SE461502B - Komposition foer reglerad frisaettning av ett vattenloesligt laekemedel fraan en mikrofasseparerad hydrogel - Google Patents
Komposition foer reglerad frisaettning av ett vattenloesligt laekemedel fraan en mikrofasseparerad hydrogelInfo
- Publication number
- SE461502B SE461502B SE8404568A SE8404568A SE461502B SE 461502 B SE461502 B SE 461502B SE 8404568 A SE8404568 A SE 8404568A SE 8404568 A SE8404568 A SE 8404568A SE 461502 B SE461502 B SE 461502B
- Authority
- SE
- Sweden
- Prior art keywords
- water
- weight
- copolymer
- soluble
- mixture
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 62
- 239000000017 hydrogel Substances 0.000 title description 2
- 230000001105 regulatory effect Effects 0.000 title description 2
- 229920001577 copolymer Polymers 0.000 claims description 54
- 239000000178 monomer Substances 0.000 claims description 25
- JYGXADMDTFJGBT-VWUMJDOOSA-N Hydrocortisone Natural products O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 20
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 17
- 229960000890 hydrocortisone Drugs 0.000 claims description 12
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 10
- 229920001519 homopolymer Polymers 0.000 claims description 9
- 229960003387 progesterone Drugs 0.000 claims description 9
- 239000000186 progesterone Substances 0.000 claims description 9
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 5
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 4
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229920003169 water-soluble polymer Polymers 0.000 claims description 3
- 125000000017 cortisol group Chemical group 0.000 claims 1
- 239000000499 gel Substances 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- 239000013543 active substance Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- 238000013270 controlled release Methods 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 7
- 229920002959 polymer blend Polymers 0.000 description 7
- 150000003431 steroids Chemical class 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000005192 partition Methods 0.000 description 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000003433 contraceptive agent Substances 0.000 description 3
- 238000013267 controlled drug release Methods 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 2
- OLQFXOWPTQTLDP-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl 2-methylprop-2-enoate Chemical group CC(=C)C(=O)OCCOCCO OLQFXOWPTQTLDP-UHFFFAOYSA-N 0.000 description 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
- MZGMQAMKOBOIDR-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCO MZGMQAMKOBOIDR-UHFFFAOYSA-N 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- 125000005670 ethenylalkyl group Chemical group 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 description 1
- HQGPZXPTJWUDQR-UHFFFAOYSA-N 1-ethenyl-5-methylpyrrolidin-2-one Chemical compound CC1CCC(=O)N1C=C HQGPZXPTJWUDQR-UHFFFAOYSA-N 0.000 description 1
- PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 description 1
- GSSDUXHQPXODCN-UHFFFAOYSA-N 1-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C(=C)C1=CC=CC=C1 GSSDUXHQPXODCN-UHFFFAOYSA-N 0.000 description 1
- DAVVKEZTUOGEAK-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound COCCOCCOC(=O)C(C)=C DAVVKEZTUOGEAK-UHFFFAOYSA-N 0.000 description 1
- PRAMZQXXPOLCIY-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethanesulfonic acid Chemical compound CC(=C)C(=O)OCCS(O)(=O)=O PRAMZQXXPOLCIY-UHFFFAOYSA-N 0.000 description 1
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
- YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
- GAVHQOUUSHBDAA-UHFFFAOYSA-N 3-butyl-1-ethenylaziridin-2-one Chemical compound CCCCC1N(C=C)C1=O GAVHQOUUSHBDAA-UHFFFAOYSA-N 0.000 description 1
- GKGOIYMLPJJVQI-UHFFFAOYSA-N 4-ethenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=C(C=C)C=C1 GKGOIYMLPJJVQI-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 240000002024 Gossypium herbaceum Species 0.000 description 1
