ES8607357A1 - Un dispositivo para la entrega controlada y uniforme de un farmaco, agente bioactivo, o similar - Google Patents
Un dispositivo para la entrega controlada y uniforme de un farmaco, agente bioactivo, o similarInfo
- Publication number
- ES8607357A1 ES8607357A1 ES535923A ES535923A ES8607357A1 ES 8607357 A1 ES8607357 A1 ES 8607357A1 ES 535923 A ES535923 A ES 535923A ES 535923 A ES535923 A ES 535923A ES 8607357 A1 ES8607357 A1 ES 8607357A1
- Authority
- ES
- Spain
- Prior art keywords
- microphase separated
- controlled release
- bioactive materials
- blend
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000017 hydrogel Substances 0.000 title abstract 3
- 230000000975 bioactive effect Effects 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000012867 bioactive agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- -1 therapeutic drugs Substances 0.000 abstract 1
- 229920001169 thermoplastic Polymers 0.000 abstract 1
- 239000004416 thermosoftening plastic Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L57/00—Compositions of unspecified polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE FABRICACION DE UN GEL QUE LIBERA CONTROLADAMENTE AGENTES FARMACOLOGICOS. COMPRENDE: A) DISOLVER UN MATERIAL BIOACTIVO LIBERABLE, JUNTO CON UN COMPONENTE POLIMERO NO RETICULADO SOLUBLE EN AGUA Y UN COPOLIMERO NO RETICULADO INSOLUBLE EN AGUA, EN UN DISOLVENTE ELEGIDO ENTRE 2-METOXIETANOL, N, N-DIMETILFORMAMIDA Y METANOL; B) SEPARAR EL DISOLVENTE POR EVAPORACION, BAJO VACIO A UNA TEMPERATURA COMPRENDIDA ENTRE 60 Y 100JC; Y C) TRANSFORMAR LA MEZCLA DE HIDROGEL ASI FORMULADA, MEDIANTE EXTRUSION DE MASA FUNDIDA, MOLDEO, O COLADA EN SOLUCION, EN UN DISPOSITIVO DE LIBERACION CONTROLADA DE MATERIALES BIOACTIVOS EN EL QUE DICHOS COMPONENTES POLIMEROS, SOLUBLE EN AGUA E INSOLUBLE EN AGUA, Y DICHO MATERIAL BIOACTIVO LIBERABLE QUEDAN DISPERSOS POR TODAS PARTES SEGUN UNA MORFOLOGIA DE DOMINIOS DE MICROFASES. SIENDO: EL POLIMERO HIDROSOLUBLE, HOMOPOLIMERO DE N-VINIL-LACTAMA; Y EL INSOLUBLE, UN 50-90% EN PESO DE UN MONOMERO ETILINICAMENTE INSATURADO, UN 2-12% DE UN MONOMERO SIN GRUPOS ACIDOS E HIDROFILO. SE UTILIZA EN FARMACOLOGIA PARA APLICAR DOSIS DE EFECTO SUAVE Y CONTINUADO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53264383A | 1983-09-15 | 1983-09-15 | |
US06/606,794 US4693887A (en) | 1983-09-15 | 1984-05-03 | Microphase separated hydrogels for controlled release of bioactive materials |
Publications (2)
Publication Number | Publication Date |
---|---|
ES535923A0 ES535923A0 (es) | 1986-05-16 |
ES8607357A1 true ES8607357A1 (es) | 1986-05-16 |
Family
ID=27063895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535923A Expired ES8607357A1 (es) | 1983-09-15 | 1984-09-14 | Un dispositivo para la entrega controlada y uniforme de un farmaco, agente bioactivo, o similar |
Country Status (18)
Country | Link |
---|---|
US (1) | US4693887A (es) |
AT (1) | ATA290884A (es) |
AU (1) | AU577056B2 (es) |
BE (1) | BE900581A (es) |
BR (1) | BR8404409A (es) |
CA (1) | CA1232201A (es) |
CH (1) | CH666415A5 (es) |
DE (1) | DE3432573A1 (es) |
DK (1) | DK410984A (es) |
ES (1) | ES8607357A1 (es) |
FR (1) | FR2551976B1 (es) |
GB (2) | GB2147002B (es) |
IT (1) | IT1178430B (es) |
NL (1) | NL8402833A (es) |
NO (1) | NO843650L (es) |
NZ (1) | NZ209323A (es) |
PT (1) | PT79192B (es) |
SE (1) | SE461502B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2062900A1 (es) * | 1991-07-29 | 1994-12-16 | Univ Madrid Nac Educacion | Hidrogeles de polimero heterociclico, su procedimiento de obtencion y su utilizacion como pastillas insolubles reguladoras del ph. |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
US4883669A (en) * | 1985-02-25 | 1989-11-28 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration |
DE3517080A1 (de) * | 1985-05-11 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | Komponente fuer therapeutische wirkstoffabgabesysteme |
IE59361B1 (en) * | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
US4867969A (en) * | 1986-02-07 | 1989-09-19 | Alza Corporation | Hydrogel formulation for administering non-steroidal drugs |
US4971790A (en) * | 1986-02-07 | 1990-11-20 | Alza Corporation | Dosage form for lessening irritation of mocusa |
JPS62223112A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
DE3617158C2 (de) * | 1986-05-22 | 1994-10-06 | Lohmann Therapie Syst Lts | Transdermales Arzneimittel |
US5145682A (en) * | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
US4965253A (en) * | 1987-10-14 | 1990-10-23 | University Of Florida | Viscoelastic material for ophthalmic surgery |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5133992A (en) * | 1988-03-21 | 1992-07-28 | Eastman Kodak Company | Colloidally stabilized suspension process |
US4931287A (en) * | 1988-06-14 | 1990-06-05 | University Of Utah | Heterogeneous interpenetrating polymer networks for the controlled release of drugs |
EP0347145A3 (en) * | 1988-06-14 | 1990-10-24 | University Of Utah Research Foundation | Heterogeneous interpenetrating polymer networks for the controlled release of drugs |
US5073381A (en) * | 1988-08-15 | 1991-12-17 | University Of Akron | Amphiphilic networks |
US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
JP3457308B2 (ja) * | 1991-11-15 | 2003-10-14 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | 二相複合導性感圧接着剤の施された生物医療電極 |
US5352448A (en) * | 1992-07-20 | 1994-10-04 | Purdue Research Foundatioin | Oral administration of antigens |
DE69310887T2 (de) * | 1992-07-29 | 1998-01-22 | Baxter Int | Pharmazeutische behälter und medizinische geräte mit hydrophilen, proteinverträglichen oberflächen |
DE4341156C2 (de) * | 1993-12-02 | 1997-11-13 | Wacker Chemie Gmbh | Verwendung von in Wasser redispergierbaren Kunststoffdispersionspulvern als Arzneimittelträger |
US5840338A (en) * | 1994-07-18 | 1998-11-24 | Roos; Eric J. | Loading of biologically active solutes into polymer gels |
US5603955A (en) * | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
DE19622355A1 (de) * | 1996-06-04 | 1997-12-11 | Bayer Ag | Formkörper die agrochemische Mittel freisetzen |
DE19629468A1 (de) * | 1996-07-11 | 1998-01-15 | Schering Ag | Transdermale therapeutische Systeme |
US6566406B1 (en) | 1998-12-04 | 2003-05-20 | Incept, Llc | Biocompatible crosslinked polymers |
US8003705B2 (en) | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
US5814329A (en) * | 1996-11-12 | 1998-09-29 | Polytherapeutics, Inc. | Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents |
DE19753298A1 (de) * | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
