MXPA02005088A - Tratamiento de trastornos del ritmo cardiaco con n6-substituida-5'(n-substituida) carboxamidoadenosinas. - Google Patents

Tratamiento de trastornos del ritmo cardiaco con n6-substituida-5'(n-substituida) carboxamidoadenosinas.

Info

Publication number
MXPA02005088A
MXPA02005088A MXPA02005088A MXPA02005088A MXPA02005088A MX PA02005088 A MXPA02005088 A MX PA02005088A MX PA02005088 A MXPA02005088 A MX PA02005088A MX PA02005088 A MXPA02005088 A MX PA02005088A MX PA02005088 A MXPA02005088 A MX PA02005088A
Authority
MX
Mexico
Prior art keywords
heart rhythm
rhythm disturbances
treatment
mammal
cycloalkyl
Prior art date
Application number
MXPA02005088A
Other languages
English (en)
Inventor
L Martin Pauline
Original Assignee
Aderis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals Inc filed Critical Aderis Pharmaceuticals Inc
Publication of MXPA02005088A publication Critical patent/MXPA02005088A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion describe un metodo para tratar trastornos dla frecuencia cardiaca en un mamifero con necesidad del mismo por medio de la administracion de N6- substituida-5??-(N-substituida) carboxamidoadenosinas. Mas particularmente la invencion esta dirigida a un metodo para el tratamiento de trastornos dla frecuencia cardiaca en un mamifero que se beneficiaria de la induccion de las acciones dromotropica negativa y/o cronotropica negativa, que comprende la administracion al mamifero de una cantidad efectiva de un compuesto de formula (I) o de una sal o ester del mismo, aceptable farmaceuticamente; en donde R1, es alquilo secundario con 3 a 7 atomos de carbono, o cicloalquilo con 3 a 8 atomos de carbono; y R2 es alquilo de 1 a 4 atomos de carbono o cicloalquilo con 3 a 5 atomos de carbono. La invencion esta tambien dirigida hacia nuevas formas de dosificacion que comprenden los compuestos.
MXPA02005088A 1999-11-23 2000-11-16 Tratamiento de trastornos del ritmo cardiaco con n6-substituida-5'(n-substituida) carboxamidoadenosinas. MXPA02005088A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16701499P 1999-11-23 1999-11-23
PCT/US2000/031417 WO2001037845A1 (en) 1999-11-23 2000-11-16 Treatment of heart rhythm disturbances with n6-substituted-5'-(n-substituted) carboxamidoadenosines

Publications (1)

Publication Number Publication Date
MXPA02005088A true MXPA02005088A (es) 2004-08-23

Family

ID=22605594

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005088A MXPA02005088A (es) 1999-11-23 2000-11-16 Tratamiento de trastornos del ritmo cardiaco con n6-substituida-5'(n-substituida) carboxamidoadenosinas.

Country Status (12)

Country Link
EP (1) EP1239864A1 (es)
JP (1) JP2003514863A (es)
KR (1) KR20020069188A (es)
AU (1) AU782715B2 (es)
CA (1) CA2392369A1 (es)
IL (1) IL149470A0 (es)
MX (1) MXPA02005088A (es)
MY (1) MY135962A (es)
NO (1) NO20022393L (es)
NZ (1) NZ518861A (es)
TW (1) TWI257306B (es)
WO (1) WO2001037845A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004238217A1 (en) * 2003-04-24 2004-11-25 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
US7829526B2 (en) 2004-04-02 2010-11-09 Japan Science And Technology Agency Cardioinhibitory/antihypertensive novel endogenous physiologically active peptide
JP5042996B2 (ja) 2005-05-19 2012-10-03 ギリアード・パロ・アルト・インコーポレイテッド Ａ１アデノシンレセプターアゴニスト
AU2008340179B2 (en) 2007-12-21 2014-10-23 Aop Orphan Pharmaceuticals Gmbh Pharmaceutical composition for the parenteral administration of ultrashort-effective beta-adrenoreceptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
EP0169009A3 (en) * 1984-07-17 1988-08-31 FISONS plc Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
US4738954A (en) * 1985-11-06 1988-04-19 Warner-Lambert Company Novel N6 -substituted-5'-oxidized adenosine analogs

Also Published As

Publication number Publication date
NO20022393D0 (no) 2002-05-21
IL149470A0 (en) 2002-11-10
WO2001037845A1 (en) 2001-05-31
MY135962A (en) 2008-07-31
KR20020069188A (ko) 2002-08-29
TWI257306B (en) 2006-07-01
NO20022393L (no) 2002-06-24
CA2392369A1 (en) 2001-05-31
JP2003514863A (ja) 2003-04-22
AU1613201A (en) 2001-06-04
EP1239864A1 (en) 2002-09-18
NZ518861A (en) 2004-11-26
AU782715B2 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
LV10860A (lv) Fenilalkilaminu iegusanas panemiens
HUT75111A (en) Use of pyridyl-,oxadiazole or thiadiazole derivatives for producing pharmaceutical compositions having effect
CA2102209A1 (en) Novel Isoxazole Derivative and Salt Thereof
MXPA02001571A (es) Metodo de tratamiento para el cancer.
RU94044454A (ru) Ингибитор аутоимунных заболеваний
RU94037233A (ru) Применение 2-фенил-3-ароилбензотиофенов для лечения лекарственноустойчивых новообразований
GB0130677D0 (en) Medicaments and novel compounds
FI861410A (fi) Foerfarande foer framstaellning av terapeutiskt aktiva aminopropanolderivat.
RU94044489A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования миелопероксидазной активности
ZA881726B (en) Method of treating anxiety with tetrahydrobenz(c,d)indole-6-carbozamides
MY111702A (en) 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
ES2053668T3 (es) Derivados de poliamina como agentes antineoplasicos.
ATE26273T1 (de) 3-indolcarboxamid-verbindungen.
MXPA02005088A (es) Tratamiento de trastornos del ritmo cardiaco con n6-substituida-5'(n-substituida) carboxamidoadenosinas.
NZ503085A (en) Lipophilic diesters of 1,2-bis(2-amino-phenoxy)ethane-N,N,N,N-tetraacetic acid
ATE169217T1 (de) Verwendung von furanonderivaten zur vorbeugung oder behandlung von autoimmunkrankheiten
MY104521A (en) Treatment of depression.
IL115617A0 (en) Pharmaceutical composition for prophylaxis and treatment of type i allergic diseases
TW244336B (es)
ES8405358A1 (es) Procedimiento de obtencion de agentes de beta bloqueantes conteniendo grupos de ester con propiedades oftalmologicas.
ATE131055T1 (de) Behandlung von kognitiven störungen.
NZ332687A (en) use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents
TW349864B (en) Use of N-(pyridinyl)-1H-indol-a-amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders
EA199800665A1 (ru) Способы лечения и предупреждения неблагоприятного воздействия активных форм кислорода
EP0116255A3 (en) Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives