ES8401928A1 - Procedimiento de obtencion de composiciones oftalmologicas. - Google Patents

Procedimiento de obtencion de composiciones oftalmologicas.

Info

Publication number
ES8401928A1
ES8401928A1 ES513387A ES513387A ES8401928A1 ES 8401928 A1 ES8401928 A1 ES 8401928A1 ES 513387 A ES513387 A ES 513387A ES 513387 A ES513387 A ES 513387A ES 8401928 A1 ES8401928 A1 ES 8401928A1
Authority
ES
Spain
Prior art keywords
aralkyl
mammal
compounds
action
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513387A
Other languages
English (en)
Other versions
ES513387A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of ES8401928A1 publication Critical patent/ES8401928A1/es
Publication of ES513387A0 publication Critical patent/ES513387A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AGENTES B-BLOQUEANTES QUE CONTIENEN GRUPOS ESTER Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A ES ENLACE, ALQUENILO O ALQUILENILO; R, AR Y R1 PUEDEN SER VARIOS RADICALES; Y N VALE 1-3; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES OFTALMOLOGICAS EN EL TRATAMIENTO DE GLAUCOMA O PARA DISMINUIR LA PRESION INTRAOCULAR.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I),EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A REFLUJO; SEGUIDA DE LA REACCION DEL PRODUCTO OBTENIDO CON UNA AMINA DE FORMULA R1NH, EN LA QUE R1 ES EL MISMO QUE EN LA FORMULA (I); Y RECUPERACION DEL COMPUESTO OBTENIDO.
ES513387A 1981-06-23 1982-06-23 Procedimiento de obtencion de composiciones oftalmologicas. Granted ES513387A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/276,658 US4454154A (en) 1981-06-23 1981-06-23 Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents

Publications (2)

Publication Number Publication Date
ES8401928A1 true ES8401928A1 (es) 1984-01-01
ES513387A0 ES513387A0 (es) 1984-01-01

Family

ID=23057573

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513387A Granted ES513387A0 (es) 1981-06-23 1982-06-23 Procedimiento de obtencion de composiciones oftalmologicas.

Country Status (17)

Country Link
US (1) US4454154A (es)
EP (1) EP0082873B1 (es)
JP (1) JPH0653663B2 (es)
AU (1) AU565752B2 (es)
CA (1) CA1188224A (es)
CH (1) CH654205A5 (es)
ES (1) ES513387A0 (es)
GB (1) GB2111387B (es)
GR (1) GR76847B (es)
IL (1) IL66070A (es)
IT (1) IT1156058B (es)
NL (1) NL8220252A (es)
NZ (1) NZ200972A (es)
PH (1) PH18970A (es)
SE (1) SE462075B (es)
WO (1) WO1983000014A1 (es)
ZA (1) ZA824340B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334601A (en) * 1984-03-14 1994-08-02 Bodor Nicholas S Soft β-adrenergic blocking agents
US5135926A (en) * 1984-03-14 1992-08-04 Bodor Nicholas S Soft β-adrenergic blocking agents
US5202347A (en) * 1984-03-14 1993-04-13 Bodor Nicholas S Soft β-adrenergic blocking agents
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
ES2042625T5 (es) * 1987-04-03 2000-07-16 Univ Columbia Uso de una prostaglandina en combinacion con un agente bloqueante adrenergico para la reduccion de presion intraocular.
CA1334168C (en) * 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US4857552A (en) * 1988-06-08 1989-08-15 E. I. Du Pont De Nemours And Co. Stable pharmaceutical composition
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
US6197817B1 (en) 1999-01-22 2001-03-06 Selectus Pharmaceuticals, Inc. Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
WO2005115375A1 (en) * 2004-05-25 2005-12-08 Othera Pharmaceuticals, Inc. Oculoselective drugs and prodrugs

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868460A (en) * 1967-02-06 1975-02-25 Boehringer Sohn Ingelheim Therapeutic compositions and method
DE1593762A1 (de) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen
US3740444A (en) * 1968-01-25 1973-06-19 Boehringer Sohn Ingelheim Therapeutic compositions and method
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE1922003C3 (de) * 1969-04-30 1979-10-11 Boehringer Mannheim Gmbh, 6800 Mannheim N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz
DE2048838A1 (de) * 1970-10-05 1972-04-06 C H Boehnnger Sohn, 6507 Ingel heim Neue 1 Phenoxy 2 hydroxy 3 hydroxyal kylaminopropane und Verfahren zu ihrer Her stellung
FR2132570B1 (es) * 1971-04-09 1974-08-02 Lipha
JPS4875539A (es) * 1972-01-12 1973-10-11
JPS49247A (es) * 1972-04-17 1974-01-05
US3839584A (en) * 1972-08-31 1974-10-01 Interx Research Corp Pharmaceutical compositions containing a novel ester of ((methylamino)methyl)benzyl alcohol and methods of using same
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
US3825583A (en) * 1973-04-26 1974-07-23 Interx Research Corp Ester of 3-hydroxy-alpha-((methylamino)methyl)benzyl alcohol
US4195085A (en) * 1975-09-26 1980-03-25 Merck & Co., Inc. Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
US4080471A (en) * 1976-06-25 1978-03-21 Aktiebolaget Hassle Use of substituted isopropylaminopropanols for inducing inotropic effects of the human heart
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4127674A (en) * 1977-03-21 1978-11-28 Allergan Pharmaceuticals, Inc. Method of treatment for glaucoma
DE2962112D1 (en) * 1978-02-08 1982-03-25 Ici Plc Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
SE8004088L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ...
SE8004087L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
NL8220252A (nl) 1983-05-02
GB8303061D0 (en) 1983-03-09
SE8300913L (en) 1983-02-18
SE8300913D0 (sv) 1983-02-18
IT8267796A0 (it) 1982-06-22
ZA824340B (en) 1983-04-27
JPS58500996A (ja) 1983-06-23
PH18970A (en) 1985-11-26
CA1188224A (en) 1985-06-04
IT1156058B (it) 1987-01-28
GR76847B (es) 1984-09-04
JPH0653663B2 (ja) 1994-07-20
SE462075B (sv) 1990-05-07
IL66070A (en) 1987-03-31
IL66070A0 (en) 1982-09-30
EP0082873A4 (en) 1983-11-11
ES513387A0 (es) 1984-01-01
AU8737482A (en) 1983-01-18
US4454154A (en) 1984-06-12
AU565752B2 (en) 1987-09-24
GB2111387B (en) 1986-02-05
CH654205A5 (de) 1986-02-14
GB2111387A (en) 1983-07-06
EP0082873B1 (en) 1988-12-07
EP0082873A1 (en) 1983-07-06
WO1983000014A1 (en) 1983-01-06
NZ200972A (en) 1986-10-08

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