SE7909281L - Prostansyraderivat - Google Patents
ProstansyraderivatInfo
- Publication number
- SE7909281L SE7909281L SE7909281A SE7909281A SE7909281L SE 7909281 L SE7909281 L SE 7909281L SE 7909281 A SE7909281 A SE 7909281A SE 7909281 A SE7909281 A SE 7909281A SE 7909281 L SE7909281 L SE 7909281L
- Authority
- SE
- Sweden
- Prior art keywords
- carbon atoms
- alkyl
- compound
- enantiomer
- fluorine
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 claims 1
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (1)
1. PATENTKRAV F5rfarande for framstallning av en opt1skt aktly f8rening med formeln HO' 0 CH=N-NH-C-NH2 -NH2 kannetecknat av stegen (1) bfldning av en blandad anhydrid av den optiskt aktiva farerangen med formeln 0 0 „CH2N-0-E c H/ NH C=C7H R3(T). HZc-L. eller en racemisk blandning av denna f5rening och dess enantiomer, dar R3 och R4 betecknar vate, metyl eller etyl; dr T betecknar alkyl med 1-4 kolatomer, fluor, klor, tr1fluOrmetyl eller -OR, dNr R, betecknar vate eller alkyl med 1-4 kolatomer och dar s Az- 0, 1, 2 eller 3 varvid howit tvA T her annan betydelse an alkyl; dar Y betecknareller /No och dar Z beted,--, en oxaatom) eller C.H23 dat N OH ....„(CH2)3-g-OH H7 N.H HO Y 4 CjIi2j 'dr en valensbindning eller en alkylengrUpp med 1-9 kolatomer, substituerad med 0, 1 eller 2 fluor, med 1-6 kolatomer mellan -CR3R4- och ringen och dar E betecknar: (:).-NRICH3 0-NH -g-0 o-gNR -g -CH3 ONH-g-e-NR-LO 0-NH-g-NR2 eller en racemisk blandning av denna forening och enantiomeren dgrav, dgr R3, R4, T, s, Y och Z tidigare deflnierats, genom reaktion med isobutylkloroformiat i ngrvaro av en tertigr amin och (2) att anhydriden Mr reagera med motsvarande fenol eller naftol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/523,568 US3998869A (en) | 1974-11-14 | 1974-11-14 | Substituted anilide esters of 16-substituted PGE2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7909281L true SE7909281L (sv) | 1979-11-09 |
| SE437020B SE437020B (sv) | 1985-02-04 |
Family
ID=24085532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7512743A SE422058B (sv) | 1974-11-14 | 1975-11-13 | Forfarande for framstellning av substituerade fenylestrar av vissa prostaglandiner av typ e?712 |
| SE7909281A SE437020B (sv) | 1974-11-14 | 1979-11-09 | Forfarande for framstellning av substituerade fenylestrar av vissa prostaglandinanaloger av typ e?712 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7512743A SE422058B (sv) | 1974-11-14 | 1975-11-13 | Forfarande for framstellning av substituerade fenylestrar av vissa prostaglandiner av typ e?712 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3998869A (sv) |
| JP (2) | JPS5858345B2 (sv) |
| AU (1) | AU498539B2 (sv) |
| BE (1) | BE835603A (sv) |
| CA (1) | CA1049510A (sv) |
| DE (1) | DE2543775A1 (sv) |
| ES (2) | ES442122A1 (sv) |
| FR (1) | FR2290895A1 (sv) |
| GB (1) | GB1492439A (sv) |
| HU (1) | HU173669B (sv) |
| NL (1) | NL7513116A (sv) |
| SE (2) | SE422058B (sv) |
| ZA (1) | ZA756628B (sv) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2644972C2 (de) * | 1976-10-06 | 1986-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Thiaprostansäurederivate, deren Herstellung und diese Verbindungen enthaltende Mittel |
| US4203829A (en) * | 1978-09-28 | 1980-05-20 | Standard Oil Company (Indiana) | Catalyst, method of preparation and use thereof in hydrodesulfurizing cracked naphtha |
| JPS6436059A (en) * | 1987-07-31 | 1989-02-07 | Kyushu Nippon Electric | Lead frame of semiconductor device |
| EP4055007A4 (en) * | 2019-11-07 | 2024-02-14 | Lifex Biolabs, Inc. | PROSTAGLANDIN ANALOGS AND USES THEREOF |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4920766B1 (sv) * | 1970-11-10 | 1974-05-27 | ||
| AR204816A1 (es) * | 1972-11-08 | 1976-03-05 | Pfizer | Procedimiento para preparar una prostaglandina |
| CA1045132A (en) * | 1973-11-23 | 1978-12-26 | Walter Morozowich | Phenyl and naphthyl esters of prostaglandins |
-
1974
- 1974-11-14 US US05/523,568 patent/US3998869A/en not_active Expired - Lifetime
-
1975
- 1975-10-01 DE DE19752543775 patent/DE2543775A1/de not_active Withdrawn
- 1975-10-06 CA CA237,115A patent/CA1049510A/en not_active Expired
- 1975-10-17 GB GB42611/75A patent/GB1492439A/en not_active Expired
- 1975-10-21 ZA ZA00756628A patent/ZA756628B/xx unknown
- 1975-10-21 AU AU85877/75A patent/AU498539B2/en not_active Expired
- 1975-10-27 ES ES442122A patent/ES442122A1/es not_active Expired
- 1975-11-05 JP JP50132228A patent/JPS5858345B2/ja not_active Expired
- 1975-11-10 NL NL7513116A patent/NL7513116A/xx not_active Application Discontinuation
- 1975-11-10 HU HU75UO113A patent/HU173669B/hu unknown
- 1975-11-13 FR FR7534660A patent/FR2290895A1/fr active Granted
- 1975-11-13 SE SE7512743A patent/SE422058B/sv unknown
- 1975-11-14 BE BE161899A patent/BE835603A/xx not_active IP Right Cessation
-
1977
- 1977-02-28 ES ES456372A patent/ES456372A1/es not_active Expired
-
1979
- 1979-11-09 SE SE7909281A patent/SE437020B/sv unknown
-
1984
- 1984-11-16 JP JP59240872A patent/JPS60120859A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2290895A1 (fr) | 1976-06-11 |
| NL7513116A (nl) | 1976-05-18 |
| JPS5170753A (sv) | 1976-06-18 |
| ZA756628B (en) | 1976-09-29 |
| AU8587775A (en) | 1977-04-28 |
| GB1492439A (en) | 1977-11-16 |
| CA1049510A (en) | 1979-02-27 |
| SE7512743L (sv) | 1976-05-17 |
| SE422058B (sv) | 1982-02-15 |
| FR2290895B1 (sv) | 1978-07-28 |
| DE2543775A1 (de) | 1976-10-07 |
| US3998869A (en) | 1976-12-21 |
| JPS5858345B2 (ja) | 1983-12-24 |
| JPS60120859A (ja) | 1985-06-28 |
| HU173669B (en) | 1979-07-28 |
| SE437020B (sv) | 1985-02-04 |
| BE835603A (fr) | 1976-05-14 |
| AU498539B2 (en) | 1979-03-15 |
| ES456372A1 (es) | 1978-02-01 |
| ES442122A1 (es) | 1977-07-01 |
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