
RS (2) RS55595B1 (es)
RU (2) RU2587624C2 (es)
SG (4) SG182527A1 (es)
SI (2) SI2528945T1 (es)
SM (2) SMT201600412B (es)
TW (2) TWI600433B (es)
UY (1) UY33206A (es)
WO (2) WO2011094467A2 (es)

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BR112012021941A2 (pt) 2010-03-02 2022-02-01 Abbvie Inc Proteínas terapêuticas de ligação a dll4
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SG11201503412RA (en) 2012-11-01 2015-05-28 Abbvie Inc Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
TW201438736A (zh) * 2012-11-14 2014-10-16 Regeneron Pharma 以ｄｌｌ４拮抗劑治療卵巢癌之方法
PL3020731T3 (pl) 2013-07-09 2019-11-29 Ablbio Nowe podwójnie nakierowane białko specyficznie wiążące się z dll4 i vegf oraz zastosowanie tego białka
JP6560200B2 (ja) * 2013-10-17 2019-08-14 ザ ジェネラル ホスピタル コーポレイション 自己免疫疾患の治療に応答性の対象を同定する方法およびそれを治療するための組成物
US10413605B2 (en) * 2014-04-08 2019-09-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Combination therapy for the treatment of autoimmune diseases
JP6827415B2 (ja) 2014-10-31 2021-02-10 メレオ バイオファーマ ５ インコーポレイテッド 疾患の処置のための併用療法
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
US11446262B2 (en) 2018-11-29 2022-09-20 Debora Zucco Sassi Yonezawa Siviglia Neuroquiescence—a treatment for neurodevelopmental and neurodegenerative bioelectrical dysregulation and demyelination
BR112021010336A2 (pt) * 2018-11-29 2021-08-24 Debora Zucco Sassi Yonezawa Siviglia Método para tratar ou prevenir convulsões associadas a um distúrbio epiléptico
WO2022210802A1 (ja) * 2021-03-30 2022-10-06 国立大学法人熊本大学 筋萎縮症治療剤
WO2023159166A1 (en) * 2022-02-18 2023-08-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Single-domain antibodies (nanobodies) targeting the notch ligand dll4 and methods of their use

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JO3183B1 (ar) 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4

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DK2528946T3 (en) 2017-02-20
MY156538A (en) 2016-02-26
US20110189200A1 (en) 2011-08-04
HRP20170130T1 (hr) 2017-03-24
EP2528946A1 (en) 2012-12-05
BR112012018820A2 (pt) 2017-01-10
CA2787615C (en) 2019-01-15
KR101797918B1 (ko) 2017-11-15
RU2012136816A (ru) 2014-03-10
MX343555B (es) 2016-11-10
JP2013518122A (ja) 2013-05-20
TWI564019B (zh) 2017-01-01
US8889133B2 (en) 2014-11-18
SMT201700021B (it) 2017-03-08
RS55715B1 (sr) 2017-07-31
EP2528946B1 (en) 2016-11-16
CA2787394A1 (en) 2011-08-04
CA2787615A1 (en) 2011-08-04
JO3183B1 (ar) 2018-03-08
KR101832118B1 (ko) 2018-02-26
CA2787394C (en) 2019-01-08
RU2587624C2 (ru) 2016-06-20
RU2587620C2 (ru) 2016-06-20
PT2528946T (pt) 2016-12-14
UY33206A (es) 2011-08-31
JP5883801B2 (ja) 2016-03-15
IL220889A (en) 2017-07-31
US8765125B2 (en) 2014-07-01
SG182528A1 (en) 2012-08-30
PL2528946T3 (pl) 2017-04-28
JO3242B1 (ar) 2018-03-08
SI2528946T1 (sl) 2017-01-31
EP2528945A2 (en) 2012-12-05
WO2011094465A1 (en) 2011-08-04
SMT201600412B (it) 2017-01-10
US20140255429A1 (en) 2014-09-11
MX2012008638A (es) 2012-12-05
AU2011210773A1 (en) 2012-08-23
HUE032985T2 (en) 2017-11-28
MX2012008740A (es) 2012-08-31
SI2528945T1 (sl) 2017-01-31
AU2011210771B2 (en) 2015-12-10
RU2012136817A (ru) 2014-03-10
US20110189176A1 (en) 2011-08-04
EP2528945B1 (en) 2016-10-26
BR112012018820A8 (pt) 2018-03-13
KR20120123745A (ko) 2012-11-09
WO2011094467A2 (en) 2011-08-04
HRP20170249T1 (hr) 2017-04-07
AU2011210773B2 (en) 2015-11-19
LT2528946T (lt) 2017-01-25
CN102947336B (zh) 2015-12-02
TW201136601A (en) 2011-11-01
TW201615207A (zh) 2016-05-01
TWI600433B (zh) 2017-10-01
LT2528945T (lt) 2017-01-25
RS55595B1 (sr) 2017-06-30
KR20130008017A (ko) 2013-01-21
IL220887A (en) 2017-07-31
SG182527A1 (en) 2012-08-30
DK2528945T3 (en) 2017-02-06
AU2011210771A1 (en) 2012-08-23
BR112012018766A2 (pt) 2017-01-10
CY1118223T1 (el) 2017-06-28
JP5997613B2 (ja) 2016-09-28
AR080026A1 (es) 2012-03-07
ES2605430T3 (es) 2017-03-14
WO2011094465A4 (en) 2011-09-22
WO2011094467A3 (en) 2011-12-22
ES2609663T3 (es) 2017-04-21
CY1118551T1 (el) 2017-07-12
MY156353A (en) 2016-02-15
HUE031432T2 (en) 2017-07-28
SG10201500416RA (en) 2015-04-29
IL220889A0 (en) 2012-09-24
PT2528945T (pt) 2016-12-14
SG10201500404QA (en) 2015-03-30
CN102884081A (zh) 2013-01-16
PL2528945T3 (pl) 2017-02-28
JP2013518123A (ja) 2013-05-20
CN102947336A (zh) 2013-02-27

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