SE7608265L - 1- (BENSAZOLYLALKYL) -PIPERIDINES - Google Patents

1- (BENSAZOLYLALKYL) -PIPERIDINES

Info

Publication number
SE7608265L
SE7608265L SE7608265A SE7608265A SE7608265L SE 7608265 L SE7608265 L SE 7608265L SE 7608265 A SE7608265 A SE 7608265A SE 7608265 A SE7608265 A SE 7608265A SE 7608265 L SE7608265 L SE 7608265L
Authority
SE
Sweden
Prior art keywords
formula
salts
compounds
image
bensazolylalkyl
Prior art date
Application number
SE7608265A
Other languages
Swedish (sv)
Other versions
SE426490B (en
Inventor
J Vanderberk
L E F Kennis
M J M C Van Der Aa
A H M T Van Heertum
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SE7608265L publication Critical patent/SE7608265L/en
Publication of SE426490B publication Critical patent/SE426490B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1-(Benzazolylalkyl)piperidine derivatives of formula I <IMAGE> and their salts are prepared by subjecting an amine of formula <IMAGE> to N-alkylation to introduce the corresponding substituted alkyl radical. In the compounds of formula I, the substituents have the meanings given in Patent Claim 1. These compounds and their salts have a spasmolytic action and they are in particular used in agents to prevent vomiting.
SE7608265A 1975-07-21 1976-07-20 ANALOGY PROCEDURE FOR PREPARATION OF 1- (BENSAZOLYLALKYL) PIPERIDINES SE426490B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (en) 1975-07-21 1976-07-12 Process for preparation 1-(benzazolylalkyl)-piperidine derivatives

Publications (2)

Publication Number Publication Date
SE7608265L true SE7608265L (en) 1977-01-22
SE426490B SE426490B (en) 1983-01-24

Family

ID=27348142

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7608265A SE426490B (en) 1975-07-21 1976-07-20 ANALOGY PROCEDURE FOR PREPARATION OF 1- (BENSAZOLYLALKYL) PIPERIDINES
SE8008713A SE435621B (en) 1975-07-21 1980-12-11 Analogue process for the production of 1-(benzimidazolylalkyl)piperidines

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8008713A SE435621B (en) 1975-07-21 1980-12-11 Analogue process for the production of 1-(benzimidazolylalkyl)piperidines

Country Status (25)

Country Link
JP (1) JPS5217475A (en)
AT (1) AT364358B (en)
AU (1) AU511027B2 (en)
BG (1) BG26526A3 (en)
CA (1) CA1085852A (en)
CH (1) CH623820A5 (en)
CS (1) CS202550B2 (en)
DE (1) DE2632870A1 (en)
DK (1) DK154950C (en)
ES (3) ES449740A1 (en)
FI (1) FI62667C (en)
GB (1) GB1542514A (en)
HK (1) HK14180A (en)
IE (1) IE43496B1 (en)
IT (1) IT1062614B (en)
KE (1) KE3215A (en)
LU (1) LU75354A1 (en)
MY (1) MY8100017A (en)
NL (1) NL187442C (en)
NZ (1) NZ181256A (en)
PH (1) PH13710A (en)
PT (1) PT65387B (en)
RO (1) RO70566A (en)
SE (2) SE426490B (en)
YU (1) YU39969B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
JPS6248684A (en) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd Novel iodobutyrophenone derivative and production thereof
JPS62251313A (en) * 1986-04-25 1987-11-02 信越ポリマー株式会社 Bundling device
FR2723091B1 (en) * 1994-07-29 1996-11-08 Esteve Labor Dr TETRAHYDROPYRIDINE- (6,4-HYDROXYPIPERIDINE) ALKYLAZOLES
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
UA83881C2 (en) 2003-12-18 2008-08-26 Янссен Фармацевтика Н.В. Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
NI200700147A (en) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv QUINAZOLINE DERIVATIVES KINE INHIBITORS TARGETING MULTIP
DK2044084T3 (en) 2006-07-13 2016-05-09 Janssen Pharmaceutica Nv MTKI-quinazoline derivatives
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
DK2185562T3 (en) 2007-07-27 2016-02-22 Janssen Pharmaceutica Nv PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES
BRPI0815327A2 (en) 2007-08-31 2015-12-15 Purdue Pharma Lp "Substituted quinoxaline-type piperidine compounds and their uses"
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
EA035515B1 (en) * 2016-02-04 2020-06-29 Синдом Фарма, Инк. Deuterated domperidone compositions and methods for therapy of disorders
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (en) * 1962-06-13
BE633914A (en) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Also Published As

Publication number Publication date
NL187442B (en) 1991-05-01
DK154950B (en) 1989-01-09
PT65387A (en) 1976-08-01
NL7608023A (en) 1977-01-25
FI62667B (en) 1982-10-29
PH13710A (en) 1980-09-09
SE426490B (en) 1983-01-24
DK327576A (en) 1977-01-22
NZ181256A (en) 1978-04-28
DE2632870A1 (en) 1977-02-10
CH623820A5 (en) 1981-06-30
YU39969B (en) 1985-06-30
IE43496L (en) 1977-01-21
DE2632870C2 (en) 1989-02-16
CS202550B2 (en) 1981-01-30
RO70566A (en) 1982-10-11
JPS5217475A (en) 1977-02-09
SE435621B (en) 1984-10-08
AT364358B (en) 1981-10-12
DK154950C (en) 1989-05-29
BG26526A3 (en) 1979-04-12
FI762086A (en) 1977-01-22
ES461630A1 (en) 1978-06-16
GB1542514A (en) 1979-03-21
JPS6131109B2 (en) 1986-07-17
YU179476A (en) 1983-01-21
ES461631A1 (en) 1978-12-01
AU511027B2 (en) 1980-07-24
ATA534776A (en) 1981-03-15
CA1085852A (en) 1980-09-16
SE8008713L (en) 1980-12-11
LU75354A1 (en) 1977-02-28
FI62667C (en) 1983-02-10
HK14180A (en) 1980-03-28
ES449740A1 (en) 1978-02-16
AU1596476A (en) 1978-01-19
NL187442C (en) 1991-10-01
MY8100017A (en) 1981-12-31
IE43496B1 (en) 1981-03-11
PT65387B (en) 1978-06-09
KE3215A (en) 1982-07-09
IT1062614B (en) 1984-10-20

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