CA1272733C - Compositions for treating glaucoma - Google Patents
Compositions for treating glaucomaInfo
- Publication number
- CA1272733C CA1272733C CA 405106 CA405106A CA1272733C CA 1272733 C CA1272733 C CA 1272733C CA 405106 CA405106 CA 405106 CA 405106 A CA405106 A CA 405106A CA 1272733 C CA1272733 C CA 1272733C
- Authority
- CA
- Canada
- Prior art keywords
- carbon atoms
- hydroxy
- benzoyl
- phenyl substituted
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000010412 Glaucoma Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- -1 chloro, nitro, hydroxy, amino Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000521655A CA1272733A (en) | 1981-06-23 | 1986-10-28 | Compositions for treating glaucoma |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US276,657 | 1981-06-23 | ||
| US06/276,657 US4402974A (en) | 1981-06-23 | 1981-06-23 | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000521655A Division CA1272733A (en) | 1981-06-23 | 1986-10-28 | Compositions for treating glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA1220716A CA1220716A (en) | 1987-04-21 |
| CA1272733C true CA1272733C (en) | 1990-08-14 |
Family
ID=23057572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 405106 Expired - Lifetime CA1272733C (en) | 1981-06-23 | 1982-06-14 | Compositions for treating glaucoma |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4402974A (xx) |
| EP (1) | EP0081580B1 (xx) |
| JP (1) | JPS58500997A (xx) |
| AT (1) | AT384017B (xx) |
| AU (1) | AU559541B2 (xx) |
| CA (1) | CA1272733C (xx) |
| CH (1) | CH655497B (xx) |
| ES (1) | ES8401927A1 (xx) |
| GB (2) | GB2112785B (xx) |
| GR (1) | GR76848B (xx) |
| IL (1) | IL66069A0 (xx) |
| IT (1) | IT1156057B (xx) |
| NL (1) | NL8220251A (xx) |
| NZ (1) | NZ200971A (xx) |
| PH (1) | PH18383A (xx) |
| SE (1) | SE464300B (xx) |
| WO (1) | WO1983000043A1 (xx) |
| ZA (1) | ZA824339B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
| DK330880A (da) * | 1979-08-03 | 1981-02-04 | Beecham Group Ltd | Fremgangsmaade til fremstilling af clavulansyrederivater |
| US4604481A (en) * | 1980-11-28 | 1986-08-05 | American Hospital Supply Corporation | Compounds for treatment or prophylaxis of cardiac disorders |
| EP0053893B1 (en) * | 1980-12-09 | 1985-03-20 | Beecham Group Plc | Derivatives of clavulanic acid, their preparation and their use |
| NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
| US4579867A (en) * | 1984-04-09 | 1986-04-01 | American Hospital Supply Corporation | Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents |
| CA1334168C (en) * | 1988-04-26 | 1995-01-31 | Louis M. De Santis | Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers |
| US4966914A (en) * | 1988-12-15 | 1990-10-30 | E. I. Du Pont De Nemours And Company | Oculoselective beta-blockers as antiglaucoma agents |
| US4897417A (en) * | 1988-12-15 | 1990-01-30 | E. I. Du Pont De Nemours & Co. | Prodrugs of 3,4-hydroxy benzoyloxypropanolamines |
| CH679856A5 (xx) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5543083A (en) * | 1994-07-26 | 1996-08-06 | The Procter & Gamble Company | Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation |
| US5536749A (en) * | 1994-10-13 | 1996-07-16 | Sl Pharmaceuticals, Inc. | Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents |
| US6197817B1 (en) | 1999-01-22 | 2001-03-06 | Selectus Pharmaceuticals, Inc. | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders |
| US7209743B2 (en) * | 2004-04-22 | 2007-04-24 | Telefonaktiebolaget Lm Ericsson (Publ) | Base station system and method for compensating traffic channel signal strength measurements in a cellular radio telecommunication network |
