SE7909754L - Forfarande for framstellning av endolderivat - Google Patents

Forfarande for framstellning av endolderivat

Info

Publication number
SE7909754L
SE7909754L SE7909754A SE7909754A SE7909754L SE 7909754 L SE7909754 L SE 7909754L SE 7909754 A SE7909754 A SE 7909754A SE 7909754 A SE7909754 A SE 7909754A SE 7909754 L SE7909754 L SE 7909754L
Authority
SE
Sweden
Prior art keywords
formula
protected
amino
hydroxy
optionally
Prior art date
Application number
SE7909754A
Other languages
English (en)
Other versions
SE434265B (sv
Inventor
R B Woodward
H Bickel
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH215775A external-priority patent/CH626091A5/de
Priority claimed from CH1096275A external-priority patent/CH627759A5/de
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7909754L publication Critical patent/SE7909754L/sv
Publication of SE434265B publication Critical patent/SE434265B/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (1)

1. Patentkrav satt att framstglla 7p-amin0-3-oefem-3-01karb0nsyraforeningar med formeln NH () Y-O_R(IA) OC— R2 marlbetecknar vate, en acylgrupp med formeln 0 Pa - (X)m - pH - C(B) van i Ra betecknar renal, hydroxifenyl, hydroxi-klorfenyl, tienyl, PYridyl, aminopyridinium, furyl, isotiazyl, tetrazolyl eller 1,4-cyklohexadienyl varvid hydroxisubstituenterna i sAdana grupper ken vane skyddade med acylrester, X beteeknar syre eller svavel, m betecknar 0 eller 1 och Rb betecknar cite eller, om m betecknar 0 eventuellt skyddad amino, karboxi, sulfo eller hydroxi, eller 0-lagalkylfosfono eller 0,0--dilAgalkyl-fosfcno eller, betecknar Nip en 5-amino-5-karboxi-valerylrest van i amino- och karboxigruppen eventuellt Or skyddade, R2 betecknar hydroxi eller bildar tillsammans med karbonylgrupnen -C(=0)- en skyddad karboxylgrupp, 4 och 143 betecknar Irate samt 1-oxiden ay 3-cefemforeningar med fornel IA, motsvarande 2-cefem-fbreningar med formeln 1\ PP 1S (IB) _R3 CR3 van iR, oca 143 har ovan angivna betydelser, eller bland- ningar av 3-cefem- och 2-cefemfbreningar med formeln IA och IS, eller salter an sadana fbreningar med saltbildande grupper, kannetecknat av att manien beefing med formeln hexylamino, N-metyl-cyklohexylamino, dibensylamioo,rr.tyl- bensylamino, N-cyklopropyl-bensylamino, 1-aziridinyl, 1-pyrrelidinyl, 1-piperidyl, 11-2,3,4,5,0,7-hexahydroazepinyl, 4- morfolinyl, 4-tiomorfolinyl, 1-piperazinyl eller 4-meey1-1- piperazinyl genom tillsats an vatten och eventuellt en katalytisk till ekvimolar mangd an en organisk eller ocrganisk s),ra vii temperatmTmellan -° och 01 solvolyserar aminogruppen -N(11) ■Rd till gruppen -0R3:och eventuellt i en erhAllen firening med formeln IA rasp. IB overfbr den fOrestrade karboxylgruppen med formel -C(=0)-4 genom fbrtvalning till den fria karboxylgruppen och eventuellt i en erhAllen fbrening med formeln IA reap. Ii, earl R3 betecknar en acylrest avspaltas dense acylrest gencm behandling med ett iffidhalogenid-hildande medel, omsattning av den erhallna inidhalogeniden med at alkchol till en motsvarande iminoeter ouh solvolysering av den bildade iminoetern, och om sa Onskas, frigbres i en erhAllen fbrening med formeln IA rasp. IB i en hydroxifenylrest Ra eventuellt forevarande skyddad hydroxi och/eller skyddad amino, karboxi, sulfo eller hydroxi Rb och, om sO briskas bverfores en erhAllen fbrening med formeln IA resp, Ii med saltbildande grupp till ett salt eller ett erhallet salt till en fri fOrening och/eller, om sa onskes, separeras en erhallen blandning av isomera fbreningar i de enskilda isomererna. 0—
SE7909754A 1975-02-20 1979-11-26 Sett att framstella 7beta-amino-3-cefem-3-ol-4-karbonsyraforeningar SE434265B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH215775A CH626091A5 (en) 1975-02-20 1975-02-20 Process for preparing enol derivatives
CH1096275A CH627759A5 (en) 1975-08-25 1975-08-25 Process for preparing enol ether compounds

Publications (2)

Publication Number Publication Date
SE7909754L true SE7909754L (sv) 1979-11-26
SE434265B SE434265B (sv) 1984-07-16