- 235000004341 Gossypium herbaceum Nutrition 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003732 agents acting on the eye Substances 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 229930000755 gossypol Natural products 0.000 description 1
- 229950005277 gossypol Drugs 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229940023490 ophthalmic product Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L57/00—Compositions of unspecified polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53264383A | 1983-09-15 | 1983-09-15 | |
| US06/606,794 US4693887A (en) | 1983-09-15 | 1984-05-03 | Microphase separated hydrogels for controlled release of bioactive materials |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8404568D0 SE8404568D0 (sv) | 1984-09-12 |
| SE8404568L SE8404568L (sv) | 1985-03-16 |
| SE461502B true SE461502B (sv) | 1990-02-26 |
Family
ID=27063895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8404568A SE461502B (sv) | 1983-09-15 | 1984-09-12 | Komposition foer reglerad frisaettning av ett vattenloesligt laekemedel fraan en mikrofasseparerad hydrogel |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4693887A (fr) |
| AT (1) | ATA290884A (fr) |
| AU (1) | AU577056B2 (fr) |
| BE (1) | BE900581A (fr) |
| BR (1) | BR8404409A (fr) |
| CA (1) | CA1232201A (fr) |
| CH (1) | CH666415A5 (fr) |
| DE (1) | DE3432573A1 (fr) |
| DK (1) | DK410984A (fr) |
| ES (1) | ES8607357A1 (fr) |
| FR (1) | FR2551976B1 (fr) |
| GB (2) | GB2147002B (fr) |
| IT (1) | IT1178430B (fr) |
| NL (1) | NL8402833A (fr) |
| NO (1) | NO843650L (fr) |
| NZ (1) | NZ209323A (fr) |
| PT (1) | PT79192B (fr) |
| SE (1) | SE461502B (fr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
| US4883669A (en) * | 1985-02-25 | 1989-11-28 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration |
| DE3517080A1 (de) * | 1985-05-11 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | Komponente fuer therapeutische wirkstoffabgabesysteme |
| IE59361B1 (en) * | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
| US4867969A (en) * | 1986-02-07 | 1989-09-19 | Alza Corporation | Hydrogel formulation for administering non-steroidal drugs |
| US4971790A (en) * | 1986-02-07 | 1990-11-20 | Alza Corporation | Dosage form for lessening irritation of mocusa |
| JPS62223112A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
| DE3617158C2 (de) * | 1986-05-22 | 1994-10-06 | Lohmann Therapie Syst Lts | Transdermales Arzneimittel |
| US5145682A (en) * | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
| US4965253A (en) * | 1987-10-14 | 1990-10-23 | University Of Florida | Viscoelastic material for ophthalmic surgery |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5133992A (en) * | 1988-03-21 | 1992-07-28 | Eastman Kodak Company | Colloidally stabilized suspension process |
| US4931287A (en) * | 1988-06-14 | 1990-06-05 | University Of Utah | Heterogeneous interpenetrating polymer networks for the controlled release of drugs |
| EP0347145A3 (fr) * | 1988-06-14 | 1990-10-24 | University Of Utah Research Foundation | Réseaux polymères hétérogènes interpénétrants pour la libération commandée de substances pharmaceutiques |
| US5073381A (en) * | 1988-08-15 | 1991-12-17 | University Of Akron | Amphiphilic networks |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| ES2062900B1 (es) * | 1991-07-29 | 1995-07-01 | Univ Madrid Nac Educacion | Hidrogeles de polimero heterociclico, su procedimiento de obtencion y su utilizacion como pastillas insolubles reguladoras del ph. |
| DK0616505T3 (fr) * | 1991-11-15 | 1997-02-24 | Minnesota Mining & Mfg | |
| US5352448A (en) * | 1992-07-20 | 1994-10-04 | Purdue Research Foundatioin | Oral administration of antigens |
| JP3624315B2 (ja) * | 1992-07-29 | 2005-03-02 | バクスター、インターナショナル、インコーポレイテッド | 親水性表面を有する生物材料 |
| DE4341156C2 (de) * | 1993-12-02 | 1997-11-13 | Wacker Chemie Gmbh | Verwendung von in Wasser redispergierbaren Kunststoffdispersionspulvern als Arzneimittelträger |
| US5603955A (en) * | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
| US5840338A (en) * | 1994-07-18 | 1998-11-24 | Roos; Eric J. | Loading of biologically active solutes into polymer gels |
