SE9803838D0 - A chromatography method and a column material useful in said method - Google Patents

A chromatography method and a column material useful in said method

Info

Publication number
SE9803838D0
SE9803838D0 SE9803838A SE9803838A SE9803838D0 SE 9803838 D0 SE9803838 D0 SE 9803838D0 SE 9803838 A SE9803838 A SE 9803838A SE 9803838 A SE9803838 A SE 9803838A SE 9803838 D0 SE9803838 D0 SE 9803838D0
Authority
SE
Sweden
Prior art keywords
ion exchange
chromatography
zwitterionic
column material
material useful
Prior art date
Application number
SE9803838A
Other languages
English (en)
Swedish (sv)
Inventor
Knut Irgum
Camilla Viklund
Original Assignee
Knut Irgum
Camilla Viklund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knut Irgum, Camilla Viklund filed Critical Knut Irgum
Priority to SE9803838A priority Critical patent/SE9803838D0/xx
Publication of SE9803838D0 publication Critical patent/SE9803838D0/xx
Priority to AU15919/00A priority patent/AU759683B2/en
Priority to EP99958580A priority patent/EP1137466B1/en
Priority to AT99958580T priority patent/ATE337058T1/de
Priority to US09/831,162 priority patent/US6884345B1/en
Priority to CA002349948A priority patent/CA2349948C/en
Priority to JP2000580718A priority patent/JP4440474B2/ja
Priority to DE69932944T priority patent/DE69932944T2/de
Priority to PCT/SE1999/002032 priority patent/WO2000027496A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/364—Amphoteric or zwitterionic ion-exchanger
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3092—Packing of a container, e.g. packing a cartridge or column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3278—Polymers being grafted on the carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J43/00—Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groups; Use of material as amphoteric ion-exchangers; Treatment of material for improving their amphoteric ion-exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/82—Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G01N2030/528—Monolithic sorbent material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
SE9803838A 1998-11-09 1998-11-09 A chromatography method and a column material useful in said method SE9803838D0 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE9803838A SE9803838D0 (sv) 1998-11-09 1998-11-09 A chromatography method and a column material useful in said method
AU15919/00A AU759683B2 (en) 1998-11-09 1999-11-09 A chromatography method and a column material useful in said method
EP99958580A EP1137466B1 (en) 1998-11-09 1999-11-09 A chromatography method and a column material useful in said method
AT99958580T ATE337058T1 (de) 1998-11-09 1999-11-09 Kolonne und mit dieser durchgeführtes chromatographisches verfahren
US09/831,162 US6884345B1 (en) 1998-11-09 1999-11-09 Chromatography method and a column material useful in said method
CA002349948A CA2349948C (en) 1998-11-09 1999-11-09 A chromatography method and a column material useful in said method
JP2000580718A JP4440474B2 (ja) 1998-11-09 1999-11-09 クロマトグラフィー分離法および選択吸着体
DE69932944T DE69932944T2 (de) 1998-11-09 1999-11-09 Chromatographisches verfahren und für das verfahren geeignetes säulenmaterial
PCT/SE1999/002032 WO2000027496A1 (en) 1998-11-09 1999-11-09 A chromatography method and a column material useful in said method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803838A SE9803838D0 (sv) 1998-11-09 1998-11-09 A chromatography method and a column material useful in said method

Publications (1)

Publication Number Publication Date
SE9803838D0 true SE9803838D0 (sv) 1998-11-09

Family

ID=20413235

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9803838A SE9803838D0 (sv) 1998-11-09 1998-11-09 A chromatography method and a column material useful in said method

Country Status (9)

