SE7810947L - 3-alkylxanthines - Google Patents

3-alkylxanthines

Info

Publication number
SE7810947L
SE7810947L SE7810947A SE7810947A SE7810947L SE 7810947 L SE7810947 L SE 7810947L SE 7810947 A SE7810947 A SE 7810947A SE 7810947 A SE7810947 A SE 7810947A SE 7810947 L SE7810947 L SE 7810947L
Authority
SE
Sweden
Prior art keywords
methylbutyl
compound
formula
produced
aminouracil
Prior art date
Application number
SE7810947A
Other languages
English (en)
Swedish (sv)
Inventor
P G Kjellin
C G A Persson
Original Assignee
Draco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco Ab filed Critical Draco Ab
Priority to SE7810947A priority Critical patent/SE7810947L/xx
Priority to ZA00795113A priority patent/ZA795113B/xx
Priority to EP79850090A priority patent/EP0010531B1/en
Priority to DE7979850090T priority patent/DE2963021D1/de
Priority to AT79850090T priority patent/ATE1145T1/de
Priority to CA337,077A priority patent/CA1131632A/en
Priority to SU792824353A priority patent/SU952105A3/ru
Priority to DK432179A priority patent/DK148884C/da
Priority to PH23182A priority patent/PH16676A/en
Priority to FI793224A priority patent/FI66867C/fi
Priority to NZ191870A priority patent/NZ191870A/en
Priority to AU51871/79A priority patent/AU530717B2/en
Priority to IE1987/79A priority patent/IE49184B1/en
Priority to GR60300A priority patent/GR72945B/el
Priority to PT70350A priority patent/PT70350A/pt
Priority to NO793377A priority patent/NO152561C/no
Priority to DD79216348A priority patent/DD146708A5/de
Priority to JP13584579A priority patent/JPS5557589A/ja
Priority to ES485178A priority patent/ES485178A1/es
Priority to PL1979219065A priority patent/PL119413B1/pl
Priority to HU79DA367A priority patent/HU180220B/hu
Publication of SE7810947L publication Critical patent/SE7810947L/xx
Priority to US06/323,955 priority patent/US4548818A/en
Priority to CA000391134A priority patent/CA1142928A/en
Priority to US06/634,650 priority patent/US4644001A/en
Priority to SG860/84A priority patent/SG86084G/en
Priority to HK77/85A priority patent/HK7785A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE7810947A 1978-10-20 1978-10-20 3-alkylxanthines SE7810947L (sv)

Priority Applications (26)

Application Number Priority Date Filing Date Title
SE7810947A SE7810947L (sv) 1978-10-20 1978-10-20 3-alkylxanthines
ZA00795113A ZA795113B (en) 1978-10-20 1979-09-26 3-alkylxanthines intermediates and their preparation and use
EP79850090A EP0010531B1 (en) 1978-10-20 1979-09-28 3-alkylxanthines, processes for their preparation and compositions for use in the treatment of chronic obstructive airway disease and cardiac disease
DE7979850090T DE2963021D1 (en) 1978-10-20 1979-09-28 3-alkylxanthines, processes for their preparation and compositions for use in the treatment of chronic obstructive airway disease and cardiac disease
AT79850090T ATE1145T1 (de) 1978-10-20 1979-09-28 3-alkylxanthine, verfahren zu ihrer herstellung und zusammensetzungen zur benutzung in der behandlung chronisch verlegter atemwege und von herzkrankheiten.
CA337,077A CA1131632A (en) 1978-10-20 1979-10-05 3-alkylxanthines, intermediates, processes for their preparation, composition and methods for the treatment of chronic obstructive airway disease and cardiac disease
SU792824353A SU952105A3 (ru) 1978-10-20 1979-10-11 Способ получени производных ксантина или их солей
DK432179A DK148884C (da) 1978-10-20 1979-10-12 Analogifremgangsmaade til fremstilling af 3-alkylxantinderivater eller fysiologisk acceptable salte deraf
PH23182A PH16676A (en) 1978-10-20 1979-10-16 3-alkylxanthines,composition and methods for the treatment of chronic obstructive airway disease and cardiac disease
FI793224A FI66867C (fi) 1978-10-20 1979-10-17 Foerfarande foer framstaellning av nya farmakologiskt aktiva 3-alkylxantiner
NZ191870A NZ191870A (en) 1978-10-20 1979-10-17 Certain 3-hydrocarbyl-3,7-dihydro-1h-purine-2,6-diones
AU51871/79A AU530717B2 (en) 1978-10-20 1979-10-17 Purines
IE1987/79A IE49184B1 (en) 1978-10-20 1979-10-18 3-alkylxanthines,processes for their preparation and compositions for use in the treatment of chronic obstructive airway disease and cardiac disease
GR60300A GR72945B (xx) 1978-10-20 1979-10-19
HU79DA367A HU180220B (en) 1978-10-20 1979-10-19 Process for preparing 3-alkyl-xanthine derivatives
NO793377A NO152561C (no) 1978-10-20 1979-10-19 Analogifremgangsmaate for fremstilling av terapeutisk virksomme 3-alkylxantin-forbindelser
DD79216348A DD146708A5 (de) 1978-10-20 1979-10-19 Verfahren zur herstellung von 3-alkylxanthinen
JP13584579A JPS5557589A (en) 1978-10-20 1979-10-19 33alkylqithantine compoumd
ES485178A ES485178A1 (es) 1978-10-20 1979-10-19 Un metodo para la preparacion de 3-alcohilxantinas
PL1979219065A PL119413B1 (en) 1978-10-20 1979-10-19 Process for preparing novel derivatives of xanthine
PT70350A PT70350A (en) 1978-10-20 1979-10-19 Process for preparing 3-alkylxanthines intermediate compounds and pharmaceutical compositions useful for the treatment of chronic obstrutive airway diseases and cardiac diseases
US06/323,955 US4548818A (en) 1978-10-20 1981-11-23 Composition and methods for the treatment of chronic obstructive airway disease and cardiac disease using 3-alkylxanthines
CA000391134A CA1142928A (en) 1978-10-20 1981-11-27 3-alkylxanthines, intermediates, processes for their preparation, composition and methods for the treatment of chronic obstructive airway disease and cardiac disease
US06/634,650 US4644001A (en) 1978-10-20 1984-07-25 3-Alkylxanthines, composition and methods for the treatment of chronic obstructive-airway disease and cardiac disease
SG860/84A SG86084G (en) 1978-10-20 1984-11-29 3-alkylxanthines,processes for their preparation and compositions for use in the treatment of chronic obstructive airway disease and cardiac disease
HK77/85A HK7785A (en) 1978-10-20 1985-01-31 3-alkylxanthines,process for their preparation and compositions for use in the treatment of chronic obstructive airway diseasse and cardiac disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7810947A SE7810947L (sv) 1978-10-20 1978-10-20 3-alkylxanthines