| DE19622355A1 (de) * | 1996-06-04 | 1997-12-11 | Bayer Ag | Formkörper die agrochemische Mittel freisetzen |
| DE19629468A1 (de) * | 1996-07-11 | 1998-01-15 | Schering Ag | Transdermale therapeutische Systeme |
| US8003705B2 (en) | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
| US5814329A (en) * | 1996-11-12 | 1998-09-29 | Polytherapeutics, Inc. | Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents |
| DE19753298A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| ATE219693T1 (de) | 1998-04-27 | 2002-07-15 | Surmodics Inc | Bioaktive wirkstoffe freisetzende beschichtungen |
| US20020188037A1 (en) * | 1999-04-15 | 2002-12-12 | Chudzik Stephen J. | Method and system for providing bioactive agent release coating |
| US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| WO2000033764A1 (fr) | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Polymeres reticules biocompatibles |
| US8323693B2 (en) | 2002-03-14 | 2012-12-04 | Medrx Co., Ltd. | External preparation for wounds |
| US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
| US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
| WO2005003192A1 (fr) * | 2003-06-26 | 2005-01-13 | Symyx Technologies, Inc. | Synthese de polymeres photosensibles |
| US20050152855A1 (en) * | 2003-09-19 | 2005-07-14 | Damian Hajduk | Materials for enhanced delivery of hydrophilic active agents in personal care formulations |
| WO2005099787A1 (fr) | 2004-04-06 | 2005-10-27 | Surmodics, Inc. | Compositions de revetement par agents bioactifs |
| US8148560B2 (en) * | 2005-09-23 | 2012-04-03 | Teva Women's Health, Inc. | Vaginal tablets comprising misoprostol and methods of making and using the same |
| WO2009113972A2 (fr) * | 2006-02-08 | 2009-09-17 | Tyrx Pharma, Inc. | Prothèses de type treillis temporairement raidies |
| CA2677532A1 (fr) * | 2007-02-06 | 2008-08-14 | Incept, Llc | Polymerisation avec precipitation de proteines pour elution dans une solution physiologique |
| CN201075472Y (zh) * | 2007-05-28 | 2008-06-18 | 富士康(昆山)电脑接插件有限公司 | 电连接器 |
| US9125807B2 (en) * | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| US8745133B2 (en) * | 2008-03-28 | 2014-06-03 | Yahoo! Inc. | System and method for optimizing the storage of data |
| EP2396070A4 (fr) * | 2009-02-12 | 2012-09-19 | Incept Llc | Délivrance de médicament par bouchons d'hydrogels |
| US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4085168A (en) * | 1971-02-22 | 1978-04-18 | Cpc International Inc. | Chemically joined, phase separated self-cured hydrophilic thermoplastic graft copolymers and their preparation |
| US4277582A (en) * | 1978-03-03 | 1981-07-07 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
| SU806037A1 (ru) * | 1978-04-06 | 1981-02-23 | Всесоюзный Кардиологический Научныйцентр Amh Cccp | Антиангинальное средство |
| SE448544B (sv) * | 1979-12-05 | 1987-03-02 | Kendall & Co | Vattenabsorberande komposition och anvendning derav som berare for ett lekemedel |
| SU1243627A3 (ru) * | 1979-12-05 | 1986-07-07 | Дзе Кендалл Компани (Фирма) | Гелеобразующа композици |
| US4259314A (en) * | 1979-12-10 | 1981-03-31 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals |
| US4423099A (en) * | 1980-07-28 | 1983-12-27 | Ciba-Geigy Corporation | Membrane modified hydrogels |
| JPS5776046A (en) * | 1980-10-27 | 1982-05-12 | Kendall & Co | Water absorbing composition |
-
1984
- 1984-05-03 US US06/606,794 patent/US4693887A/en not_active Expired - Fee Related
- 1984-08-22 AU AU32268/84A patent/AU577056B2/en not_active Ceased
- 1984-08-23 NZ NZ209323A patent/NZ209323A/en unknown
- 1984-08-28 DK DK410984A patent/DK410984A/da not_active Application Discontinuation
- 1984-09-04 BR BR8404409A patent/BR8404409A/pt unknown
- 1984-09-05 DE DE19843432573 patent/DE3432573A1/de not_active Withdrawn
- 1984-09-10 FR FR8413866A patent/FR2551976B1/fr not_active Expired
- 1984-09-11 AT AT842908A patent/ATA290884A/de not_active Application Discontinuation
- 1984-09-11 PT PT79192A patent/PT79192B/pt not_active IP Right Cessation
