MY135962A - Treatment of heart rhythm disturbances with n6-substituted-5'-(n-substituted) carboxamidoadenosines - Google Patents

Treatment of heart rhythm disturbances with n6-substituted-5'-(n-substituted) carboxamidoadenosines

Info

Publication number
MY135962A
MY135962A MYPI20005377A MYPI20005377A MY135962A MY 135962 A MY135962 A MY 135962A MY PI20005377 A MYPI20005377 A MY PI20005377A MY PI20005377 A MYPI20005377 A MY PI20005377A MY 135962 A MY135962 A MY 135962A
Authority
MY
Malaysia
Prior art keywords
substituted
heart rhythm
rhythm disturbances
carboxamidoadenosines
treatment
Prior art date
Application number
MYPI20005377A
Inventor
Pauline L Martin
Original Assignee
Aderis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals Inc filed Critical Aderis Pharmaceuticals Inc
Publication of MY135962A publication Critical patent/MY135962A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

THE PRESENT INVENTION DISCLOSES A METHOD FOR TREATING HEART RHYTHM DISTURBANCES IN A MAMMAL IN NEED THEREOF BY THE ADMINISTRATION OF N6-SUBSTITUTED- 5''(N-SUBSTITUTED)CARBOXAMIDOADENOSINES. MORE PARTICULARLY, THE INVENTION IS DIRECTED TO A METHOD FOR TREATMENT OF HEART RHYTHM DISTURBANCES IN A MAMMAL THAT WOULD BENEFIT FROM THE INDUCTION OF NEGATIVE DROMOTROPIC AND/OR NEGATIVE CHRONOTROPIC ACTIONS, COMPRISING THE ADMINISTRATION TO SAID MAMMAM AN EFFECTIVE AMOUNT OF A COMPOUND OF THE FORMULA :(FORMULA)OR A PHARMACEUTICALLY ACCEPTABLE SALT OR ESTER THEREOF; WHEREIN R1 IS C3-7 SECONDARY ALKYL, OR C3-8 CYCLOALKYL; ANDR2 IS C1-4 ALKYL OR C3-5 CYCLOALKYLTHE INVENTION IS ALSO DIRECTED TO NOVEL DOSAGE FORMS COMPRISING SAID COMPOUNDS.
MYPI20005377A 1999-11-23 2000-11-16 Treatment of heart rhythm disturbances with n6-substituted-5'-(n-substituted) carboxamidoadenosines MY135962A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16701499P 1999-11-23 1999-11-23

Publications (1)

Publication Number Publication Date
MY135962A true MY135962A (en) 2008-07-31

Family

ID=22605594

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20005377A MY135962A (en) 1999-11-23 2000-11-16 Treatment of heart rhythm disturbances with n6-substituted-5'-(n-substituted) carboxamidoadenosines

Country Status (12)

Country Link
EP (1) EP1239864A1 (en)
JP (1) JP2003514863A (en)
KR (1) KR20020069188A (en)
AU (1) AU782715B2 (en)
CA (1) CA2392369A1 (en)
IL (1) IL149470A0 (en)
MX (1) MXPA02005088A (en)
MY (1) MY135962A (en)
NO (1) NO20022393L (en)
NZ (1) NZ518861A (en)
TW (1) TWI257306B (en)
WO (1) WO2001037845A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004238217A1 (en) * 2003-04-24 2004-11-25 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
EP1743940B1 (en) 2004-04-02 2012-01-18 Japan Science and Technology Agency Cardioinhibitory/ antihypertensive novel endogenous physiologically active peptide
US7381714B2 (en) 2005-05-19 2008-06-03 Cv Therapeutics, Inc. A1 adenosine receptor agonists
DK2234614T3 (en) 2007-12-21 2013-02-11 Aop Orphan Pharmaceuticals Ag PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION OF AN ULTRA CARD EFFECTING BETA-RECEPTOR BLOCKING AGENT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
EP0169009A3 (en) * 1984-07-17 1988-08-31 FISONS plc Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
US4738954A (en) * 1985-11-06 1988-04-19 Warner-Lambert Company Novel N6 -substituted-5'-oxidized adenosine analogs

Also Published As

Publication number Publication date
WO2001037845A1 (en) 2001-05-31
TWI257306B (en) 2006-07-01
EP1239864A1 (en) 2002-09-18
NO20022393L (en) 2002-06-24
NO20022393D0 (en) 2002-05-21
MXPA02005088A (en) 2004-08-23
KR20020069188A (en) 2002-08-29
IL149470A0 (en) 2002-11-10
AU782715B2 (en) 2005-08-25
NZ518861A (en) 2004-11-26
JP2003514863A (en) 2003-04-22
CA2392369A1 (en) 2001-05-31
AU1613201A (en) 2001-06-04

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