SE510587C2 - Koncentrat för dialyslösning och användning därav - Google Patents
Koncentrat för dialyslösning och användning däravInfo
- Publication number
- SE510587C2 SE510587C2 SE9703650A SE9703650A SE510587C2 SE 510587 C2 SE510587 C2 SE 510587C2 SE 9703650 A SE9703650 A SE 9703650A SE 9703650 A SE9703650 A SE 9703650A SE 510587 C2 SE510587 C2 SE 510587C2
- Authority
- SE
- Sweden
- Prior art keywords
- concentration
- glucose
- concentrate
- gluconic acid
- acid
- Prior art date
Links
- 239000012141 concentrate Substances 0.000 title claims abstract description 48
- 239000000385 dialysis solution Substances 0.000 title description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 41
- 239000008103 glucose Substances 0.000 claims abstract description 41
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 38
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 35
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000000174 gluconic acid Substances 0.000 claims abstract description 34
- 238000000502 dialysis Methods 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract 4
- 239000003978 infusion fluid Substances 0.000 claims abstract 3
- 239000000243 solution Substances 0.000 claims description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- RGHNJXZEOKUKBD-KLVWXMOXSA-N L-gluconic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-KLVWXMOXSA-N 0.000 claims 4
- 238000001631 haemodialysis Methods 0.000 claims 2
- 230000000322 hemodialysis Effects 0.000 claims 2
- 238000002615 hemofiltration Methods 0.000 claims 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 7
- 238000010790 dilution Methods 0.000 abstract description 3
- 239000012895 dilution Substances 0.000 abstract description 3
- 239000007864 aqueous solution Substances 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 66
- 238000002474 experimental method Methods 0.000 description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 239000002253 acid Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 230000007423 decrease Effects 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 235000012209 glucono delta-lactone Nutrition 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 239000000176 sodium gluconate Substances 0.000 description 2
- 235000012207 sodium gluconate Nutrition 0.000 description 2
- 229940005574 sodium gluconate Drugs 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 206010068780 Acetate intolerance Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- UYUXSRADSPPKRZ-UHFFFAOYSA-N D-glucuronic acid gamma-lactone Natural products O=CC(O)C1OC(=O)C(O)C1O UYUXSRADSPPKRZ-UHFFFAOYSA-N 0.000 description 1
- UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 229950002441 glucurolactone Drugs 0.000 description 1
- -1 glycuronic acid Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703650A SE510587C2 (sv) | 1997-10-07 | 1997-10-07 | Koncentrat för dialyslösning och användning därav |
| PCT/SE1998/001785 WO1999017762A1 (en) | 1997-10-07 | 1998-10-05 | Concentrate for medical solution and use thereof |
| JP2000514633A JP4346818B2 (ja) | 1997-10-07 | 1998-10-05 | 医療用溶液の濃縮物及びその使用 |
| AT98948026T ATE227985T1 (de) | 1997-10-07 | 1998-10-05 | Konzentrat für medizinische lösung und dessen verwendung |
| DE69809587T DE69809587T2 (de) | 1997-10-07 | 1998-10-05 | Konzentrat für medizinische lösung und dessen verwendung |
| AU94689/98A AU9468998A (en) | 1997-10-07 | 1998-10-05 | Concentrate for medical solution and use thereof |
| US09/529,213 US6323182B1 (en) | 1997-10-07 | 1998-10-05 | Concentrate for medical solution and use thereof |
| EP98948026A EP1033984B1 (en) | 1997-10-07 | 1998-10-05 | Concentrate for medical solution and use thereof |
| ES98948026T ES2183417T3 (es) | 1997-10-07 | 1998-10-05 | Concentrado para solucion medica y su utilizacion. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703650A SE510587C2 (sv) | 1997-10-07 | 1997-10-07 | Koncentrat för dialyslösning och användning därav |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9703650D0 SE9703650D0 (sv) | 1997-10-07 |
| SE9703650L SE9703650L (sv) | 1999-04-08 |
| SE510587C2 true SE510587C2 (sv) | 1999-06-07 |
Family
ID=20408531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9703650A SE510587C2 (sv) | 1997-10-07 | 1997-10-07 | Koncentrat för dialyslösning och användning därav |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6323182B1 (ja) |
