ES471594A1 - Procedimiento para la preparacion de alfa-halometil deriva- dos de amino acido - Google Patents
Procedimiento para la preparacion de alfa-halometil deriva- dos de amino acidoInfo
- Publication number
- ES471594A1 ES471594A1 ES471594A ES471594A ES471594A1 ES 471594 A1 ES471594 A1 ES 471594A1 ES 471594 A ES471594 A ES 471594A ES 471594 A ES471594 A ES 471594A ES 471594 A1 ES471594 A1 ES 471594A1
- Authority
- ES
- Spain
- Prior art keywords
- straight
- carbon atoms
- hydrogen
- branched
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la preparación de alfahalometil derivados de amino ácido, especialmente derivados de histidina y compuestos relacionados, farmaceúticamente útiles. La mayor parte del tejido de los mamíferos contiene histamina, siendo la concentración particularmente alta en la piel, en la mucosa intestinal y en los pulmones. Todo tejido de mamíferos, que contiene histamina, incluyendo las células sanguíneas blancas, aparece como capaz de sintetizar la amina de histidina. La principal enzima, comprendida en la catalización en vivo de la conversión de histidina en histamina, es decarboxilasa de histidina, que es específica para el substrato L-histidina. En muchos tejidos el principal lugar de almacenaje de histamina es la célula de mástil, o en el caso de sangre, el basófilo que es la contrapartida circulante de la célula de mástil de tejido. Las células de mástil no son la única fuente de tejido de histamina, que está presente en cantidades sustanciales en la epidermis humana, el sistemanervioso central y la mucosa gastrointestinal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/819,975 US4315095A (en) | 1977-07-28 | 1977-07-28 | α-Halomethyl derivatives of amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471594A1 true ES471594A1 (es) | 1979-10-01 |
Family
ID=25229573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471594A Expired ES471594A1 (es) | 1977-07-28 | 1978-07-10 | Procedimiento para la preparacion de alfa-halometil deriva- dos de amino acido |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4315095A (es) |
| JP (1) | JPS5436262A (es) |
| AU (1) | AU521354B2 (es) |
| BE (1) | BE869322A (es) |
| CA (1) | CA1120041A (es) |
| CH (1) | CH638790A5 (es) |
| DE (1) | DE2832309A1 (es) |
| ES (1) | ES471594A1 (es) |
| FR (1) | FR2398736A1 (es) |
| GB (1) | GB2001626B (es) |
| IE (1) | IE46928B1 (es) |
| IL (1) | IL54914A0 (es) |
| IT (1) | IT1107454B (es) |
| NL (1) | NL7807871A (es) |
| NZ (1) | NZ187537A (es) |
| ZA (1) | ZA783350B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4413141A (en) * | 1977-07-11 | 1983-11-01 | Merrell Toraude Et Compagnie | 2-(Difluoromethyl)-2,5-diaminopentanoic acid |
| JPS591490A (ja) * | 1982-06-29 | 1984-01-06 | Dai Ichi Seiyaku Co Ltd | ３−セフェム−４−カルボン酸誘導体 |
| CA1302919C (en) * | 1985-07-03 | 1992-06-09 | Robert T. Buckler | Histamine derivatives, immunogen conjugates and antibodies raised thereto |
| US5030645A (en) * | 1990-10-15 | 1991-07-09 | Merck & Co., Inc. | Method of treating asthma using (S)-α-fluoromethyl-histidine and esters thereof |
| US6001926A (en) * | 1997-10-02 | 1999-12-14 | The United States Of America As Represented By The Secretary Of The Navy | Fiber-reinforced phthalonitrile composite cured with low-reactivity aromatic amine curing agent |
| EP1321169A1 (en) * | 2001-12-18 | 2003-06-25 | Biofrontera Pharmaceuticals AG | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169971A (en) * | 1965-02-16 | A-alkyl histidines | ||
| GB715182A (en) * | 1951-09-19 | 1954-09-08 | Roche Products Ltd | A novel imidazole derivative and process for the manufacture thereof |
| FR1493402A (fr) * | 1962-01-22 | 1967-09-01 | Merck & Co Inc | Hydrazino-acides |
| US3387031A (en) * | 1961-06-08 | 1968-06-04 | Union Carbide Corp | Synthesis of alpha-amino acid amide hydrohalides |
| FR1457259A (fr) * | 1961-08-18 | 1966-01-24 | Merck & Co Inc | Production d'amino-acides du type alpha-alkyl-histidine |
| NZ187377A (en) * | 1977-06-01 | 1981-05-15 | Merck & Co Inc | A-amino-a-substituted alkyl-a-fluoromethylacetic acids |
-
1977
- 1977-07-28 US US05/819,975 patent/US4315095A/en not_active Expired - Lifetime
-
1978
- 1978-06-06 IE IE1149/78A patent/IE46928B1/en not_active IP Right Cessation
- 1978-06-06 CA CA000304902A patent/CA1120041A/en not_active Expired
- 1978-06-12 ZA ZA00783350A patent/ZA783350B/xx unknown
- 1978-06-13 NZ NZ187537A patent/NZ187537A/xx unknown
- 1978-06-15 IL IL7854914A patent/IL54914A0/xx not_active IP Right Cessation
- 1978-06-21 AU AU37317/78A patent/AU521354B2/en not_active Expired
- 1978-06-27 GB GB787827962A patent/GB2001626B/en not_active Expired
- 1978-07-10 ES ES471594A patent/ES471594A1/es not_active Expired
- 1978-07-19 CH CH779078A patent/CH638790A5/de not_active IP Right Cessation
- 1978-07-22 DE DE19782832309 patent/DE2832309A1/de active Granted
- 1978-07-25 JP JP9002378A patent/JPS5436262A/ja active Granted
- 1978-07-25 NL NL7807871A patent/NL7807871A/xx not_active Application Discontinuation
- 1978-07-25 IT IT50463/78A patent/IT1107454B/it active
- 1978-07-27 BE BE189541A patent/BE869322A/xx not_active IP Right Cessation
- 1978-07-27 FR FR7822279A patent/FR2398736A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IL54914A0 (en) | 1978-08-31 |
| GB2001626A (en) | 1979-02-07 |
| IT1107454B (it) | 1985-11-25 |
| JPS6123792B2 (es) | 1986-06-07 |
| FR2398736A1 (fr) | 1979-02-23 |
| AU3731778A (en) | 1980-01-03 |
| IT7850463A0 (it) | 1978-07-25 |
| CH638790A5 (de) | 1983-10-14 |
| CA1120041A (en) | 1982-03-16 |
| BE869322A (fr) | 1978-11-16 |
| FR2398736B1 (es) | 1980-09-19 |
| DE2832309A1 (de) | 1979-02-08 |
| JPS5436262A (en) | 1979-03-16 |
| ZA783350B (en) | 1979-06-27 |
| DE2832309C2 (es) | 1989-07-06 |
| IE781149L (en) | 1979-01-28 |
| IE46928B1 (en) | 1983-11-02 |
| AU521354B2 (en) | 1982-04-01 |
| US4315095A (en) | 1982-02-09 |
| GB2001626B (en) | 1982-04-07 |
| NZ187537A (en) | 1980-08-26 |
| NL7807871A (nl) | 1979-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001102 |