SE464300B - Beta-adrenergiskt blockerande foerening samt kompositioner foer behandling av glaukom - Google Patents
Beta-adrenergiskt blockerande foerening samt kompositioner foer behandling av glaukomInfo
- Publication number
- SE464300B SE464300B SE8300912A SE8300912A SE464300B SE 464300 B SE464300 B SE 464300B SE 8300912 A SE8300912 A SE 8300912A SE 8300912 A SE8300912 A SE 8300912A SE 464300 B SE464300 B SE 464300B
- Authority
- SE
- Sweden
- Prior art keywords
- carbon atoms
- hydroxy
- butyl
- compound
- composition according
- Prior art date
Links
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- 239000002808 molecular sieve Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940039748 oxalate Drugs 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- YOLFMTDVRJWTQZ-UHFFFAOYSA-N oxiran-2-ylmethyl 2-fluorobenzoate Chemical compound FC1=CC=CC=C1C(=O)OCC1OC1 YOLFMTDVRJWTQZ-UHFFFAOYSA-N 0.000 description 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- MDDFICUIFWUSDO-UHFFFAOYSA-N propyl 4-(hydroxymethyl)benzoate Chemical compound CCCOC(=O)C1=CC=C(CO)C=C1 MDDFICUIFWUSDO-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 235000011091 sodium acetates Nutrition 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- KEAYESYHFKHZAL-OUBTZVSYSA-N sodium-24 Chemical compound [24Na] KEAYESYHFKHZAL-OUBTZVSYSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/276,657 US4402974A (en) | 1981-06-23 | 1981-06-23 | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8300912D0 SE8300912D0 (sv) | 1983-02-18 |
| SE8300912L SE8300912L (sv) | 1983-02-18 |
| SE464300B true SE464300B (sv) | 1991-04-08 |
Family
ID=23057572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8300912A SE464300B (sv) | 1981-06-23 | 1983-02-18 | Beta-adrenergiskt blockerande foerening samt kompositioner foer behandling av glaukom |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4402974A (el) |
| EP (1) | EP0081580B1 (el) |
| JP (1) | JPS58500997A (el) |
| AT (1) | AT384017B (el) |
| AU (1) | AU559541B2 (el) |
| CA (1) | CA1272733C (el) |
| CH (1) | CH655497B (el) |
| ES (1) | ES513386A0 (el) |
| GB (2) | GB2112785B (el) |
| GR (1) | GR76848B (el) |
| IL (1) | IL66069A0 (el) |
| IT (1) | IT1156057B (el) |
| NL (1) | NL8220251A (el) |
| NZ (1) | NZ200971A (el) |
| PH (1) | PH18383A (el) |
| SE (1) | SE464300B (el) |
| WO (1) | WO1983000043A1 (el) |
| ZA (1) | ZA824339B (el) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
| ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
| US4604481A (en) * | 1980-11-28 | 1986-08-05 | American Hospital Supply Corporation | Compounds for treatment or prophylaxis of cardiac disorders |
| EP0053893B1 (en) * | 1980-12-09 | 1985-03-20 | Beecham Group Plc | Derivatives of clavulanic acid, their preparation and their use |
| NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
| US4579867A (en) * | 1984-04-09 | 1986-04-01 | American Hospital Supply Corporation | Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents |
| CA1334168C (en) * | 1988-04-26 | 1995-01-31 | Louis M. De Santis | Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers |
| US4897417A (en) * | 1988-12-15 | 1990-01-30 | E. I. Du Pont De Nemours & Co. | Prodrugs of 3,4-hydroxy benzoyloxypropanolamines |
| US4966914A (en) * | 1988-12-15 | 1990-10-30 | E. I. Du Pont De Nemours And Company | Oculoselective beta-blockers as antiglaucoma agents |
| CH679856A5 (el) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5543083A (en) * | 1994-07-26 | 1996-08-06 | The Procter & Gamble Company | Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation |
| US5536749A (en) * | 1994-10-13 | 1996-07-16 | Sl Pharmaceuticals, Inc. | Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents |
| US6197817B1 (en) | 1999-01-22 | 2001-03-06 | Selectus Pharmaceuticals, Inc. | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders |
| US7209743B2 (en) * | 2004-04-22 | 2007-04-24 | Telefonaktiebolaget Lm Ericsson (Publ) | Base station system and method for compensating traffic channel signal strength measurements in a cellular radio telecommunication network |
| US20070254950A1 (en) * | 2004-05-25 | 2007-11-01 | Othera Pharmaceuticals, Inc. | Oculoselective Drugs and Prodrugs |
| CA2576279A1 (en) * | 2004-11-08 | 2006-05-18 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL75127C (el) * | 1943-10-05 | |||
| FR1047364A (fr) * | 1950-12-28 | 1953-12-14 | Hoechst Ag | Esters d'acides alcoylamino-benzoïques, sels d'acides minéraux de ces esters et procédé de préparation de ces corps |
| NL300886A (el) * | 1962-11-23 | |||
| US3959351A (en) * | 1972-07-24 | 1976-05-25 | Research Corporation | Haloalkylbenzoyl esters of di-lower alkylamino alkanols and quaternary lower alkyl salts thereof |
| US4195085A (en) * | 1975-09-26 | 1980-03-25 | Merck & Co., Inc. | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate |
| DE2752659A1 (de) | 1976-12-07 | 1978-06-08 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
| US4127674A (en) * | 1977-03-21 | 1978-11-28 | Allergan Pharmaceuticals, Inc. | Method of treatment for glaucoma |
| EP0003664B1 (en) * | 1978-02-08 | 1982-02-17 | Imperial Chemical Industries Plc | Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them |
| US4405642A (en) * | 1980-11-28 | 1983-09-20 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
-
1981
- 1981-06-23 US US06/276,657 patent/US4402974A/en not_active Expired - Fee Related
-
1982
- 1982-06-14 PH PH27417A patent/PH18383A/en unknown
- 1982-06-14 CA CA 405106 patent/CA1272733C/xx not_active Expired - Lifetime
- 1982-06-15 NZ NZ200971A patent/NZ200971A/en unknown
- 1982-06-16 IL IL66069A patent/IL66069A0/xx not_active IP Right Cessation
- 1982-06-18 ZA ZA824339A patent/ZA824339B/xx unknown
- 1982-06-18 GR GR68484A patent/GR76848B/el unknown
- 1982-06-22 IT IT67795/82A patent/IT1156057B/it active
- 1982-06-23 JP JP57502294A patent/JPS58500997A/ja active Granted
- 1982-06-23 AU AU87375/82A patent/AU559541B2/en not_active Ceased
- 1982-06-23 WO PCT/US1982/000848 patent/WO1983000043A1/en active IP Right Grant
- 1982-06-23 CH CH110483A patent/CH655497B/de unknown
- 1982-06-23 EP EP82902332A patent/EP0081580B1/en not_active Expired
- 1982-06-23 AT AT0903482A patent/AT384017B/de not_active IP Right Cessation
- 1982-06-23 NL NL8220251A patent/NL8220251A/nl unknown
- 1982-06-23 ES ES513386A patent/ES513386A0/es active Granted
- 1982-06-23 GB GB08303060A patent/GB2112785B/en not_active Expired
-
1983
- 1983-02-18 SE SE8300912A patent/SE464300B/sv not_active IP Right Cessation
-
1984
- 1984-08-30 GB GB08421939A patent/GB2145721B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| WO1983000043A1 (en) | 1983-01-06 |
| US4402974A (en) | 1983-09-06 |
| EP0081580B1 (en) | 1987-04-22 |
| JPS58500997A (ja) | 1983-06-23 |
| IT1156057B (it) | 1987-01-28 |
| GB2145721A (en) | 1985-04-03 |
| ES8401927A1 (es) | 1984-01-01 |
| AU8737582A (en) | 1983-01-18 |
| GB8303060D0 (en) | 1983-03-09 |
| ES513386A0 (es) | 1984-01-01 |
| NL8220251A (nl) | 1983-05-02 |
| EP0081580A1 (en) | 1983-06-22 |
| ATA903482A (de) | 1987-02-15 |
| IT8267795A0 (it) | 1982-06-22 |
| GB2112785A (en) | 1983-07-27 |
| CA1220716A (en) | 1987-04-21 |
| CH655497B (el) | 1986-04-30 |
| JPH0428696B2 (el) | 1992-05-15 |
| IL66069A0 (en) | 1982-09-30 |
| GB2145721B (en) | 1986-02-19 |
| NZ200971A (en) | 1985-12-13 |
| SE8300912D0 (sv) | 1983-02-18 |
| AT384017B (de) | 1987-09-25 |
| EP0081580A4 (en) | 1983-12-01 |
| PH18383A (en) | 1985-06-19 |
| GB8421939D0 (en) | 1984-10-03 |
| SE8300912L (sv) | 1983-02-18 |
| GR76848B (el) | 1984-09-04 |
| ZA824339B (en) | 1983-04-27 |
| GB2112785B (en) | 1985-06-05 |
| AU559541B2 (en) | 1987-03-12 |
| CA1272733C (en) | 1990-08-14 |
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| NUG | Patent has lapsed |
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