ES472738A1 - Procedimiento para la obtencion de alfa-halometil derivados de aminas - Google Patents

Procedimiento para la obtencion de alfa-halometil derivados de aminas

Info

Publication number
ES472738A1
ES472738A1 ES472738A ES472738A ES472738A1 ES 472738 A1 ES472738 A1 ES 472738A1 ES 472738 A ES472738 A ES 472738A ES 472738 A ES472738 A ES 472738A ES 472738 A1 ES472738 A1 ES 472738A1
Authority
ES
Spain
Prior art keywords
hydrogen
methylthioethyl
beta
image
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472738A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of ES472738A1 publication Critical patent/ES472738A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compuestos de la fórmula en que beta-benciltioetilo, son inhibidores irreversibles de enzimas de decarboxilasa que están comprendidas en la formación de poliamina haciendo dichos compuestos útiles como agentes farmacológicos. Poliaminas, particularmente putrescina, espermidina y espermina están presentes en tejidos de plantas y animales y en algunos microorganismos. Aunque no se han delineado claramente los papeles fisiológicos exactos de las poliaminas, existe evidencia para sugerir que las poliaminas están comprendidas en la división y en el crecimiento de las células, están comprendidas en los procesos de crecimiento de ciertos micro-organismos, crecimiento neoplástico rápido, haciendo un incremento en la síntesis y acumulación de poliamina, siguiendo a un estímulo, que cause proliferación celular.
ES472738A 1977-09-06 1978-08-22 Procedimiento para la obtencion de alfa-halometil derivados de aminas Expired ES472738A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/830,998 US4134918A (en) 1977-09-06 1977-09-06 Alpha-halomethyl derivatives of amines

Publications (1)

Publication Number Publication Date
ES472738A1 true ES472738A1 (es) 1979-10-16

Family

ID=25258071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES472738A Expired ES472738A1 (es) 1977-09-06 1978-08-22 Procedimiento para la obtencion de alfa-halometil derivados de aminas

Country Status (14)

Country Link
US (1) US4134918A (es)
JP (1) JPS5448709A (es)
AU (1) AU517161B2 (es)
BE (1) BE870266A (es)
CA (1) CA1113089A (es)
CH (1) CH636842A5 (es)
DE (1) DE2836616A1 (es)
ES (1) ES472738A1 (es)
FR (1) FR2403989A1 (es)
GB (1) GB2003876B (es)
IT (1) IT1106111B (es)
NL (1) NL7809085A (es)
NZ (1) NZ188168A (es)
ZA (1) ZA784635B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811555B (en) * 1980-03-25 1982-03-31 Merrell Toraude & Co Substituted deoxyadenosine derivatives
CA1174603A (en) * 1980-06-16 1984-09-18 Albert Sjoerdsma Method of inhibiting the growth of protozoa
GB2082578B (en) * 1980-08-23 1984-05-23 Merrell Toraude & Co Fluorinated amino-butyric acid and diaminobutane derivatives
GB2082579B (en) * 1980-08-23 1984-02-08 Merrell Toraude & Co Fluorinated diaminobutane derivatives
GB2083030B (en) * 1980-08-23 1984-03-07 Merrell Toraude & Co Fluorinated pentene diamine derivatives
US4437873A (en) 1981-03-23 1984-03-20 Merrell Dow Pharmaceuticals Inc. Method of inhibiting algae
US4415591A (en) * 1981-06-04 1983-11-15 Georgia Tech Research Institute Use of aminoalkyl phenyl sulfide derivatives for the treatment of hypertension
IE54303B1 (en) * 1981-08-19 1989-08-16 Merrell Dow France Fluorinated diaminoalkene derivatives
IE54304B1 (en) * 1981-08-19 1989-08-16 Merrell Dow France Fluorinated diamino-heptene and -heptyne derivatives
US4423073A (en) 1981-08-19 1983-12-27 Merrell Toraude Et Compagnie Fluorinated diaminopentene derivatives
US4435425A (en) 1982-04-09 1984-03-06 Merrell Toraude Et Compagnie Fluorinated diaminobutane derivatives
US4421768A (en) 1982-08-11 1983-12-20 Merrell Toraude Et Compagnie Fluorinated diamino-heptene and-heptyne derivatives
US4760091A (en) * 1985-10-01 1988-07-26 The Dow Chemical Company Method of controlling phytopathogenic fungus
JPS62148462A (ja) * 1985-12-19 1987-07-02 メレルダウフア−マス−テイカルズ　インコ−ポレ−テツド 原生動物の生長を抑制する新規な方法
US5196450A (en) * 1985-12-19 1993-03-23 Merrell Dow Pharmaceuticals Inc. Method of inhibiting protozoal growth
EP0351475A1 (en) * 1988-07-21 1990-01-24 Merrell Dow Pharmaceuticals Inc. S-Adenosylmethionine decarboxylase inhibitors
CA2122342A1 (en) * 1992-09-04 1994-03-17 Hironori Kawabata Pharmaceutical composition
US5677349A (en) * 1995-04-27 1997-10-14 Gilad; Gad M. Agmatine for the treatment of neurotrauma and neurodegenerative diseases
DE19712633A1 (de) * 1997-03-26 1998-10-08 Laves Arzneimittel Verwendung von gamma-Aminobuttersäure als Interleukinbildungsstimulans
US6521641B1 (en) * 1998-10-08 2003-02-18 Allergan, Inc. Male anti-fertility agents
US7816407B2 (en) * 2000-06-15 2010-10-19 University Of Kentucky Research Foundation Agmatine and agmatine analogs in the treatment of epilepsy, seizure, and electroconvulsive disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA677908A (en) * 1964-01-14 V. Cohen Werner Process for preparing polyfluoroalkylamines
US2515246A (en) * 1946-06-30 1950-07-18 Purdue Research Foundation Polyfluoro aliphatic diamines
US2769839A (en) * 1950-06-23 1956-11-06 Monsanto Chemicals Preparation of mercapto amines
DE2018461A1 (de) * 1969-05-20 1971-11-04 Walter Bloechl Fluoralkyldi- und -polyamine mit grenzflächenaktiven Eigenschaften, uhre Herstellung und Anwendung

Also Published As

Publication number Publication date
BE870266A (fr) 1979-01-02
FR2403989B1 (es) 1983-08-19
US4134918A (en) 1979-01-16
JPS5448709A (en) 1979-04-17
IT1106111B (it) 1985-11-11
AU517161B2 (en) 1981-07-09
ZA784635B (en) 1979-08-29
GB2003876A (en) 1979-03-21
CH636842A5 (de) 1983-06-30
CA1113089A (en) 1981-11-24
AU3905678A (en) 1980-02-21
DE2836616A1 (de) 1979-03-08
NZ188168A (en) 1982-09-07
JPS6315260B2 (es) 1988-04-04
FR2403989A1 (fr) 1979-04-20
IT7850947A0 (it) 1978-09-01
NL7809085A (nl) 1979-03-08
GB2003876B (en) 1982-02-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102