SE7711039L - NEW 9-CHLOROPREDNISOLON DERIVATIVES AND WAY TO PRODUCE THE SAME - Google Patents

NEW 9-CHLOROPREDNISOLON DERIVATIVES AND WAY TO PRODUCE THE SAME

Info

Publication number
SE7711039L
SE7711039L SE7711039A SE7711039A SE7711039L SE 7711039 L SE7711039 L SE 7711039L SE 7711039 A SE7711039 A SE 7711039A SE 7711039 A SE7711039 A SE 7711039A SE 7711039 L SE7711039 L SE 7711039L
Authority
SE
Sweden
Prior art keywords
derivatives
chloroprednisolon
produce
new
way
Prior art date
Application number
SE7711039A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE431655B (en
Inventor
K Annen
H Laurent
H Hofmeister
R Wiechert
H Wendt
J F Kapp
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2645105A external-priority patent/DE2645105C2/en
Priority claimed from DE19772742982 external-priority patent/DE2742982C2/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of SE7711039L publication Critical patent/SE7711039L/en
Publication of SE431655B publication Critical patent/SE431655B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivatives of 9-chloroprednisolone of the formula <IMAGE> in which R1 is alkanoyl with 1 to 8 carbon atoms or benzoyl, and X is fluorine, chlorine, hydroxyl, alkanoyloxy with 1 to 8 carbon atoms or benzoyloxy, are prepared. These compounds are obtained by adding HOCl onto the corresponding DELTA <9,11>-prednisolones. The compounds can be used for the treatment of inflammations.
SE7711039A 1976-10-04 1977-10-03 ANALOGY PROCEDURES FOR THE PREPARATION OF NEW 9-CHLOROPEDNISOLONE DERIVATIVES SE431655B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2645105A DE2645105C2 (en) 1976-10-04 1976-10-04 Derivatives of 9-chlorprednisolone, process for their preparation and pharmaceutical preparation containing them
DE19772742982 DE2742982C2 (en) 1977-09-21 1977-09-21 9-chlorprednisolone derivatives, process for their production and pharmaceutical preparation containing them

Publications (2)

Publication Number Publication Date
SE7711039L true SE7711039L (en) 1978-04-05
SE431655B SE431655B (en) 1984-02-20

Family

ID=25770978

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7711039A SE431655B (en) 1976-10-04 1977-10-03 ANALOGY PROCEDURES FOR THE PREPARATION OF NEW 9-CHLOROPEDNISOLONE DERIVATIVES

Country Status (21)

Country Link
JP (1) JPS5359654A (en)
AT (1) AT358202B (en)
CH (4) CH630098A5 (en)
DK (1) DK438277A (en)
ES (1) ES462887A1 (en)
FI (1) FI58645C (en)
FR (1) FR2366313A1 (en)
GB (1) GB1594852A (en)
GR (1) GR73041B (en)
HU (1) HU179593B (en)
IE (1) IE45877B1 (en)
IL (1) IL53030A (en)
IT (1) IT1113623B (en)
LU (1) LU78223A1 (en)
NL (1) NL7710869A (en)
NO (1) NO148597C (en)
NZ (1) NZ185295A (en)
PL (1) PL110392B1 (en)
PT (1) PT67109B (en)
SE (1) SE431655B (en)
SU (2) SU743581A3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853785A1 (en) * 1978-12-11 1980-06-19 Schering Ag NEW PREDNISON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND THE USE THEREOF
JPH0374245A (en) * 1989-08-12 1991-03-28 Mk Seiko Co Ltd Car washing machine
KR20170018974A (en) 2010-03-26 2017-02-20 갈데르마 리써어치 앤드 디벨로프먼트 Improved methods and compositions for safe and effective treatment of erythema
CA2850273A1 (en) 2011-10-19 2013-04-25 Galderma S.A. Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors
CN106632561A (en) * 2016-12-16 2017-05-10 广州仁恒医药科技股份有限公司 Method for preparing difluprednate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH429716A (en) * 1961-06-24 1967-02-15 Vismara Francesco Spa Process for the preparation of 17a-acyloxy-21-hydroxy steroids
DE2055221A1 (en) * 1970-11-10 1972-05-18 Laboratorio Chimico Farmaceutico Dr. P. Blasina S.R.L., Mailand (Italien) 17-acyloxy-3-keto-pregn-4-enes prepn - by acylating 17-hydroxy steroids in presence ofstannic chloride

Also Published As

Publication number Publication date
IL53030A (en) 1982-11-30
IT1113623B (en) 1986-01-20
FR2366313B1 (en) 1980-02-01
ES462887A1 (en) 1978-12-16
JPS6129960B2 (en) 1986-07-10
SU751327A3 (en) 1980-07-23
ATA703577A (en) 1980-01-15
FI772922A (en) 1978-04-05
PL201161A1 (en) 1979-01-29
NL7710869A (en) 1978-04-06
DK438277A (en) 1978-04-05
NO148597C (en) 1983-11-09
GB1594852A (en) 1981-08-05
AT358202B (en) 1980-08-25
PT67109A (en) 1977-11-01
NO773362L (en) 1978-04-05
PL110392B1 (en) 1980-07-31
HU179593B (en) 1982-11-29
PT67109B (en) 1979-03-14
JPS5359654A (en) 1978-05-29
CH631997A5 (en) 1982-09-15
IE45877L (en) 1978-04-04
CH630098A5 (en) 1982-05-28
CH632278A5 (en) 1982-09-30
LU78223A1 (en) 1978-02-01
NO148597B (en) 1983-08-01
SU743581A3 (en) 1980-06-25
GR73041B (en) 1984-01-26
NZ185295A (en) 1980-04-28
FI58645C (en) 1981-03-10
FI58645B (en) 1980-11-28
IE45877B1 (en) 1982-12-15
SE431655B (en) 1984-02-20
FR2366313A1 (en) 1978-04-28
CH632772A5 (en) 1982-10-29
IL53030A0 (en) 1977-11-30

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