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Asahi Chemical Industry Co Ltd
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Asahi Chemical Industry Co Ltd
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Application filed by Asahi Chemical Industry Co LtdfiledCriticalAsahi Chemical Industry Co Ltd
Priority to JP15747977ApriorityCriticalpatent/JPS5492989A/en
Publication of JPS5492989ApublicationCriticalpatent/JPS5492989A/en
PURPOSE: To obtain a substituted theobromine which is a vasolidator and a hematocytolysis enhancer of low toxicity in a high yield with ease, by reacting a theobromine derivative with an acetoacetic ester in the presence of a base, followed by hydrolysis and decarboxylation.
CONSTITUTION: A theobromine derivative of formula I is reacted with a compound of formula II: (R is lower alkyl group) in the presence of an alkali metal alkoxide, or hydride in a solvent, e.g. methanol or DMF, preferably at 60W120°C to give a reaction product, which is then hydrolyzed by NaOH, etc., and decarboxylated by sulfuric acid under refluxing and heating, to give 1-(5-oxohexyl)theobromine of formula III.
EFFECT: The raw material is easily available, and the objective compound can be readily purified with little formation of by-products.
COPYRIGHT: (C)1979,JPO&Japio
JP15747977A1977-12-281977-12-28Preparation of substituted theobromine
PendingJPS5492989A
(en)