GB1451029A - Imidazole derivatives - Google Patents

Imidazole derivatives

Info

Publication number
GB1451029A
GB1451029A GB5158274A GB5158274A GB1451029A GB 1451029 A GB1451029 A GB 1451029A GB 5158274 A GB5158274 A GB 5158274A GB 5158274 A GB5158274 A GB 5158274A GB 1451029 A GB1451029 A GB 1451029A
Authority
GB
United Kingdom
Prior art keywords
imidazoles
substituted imidazoles
novel
imidazole derivatives
denotes halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5158274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1451029A publication Critical patent/GB1451029A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel substituted imidazoles of the formula <IMAGE> in which R1 is hydrogen or alkyl having 1-3 C atoms and R2 denotes halogen and R3 denotes halogen or -CF3, are prepared. These compounds are obtained by reaction of appropriate pyridyl-substituted imidazoles with a halogenating agent. The novel imidazoles can also be present as pharmaceutically acceptable salts. The said substituted imidazoles can be used as xanthine oxidase inhibitors or for the treatment of hypertension.
GB5158274A 1973-12-04 1974-11-28 Imidazole derivatives Expired GB1451029A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42155373A 1973-12-04 1973-12-04

Publications (1)

Publication Number Publication Date
GB1451029A true GB1451029A (en) 1976-09-29

Family

ID=23671021

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5158274A Expired GB1451029A (en) 1973-12-04 1974-11-28 Imidazole derivatives

Country Status (10)

Country Link
AU (1) AU7575074A (en)
BE (1) BE822881A (en)
CH (1) CH609976A5 (en)
DE (1) DE2457127A1 (en)
DK (1) DK138947B (en)
FR (1) FR2253517B1 (en)
GB (1) GB1451029A (en)
HU (1) HU168824B (en)
NL (1) NL7415142A (en)
SE (1) SE412587B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2267705A (en) * 1990-06-05 1993-12-15 Nippon Synthetic Chem Ind Imidazoles
US6191136B1 (en) 1997-11-07 2001-02-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
US7799794B2 (en) 2000-06-28 2010-09-21 Merck Sharp & Dohme Corp. Treatment for cardiovascular disease

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8405588D0 (en) * 1984-11-08 1984-11-08 Haessle Ab NEW COMPOUNDS

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2267705A (en) * 1990-06-05 1993-12-15 Nippon Synthetic Chem Ind Imidazoles
GB2267705B (en) * 1990-06-05 1996-01-03 Nippon Synthetic Chem Ind Process for producing 2-alkyl-4-halo-5-formylimidazoles
US6191136B1 (en) 1997-11-07 2001-02-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
US6569862B1 (en) 1997-11-07 2003-05-27 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
US7799794B2 (en) 2000-06-28 2010-09-21 Merck Sharp & Dohme Corp. Treatment for cardiovascular disease

Also Published As

Publication number Publication date
CH609976A5 (en) 1979-03-30
DK138947B (en) 1978-11-20
AU7575074A (en) 1976-05-27
HU168824B (en) 1976-07-28
FR2253517A1 (en) 1975-07-04
DK138947C (en) 1979-05-07
NL7415142A (en) 1975-06-06
DE2457127A1 (en) 1975-06-05
FR2253517B1 (en) 1978-03-24
SE412587B (en) 1980-03-10
BE822881A (en) 1975-06-03
DK601974A (en) 1975-07-28
SE7414512L (en) 1975-06-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee