IE39803B1 - Improved process for 11a-chlorination of oxytetracycline - Google Patents

Improved process for 11a-chlorination of oxytetracycline

Info

Publication number
IE39803B1
IE39803B1 IE1360/74A IE136074A IE39803B1 IE 39803 B1 IE39803 B1 IE 39803B1 IE 1360/74 A IE1360/74 A IE 1360/74A IE 136074 A IE136074 A IE 136074A IE 39803 B1 IE39803 B1 IE 39803B1
Authority
IE
Ireland
Prior art keywords
oxytetracycline
chlorination
improved process
hemiketal
chloro
Prior art date
Application number
IE1360/74A
Other versions
IE39803L (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE39803L publication Critical patent/IE39803L/en
Publication of IE39803B1 publication Critical patent/IE39803B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1465542 11a-Chloro-5-oxytetracycline-6,12- hemiketal PFIZER Inc 4 Feb 1974 [2 Aug 1973] 05124/74 Heading C2C 11a - Chloro - 5 - oxytetracycline - 6,12 - hemiketal is obtained in the form of a strong mineral acid addition salt by chlorinating 5-oxytetracycline or an acid addition salt thereof at - 10‹ to - 40‹ C. and pH 6À5-7À7 in a water-miscible reaction-inert solvent or its mixture with water and then adding a strong mineral acid to lower the pH of the reaction mixture thus obtained to <1À0. Reference has been directed by the Comptroller to Specification 998,294. [GB1465542A]
IE1360/74A 1973-08-02 1974-06-26 Improved process for 11a-chlorination of oxytetracycline IE39803B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38496973A 1973-08-02 1973-08-02

Publications (2)

Publication Number Publication Date
IE39803L IE39803L (en) 1975-02-02
IE39803B1 true IE39803B1 (en) 1979-01-03

Family

ID=23519498

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1360/74A IE39803B1 (en) 1973-08-02 1974-06-26 Improved process for 11a-chlorination of oxytetracycline

Country Status (28)

Country Link
JP (1) JPS5835982B2 (en)
AR (1) AR199626A1 (en)
AT (1) AT333426B (en)
AU (1) AU476600B2 (en)
BE (1) BE817406A (en)
CA (1) CA1008068A (en)
CH (1) CH582650A5 (en)
CS (1) CS183754B2 (en)
DD (1) DD113527A5 (en)
DE (1) DE2433608C2 (en)
DK (1) DK153400C (en)
ES (1) ES428365A1 (en)
FI (1) FI59394C (en)
FR (1) FR2239450B1 (en)
GB (1) GB1465542A (en)
HK (1) HK28479A (en)
HU (1) HU170051B (en)
IE (1) IE39803B1 (en)
IL (1) IL45119A (en)
KE (1) KE2934A (en)
LU (1) LU70504A1 (en)
MY (1) MY7900241A (en)
NL (1) NL177596C (en)
PH (1) PH10821A (en)
PL (1) PL94201B1 (en)
SE (1) SE416727B (en)
YU (1) YU39463B (en)
ZA (1) ZA744126B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984686A (en) * 1960-12-19 1961-05-16 Pfizer & Co C 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines

Also Published As

Publication number Publication date
JPS5041848A (en) 1975-04-16
IE39803L (en) 1975-02-02
CS183754B2 (en) 1978-07-31
NL177596C (en) 1985-10-16
SE7408295L (en) 1975-02-03
IL45119A (en) 1977-05-31
SE416727B (en) 1981-02-02
DK153400C (en) 1988-11-28
KE2934A (en) 1979-03-30
DK370074A (en) 1975-04-01
MY7900241A (en) 1979-12-31
IL45119A0 (en) 1974-09-10
CA1008068A (en) 1977-04-05
YU39463B (en) 1984-12-31
YU178874A (en) 1982-05-31
PH10821A (en) 1977-09-08
AT333426B (en) 1976-11-25
NL177596B (en) 1985-05-17
ES428365A1 (en) 1976-07-16
NL7409249A (en) 1975-02-04
ZA744126B (en) 1975-07-30
FI59394B (en) 1981-04-30
LU70504A1 (en) 1975-03-27
BE817406A (en) 1975-01-09
CH582650A5 (en) 1976-12-15
PL94201B1 (en) 1977-07-30
AR199626A1 (en) 1974-09-13
DE2433608A1 (en) 1975-02-20
FI59394C (en) 1981-08-10
HU170051B (en) 1977-03-28
JPS5835982B2 (en) 1983-08-05
DK153400B (en) 1988-07-11
ATA579274A (en) 1976-03-15
GB1465542A (en) 1977-02-23
FR2239450A1 (en) 1975-02-28
FR2239450B1 (en) 1977-10-07
DD113527A5 (en) 1975-06-12
HK28479A (en) 1979-05-11
DE2433608C2 (en) 1983-03-17
AU476600B2 (en) 1976-09-30
AU7088574A (en) 1976-01-08
FI207274A (en) 1975-02-03

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