ES444064A1 - 1-(2'-aroyl ethyl)2-(4"-carbamoyl-methyl-piperazin-1"-yl methyl)benzimidazoles their therapeutical applications and method for their preparation - Google Patents

1-(2'-aroyl ethyl)2-(4"-carbamoyl-methyl-piperazin-1"-yl methyl)benzimidazoles their therapeutical applications and method for their preparation

Info

Publication number
ES444064A1
ES444064A1 ES444064A ES444064A ES444064A1 ES 444064 A1 ES444064 A1 ES 444064A1 ES 444064 A ES444064 A ES 444064A ES 444064 A ES444064 A ES 444064A ES 444064 A1 ES444064 A1 ES 444064A1
Authority
ES
Spain
Prior art keywords
formula
group
methyl
carbon atoms
benzimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES444064A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7500724A external-priority patent/FR2297045A1/en
Priority claimed from FR7537297A external-priority patent/FR2333510A2/en
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES444064A1 publication Critical patent/ES444064A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Abstract

Preparation process of new (aroyl-2'-et-1'-yl)-l-(acetamido-4"-piperazin-l"-yl-methyl) -2-benzimidazoles, corresponding to the following formula (I) ; ** (see formula) ** Wherein: Ar denotes a phenyl nucleus optionally substituted by an alkoxy group consisting of a maximum of 4 carbon atoms, by an alkyl group consisting of 1 to 4 carbon atoms, by a nitro group or by a halogen atom, or a α-furyl or α-thienyl radical, and R denotes: a group -NH2, a group -NHR', wherein R' represents an alkyl group consisting of 1 to 4 carbon atoms, or a cycloalkoxy group which consists of a maximum of 6 carbon atoms, or a group -NR1R2 in which R1 and R2 designate an alkyl group consisting of 1 to 4 carbon atoms or form together with the nitrogen atom to which they are attached, a heterocyclic radical chosen from the following: piperidino, pyrrolidino, morpholino and hexamethyleneimino, characterized in that it consists in condensing a compound of the formula (II): ** (see formula) ** Wherein ar has the same meaning as in the formula (I), with a piperazine of the formula (III) ** (see formula) ** In which R has the same meaning as in formula (I). (Machine-translation by Google Translate, not legally binding)
ES444064A 1975-01-10 1976-01-03 1-(2'-aroyl ethyl)2-(4"-carbamoyl-methyl-piperazin-1"-yl methyl)benzimidazoles their therapeutical applications and method for their preparation Expired ES444064A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7500724A FR2297045A1 (en) 1975-01-10 1975-01-10 NEW (AROYL-2 'ETH-1' YL) -1 (ACETAMIDO-4 '' PIPERAZIN-1 '' YL METHYL) -2 BENZIMIDAZOLES WITH GASTRIC AND ANTIULCEROUS ANTI-SECRETORY PROPERTIES
FR7537297A FR2333510A2 (en) 1975-12-05 1975-12-05 1-Aroylethyl 2-piperazinomethyl benzimidazoles - useful eg for treatment of ulcers, asthma, hypertension, oedemand pain

Publications (1)

Publication Number Publication Date
ES444064A1 true ES444064A1 (en) 1977-08-16

Family

ID=26218682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES444064A Expired ES444064A1 (en) 1975-01-10 1976-01-03 1-(2'-aroyl ethyl)2-(4"-carbamoyl-methyl-piperazin-1"-yl methyl)benzimidazoles their therapeutical applications and method for their preparation

Country Status (13)

Country Link
JP (1) JPS6020386B2 (en)
AU (1) AU509084B2 (en)
CA (1) CA1073455A (en)
CH (1) CH612675A5 (en)
DE (1) DE2557446C2 (en)
ES (1) ES444064A1 (en)
GB (1) GB1487128A (en)
IT (1) IT1062803B (en)
LU (1) LU74043A1 (en)
MX (1) MX3428E (en)
NL (1) NL7600224A (en)
SE (1) SE421527B (en)
SU (1) SU651701A3 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190439B1 (en) * 1972-07-06 1975-06-20 Delalande Sa

Also Published As

Publication number Publication date
DE2557446C2 (en) 1984-11-29
GB1487128A (en) 1977-09-28
AU509084B2 (en) 1980-04-17
MX3428E (en) 1980-11-21
NL7600224A (en) 1976-07-13
LU74043A1 (en) 1976-11-11
AU1011776A (en) 1977-07-14
CA1073455A (en) 1980-03-11
CH612675A5 (en) 1979-08-15
JPS51131885A (en) 1976-11-16
JPS6020386B2 (en) 1985-05-21
SU651701A3 (en) 1979-03-05
SE421527B (en) 1982-01-04
DE2557446A1 (en) 1976-07-15
SE7600116L (en) 1976-07-12
IT1062803B (en) 1985-02-11

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