SE7408295L - PROCEDURE FOR CHLORINATION OF OXITETRACYCLINE. - Google Patents

PROCEDURE FOR CHLORINATION OF OXITETRACYCLINE.

Info

Publication number
SE7408295L
SE7408295L SE7408295A SE7408295A SE7408295L SE 7408295 L SE7408295 L SE 7408295L SE 7408295 A SE7408295 A SE 7408295A SE 7408295 A SE7408295 A SE 7408295A SE 7408295 L SE7408295 L SE 7408295L
Authority
SE
Sweden
Prior art keywords
oxytetracycline
oxitetracycline
chlorination
procedure
hemiketal
Prior art date
Application number
SE7408295A
Other languages
Swedish (sv)
Other versions
SE416727B (en
Inventor
N M Scollick
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7408295L publication Critical patent/SE7408295L/en
Publication of SE416727B publication Critical patent/SE416727B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1465542 11a-Chloro-5-oxytetracycline-6,12- hemiketal PFIZER Inc 4 Feb 1974 [2 Aug 1973] 05124/74 Heading C2C 11a - Chloro - 5 - oxytetracycline - 6,12 - hemiketal is obtained in the form of a strong mineral acid addition salt by chlorinating 5-oxytetracycline or an acid addition salt thereof at - 10‹ to - 40‹ C. and pH 6À5-7À7 in a water-miscible reaction-inert solvent or its mixture with water and then adding a strong mineral acid to lower the pH of the reaction mixture thus obtained to <1À0. Reference has been directed by the Comptroller to Specification 998,294.
SE7408295A 1973-08-02 1974-06-24 PROCEDURE FOR 11A-CHLORATION OF 5-OXITETRACYCLINE OR A NON-ADDITIONAL SALT THEREOF FOR THE PREPARATION OF A MINERAL ACID SALT OF 11A-CHLORO-5-OXITETRACYCLINE-6,12-HEMICETAL SE416727B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38496973A 1973-08-02 1973-08-02

Publications (2)

Publication Number Publication Date
SE7408295L true SE7408295L (en) 1975-02-03
SE416727B SE416727B (en) 1981-02-02

Family

ID=23519498

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7408295A SE416727B (en) 1973-08-02 1974-06-24 PROCEDURE FOR 11A-CHLORATION OF 5-OXITETRACYCLINE OR A NON-ADDITIONAL SALT THEREOF FOR THE PREPARATION OF A MINERAL ACID SALT OF 11A-CHLORO-5-OXITETRACYCLINE-6,12-HEMICETAL

Country Status (28)

Country Link
JP (1) JPS5835982B2 (en)
AR (1) AR199626A1 (en)
AT (1) AT333426B (en)
AU (1) AU476600B2 (en)
BE (1) BE817406A (en)
CA (1) CA1008068A (en)
CH (1) CH582650A5 (en)
CS (1) CS183754B2 (en)
DD (1) DD113527A5 (en)
DE (1) DE2433608C2 (en)
DK (1) DK153400C (en)
ES (1) ES428365A1 (en)
FI (1) FI59394C (en)
FR (1) FR2239450B1 (en)
GB (1) GB1465542A (en)
HK (1) HK28479A (en)
HU (1) HU170051B (en)
IE (1) IE39803B1 (en)
IL (1) IL45119A (en)
KE (1) KE2934A (en)
LU (1) LU70504A1 (en)
MY (1) MY7900241A (en)
NL (1) NL177596C (en)
PH (1) PH10821A (en)
PL (1) PL94201B1 (en)
SE (1) SE416727B (en)
YU (1) YU39463B (en)
ZA (1) ZA744126B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984686A (en) * 1960-12-19 1961-05-16 Pfizer & Co C 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines

Also Published As

Publication number Publication date
IE39803L (en) 1975-02-02
SE416727B (en) 1981-02-02
FI59394B (en) 1981-04-30
JPS5835982B2 (en) 1983-08-05
AR199626A1 (en) 1974-09-13
FI207274A (en) 1975-02-03
PH10821A (en) 1977-09-08
DD113527A5 (en) 1975-06-12
NL177596C (en) 1985-10-16
DK153400C (en) 1988-11-28
YU39463B (en) 1984-12-31
DE2433608A1 (en) 1975-02-20
FR2239450B1 (en) 1977-10-07
NL177596B (en) 1985-05-17
DK370074A (en) 1975-04-01
GB1465542A (en) 1977-02-23
AU7088574A (en) 1976-01-08
IL45119A (en) 1977-05-31
ES428365A1 (en) 1976-07-16
MY7900241A (en) 1979-12-31
DK153400B (en) 1988-07-11
ATA579274A (en) 1976-03-15
NL7409249A (en) 1975-02-04
AT333426B (en) 1976-11-25
BE817406A (en) 1975-01-09
HU170051B (en) 1977-03-28
FI59394C (en) 1981-08-10
CS183754B2 (en) 1978-07-31
FR2239450A1 (en) 1975-02-28
CH582650A5 (en) 1976-12-15
PL94201B1 (en) 1977-07-30
IL45119A0 (en) 1974-09-10
IE39803B1 (en) 1979-01-03
HK28479A (en) 1979-05-11
JPS5041848A (en) 1975-04-16
ZA744126B (en) 1975-07-30
YU178874A (en) 1982-05-31
CA1008068A (en) 1977-04-05
AU476600B2 (en) 1976-09-30
KE2934A (en) 1979-03-30
LU70504A1 (en) 1975-03-27
DE2433608C2 (en) 1983-03-17

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