Family

ID=25689673

Family Applications (4)

Application Number Title Priority Date Filing Date
SE7601873A SE434951B (sv) 1975-02-20 1976-02-18 Nytt forfarande for framstellning av 7beta-amino-3-cefem-3-ol-4-karboxylsyraforeningar
SE7909754A SE434265B (sv) 1975-02-20 1979-11-26 Sett att framstella 7beta-amino-3-cefem-3-ol-4-karbonsyraforeningar
SE7909753A SE445644B (sv) 1975-02-20 1979-11-26 7beta-amino-3-cefem-3-amino-4-karbonsyra-foreningar som mellanprodukter for framstellning av 7beta-amino-3-cefem-3-ol-4-karbonsyra-foreningar
SE7909752A SE440349B (sv) 1975-02-20 1979-11-26 2-(2-oxoazetidin-1-yl)-krotonsyra-foreningar till anvendning som mellanprodukt vid framstellning av terapeutiskt verdefulla 7beta-amino-3-cefem-foreningar

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7601873A SE434951B (sv) 1975-02-20 1976-02-18 Nytt forfarande for framstellning av 7beta-amino-3-cefem-3-ol-4-karboxylsyraforeningar

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE7909753A SE445644B (sv) 1975-02-20 1979-11-26 7beta-amino-3-cefem-3-amino-4-karbonsyra-foreningar som mellanprodukter for framstellning av 7beta-amino-3-cefem-3-ol-4-karbonsyra-foreningar
SE7909752A SE440349B (sv) 1975-02-20 1979-11-26 2-(2-oxoazetidin-1-yl)-krotonsyra-foreningar till anvendning som mellanprodukt vid framstellning av terapeutiskt verdefulla 7beta-amino-3-cefem-foreningar

Country Status (19)

Country Link
US (3) US4110533A (sv)
JP (1) JPS6145627B2 (sv)
AT (1) AT342197B (sv)
AU (1) AU498501B2 (sv)
CA (1) CA1080695A (sv)
CS (3) CS194748B2 (sv)
DE (1) DE2606196A1 (sv)
DK (4) DK157027C (sv)
ES (3) ES445282A1 (sv)
FR (1) FR2301529A1 (sv)
GB (1) GB1530501A (sv)
HU (1) HU174553B (sv)
IE (1) IE43703B1 (sv)
IL (2) IL49064A (sv)
MX (1) MX3311E (sv)
NL (1) NL7601514A (sv)
NZ (1) NZ180049A (sv)
PT (1) PT64823B (sv)
SE (4) SE434951B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
US4579684A (en) * 1975-02-20 1986-04-01 Ciba-Geigy Corporation Process for the manufacture of enol derivatives
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4434287A (en) 1975-02-20 1984-02-28 Ciba-Geigy Corporation Cephalosporin derivatives
US4013651A (en) * 1975-05-12 1977-03-22 Eli Lilly And Company 3-substituted amino-cephalosporins
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
US4301279A (en) 1979-02-23 1981-11-17 Ciba-Geigy Corporation Process for the production of 3-hydroxy compounds
US4436903A (en) * 1980-12-22 1984-03-13 Ciba-Geigy Corporation Process for the production of 7 β-substituted-3-unsubstituted-3-cephem-4-carboxylic acid compounds
DE3265390D1 (en) * 1981-05-19 1985-09-19 Ciba Geigy Ag Process for the preparation of 4-thio-azetidinone compounds
JPS59134779A (ja) * 1983-01-19 1984-08-02 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPH02159453A (ja) * 1988-12-09 1990-06-19 Miyano:Kk カム制御装置
JPH04316593A (ja) * 1991-02-21 1992-11-06 Japan Tobacco Inc D−アロサンの製造方法
JP3227497B2 (ja) 1992-02-18 2001-11-12 大塚化学株式会社 β−ラクタム化合物及びその製造法
WO1993016043A1 (en) * 1992-02-18 1993-08-19 Otsuka Kagaku Kabushiki Kaisha β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
US6696594B2 (en) 2002-05-13 2004-02-24 Saudi Basic Industries Corporation Process for the conversion of aldehydes to esters
US20090324742A1 (en) * 2006-09-08 2009-12-31 Sonke Svenson Peham dendrimers as excipients
CN113563365B (zh) * 2021-08-17 2024-05-28 华中药业股份有限公司 一种7-氨基-3-甲氧基-4-头孢烷酸的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518260A (en) * 1965-03-08 1970-06-30 Lilly Co Eli Method for preparing aminoacyl cephalosporins
BE791160A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Nouveaux cephemes substitues
BE791161A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Procede pour la preparation d'analogues des cephalosporines
US3950352A (en) * 1972-04-10 1976-04-13 Queen's University 2,2-Dimethyl-3R-carboxy-6S-phenyl(or phenoxy)acetamido-1-oxa-4-aza-5R-bicyclo[3,2,0]heptan-7-one and processes for their production
US3960881A (en) * 1972-04-24 1976-06-01 Phillips Petroleum Company Method for preparing 4-carboxythiazolidine-2-thione
US3944545A (en) * 1972-05-10 1976-03-16 Eli Lilly And Company Process for preparing desacetoxycephalosporins
US3960851A (en) * 1972-05-15 1976-06-01 Eli Lilly And Company Preparation of desacetoxy-cephalosporin sulfoxides from penicillin sulfoxides
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
GB1431174A (en) * 1972-06-30 1976-04-07 Clin Midy Process for the conversion of a penicillin s-oxide into a corresponding desacetoxycephalosporin
US3917588A (en) * 1972-11-28 1975-11-04 Lilly Co Eli {60 -Aminoacyl cephalosporin ethers
AR208068A1 (es) * 1973-02-23 1976-11-30 Lilly Co Eli Un procedimiento para preparar derivados de acidos 7-acilamido-3-halo-cefem-4-carboxilico los esteres y las sales farmaceuticamente aceptables de los mismos
YU36970B (en) * 1973-02-23 1984-08-31 Lilly Co Eli Process for obtaining 7-(amino)-acylamido-3-halocephalosporins
AU498131B2 (en) * 1974-02-26 1979-02-15 Ciba-Geigy Ag Production of cephems by cyclization
US4036835A (en) * 1974-05-22 1977-07-19 Societa' Farmaceutici Italia Process for preparing cephalosporins
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4013651A (en) * 1975-05-12 1977-03-22 Eli Lilly And Company 3-substituted amino-cephalosporins
JPS5214789A (en) * 1975-07-22 1977-02-03 Shionogi & Co Ltd Process for preparing 3-substiuted cephem compounds by ring closure
US4024152A (en) * 1975-09-19 1977-05-17 Eli Lilly And Company 4-Dithio-3-imido-azetidin-2-ones
US4008230A (en) * 1975-10-29 1977-02-15 Eli Lilly And Company Process for preparing 3-hydroxy cephalosporins
US4048162A (en) * 1975-10-29 1977-09-13 Eli Lilly And Company Process for preparing 3-hydroxy cephalosporins
IE45158B1 (en) * 1976-08-16 1982-06-30 Lilly Co Eli 3-chloro-cephem synthesis

