SE513815C2 - Förfarande för framställning av tabletter innehållande levande mikroorganismer och med oligosacharider i tablettmaterialet - Google Patents
Förfarande för framställning av tabletter innehållande levande mikroorganismer och med oligosacharider i tablettmaterialetInfo
- Publication number
- SE513815C2 SE513815C2 SE9502941A SE9502941A SE513815C2 SE 513815 C2 SE513815 C2 SE 513815C2 SE 9502941 A SE9502941 A SE 9502941A SE 9502941 A SE9502941 A SE 9502941A SE 513815 C2 SE513815 C2 SE 513815C2
- Authority
- SE
- Sweden
- Prior art keywords
- oligosaccharides
- tablet
- tablets
- tablet material
- microorganisms
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 17
- 150000002482 oligosaccharides Chemical class 0.000 title claims abstract description 17
- 239000000463 material Substances 0.000 title claims abstract description 13
- 244000005700 microbiome Species 0.000 title claims abstract description 12
- 230000008569 process Effects 0.000 title claims description 6
- 229920001202 Inulin Polymers 0.000 claims abstract description 6
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 6
- 229940029339 inulin Drugs 0.000 claims abstract description 6
- 238000003825 pressing Methods 0.000 claims abstract description 3
- 230000035899 viability Effects 0.000 claims description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 7
- 229930091371 Fructose Natural products 0.000 claims description 6
- 239000005715 Fructose Substances 0.000 claims description 6
- -1 fructose oligosaccharides Chemical class 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 4
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 claims description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
- 150000002772 monosaccharides Chemical class 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000009467 reduction Effects 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 241001134770 Bifidobacterium animalis Species 0.000 description 2
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 2
- 240000006024 Lactobacillus plantarum Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000010009 beating Methods 0.000 description 2
- 229940118852 bifidobacterium animalis Drugs 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 238000011194 good manufacturing practice Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000020169 heat generation Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Glanulating (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9502941A SE513815C2 (sv) | 1995-08-25 | 1995-08-25 | Förfarande för framställning av tabletter innehållande levande mikroorganismer och med oligosacharider i tablettmaterialet |
| ES96929617T ES2171713T3 (es) | 1995-08-25 | 1996-08-23 | Metodo para producir tabletas mediante prensado y tabletas producidas por este metodo. |
| RU98104918/14A RU2155070C2 (ru) | 1995-08-25 | 1996-08-23 | Способ изготовления таблеток путем прессования и таблетки, изготовленные этим способом |
| PCT/SE1996/001043 WO1997007822A1 (en) | 1995-08-25 | 1996-08-23 | Method for the production of tablets by pressing and tablets produced by the method |
| DE69619681T DE69619681T2 (de) | 1995-08-25 | 1996-08-23 | Verfahren zur herstellung von tabletten durch verpressung und durch dieses verfahren hergestellte tabletten |
| DK96929617T DK0845999T3 (da) | 1995-08-25 | 1996-08-23 | Fremstillingsmåde til produktion af tabletter ved komprimering og tabletter produceret ved denne fremstillingsmåde |
| JP9510182A JPH11511458A (ja) | 1995-08-25 | 1996-08-23 | 圧縮することにより錠剤を生産する方法およびその方法により生産される錠剤 |
| BR9610015A BR9610015A (pt) | 1995-08-25 | 1996-08-23 | Processos para produção de tabletes por prensagem e tabletes produzidos pelo mesmo |
| CNB961976276A CN1157228C (zh) | 1995-08-25 | 1996-08-23 | 经压片生产片剂的方法以及由该方法得到的片剂 |
| PL96325061A PL185694B1 (pl) | 1995-08-25 | 1996-08-23 | Sposób wytwarzania tabletek zawierających drobnoustroje o wysokiej żywotności |
| AU68931/96A AU705507B2 (en) | 1995-08-25 | 1996-08-23 | Method for the production of tablets by pressing and tablets produced by the method |
| AT96929617T ATE213957T1 (de) | 1995-08-25 | 1996-08-23 | Verfahren zur herstellung von tabletten durch verpressung und durch dieses verfahren hergestellte tabletten |
| EP96929617A EP0845999B1 (en) | 1995-08-25 | 1996-08-23 | Method for the production of tablets by pressing and tablets produced by the method |
| CA002230238A CA2230238A1 (en) | 1995-08-25 | 1996-08-23 | Method for the production of pressed tablets containing live microorganisms and tablets produced by the method |
| NO19980777A NO321095B1 (no) | 1995-08-25 | 1998-02-24 | Fremgangsmate til produksjon av tabletter ved pressing og tabletter produsert ved metoden |
| US09/465,667 US20030157164A1 (en) | 1995-08-25 | 1999-12-17 | Method for the production of tablets by pressing and tablets produced by the method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9502941A SE513815C2 (sv) | 1995-08-25 | 1995-08-25 | Förfarande för framställning av tabletter innehållande levande mikroorganismer och med oligosacharider i tablettmaterialet |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9502941D0 SE9502941D0 (sv) | 1995-08-25 |
| SE9502941L SE9502941L (sv) | 1997-02-26 |
| SE513815C2 true SE513815C2 (sv) | 2000-11-06 |
Family
ID=20399273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9502941A SE513815C2 (sv) | 1995-08-25 | 1995-08-25 | Förfarande för framställning av tabletter innehållande levande mikroorganismer och med oligosacharider i tablettmaterialet |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0845999B1 (pl) |
| JP (1) | JPH11511458A (pl) |
| CN (1) | CN1157228C (pl) |
| AT (1) | ATE213957T1 (pl) |
| AU (1) | AU705507B2 (pl) |
| BR (1) | BR9610015A (pl) |
| CA (1) | CA2230238A1 (pl) |
| DE (1) | DE69619681T2 (pl) |
| DK (1) | DK0845999T3 (pl) |
| ES (1) | ES2171713T3 (pl) |
| NO (1) | NO321095B1 (pl) |
| PL (1) | PL185694B1 (pl) |
| RU (1) | RU2155070C2 (pl) |
| SE (1) | SE513815C2 (pl) |
| WO (1) | WO1997007822A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0986314T3 (da) * | 1997-06-03 | 2009-01-19 | Ganeden Biotech Inc | Probiotisk mælkesyrebakterie til behandling af bakterielle infektioner associeret med SIDS |
| IT1307850B1 (it) * | 1999-03-15 | 2001-11-19 | Italmed Di Galli Giovanna E Pa | Composizione farmaceutica a base di fermenti lattici e carboidratinon assorbibili contenente un sale di calcio ed un sale di alluminio |
| SE515310C2 (sv) * | 1999-11-25 | 2001-07-09 | Wasa Medicals Ab | Tabletter innehållande mikroorganismer och förfarande för framställning därav |
| FI20001402A7 (fi) * | 2000-06-13 | 2001-12-14 | Yves Delatte | Menetelmä maitohappobakteeritablettien valmistamiseksi ja pakkaamiseksi |
| GB2369777B (en) * | 2000-10-05 | 2004-10-27 | St Ivel Ltd | Food products with antimicrobial lactic acid bacteria |
| US20040109889A1 (en) | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| AT413334B (de) * | 2002-12-23 | 2006-02-15 | Belihart Josephine | Feste darreichungsformen mit lebenden milchsäurebakterien |
| GB0330009D0 (en) | 2003-12-24 | 2004-01-28 | Ferrosan As | Probiotic tablet formulations |
| FR2869622B1 (fr) * | 2004-04-28 | 2008-04-18 | Rhodia Chimie Sa | Comprimes de micro-organismes pour ensemencement direct |
| ITMI20070452A1 (it) * | 2007-03-07 | 2008-09-08 | Anidral Srl | Compressa comprendente microrganismi ed una combinazione di eccipienti e relativo procedimento di produzione |
| FR2938405B1 (fr) * | 2008-11-20 | 2011-04-22 | Florane | Complement alimentaire et procede de distribution d'un tel complement |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3679298D1 (de) * | 1985-12-20 | 1991-06-20 | Du Pont | Herstellung von tabletten aus mikrobiologischen substanzen. |
| JPH0441434A (ja) * | 1990-06-07 | 1992-02-12 | Asahi Breweries Ltd | 腸溶性コーティングを施した乳酸菌錠剤 |
| RU2020932C1 (ru) * | 1992-04-01 | 1994-10-15 | Московская медицинская академия им.И.М.Сеченова | Средство, обладающее эубиотическими свойствами |
-
1995
- 1995-08-25 SE SE9502941A patent/SE513815C2/sv not_active IP Right Cessation
-
1996
- 1996-08-23 AU AU68931/96A patent/AU705507B2/en not_active Ceased
- 1996-08-23 WO PCT/SE1996/001043 patent/WO1997007822A1/en not_active Ceased
- 1996-08-23 CN CNB961976276A patent/CN1157228C/zh not_active Expired - Fee Related
- 1996-08-23 AT AT96929617T patent/ATE213957T1/de active
- 1996-08-23 DK DK96929617T patent/DK0845999T3/da active
- 1996-08-23 CA CA002230238A patent/CA2230238A1/en not_active Abandoned
- 1996-08-23 JP JP9510182A patent/JPH11511458A/ja not_active Ceased
- 1996-08-23 EP EP96929617A patent/EP0845999B1/en not_active Expired - Lifetime
- 1996-08-23 PL PL96325061A patent/PL185694B1/pl not_active IP Right Cessation
- 1996-08-23 DE DE69619681T patent/DE69619681T2/de not_active Expired - Lifetime
- 1996-08-23 ES ES96929617T patent/ES2171713T3/es not_active Expired - Lifetime
- 1996-08-23 BR BR9610015A patent/BR9610015A/pt not_active IP Right Cessation
- 1996-08-23 RU RU98104918/14A patent/RU2155070C2/ru not_active IP Right Cessation
-
1998
- 1998-02-24 NO NO19980777A patent/NO321095B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1200038A (zh) | 1998-11-25 |
| NO980777L (no) | 1998-02-24 |
| BR9610015A (pt) | 1999-07-06 |
| CN1157228C (zh) | 2004-07-14 |
| AU705507B2 (en) | 1999-05-27 |
| CA2230238A1 (en) | 1997-03-06 |
| PL185694B1 (pl) | 2003-07-31 |
| RU2155070C2 (ru) | 2000-08-27 |
| DK0845999T3 (da) | 2002-05-27 |
| ES2171713T3 (es) | 2002-09-16 |
| WO1997007822A1 (en) | 1997-03-06 |
| JPH11511458A (ja) | 1999-10-05 |
| NO321095B1 (no) | 2006-03-13 |
| EP0845999A1 (en) | 1998-06-10 |
| DE69619681D1 (de) | 2002-04-11 |
| DE69619681T2 (de) | 2002-10-17 |
| ATE213957T1 (de) | 2002-03-15 |
| EP0845999B1 (en) | 2002-03-06 |
| AU6893196A (en) | 1997-03-19 |
| PL325061A1 (en) | 1998-07-06 |
| SE9502941D0 (sv) | 1995-08-25 |
| NO980777D0 (no) | 1998-02-24 |
| SE9502941L (sv) | 1997-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |