CH612675A5 - Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les - Google Patents

Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les

Info

Publication number
CH612675A5
CH612675A5 CH12876A CH12876A CH612675A5 CH 612675 A5 CH612675 A5 CH 612675A5 CH 12876 A CH12876 A CH 12876A CH 12876 A CH12876 A CH 12876A CH 612675 A5 CH612675 A5 CH 612675A5
Authority
CH
Switzerland
Prior art keywords
aroyl
ethyl
piperazinylmethyl
acetamido
benzimidazo
Prior art date
Application number
CH12876A
Inventor
Claude Fauran
Michel Turin
Thierry Imbert
Guy Raynaud
Nicole Dorme
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7500724A external-priority patent/FR2297045A1/en
Priority claimed from FR7537297A external-priority patent/FR2333510A2/en
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of CH612675A5 publication Critical patent/CH612675A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1-(2'-Aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimid azoles of formula I, in which Ar and R are defined as in Claim 1, are obtained by condensation of 4-acetamidopiperazine with the corresponding 1-(2'-aroyl-1'-ethyl)-2-(chloromethyl)benzimidazole. The latter is obtained by chlorination of the corresponding 2-hydroxymethyl compound with SOCl2. The compounds of formula I can be used as a medicament in the treatment of gastroduodenal ulcers, hyperchlorhydrias, visceral spasms, asthma, hypertension, oedemas and aches of various origins and especially inflammatory aches. <IMAGE>
CH12876A 1975-01-10 1976-01-07 Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les CH612675A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7500724A FR2297045A1 (en) 1975-01-10 1975-01-10 NEW (AROYL-2 'ETH-1' YL) -1 (ACETAMIDO-4 '' PIPERAZIN-1 '' YL METHYL) -2 BENZIMIDAZOLES WITH GASTRIC AND ANTIULCEROUS ANTI-SECRETORY PROPERTIES
FR7537297A FR2333510A2 (en) 1975-12-05 1975-12-05 1-Aroylethyl 2-piperazinomethyl benzimidazoles - useful eg for treatment of ulcers, asthma, hypertension, oedemand pain

Publications (1)

Publication Number Publication Date
CH612675A5 true CH612675A5 (en) 1979-08-15

Family

ID=26218682

Family Applications (1)

Application Number Title Priority Date Filing Date
CH12876A CH612675A5 (en) 1975-01-10 1976-01-07 Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les

Country Status (13)

Country Link
JP (1) JPS6020386B2 (en)
AU (1) AU509084B2 (en)
CA (1) CA1073455A (en)
CH (1) CH612675A5 (en)
DE (1) DE2557446C2 (en)
ES (1) ES444064A1 (en)
GB (1) GB1487128A (en)
IT (1) IT1062803B (en)
LU (1) LU74043A1 (en)
MX (1) MX3428E (en)
NL (1) NL7600224A (en)
SE (1) SE421527B (en)
SU (1) SU651701A3 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190439B1 (en) * 1972-07-06 1975-06-20 Delalande Sa

Also Published As

Publication number Publication date
GB1487128A (en) 1977-09-28
ES444064A1 (en) 1977-08-16
CA1073455A (en) 1980-03-11
DE2557446C2 (en) 1984-11-29
JPS6020386B2 (en) 1985-05-21
SE421527B (en) 1982-01-04
AU509084B2 (en) 1980-04-17
MX3428E (en) 1980-11-21
AU1011776A (en) 1977-07-14
JPS51131885A (en) 1976-11-16
IT1062803B (en) 1985-02-11
LU74043A1 (en) 1976-11-11
NL7600224A (en) 1976-07-13
DE2557446A1 (en) 1976-07-15
SU651701A3 (en) 1979-03-05
SE7600116L (en) 1976-07-12

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Legal Events

Date Code Title Description
PL Patent ceased