Publications (1)

Publication Number Publication Date
SE7810947L true SE7810947L (sv) 1980-04-21

Family

ID=20336145

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7810947A SE7810947L (sv) 1978-10-20 1978-10-20 3-alkylxanthines

Country Status (24)

Country Link
US (2) US4548818A (xx)
EP (1) EP0010531B1 (xx)
JP (1) JPS5557589A (xx)
AT (1) ATE1145T1 (xx)
AU (1) AU530717B2 (xx)
CA (1) CA1131632A (xx)
DD (1) DD146708A5 (xx)
DE (1) DE2963021D1 (xx)
DK (1) DK148884C (xx)
ES (1) ES485178A1 (xx)
FI (1) FI66867C (xx)
GR (1) GR72945B (xx)
HK (1) HK7785A (xx)
HU (1) HU180220B (xx)
IE (1) IE49184B1 (xx)
NO (1) NO152561C (xx)
NZ (1) NZ191870A (xx)
PH (1) PH16676A (xx)
PL (1) PL119413B1 (xx)
PT (1) PT70350A (xx)
SE (1) SE7810947L (xx)
SG (1) SG86084G (xx)
SU (1) SU952105A3 (xx)
ZA (1) ZA795113B (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
CH643260A5 (fr) * 1980-05-02 1984-05-30 Nestle Sa 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament.
IT1200944B (it) * 1982-08-10 1989-01-27 Malesci Sas Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico
US5338741A (en) * 1986-10-27 1994-08-16 Nestec S.A. 1-hydroxyalkylxanthines and medicaments containing them
US5246931A (en) * 1988-10-25 1993-09-21 Bristol-Myers Squibb Company Carbocyclic nucleoside analogs
IL92096A0 (en) 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US5153352A (en) * 1988-10-25 1992-10-06 Bristol-Myers Squibb Company Process for preparation of intermediates of carbocyclic nucleoside analogs
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
IT1229195B (it) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
CA2030112A1 (en) * 1989-11-24 1991-05-25 Yasuo Ito Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
DE69230349T2 (de) * 1991-03-05 2000-07-27 Ajinomoto Kk Cyclopropanderivat
US5877179A (en) * 1992-09-29 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
US5504090A (en) * 1994-03-30 1996-04-02 Trustees Of The University Of Pennsylvania Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury
US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
AU4980999A (en) 1998-07-10 2000-02-01 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A3 adenosine receptor antagonists
WO2001051490A1 (en) 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
US6623553B2 (en) * 2001-04-20 2003-09-23 John Russell Printing process with edible inks
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
EP1601649A4 (en) * 2003-02-19 2009-03-04 Endacea Inc A1-adenosine receptor antagonistic
CA2528385C (en) * 2003-06-06 2011-03-15 Endacea, Inc. A1 adenosine receptor antogonists
EP1636230A4 (en) * 2003-06-09 2010-06-16 Endacea Inc ADENOSINE A1 RECEPTOR ANTAGONISTS
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
DE102006020519A1 (de) * 2006-05-03 2007-11-08 Robert Bosch Gmbh Vorrichtung zum Einfalten zumindest einer Lasche einer Verpackung
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
US7743683B2 (en) * 2006-08-15 2010-06-29 Umagination Labs, L.P. Systems and methods of a power tool system with interchangeable functional attachments powered by a direct rotational drive
WO2011068978A1 (en) 2009-12-02 2011-06-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives and dendrimer conjugates thereof
WO2017114843A1 (en) * 2015-12-29 2017-07-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Xanthine derivative inhibitors of bet proteins

