ES8507469A1 - Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas - Google Patents

Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas

Info

Publication number
ES8507469A1
ES8507469A1 ES530209A ES530209A ES8507469A1 ES 8507469 A1 ES8507469 A1 ES 8507469A1 ES 530209 A ES530209 A ES 530209A ES 530209 A ES530209 A ES 530209A ES 8507469 A1 ES8507469 A1 ES 8507469A1
Authority
ES
Spain
Prior art keywords
aralkyl
mammal
compounds
action
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530209A
Other languages
English (en)
Other versions
ES530209A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of ES530209A0 publication Critical patent/ES530209A0/es
Publication of ES8507469A1 publication Critical patent/ES8507469A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AGENTES BETA-BLOQUEANTES CONTENIENDO GRUPOS ESTER, DE FORMULA GENERAL (I), EN LA QUE Y ES UNA CADENA CARBONADA RECTA O RAMIFICADA O ARALQUILO; R ES ALQUILO INFERIOR O ALQUENILO; X ES 1, 2 O 3; Y AR ES UN GRUPO AROMATICO INSUSTITUIDO O SUSTITUIDO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO ARILHIDROXI DE FORMULA: AROH, CON EPICLORHIDRINA, EN PRESENCIA DE UN DISOLVENTE Y DE UNA BASE, SEGUIDO POR REACCION DEL EPOXIDO DE ARILETER CON SUCCINAMIDA; Y A CONTINUACION EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON UN ACIDO ADECUADO, PARA OBTENER UNA AMINA DE FORMULA GENERAL (II). LA AMINA OBTENIDA SE HACE REACCIONAR POR ULTIMO.DE APLICACION EN EL TRATAMIENTO DEL GLAUCOMA Y PARA DISMINUIR LA PRESION INTRAOCULAR.
ES530209A 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas Expired ES8507469A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/276,465 US4455317A (en) 1981-06-23 1981-06-23 Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents

Publications (2)

Publication Number Publication Date
ES530209A0 ES530209A0 (es) 1985-09-01
ES8507469A1 true ES8507469A1 (es) 1985-09-01

Family

ID=23056760

Family Applications (4)

Application Number Title Priority Date Filing Date
ES513388A Granted ES513388A0 (es) 1981-06-23 1982-06-23 Procedimiento de obtencion de agentes de beta bloqueantes conteniendo grupos de ester con propiedades oftalmologicas.
ES530207A Expired ES8507467A1 (es) 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas
ES530208A Expired ES8507468A1 (es) 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas
ES530209A Expired ES8507469A1 (es) 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES513388A Granted ES513388A0 (es) 1981-06-23 1982-06-23 Procedimiento de obtencion de agentes de beta bloqueantes conteniendo grupos de ester con propiedades oftalmologicas.
ES530207A Expired ES8507467A1 (es) 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas
ES530208A Expired ES8507468A1 (es) 1981-06-23 1984-03-01 Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas

Country Status (18)

Country Link
US (1) US4455317A (es)
EP (1) EP0081581B1 (es)
JP (1) JPS58500995A (es)
AU (1) AU558475B2 (es)
CA (1) CA1176987A (es)
CH (1) CH655443B (es)
DE (1) DE3248837T1 (es)
EG (1) EG16713A (es)
ES (4) ES513388A0 (es)
GB (1) GB2112786B (es)
GR (1) GR76842B (es)
IL (1) IL66071A (es)
IT (1) IT1156373B (es)
NL (1) NL8220253A (es)
NZ (1) NZ200973A (es)
PH (1) PH18764A (es)
WO (1) WO1983000015A1 (es)
ZA (1) ZA824341B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
CA1334168C (en) * 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US4897417A (en) * 1988-12-15 1990-01-30 E. I. Du Pont De Nemours & Co. Prodrugs of 3,4-hydroxy benzoyloxypropanolamines
US4966914A (en) * 1988-12-15 1990-10-30 E. I. Du Pont De Nemours And Company Oculoselective beta-blockers as antiglaucoma agents
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
JP4241926B2 (ja) 1995-10-10 2009-03-18 ウィリアム ジョン ルイス ３―アミノ―プロポキシフェニル誘導体（１）
US6197817B1 (en) 1999-01-22 2001-03-06 Selectus Pharmaceuticals, Inc. Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
ZA200610032B (en) * 2004-05-25 2008-11-26 Othera Holding Inc Oculoselective drugs and prodrugs

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868460A (en) * 1967-02-06 1975-02-25 Boehringer Sohn Ingelheim Therapeutic compositions and method
US3740444A (en) * 1968-01-25 1973-06-19 Boehringer Sohn Ingelheim Therapeutic compositions and method
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE1922003C3 (de) * 1969-04-30 1979-10-11 Boehringer Mannheim Gmbh, 6800 Mannheim N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz
JPS49247A (es) * 1972-04-17 1974-01-05
US3839584A (en) * 1972-08-31 1974-10-01 Interx Research Corp Pharmaceutical compositions containing a novel ester of ((methylamino)methyl)benzyl alcohol and methods of using same
FR2208653A2 (en) * 1972-12-06 1974-06-28 Orsymonde Cardiac antiarrhythmic phloroglucinol ethers - of hydroxy alkylaminoalkanoic acids
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
US3825583A (en) * 1973-04-26 1974-07-23 Interx Research Corp Ester of 3-hydroxy-alpha-((methylamino)methyl)benzyl alcohol
US4195085A (en) * 1975-09-26 1980-03-25 Merck & Co., Inc. Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
US4080471A (en) * 1976-06-25 1978-03-21 Aktiebolaget Hassle Use of substituted isopropylaminopropanols for inducing inotropic effects of the human heart
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4127674A (en) * 1977-03-21 1978-11-28 Allergan Pharmaceuticals, Inc. Method of treatment for glaucoma
DE2962112D1 (en) * 1978-02-08 1982-03-25 Ici Plc Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
SE8004087L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
SE8004088L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ...
EP0053434B1 (en) * 1980-11-28 1986-08-27 American Hospital Supply Corporation Compounds and method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
AU558475B2 (en) 1987-01-29
ES530207A0 (es) 1985-09-01
EP0081581A1 (en) 1983-06-22
IL66071A0 (en) 1982-09-30
CA1176987A (en) 1984-10-30
GB2112786A (en) 1983-07-27
ES8405358A1 (es) 1984-06-01
IL66071A (en) 1986-09-30
IT1156373B (it) 1987-02-04
ES530208A0 (es) 1985-09-01
ZA824341B (en) 1983-04-27
ES8507467A1 (es) 1985-09-01
ES513388A0 (es) 1984-06-01
ES8507468A1 (es) 1985-09-01
EP0081581A4 (en) 1983-11-21
NZ200973A (en) 1986-04-11
EP0081581B1 (en) 1986-12-30
ES530209A0 (es) 1985-09-01
GB2112786B (en) 1986-02-19
DE3248837T1 (de) 1983-12-01
JPS58500995A (ja) 1983-06-23
US4455317A (en) 1984-06-19
EG16713A (en) 1990-10-30
CH655443B (es) 1986-04-30
AU8737082A (en) 1983-01-18
WO1983000015A1 (en) 1983-01-06
PH18764A (en) 1985-09-20
GR76842B (es) 1984-09-04
GB8303062D0 (en) 1983-03-09
IT8267794A0 (it) 1982-06-22
NL8220253A (nl) 1983-05-02

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