| EP (1) | EP1033984B1 (ja) |
| JP (1) | JP4346818B2 (ja) |
| AT (1) | ATE227985T1 (ja) |
| AU (1) | AU9468998A (ja) |
| DE (1) | DE69809587T2 (ja) |
| ES (1) | ES2183417T3 (ja) |
| SE (1) | SE510587C2 (ja) |
| WO (1) | WO1999017762A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8105258B2 (en) | 1999-04-26 | 2012-01-31 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
| US7186420B2 (en) | 1999-04-26 | 2007-03-06 | Edwards Lifesciences Corporation | Multi-part substitution infusion fluids and matching anticoagulants |
| AU4553700A (en) | 1999-04-26 | 2000-11-10 | Pe Chou Chang | Substitution infusion fluid and citrate anticoagulation |
| US7445801B2 (en) * | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
| GR1004476B (el) * | 2002-12-12 | 2004-03-05 | Ιπποκρατης Αλεξανδρου Γιατζιδης | Γλουκονικο οξυ. ενας νεος ισχυρος και ακινδυνος δεσμευτης για τη διορθωση της υπερφωσφαταιμιας των αρρωστων με τελικη νεφρικη ανεπαρκεια |
| US20040121982A1 (en) * | 2002-12-20 | 2004-06-24 | Leo Martis | Biocompatible dialysis fluids containing icodextrins |
| US20050276868A1 (en) * | 2004-06-10 | 2005-12-15 | Bart Degreve | Bicarbonate-based peritoneal dialysis solutions |
| US20100247694A1 (en) * | 2008-01-31 | 2010-09-30 | Joseph Di Bartolomeo | Composition and method for treament of inflamation and infections of the outer ear canal, nose and paranasal sinuses |
| US20100051552A1 (en) * | 2008-08-28 | 2010-03-04 | Baxter International Inc. | In-line sensors for dialysis applications |
| DE102010039489A1 (de) * | 2010-08-18 | 2012-02-23 | Fresenius Medical Care Deutschland Gmbh | Konzentrat |
| JP5282923B2 (ja) * | 2011-12-06 | 2013-09-04 | 富田製薬株式会社 | 重炭酸透析剤 |
| WO2018201443A1 (en) * | 2017-05-05 | 2018-11-08 | Fresenius Medical Care Deutschland Gmbh | Peritoneal dialysis concentrate, peritoneal dialysis bag and set for continuous ambulatory peritoneal dialysis or automated peritoneal dialysis |
| CN114460202A (zh) * | 2022-02-11 | 2022-05-10 | 山东威高肾科医疗器械有限公司 | 一种血液透析液中葡萄糖浓度的检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4784495A (en) | 1987-02-06 | 1988-11-15 | Gambro Ab | System for preparing a fluid intended for a medical procedure by mixing at least one concentrate in powder form with water |
| ES2056497T3 (es) | 1990-01-12 | 1994-10-01 | Nephro Medica Pharma | Solucion para infusion y dialisis que contiene bicarbonato y calcio. |
| DE69233437T2 (de) | 1991-04-26 | 2005-10-13 | Mitsubishi Pharma Corp. | Infusion zur Zuführung von Nahrung |
| ATE196602T1 (de) | 1993-02-19 | 2000-10-15 | Schael Wilfried | Verfahren zur bereitung von bicarbonathaltigen dialysierflüssigkeiten für die hämodialyse |
| IT1263967B (it) * | 1993-02-24 | 1996-09-05 | Soluzioni per dialisi peritoneale | |
| KR960000223A (ko) * | 1994-06-08 | 1996-01-25 | 김정순 | 신규한 피리돈 카르복실산 화합물을 함유한 수용액 및 이의 제조방법 |
| DE19631124A1 (de) * | 1996-08-01 | 1998-02-05 | Fresenius Medical Care De Gmbh | Verfahren zur Herstellung einer Bicarbonat enthaltenden Infusions- oder Dialysierlösung |
-
1997
- 1997-10-07 SE SE9703650A patent/SE510587C2/sv not_active IP Right Cessation
-
1998
- 1998-10-05 JP JP2000514633A patent/JP4346818B2/ja not_active Expired - Fee Related
- 1998-10-05 EP EP98948026A patent/EP1033984B1/en not_active Expired - Lifetime
- 1998-10-05 AT AT98948026T patent/ATE227985T1/de not_active IP Right Cessation
- 1998-10-05 US US09/529,213 patent/US6323182B1/en not_active Expired - Lifetime
- 1998-10-05 DE DE69809587T patent/DE69809587T2/de not_active Expired - Lifetime
- 1998-10-05 AU AU94689/98A patent/AU9468998A/en not_active Abandoned
- 1998-10-05 WO PCT/SE1998/001785 patent/WO1999017762A1/en active IP Right Grant
- 1998-10-05 ES ES98948026T patent/ES2183417T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999017762A1 (en) | 1999-04-15 |
| SE9703650L (sv) | 1999-04-08 |
| EP1033984A1 (en) | 2000-09-13 |
| EP1033984B1 (en) | 2002-11-20 |
| JP2001518497A (ja) | 2001-10-16 |
| SE9703650D0 (sv) | 1997-10-07 |
| ES2183417T3 (es) | 2003-03-16 |
| JP4346818B2 (ja) | 2009-10-21 |
| AU9468998A (en) | 1999-04-27 |
| US6323182B1 (en) | 2001-11-27 |
| DE69809587D1 (de) | 2003-01-02 |
| DE69809587T2 (de) | 2003-03-27 |
| ATE227985T1 (de) | 2002-12-15 |
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