Also Published As

Publication number Publication date
DK157079B (da) 1989-11-06
SE7601873L (sv) 1976-11-11
CS194748B2 (en) 1979-12-31
ES445282A1 (es) 1977-11-01
DK157079C (da) 1990-04-09
US4110533A (en) 1978-08-29
SE7909753L (sv) 1979-11-26
DK157027C (da) 1990-04-02
PT64823A (en) 1976-03-01
FR2301529A1 (fr) 1976-09-17
SE7909752L (sv) 1979-11-26
SE445644B (sv) 1986-07-07
AU498501B2 (en) 1979-03-15
DK167278B1 (da) 1993-10-04
IE43703L (en) 1976-08-20
DK543287D0 (da) 1987-10-16
DK157027B (da) 1989-10-30
IE43703B1 (en) 1981-05-06
ES459833A1 (es) 1978-07-16
DE2606196C2 (sv) 1990-07-26
NZ180049A (en) 1978-06-20
IL49064A0 (en) 1976-04-30
DE2606196A1 (de) 1976-09-16
CS194740B2 (en) 1979-12-31
DK68976A (da) 1976-08-21
PT64823B (en) 1977-06-07
AT342197B (de) 1978-03-28
US4293462A (en) 1981-10-06
SE434265B (sv) 1984-07-16
GB1530501A (en) 1978-11-01
NL7601514A (nl) 1976-08-24
DK543387A (da) 1987-10-16
DK543387D0 (da) 1987-10-16
AU1125376A (en) 1977-08-25
DK157080B (da) 1989-11-06
SE440349B (sv) 1985-07-29
JPS51110593A (sv) 1976-09-30
IL49064A (en) 1979-11-30
DK543287A (da) 1987-10-16
CA1080695A (en) 1980-07-01
DK543187D0 (da) 1987-10-16
HU174553B (hu) 1980-02-28
IL56394A0 (en) 1979-03-12
MX3311E (es) 1980-09-10
JPS6145627B2 (sv) 1986-10-08
FR2301529B1 (sv) 1982-09-17
CS194749B2 (en) 1979-12-31
SE434951B (sv) 1984-08-27
ES459827A1 (es) 1978-07-16
DK543187A (da) 1987-10-16
ATA76976A (de) 1977-07-15
DK157080C (da) 1990-04-09
US4319027A (en) 1982-03-09

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