ES8401927A1 - Procedimiento de obtencion de composiciones oftalmologicas. - Google Patents

Procedimiento de obtencion de composiciones oftalmologicas.

Info

Publication number
ES8401927A1
ES8401927A1 ES513386A ES513386A ES8401927A1 ES 8401927 A1 ES8401927 A1 ES 8401927A1 ES 513386 A ES513386 A ES 513386A ES 513386 A ES513386 A ES 513386A ES 8401927 A1 ES8401927 A1 ES 8401927A1
Authority
ES
Spain
Prior art keywords
mammal
compounds
action
treatment
intraocular pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513386A
Other languages
English (en)
Other versions
ES513386A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of ES8401927A1 publication Critical patent/ES8401927A1/es
Publication of ES513386A0 publication Critical patent/ES513386A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTOS DE OBTENCION DE AGENTES BLOQUEANTES B-ADRENERGICOS.COMPRENDE LOS SIGUIENTES SISTEMAS: A) REACCIONAR GLICIDOL DE FORMULA (II) CON UN COMPUESTO DE FORMULA AR - C - CL, Y POSTERIOR REACCION CON COMPUESTOS DE FORMULA H2N-R, CALENTANDO LOS REACTANTES A REFLUJO CON UN DISOLVENTE, TAL COMO ALCOHOLES INFERIORES, ACEITES MINERALES Y OTROS; B) REACCIONAR COMPUESTOS DE FORMULA (II) CON COMPUESTOS DE FORMULA H2N-R Y POSTERIOR REACCION CON EL COMPUESTO AR-C-CL, CALENTANDO LOS REACTANTES A REFLUJO EN ALGUNO DE LOS DISOLVENTES MENCIONADOS, PARA OBTENER B-BLOQUEANTESCON GRUPOS ESTER DE FORMULA (I), DONDE R ES ALQUILO INFERIOR DE CADENA RECTA O RAMIFICADA CON C 1 A 10, CICLO ALQUILO CON C 3 A 7, UN GRUPO DE -Z-C-O-R1, Y OTROS, Z ES ALQUILENO, R1 ES ALQUILENO INFERIOR CON C 1 A 5 Y AR REPRESENTA UN GRUPO AROMATICO SUSTITUIDO O INSUSTITUIDO.TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE GLAUCOMA O PARA DISMINUIR LA PRESION INTRAOCULAR.
ES513386A 1981-06-23 1982-06-23 Procedimiento de obtencion de composiciones oftalmologicas. Granted ES513386A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/276,657 US4402974A (en) 1981-06-23 1981-06-23 Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents

Publications (2)

Publication Number Publication Date
ES8401927A1 true ES8401927A1 (es) 1984-01-01
ES513386A0 ES513386A0 (es) 1984-01-01

Family

ID=23057572

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513386A Granted ES513386A0 (es) 1981-06-23 1982-06-23 Procedimiento de obtencion de composiciones oftalmologicas.

Country Status (18)

Country Link
US (1) US4402974A (es)
EP (1) EP0081580B1 (es)
JP (1) JPS58500997A (es)
AT (1) AT384017B (es)
AU (1) AU559541B2 (es)
CA (1) CA1272733C (es)
CH (1) CH655497B (es)
ES (1) ES513386A0 (es)
GB (2) GB2112785B (es)
GR (1) GR76848B (es)
IL (1) IL66069A0 (es)
IT (1) IT1156057B (es)
NL (1) NL8220251A (es)
NZ (1) NZ200971A (es)
PH (1) PH18383A (es)
SE (1) SE464300B (es)
WO (1) WO1983000043A1 (es)
ZA (1) ZA824339B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
US4604481A (en) * 1980-11-28 1986-08-05 American Hospital Supply Corporation Compounds for treatment or prophylaxis of cardiac disorders
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
US4579867A (en) * 1984-04-09 1986-04-01 American Hospital Supply Corporation Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents
CA1334168C (en) * 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US4897417A (en) * 1988-12-15 1990-01-30 E. I. Du Pont De Nemours & Co. Prodrugs of 3,4-hydroxy benzoyloxypropanolamines
US4966914A (en) * 1988-12-15 1990-10-30 E. I. Du Pont De Nemours And Company Oculoselective beta-blockers as antiglaucoma agents
CH679856A5 (es) * 1990-07-04 1992-04-30 Lonza Ag
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5543083A (en) * 1994-07-26 1996-08-06 The Procter & Gamble Company Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
US6197817B1 (en) 1999-01-22 2001-03-06 Selectus Pharmaceuticals, Inc. Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
US7209743B2 (en) * 2004-04-22 2007-04-24 Telefonaktiebolaget Lm Ericsson (Publ) Base station system and method for compensating traffic channel signal strength measurements in a cellular radio telecommunication network
US20070254950A1 (en) * 2004-05-25 2007-11-01 Othera Pharmaceuticals, Inc. Oculoselective Drugs and Prodrugs
CA2576279A1 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL75127C (es) * 1943-10-05
FR1047364A (fr) * 1950-12-28 1953-12-14 Hoechst Ag Esters d'acides alcoylamino-benzoïques, sels d'acides minéraux de ces esters et procédé de préparation de ces corps
NL300886A (es) * 1962-11-23
US3959351A (en) * 1972-07-24 1976-05-25 Research Corporation Haloalkylbenzoyl esters of di-lower alkylamino alkanols and quaternary lower alkyl salts thereof
US4195085A (en) * 1975-09-26 1980-03-25 Merck & Co., Inc. Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate
DE2752659A1 (de) 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4127674A (en) * 1977-03-21 1978-11-28 Allergan Pharmaceuticals, Inc. Method of treatment for glaucoma
EP0003664B1 (en) * 1978-02-08 1982-02-17 Imperial Chemical Industries Plc Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
WO1983000043A1 (en) 1983-01-06
US4402974A (en) 1983-09-06
EP0081580B1 (en) 1987-04-22
JPS58500997A (ja) 1983-06-23
IT1156057B (it) 1987-01-28
GB2145721A (en) 1985-04-03
AU8737582A (en) 1983-01-18
GB8303060D0 (en) 1983-03-09
ES513386A0 (es) 1984-01-01
NL8220251A (nl) 1983-05-02
EP0081580A1 (en) 1983-06-22
ATA903482A (de) 1987-02-15
IT8267795A0 (it) 1982-06-22
GB2112785A (en) 1983-07-27
CA1220716A (en) 1987-04-21
CH655497B (es) 1986-04-30
JPH0428696B2 (es) 1992-05-15
IL66069A0 (en) 1982-09-30
SE464300B (sv) 1991-04-08
GB2145721B (en) 1986-02-19
NZ200971A (en) 1985-12-13
SE8300912D0 (sv) 1983-02-18
AT384017B (de) 1987-09-25
EP0081580A4 (en) 1983-12-01
PH18383A (en) 1985-06-19
GB8421939D0 (en) 1984-10-03
SE8300912L (sv) 1983-02-18
GR76848B (es) 1984-09-04
ZA824339B (en) 1983-04-27
GB2112785B (en) 1985-06-05
AU559541B2 (en) 1987-03-12
CA1272733C (en) 1990-08-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009