| AU2005247480A1 (en) * | 2004-05-25 | 2005-12-08 | Qlt Inc. | Oculoselective drugs and prodrugs |
| US20080300292A1 (en) * | 2004-11-08 | 2008-12-04 | Nitromed, Inc | Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL75127C (xx) * | 1943-10-05 | |||
| FR1047364A (fr) * | 1950-12-28 | 1953-12-14 | Hoechst Ag | Esters d'acides alcoylamino-benzoïques, sels d'acides minéraux de ces esters et procédé de préparation de ces corps |
| NL300886A (xx) * | 1962-11-23 | |||
| US3959351A (en) * | 1972-07-24 | 1976-05-25 | Research Corporation | Haloalkylbenzoyl esters of di-lower alkylamino alkanols and quaternary lower alkyl salts thereof |
| US4195085A (en) * | 1975-09-26 | 1980-03-25 | Merck & Co., Inc. | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate |
| DE2752659A1 (de) | 1976-12-07 | 1978-06-08 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
| US4127674A (en) * | 1977-03-21 | 1978-11-28 | Allergan Pharmaceuticals, Inc. | Method of treatment for glaucoma |
| DE2962112D1 (en) * | 1978-02-08 | 1982-03-25 | Ici Plc | Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them |
| US4405642A (en) * | 1980-11-28 | 1983-09-20 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
-
1981
- 1981-06-23 US US06/276,657 patent/US4402974A/en not_active Expired - Fee Related
-
1982
- 1982-06-14 CA CA 405106 patent/CA1272733C/xx not_active Expired - Lifetime
- 1982-06-14 PH PH27417A patent/PH18383A/en unknown
- 1982-06-15 NZ NZ200971A patent/NZ200971A/en unknown
- 1982-06-16 IL IL66069A patent/IL66069A0/xx not_active IP Right Cessation
- 1982-06-18 GR GR68484A patent/GR76848B/el unknown
- 1982-06-18 ZA ZA824339A patent/ZA824339B/xx unknown
- 1982-06-22 IT IT67795/82A patent/IT1156057B/it active
- 1982-06-23 EP EP82902332A patent/EP0081580B1/en not_active Expired
- 1982-06-23 NL NL8220251A patent/NL8220251A/nl unknown
- 1982-06-23 ES ES513386A patent/ES8401927A1/es not_active Expired
- 1982-06-23 GB GB08303060A patent/GB2112785B/en not_active Expired
- 1982-06-23 WO PCT/US1982/000848 patent/WO1983000043A1/en active IP Right Grant
- 1982-06-23 JP JP57502294A patent/JPS58500997A/ja active Granted
- 1982-06-23 AU AU87375/82A patent/AU559541B2/en not_active Ceased
- 1982-06-23 AT AT0903482A patent/AT384017B/de not_active IP Right Cessation
- 1982-06-23 CH CH110483A patent/CH655497B/de unknown
-
1983
- 1983-02-18 SE SE8300912A patent/SE464300B/sv not_active IP Right Cessation
-
1984
- 1984-08-30 GB GB08421939A patent/GB2145721B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA824339B (en) | 1983-04-27 |
| IT8267795A0 (it) | 1982-06-22 |
| EP0081580B1 (en) | 1987-04-22 |
| GR76848B (xx) | 1984-09-04 |
| NL8220251A (nl) | 1983-05-02 |
| EP0081580A4 (en) | 1983-12-01 |
| AU8737582A (en) | 1983-01-18 |
| SE8300912L (sv) | 1983-02-18 |
| JPS58500997A (ja) | 1983-06-23 |
| GB2112785B (en) | 1985-06-05 |
| GB8303060D0 (en) | 1983-03-09 |
| GB2145721A (en) | 1985-04-03 |
| ES513386A0 (es) | 1984-01-01 |
| IL66069A0 (en) | 1982-09-30 |
| ES8401927A1 (es) | 1984-01-01 |
| GB2112785A (en) | 1983-07-27 |
| JPH0428696B2 (xx) | 1992-05-15 |
| GB8421939D0 (en) | 1984-10-03 |
| ATA903482A (de) | 1987-02-15 |
| SE464300B (sv) | 1991-04-08 |
| NZ200971A (en) | 1985-12-13 |
| IT1156057B (it) | 1987-01-28 |
| AT384017B (de) | 1987-09-25 |
| CH655497B (xx) | 1986-04-30 |
| PH18383A (en) | 1985-06-19 |
| AU559541B2 (en) | 1987-03-12 |
| GB2145721B (en) | 1986-02-19 |
| SE8300912D0 (sv) | 1983-02-18 |
| WO1983000043A1 (en) | 1983-01-06 |
| CA1220716A (en) | 1987-04-21 |
| US4402974A (en) | 1983-09-06 |
| EP0081580A1 (en) | 1983-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20040421 |