SE9804002D0 - New manufacturing process - Google Patents

New manufacturing process

Info

Publication number
SE9804002D0
SE9804002D0 SE9804002A SE9804002A SE9804002D0 SE 9804002 D0 SE9804002 D0 SE 9804002D0 SE 9804002 A SE9804002 A SE 9804002A SE 9804002 A SE9804002 A SE 9804002A SE 9804002 D0 SE9804002 D0 SE 9804002D0
Authority
SE
Sweden
Prior art keywords
manufacturing process
new manufacturing
clevidipine
dichlorophenyl
methoxycarbonyl
Prior art date
Application number
SE9804002A
Other languages
English (en)
Swedish (sv)
Inventor
Anders Mattson
Carina Svensson
Karin Thoernblom
Christina Oedman
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9804002A priority Critical patent/SE9804002D0/xx
Publication of SE9804002D0 publication Critical patent/SE9804002D0/xx
Priority to US09/508,260 priority patent/US6350877B1/en
Priority to CA002349195A priority patent/CA2349195C/en
Priority to NZ511503A priority patent/NZ511503A/xx
Priority to DE69906787T priority patent/DE69906787T2/de
Priority to JP2000583863A priority patent/JP4553490B2/ja
Priority to PCT/SE1999/002155 priority patent/WO2000031035A1/en
Priority to AT99963732T priority patent/ATE236878T1/de
Priority to AU20105/00A priority patent/AU759211B2/en
Priority to EP99963732A priority patent/EP1133473B1/de
Priority to ARP990105951A priority patent/AR021369A1/es
Priority to ZA200103434A priority patent/ZA200103434B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
SE9804002A 1998-11-23 1998-11-23 New manufacturing process SE9804002D0 (sv)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SE9804002A SE9804002D0 (sv) 1998-11-23 1998-11-23 New manufacturing process
EP99963732A EP1133473B1 (de) 1998-11-23 1999-11-22 Neue produktionsmethode
DE69906787T DE69906787T2 (de) 1998-11-23 1999-11-22 Neue produktionsmethode
CA002349195A CA2349195C (en) 1998-11-23 1999-11-22 New manufacturing process
NZ511503A NZ511503A (en) 1998-11-23 1999-11-22 Manufacture of clevidipine by reacting an inorganic salt of a carboxylic acid with choromethyl butyrate
US09/508,260 US6350877B1 (en) 1998-11-23 1999-11-22 Manufacturing process
JP2000583863A JP4553490B2 (ja) 1998-11-23 1999-11-22 新規製造方法
PCT/SE1999/002155 WO2000031035A1 (en) 1998-11-23 1999-11-22 New manufacturing process
AT99963732T ATE236878T1 (de) 1998-11-23 1999-11-22 Neue produktionsmethode
AU20105/00A AU759211B2 (en) 1998-11-23 1999-11-22 New manufacturing process
ARP990105951A AR021369A1 (es) 1998-11-23 1999-11-23 Metodo para la fabricacion de clevidipina
ZA200103434A ZA200103434B (en) 1998-11-23 2001-04-26 New manufacturing process.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9804002A SE9804002D0 (sv) 1998-11-23 1998-11-23 New manufacturing process

Publications (1)

Publication Number Publication Date
SE9804002D0 true SE9804002D0 (sv) 1998-11-23

Family

ID=20413379

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9804002A SE9804002D0 (sv) 1998-11-23 1998-11-23 New manufacturing process

Country Status (12)

Country Link
US (1) US6350877B1 (de)
EP (1) EP1133473B1 (de)
JP (1) JP4553490B2 (de)
AR (1) AR021369A1 (de)
AT (1) ATE236878T1 (de)
AU (1) AU759211B2 (de)
CA (1) CA2349195C (de)
DE (1) DE69906787T2 (de)
NZ (1) NZ511503A (de)
SE (1) SE9804002D0 (de)
WO (1) WO2000031035A1 (de)
ZA (1) ZA200103434B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105743A1 (en) * 2008-08-01 2010-04-29 Gopal Krishna Pharmaceutical compositions and methods for stabilizing the same
PL2320740T3 (pl) * 2008-08-01 2014-09-30 The Medicines Co Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
CA2701272A1 (en) * 2010-04-21 2011-10-21 Alphora Research Inc. Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers
EP3020704A3 (de) 2010-05-07 2016-11-09 Laboratorios Lesvi, S.L. Kristalline polymorphen des clevidipins butyrate
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2627173B2 (de) 2010-10-12 2018-07-04 Chiesi Farmaceutici S.p.A. Clevidipin-emulsionsformulierungen mit antimikrobiellen mitteln
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
CN102001992B (zh) * 2010-10-14 2012-05-23 清远嘉博制药有限公司 一种丁酸氯维地平的制备方法
CN102531998A (zh) * 2010-12-09 2012-07-04 天津药物研究院 α型多晶型丁酸氯维地平结晶、其制备方法、用途和药物组合物
CA2832066C (en) 2011-04-01 2023-04-18 The Medicines Company Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage
CN102827068A (zh) * 2011-06-17 2012-12-19 张锐豪 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
UA117571C2 (uk) 2012-10-26 2018-08-27 Чіесі Фармацеутічі С.П.А. Способи контролювання кров'яного тиску та зниження диспное при серцевій недостатності
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
WO2015179334A1 (en) 2014-05-19 2015-11-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105198797B (zh) * 2015-11-12 2017-12-08 华仁药业股份有限公司 丁酸氯维地平的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
SE9303657D0 (sv) * 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
SE9303744D0 (sv) * 1993-11-12 1993-11-12 Astra Ab Pharmaceutical emulsion

Also Published As

Publication number Publication date
CA2349195A1 (en) 2000-06-02
NZ511503A (en) 2002-11-26
US6350877B1 (en) 2002-02-26
JP2002530376A (ja) 2002-09-17
EP1133473B1 (de) 2003-04-09
CA2349195C (en) 2008-12-30
WO2000031035A1 (en) 2000-06-02
JP4553490B2 (ja) 2010-09-29
EP1133473A1 (de) 2001-09-19
DE69906787T2 (de) 2004-02-05
DE69906787D1 (de) 2003-05-15
AU2010500A (en) 2000-06-13
ATE236878T1 (de) 2003-04-15
AR021369A1 (es) 2002-07-17
AU759211B2 (en) 2003-04-10
ZA200103434B (en) 2002-07-26

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