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
DE864868C (de) * 1943-10-02 1953-01-29 Hellmut Dr Bredereck Verfahren zur Herstellung von Purinverbindungen
US2646432A (en) * 1947-01-13 1953-07-21 Mallinckrodt Chemical Works Method of preparing 2, 6-diketopurines
US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
GB683523A (en) * 1948-08-18 1952-12-03 Beecham Res Lab The manufacture of purine derivatives
US2781344A (en) * 1953-05-04 1957-02-12 Monsanto Chemicals Formylation of amino-pyrimidines
US2844576A (en) * 1955-11-22 1958-07-22 American Cyanamid Co Preparation of purines
BE592753A (xx) * 1959-07-09 1900-01-01
GB982079A (en) * 1962-05-01 1965-02-03 Dresden Arzneimittel Process for the production of xanthine derivatives
GB1008454A (en) * 1963-03-26 1965-10-27 Dresden Arzneimittel Pseudoxanthines
JPS53890B2 (xx) * 1972-04-22 1978-01-12
GB1435916A (en) * 1972-05-11 1976-05-19 Beecham Group Ltd Pharmaceutical weight-reducing compositions
JPS5125009U (xx) * 1974-08-14 1976-02-24
FR2346244A1 (fr) * 1976-03-30 1977-10-28 Chamagne Pierre Nouveau conditionnement pour la conservation de liquides alimentaires
US4089959A (en) * 1976-03-31 1978-05-16 Cooper Laboratories, Inc. Long-acting xanthine bronchodilators and antiallergy agents
US4120947A (en) * 1976-03-31 1978-10-17 Cooper Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
CA1077932A (en) * 1976-03-31 1980-05-20 Berlex Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
JPS52133295U (xx) * 1976-04-05 1977-10-11
JPS5618169Y2 (xx) * 1976-09-20 1981-04-28
SE416810C (sv) * 1977-10-14 1982-05-11 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
SE7810946L (sv) * 1978-10-20 1980-04-21 Draco Ab Metod att behandla kronisk obstruktiv luftvegssjukdom
US4338319A (en) * 1979-11-27 1982-07-06 Aktiebolaget Draco Method for the treatment of chronic obstructive airway or cardiac diseases
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar

Also Published As

Publication number Publication date
SG86084G (en) 1985-06-07
JPH0130834B2 (xx) 1989-06-22
FI793224A (fi) 1980-04-21
PH16676A (en) 1983-12-13
AU5187179A (en) 1980-05-01
ES485178A1 (es) 1980-05-16
JPS5557589A (en) 1980-04-28
DK432179A (da) 1980-04-21
FI66867C (fi) 1984-12-10
US4644001A (en) 1987-02-17
IE791987L (en) 1980-04-20
AU530717B2 (en) 1983-07-28
DD146708A5 (de) 1981-02-25
NO793377L (no) 1980-04-22
HU180220B (en) 1983-02-28
HK7785A (en) 1985-02-08
DK148884C (da) 1986-04-07
GR72945B (xx) 1984-01-17
US4548818A (en) 1985-10-22
NZ191870A (en) 1984-07-06
CA1131632A (en) 1982-09-14
EP0010531B1 (en) 1982-06-02
SU952105A3 (ru) 1982-08-15
IE49184B1 (en) 1985-08-21
DK148884B (da) 1985-11-04
PL119413B1 (en) 1981-12-31
PL219065A1 (xx) 1980-06-16
DE2963021D1 (en) 1982-07-22
PT70350A (en) 1979-11-01
ATE1145T1 (de) 1982-06-15
NO152561B (no) 1985-07-08
ZA795113B (en) 1980-10-29
FI66867B (fi) 1984-08-31
EP0010531A1 (en) 1980-04-30
NO152561C (no) 1985-10-16

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