Country Link
US (1) US6884345B1 (ja)
EP (1) EP1137466B1 (ja)
JP (1) JP4440474B2 (ja)
AT (1) ATE337058T1 (ja)
AU (1) AU759683B2 (ja)
CA (1) CA2349948C (ja)
DE (1) DE69932944T2 (ja)
SE (1) SE9803838D0 (ja)
WO (1) WO2000027496A1 (ja)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10013990C2 (de) * 2000-03-22 2003-12-04 Invitek Biotechnik & Biodesign Polyfunktionelles Trägermaterial für die komplexe Nukleinsäureanalytik
US7238426B2 (en) * 2003-08-13 2007-07-03 Sequant Ab Column packing material
US7250388B2 (en) * 2003-11-07 2007-07-31 Hewlett-Packard Development Company, L.P. Medium for chromatographic separations
JP3922648B2 (ja) * 2004-05-24 2007-05-30 株式会社資生堂 アフィニティー粒子及びアフィニティー分離方法
JP4910700B2 (ja) 2004-08-30 2012-04-04 東レ株式会社 分画装置
US20100300971A1 (en) * 2005-05-18 2010-12-02 Sequant Ab Zwitterionic stationary phase as well as method for using and producing said phase
SE529259C2 (sv) * 2005-08-31 2007-06-12 Ge Healthcare Bio Sciences Ab Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi
SE0502485L (sv) * 2005-11-09 2007-05-10 Peter Viberg Partiklar
EP1962097A1 (en) * 2007-02-23 2008-08-27 SeQuant AB Mass spectrometric quantitative detection of methyl malonic acid and succinic acid using hilic on a zwitterionic stationary phase
JP2009069050A (ja) 2007-09-14 2009-04-02 Nec Corp 化合物のカラム担体への固定化方法
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
US20110121229A1 (en) * 2008-05-13 2011-05-26 Universitaet Wien Enantioselective zwitterionic ion-exchange material
US20090294362A1 (en) * 2008-05-30 2009-12-03 Persson Jonas Par Stationary phase for hydrophilic interaction chromatography
KR102178191B1 (ko) 2008-09-02 2020-11-13 머크 밀리포어 리미티드 크로마토그래피 막, 이를 포함하는 장치 및 이의 이용방법
DE102009006007B4 (de) * 2009-01-23 2015-03-12 Axagarius Gmbh & Co. Kg Verwendung von zwitterionischen Adsorbentien für die Flüssigchromatographie, Chromatographiesäule mit solchen Adsorbentien sowie deren Verwendung
EP2462188A4 (en) 2009-08-04 2016-11-23 Waters Technologies Corp HIGH-QUALITY CHROMATOGRAPHIC MATERIALS WITH A IONIZABLE MODIFIER
US10159911B2 (en) 2009-08-04 2018-12-25 Waters Technologies Corporation High purity chromatographic materials comprising an ionizable modifier
IN2012DN05130A (ja) * 2009-11-13 2015-10-23 Natrix Separations Inc
EP2521612B1 (en) * 2010-01-08 2017-05-17 University Of Tasmania Use of porous polymer monoliths
EP2571487B1 (en) * 2010-05-21 2023-01-04 Siemens Healthcare Diagnostics Inc. Zwitterionic reagents
JP5812463B2 (ja) * 2010-07-01 2015-11-11 積水メディカル株式会社 液体クロマトグラフィーによる核酸の分離検出方法
JP2013535683A (ja) * 2010-07-30 2013-09-12 イー・エム・デイー・ミリポア・コーポレイシヨン クロマトグラフィー媒体及び方法
ES2724199T3 (es) * 2010-10-27 2019-09-09 Toray Industries Vehículo para la adsorción de componentes sanguíneos y columna para la adsorción de componentes sanguíneos
JP5926484B2 (ja) 2010-11-18 2016-05-25 株式会社セルシード グリコサミノグリカンの新規な分析方法
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
CN102614847B (zh) 2011-01-28 2013-12-18 浙江华谱新创科技有限公司 一种两性离子亲水色谱固定相及其制备方法
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WO2014194268A1 (en) * 2013-05-30 2014-12-04 The University Of Akron Switchable antimicrobial and antifouling carboxybetaine-based hydrogels
KR102251127B1 (ko) 2013-07-12 2021-05-11 제넨테크, 인크. 이온 교환 크로마토그래피 입력 최적화의 설명
US9340562B1 (en) 2014-10-29 2016-05-17 Thermo Electron Manufacturing Limited Chromatographic material and method for preparation thereof
JP6729041B2 (ja) * 2016-06-17 2020-07-22 日立化成株式会社 分離材及びカラム
MY200559A (en) * 2017-06-22 2024-01-03 Archer Daniels Midland Co Process for separation and purification of a dicarboxylic acid containing mixture
CN107597079B (zh) * 2017-10-17 2020-06-16 暨南大学 一类基于两性离子交联剂的有机聚合物整体材料及制备和应用
CN109806916B (zh) * 2019-03-15 2021-12-21 中科森辉微球技术（苏州）有限公司 高性能阴离子交换介质及其制备方法
CN114618454A (zh) * 2020-12-11 2022-06-14 中国科学院大连化学物理研究所 一种极性包埋双链反相色谱固定相及其制备和应用
CN114190313B (zh) * 2021-11-25 2023-04-11 舒城县汇德水产科技有限公司 一种环保型高密度红螯螯虾的繁殖育苗方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4577013A (en) * 1983-12-22 1986-03-18 Ciba-Geigy Corporation Ionically modified cellulose material, its preparation and its use
US6039876A (en) * 1992-07-24 2000-03-21 Yang; Yan-Bo Hydrophilic polystrene divinylbenzene based matrixes for chromatography
JP3351572B2 (ja) 1992-10-05 2002-11-25 井上 聰一 イオンクロマトグラフィーによる分析体の分離・分析方法、イオンクロマトグラフィー用両荷電具備固定相及び多機能液体クロマトグラフィーによる分析体の分離・分析方法
WO1998049279A1 (en) 1997-04-25 1998-11-05 Diamyd Therapeutics Ab Use of a zwitterionic detergent/surfactant for purifying glutamic acid decarboxylase (gad) and a composition containing gad
DE19721601A1 (de) * 1997-05-23 1998-11-26 Hoechst Ag Polybetain-stabilisierte, Palladium-haltige Nanopartikel, ein Verfahren zu ihrer Herstellung sowie daraus hergestellte Katalysatoren zur Gewinnung von Vinylacetat
DE19754304A1 (de) * 1997-12-08 1999-06-10 Hoechst Ag Polybetain-stabilisierte Platin-Nanopartikel, Verfahren zu ihrer Herstellung und Verwendung für Elektrokatalysatoren in Brennstoffzellen
US6238565B1 (en) * 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules

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WO2000027496A1 (en) 2000-05-18
AU1591900A (en) 2000-05-29
CA2349948A1 (en) 2000-05-18
AU759683B2 (en) 2003-04-17
CA2349948C (en) 2008-10-14
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