SE8602339D0 - An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines - Google Patents

An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines

Info

Publication number
SE8602339D0
SE8602339D0 SE8602339A SE8602339A SE8602339D0 SE 8602339 D0 SE8602339 D0 SE 8602339D0 SE 8602339 A SE8602339 A SE 8602339A SE 8602339 A SE8602339 A SE 8602339A SE 8602339 D0 SE8602339 D0 SE 8602339D0
Authority
SE
Sweden
Prior art keywords
stereoconservative
substituted
aminomethylpyrrolidines
synthesis
effective
Prior art date
Application number
SE8602339A
Other languages
English (en)
Inventor
H-J Federsel
T Hogberg
S I Remsby
H E P Strom
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Priority to SE8602339A priority Critical patent/SE8602339D0/sv
Publication of SE8602339D0 publication Critical patent/SE8602339D0/sv
Priority to EP87850165A priority patent/EP0253785B1/en
Priority to AT87850165T priority patent/ATE82259T1/de
Priority to JP62503384A priority patent/JPH07103098B2/ja
Priority to EP87903468A priority patent/EP0270596A1/en
Priority to DE198787903468T priority patent/DE270596T1/de
Priority to DE8787850165T priority patent/DE3782566T2/de
Priority to ES87850165T priority patent/ES2044974T3/es
Priority to KR1019880700061A priority patent/KR950011407B1/ko
Priority to PCT/SE1987/000246 priority patent/WO1987007271A1/en
Priority to IE132087A priority patent/IE59896B1/en
Priority to DK011788A priority patent/DK11788D0/da
Priority to FI880265A priority patent/FI95028C/sv
Priority to US07/974,683 priority patent/US5300660A/en
Priority to GR920403017T priority patent/GR3006609T3/el
Priority to US08/203,985 priority patent/US5468876A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
SE8602339A 1986-05-22 1986-05-22 An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines SE8602339D0 (sv)

Priority Applications (16)

Application Number Priority Date Filing Date Title
SE8602339A SE8602339D0 (sv) 1986-05-22 1986-05-22 An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines
PCT/SE1987/000246 WO1987007271A1 (en) 1986-05-22 1987-05-19 A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto
DE8787850165T DE3782566T2 (de) 1986-05-22 1987-05-19 Effiziente stereokonservative synthesen von 1-substituierten (s)- und (r)-2-aminomethylpyrrolidinen und zwischenprodukte dazu.
KR1019880700061A KR950011407B1 (ko) 1986-05-22 1987-05-19 1-치환(s)-및(r)-2-아미노메틸피롤리딘 및 그의 중간체의 효과적인 입체보존 합성법
JP62503384A JPH07103098B2 (ja) 1986-05-22 1987-05-19 １‐置換（ｓ）‐および（ｒ）‐２‐アミノメチルピロリジン類の有効な立体保存的合成およびその中間体
EP87903468A EP0270596A1 (en) 1986-05-22 1987-05-19 A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto
DE198787903468T DE270596T1 (de) 1986-05-22 1987-05-19 Eine stereokonservative synthese von 1-substituierten (s)- und (r)-2-aminomethylpyrrolidinen und zwischenverbindungen.
EP87850165A EP0253785B1 (en) 1986-05-22 1987-05-19 Efficient stereoconservative syntheses of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates therein
ES87850165T ES2044974T3 (es) 1986-05-22 1987-05-19 Sintesis esteresconservadoras eficaces de (s)- y (r)-2-aminometilpirrolidinas sustituidas en 1 y sus compuestos intermedios.
AT87850165T ATE82259T1 (de) 1986-05-22 1987-05-19 Effiziente stereokonservative synthesen von 1substituierten (s)- und (r)-2aminomethylpyrrolidinen und zwischenprodukte dazu.
IE132087A IE59896B1 (en) 1986-05-22 1987-05-20 An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminoethylpyrrolidines and intermediates thereto
DK011788A DK11788D0 (da) 1986-05-22 1988-01-12 Stereobevarende syntese af 1-substituerede (s)- og (r)-2-aminometylpyrrolidiner og mellemprodukter dertil
FI880265A FI95028C (sv) 1986-05-22 1988-01-21 Effektiv stereostruktur bevarande syntes av 1-substituerad (S)- och (R)-2-aminometylpyrrolidiner och deras mellanprodukter
US07/974,683 US5300660A (en) 1986-05-22 1992-11-12 Efficient stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines and intermediates thereto
GR920403017T GR3006609T3 (sv) 1986-05-22 1992-12-21
US08/203,985 US5468876A (en) 1986-05-22 1994-02-24 Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8602339A SE8602339D0 (sv) 1986-05-22 1986-05-22 An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines

Publications (1)

Publication Number Publication Date
SE8602339D0 true SE8602339D0 (sv) 1986-05-22

Family

ID=20364616

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8602339A SE8602339D0 (sv) 1986-05-22 1986-05-22 An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines

Country Status (12)

Country Link
EP (2) EP0253785B1 (sv)
JP (1) JPH07103098B2 (sv)
KR (1) KR950011407B1 (sv)
AT (1) ATE82259T1 (sv)
DE (2) DE3782566T2 (sv)
DK (1) DK11788D0 (sv)
ES (1) ES2044974T3 (sv)
FI (1) FI95028C (sv)
GR (1) GR3006609T3 (sv)
IE (1) IE59896B1 (sv)
SE (1) SE8602339D0 (sv)
WO (1) WO1987007271A1 (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425070A1 (de) * 1994-07-15 1996-01-18 Degussa Verfahren zur Herstellung optisch aktiver l-substituierter 2-(Aminomethyl)pyrrolidine
CN1298702C (zh) * 2005-03-15 2007-02-07 江苏省原子医学研究所 一种(s)－1－烯丙基－2－胺甲基四氢吡咯的制备方法
JP6359365B2 (ja) * 2014-07-09 2018-07-18 国立研究開発法人産業技術総合研究所 アミノ酸のアミノ基及びカルボキシル基を対象としたプレカラム誘導体化ｌｃ−ｍｓ分析法
CN107641092A (zh) * 2017-10-30 2018-01-30 广东肇庆星湖生物科技股份有限公司 一种l‑脯氨酰胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3718688A (en) * 1967-10-18 1973-02-27 Radio Carbon Lab Alkylidine and arylidine amino acid esters, and alkyl and aryl amino acid esters
US3947408A (en) * 1974-08-05 1976-03-30 American Cyanamid Company Pyrrolo-benzodiazepines, method of preparation and method of use
IL52645A (en) * 1976-08-05 1980-02-29 Synthelabo Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamides
IT1095415B (it) * 1978-02-16 1985-08-10 Ravizza Spa Processo per la produzione di una benzamide otticamente attiva,benzamide otticamente attiva cosi'ottenuta e composizioni
FR2452482A1 (fr) * 1979-03-28 1980-10-24 Synthelabo Derives de benzamides et leur application en therapeutique
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives

Also Published As

Publication number Publication date
DE3782566T2 (de) 1993-03-25
JPS63503384A (ja) 1988-12-08
EP0270596A1 (en) 1988-06-15
DK11788A (da) 1988-01-12
DE270596T1 (de) 1988-10-13
DE3782566D1 (de) 1992-12-17
FI95028B (sv) 1995-08-31
ATE82259T1 (de) 1992-11-15
KR950011407B1 (ko) 1995-10-04
IE59896B1 (en) 1994-04-20
DK11788D0 (da) 1988-01-12
JPH07103098B2 (ja) 1995-11-08
EP0253785B1 (en) 1992-11-11
FI880265A (sv) 1988-01-21
KR880701226A (ko) 1988-07-26
EP0253785A1 (en) 1988-01-20
GR3006609T3 (sv) 1993-06-30
FI95028C (sv) 1995-12-11
IE871320L (en) 1987-11-22
ES2044974T3 (es) 1994-01-16
FI880265A0 (sv) 1988-01-21
WO1987007271A1 (en) 1987-12-03

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