IL52645A - Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamides - Google Patents
Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamidesInfo
- Publication number
- IL52645A IL52645A IL52645A IL5264577A IL52645A IL 52645 A IL52645 A IL 52645A IL 52645 A IL52645 A IL 52645A IL 5264577 A IL5264577 A IL 5264577A IL 52645 A IL52645 A IL 52645A
- Authority
- IL
- Israel
- Prior art keywords
- optically active
- stereospecifics
- pyrrolidylmethyl
- benzamides
- methoxy
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 title 1
- ZFRCAYVKWJHAMV-UHFFFAOYSA-N n-(pyrrolidin-1-ylmethyl)benzamide Chemical class C=1C=CC=CC=1C(=O)NCN1CCCC1 ZFRCAYVKWJHAMV-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- VMPYTOIPVPQDNX-UHFFFAOYSA-N pyrrolidin-1-ylmethanamine Chemical class NCN1CCCC1 VMPYTOIPVPQDNX-UHFFFAOYSA-N 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7623910A FR2360572A1 (en) | 1976-08-05 | 1976-08-05 | Optically active (2)-amino-methyl-(1)-substd. pyrrolidine derivs. - intermediates for benzoylamino-methyl-pyrrolidine pharmaceuticals |
| FR7635476A FR2372157A1 (en) | 1976-11-25 | 1976-11-25 | Optically active (2)-amino-methyl-(1)-substd. pyrrolidine derivs. - intermediates for benzoylamino-methyl-pyrrolidine pharmaceuticals |
| FR7719391A FR2395261A2 (en) | 1977-06-24 | 1977-06-24 | Optically active (2)-amino-methyl-(1)-substd. pyrrolidine derivs. - intermediates for benzoylamino-methyl-pyrrolidine pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL52645A0 IL52645A0 (en) | 1977-10-31 |
| IL52645A true IL52645A (en) | 1980-02-29 |
Family
ID=27250658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL52645A IL52645A (en) | 1976-08-05 | 1977-08-02 | Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamides |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5325563A (en) |
| AT (1) | AT364818B (en) |
| AU (1) | AU510454B2 (en) |
| CA (1) | CA1083586A (en) |
| CH (2) | CH624933A5 (en) |
| DE (1) | DE2735036C2 (en) |
| DK (1) | DK350377A (en) |
| ES (1) | ES461342A1 (en) |
| FI (1) | FI772363A7 (en) |
| GB (1) | GB1555890A (en) |
| GR (1) | GR63594B (en) |
| IE (1) | IE45544B1 (en) |
| IL (1) | IL52645A (en) |
| IT (1) | IT1085696B (en) |
| LU (1) | LU77917A1 (en) |
| NL (1) | NL7708571A (en) |
| NO (2) | NO772745L (en) |
| NZ (1) | NZ184832A (en) |
| PT (1) | PT66894B (en) |
| SE (2) | SE7708902L (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1095415B (en) * | 1978-02-16 | 1985-08-10 | Ravizza Spa | PROCESS FOR THE PRODUCTION OF AN OPTICALLY ACTIVE BENZAMIDE, OPTICALLY ACTIVE BENZAMIDE SO OBTAINED AND COMPOSITIONS |
| IT1141095B (en) * | 1980-11-27 | 1986-10-01 | Ravizza Spa | RESOLUTION PROCESS OF THE SULPYRID RACEMA |
| SE8602339D0 (en) * | 1986-05-22 | 1986-05-22 | Astra Laekemedel Ab | AND EFFECTIVE STEREOCONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S) - AND (R) -2-AMINOMETHYLPYRROLIDINES |
| DE4425070A1 (en) * | 1994-07-15 | 1996-01-18 | Degussa | Process for the preparation of optically active l-substituted 2- (aminomethyl) pyrrolidines |
| US7531673B2 (en) * | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
| CN104086475B (en) * | 2014-07-15 | 2016-10-05 | 苏州天马精细化学品股份有限公司 | A kind of preparation method of N-benzyloxycarbonyl group-L-prolineamide |
| CN106045869A (en) * | 2016-06-30 | 2016-10-26 | 宜兴市前成生物有限公司 | Method for preparing DL-glutamic acid |
| CN117185977A (en) * | 2023-09-20 | 2023-12-08 | 江苏阿尔法药业股份有限公司 | A kind of preparation method of amisulpride intermediate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1528014A (en) * | 1967-04-24 | 1968-06-07 | Ile De France | Process for the preparation of optical isomers of ethyl-1, aminomethyl-2-pyrrolidine |
| CH507938A (en) * | 1968-08-01 | 1971-05-31 | Ile De France | Process for the preparation of heterocyclic benzamides |
-
1977
- 1977-08-02 IL IL52645A patent/IL52645A/en unknown
- 1977-08-03 DE DE2735036A patent/DE2735036C2/en not_active Expired
- 1977-08-03 NZ NZ184832A patent/NZ184832A/en unknown
- 1977-08-03 GR GR54101A patent/GR63594B/en unknown
- 1977-08-03 NL NL7708571A patent/NL7708571A/en not_active Application Discontinuation
- 1977-08-04 FI FI772363A patent/FI772363A7/fi not_active Application Discontinuation
- 1977-08-04 DK DK350377A patent/DK350377A/en not_active Application Discontinuation
- 1977-08-04 IT IT26497/77A patent/IT1085696B/en active
- 1977-08-04 CA CA284,104A patent/CA1083586A/en not_active Expired
- 1977-08-04 CH CH959477A patent/CH624933A5/fr not_active IP Right Cessation
- 1977-08-04 IE IE1633/77A patent/IE45544B1/en unknown
- 1977-08-04 ES ES461342A patent/ES461342A1/en not_active Expired
- 1977-08-04 NO NO772745A patent/NO772745L/en unknown
- 1977-08-04 PT PT66894A patent/PT66894B/en unknown
- 1977-08-04 GB GB32790/77A patent/GB1555890A/en not_active Expired
- 1977-08-04 JP JP9404477A patent/JPS5325563A/en active Pending
- 1977-08-04 SE SE7708902A patent/SE7708902L/en not_active Application Discontinuation
- 1977-08-04 LU LU77917A patent/LU77917A1/xx unknown
- 1977-08-04 AU AU27641/77A patent/AU510454B2/en not_active Expired
- 1977-08-05 AT AT0577377A patent/AT364818B/en not_active IP Right Cessation
-
1980
- 1980-12-22 SE SE8009074A patent/SE8009074L/en not_active Application Discontinuation
-
1981
- 1981-01-06 CH CH4181A patent/CH626341A5/en not_active IP Right Cessation
- 1981-08-25 NO NO812871A patent/NO812871L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1555890A (en) | 1979-11-14 |
| CH624933A5 (en) | 1981-08-31 |
| NL7708571A (en) | 1978-02-07 |
| IL52645A0 (en) | 1977-10-31 |
| DE2735036A1 (en) | 1978-02-16 |
| IT1085696B (en) | 1985-05-28 |
| DE2735036C2 (en) | 1983-10-13 |
| CA1083586A (en) | 1980-08-12 |
| JPS5325563A (en) | 1978-03-09 |
| AU2764177A (en) | 1979-02-08 |
| ATA577377A (en) | 1981-04-15 |
| CH626341A5 (en) | 1981-11-13 |
| NO812871L (en) | 1978-02-07 |
| AT364818B (en) | 1981-11-25 |
| PT66894A (en) | 1977-09-01 |
| IE45544B1 (en) | 1982-09-22 |
| FI772363A7 (en) | 1978-02-06 |
| NO772745L (en) | 1978-02-07 |
| NZ184832A (en) | 1979-11-01 |
| LU77917A1 (en) | 1977-11-14 |
| AU510454B2 (en) | 1980-06-26 |
| GR63594B (en) | 1979-11-26 |
| IE45544L (en) | 1978-02-05 |
| PT66894B (en) | 1979-01-26 |
| ES461342A1 (en) | 1978-06-01 |
| DK350377A (en) | 1978-02-06 |
| SE7708902L (en) | 1978-02-06 |
| SE8009074L (en) | 1980-12-22 |
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