- 1984-09-12 SE SE8404568A patent/SE461502B/sv not_active IP Right Cessation
- 1984-09-13 IT IT8448836A patent/IT1178430B/it active
- 1984-09-14 CH CH4417/84A patent/CH666415A5/de not_active IP Right Cessation
- 1984-09-14 ES ES535923A patent/ES8607357A1/es not_active Expired
- 1984-09-14 BE BE0/213653A patent/BE900581A/fr not_active IP Right Cessation
- 1984-09-14 CA CA000463168A patent/CA1232201A/fr not_active Expired
- 1984-09-14 NO NO843650A patent/NO843650L/no unknown
- 1984-09-14 NL NL8402833A patent/NL8402833A/nl not_active Application Discontinuation
- 1984-09-17 GB GB08423416A patent/GB2147002B/en not_active Expired
-
1986
- 1986-08-19 GB GB08620117A patent/GB2177708A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK410984D0 (da) | 1984-08-28 |
| AU577056B2 (en) | 1988-09-15 |
| NO843650L (no) | 1985-03-18 |
| AU3226884A (en) | 1985-03-21 |
| FR2551976A1 (fr) | 1985-03-22 |
| BR8404409A (pt) | 1985-07-30 |
| PT79192B (en) | 1986-08-14 |
| GB2147002A (en) | 1985-05-01 |
| IT1178430B (it) | 1987-09-09 |
| GB2147002B (en) | 1987-11-11 |
| IT8448836A0 (it) | 1984-09-13 |
| ATA290884A (de) | 1991-07-15 |
| BE900581A (fr) | 1985-03-14 |
| DK410984A (da) | 1985-03-16 |
| NZ209323A (en) | 1987-04-30 |
| CA1232201A (fr) | 1988-02-02 |
| PT79192A (en) | 1984-10-01 |
| ES8607357A1 (es) | 1986-05-16 |
| DE3432573A1 (de) | 1985-04-18 |
| SE8404568D0 (sv) | 1984-09-12 |
| US4693887A (en) | 1987-09-15 |
| SE8404568L (sv) | 1985-03-16 |
| GB2177708A (en) | 1987-01-28 |
| FR2551976B1 (fr) | 1988-06-10 |
| IT8448836A1 (it) | 1986-03-13 |
| NL8402833A (nl) | 1985-04-01 |
| GB8620117D0 (en) | 1986-10-01 |
| ES535923A0 (es) | 1986-05-16 |
| GB8423416D0 (en) | 1984-10-24 |
| CH666415A5 (de) | 1988-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE461502B (sv) | Komposition foer reglerad frisaettning av ett vattenloesligt laekemedel fraan en mikrofasseparerad hydrogel | |
| US4591496A (en) | Process for making systems for the controlled release of macromolecules | |
| Brannon-Peppas et al. | Solute and penetrant diffusion in swellable polymers. IX. The mechanisms of drug release from pH-sensitive swelling-controlled systems | |
| Graham et al. | Hydrogels for controlled drug delivery | |
| Mandal | Swelling-controlled release system for the vaginal delivery of miconazole | |
| Yoshida et al. | A new temperature-sensitive hydrogel with α-amino acid group as side chain of polymer | |
| EP0163696B1 (fr) | Application d'une bioadhesive | |
| EP1077678B1 (fr) | Compositions mucoadhesives pour l'application d'agents biologiquement actifs a des tissus animaux | |
| CA1078734A (fr) | Implant de surfactif a liberation progressive | |
| Nasir et al. | pH-responsive smart gels of block copolymer [pluronic F127-co-poly (acrylic acid)] for controlled delivery of Ivabradine hydrochloride: Its toxicological evaluation | |
| JPS6059202B2 (ja) | 微小な密閉された医薬放出器およびその製造方法 | |
| Graham et al. | Polymeric inserts and implants for the controlled release of drugs | |
| O’Neill | Membrane systems | |
| US5352455A (en) | Controlled release compositions | |
| US10653783B2 (en) | Sustained release of bioactive factors from zwitterionic hydrogels | |
| EP0219207B1 (fr) | Formulation à effet retard contenant un système hydrophobe polymère | |
| Özkahraman et al. | Synthesis of N-vinylcaprolactam and methacrylic acid based hydrogels and investigation of drug release characteristics | |
| JP3227462B2 (ja) | 均一ヒドロゲルコポリマーの製法 | |
| JPS5838211A (ja) | 放出速度制御材料 | |
| JPS60100513A (ja) | 生物活性物質を調節して開放するための微小相の分離されたヒドロゲル | |
| US4145408A (en) | Controlled release article | |
| JPH0640890A (ja) | 徐放性製剤 | |
| Tekin et al. | Swelling of PHEMA based membranes in ethanol and their nitroglycerin permeabilities | |
| WO2005023181A2 (fr) | Systemes polymeres utilises dans des traitements medicamenteux a liberation controlee | |
| Yıldırmaz et al. | Fluoride release from microporous poly (2-hydroxyethyl methacrylate) membranes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8404568-1 Effective date: 19930406 Format of ref document f/p: F |