DE69901927T2 (de) | 1998-04-27 | 2002-10-10 | Surmodics Inc | Bioaktive wirkstoffe freisetzende beschichtungen |
US20020188037A1 (en) * | 1999-04-15 | 2002-12-12 | Chudzik Stephen J. | Method and system for providing bioactive agent release coating |
US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
KR100978905B1 (ko) | 2002-03-14 | 2010-08-31 | 가부시키가이샤 메드렉스 | 창상용 외용제 |
US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
WO2005003192A1 (en) * | 2003-06-26 | 2005-01-13 | Symyx Technologies, Inc. | Synthesis of photoresist polymers |
EP1667645A1 (en) * | 2003-09-19 | 2006-06-14 | Symyx Technologies | Materials for enhanced delivery of hydrophilic active agents in personal care formulations |
CA2563069A1 (en) | 2004-04-06 | 2005-10-27 | Surmodics, Inc. | Coating compositions for bioactive agents |
WO2007035954A2 (en) * | 2005-09-23 | 2007-03-29 | Duramed Pharmaceuticals, Inc. | Vaginal tablets comprising misoprostol and methods of making and using the same |
WO2009113972A2 (en) * | 2006-02-08 | 2009-09-17 | Tyrx Pharma, Inc. | Temporarily stiffened mesh prostheses |
EP2121057A4 (en) * | 2007-02-06 | 2012-10-10 | Incept Llc | POLYMERIZATION WITH PRECIPITATION OF PROTEINS FOR ELUTION IN A PHYSIOLOGICAL SOLUTION |
CN201075472Y (zh) * | 2007-05-28 | 2008-06-18 | 富士康(昆山)电脑接插件有限公司 | 电连接器 |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8745133B2 (en) * | 2008-03-28 | 2014-06-03 | Yahoo! Inc. | System and method for optimizing the storage of data |
CN102395401B (zh) | 2009-02-12 | 2015-08-19 | 因赛普特有限责任公司 | 经由水凝胶塞的药物递送 |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4085168A (en) * | 1971-02-22 | 1978-04-18 | Cpc International Inc. | Chemically joined, phase separated self-cured hydrophilic thermoplastic graft copolymers and their preparation |
US4277582A (en) * | 1978-03-03 | 1981-07-07 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
SU806037A1 (ru) * | 1978-04-06 | 1981-02-23 | Всесоюзный Кардиологический Научныйцентр Amh Cccp | Антиангинальное средство |
SU1243627A3 (ru) * | 1979-12-05 | 1986-07-07 | Дзе Кендалл Компани (Фирма) | Гелеобразующа композици |
SE448544B (sv) * | 1979-12-05 | 1987-03-02 | Kendall & Co | Vattenabsorberande komposition och anvendning derav som berare for ett lekemedel |
US4259314A (en) * | 1979-12-10 | 1981-03-31 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals |
US4423099A (en) * | 1980-07-28 | 1983-12-27 | Ciba-Geigy Corporation | Membrane modified hydrogels |
JPS5776046A (en) * | 1980-10-27 | 1982-05-12 | Kendall & Co | Water absorbing composition |
-
1984
- 1984-05-03 US US06/606,794 patent/US4693887A/en not_active Expired - Fee Related
- 1984-08-22 AU AU32268/84A patent/AU577056B2/en not_active Ceased
- 1984-08-23 NZ NZ209323A patent/NZ209323A/en unknown
- 1984-08-28 DK DK410984A patent/DK410984A/da not_active Application Discontinuation
- 1984-09-04 BR BR8404409A patent/BR8404409A/pt unknown
- 1984-09-05 DE DE19843432573 patent/DE3432573A1/de not_active Withdrawn
- 1984-09-10 FR FR8413866A patent/FR2551976B1/fr not_active Expired
- 1984-09-11 PT PT79192A patent/PT79192B/pt not_active IP Right Cessation
- 1984-09-11 AT AT842908A patent/ATA290884A/de not_active Application Discontinuation
- 1984-09-12 SE SE8404568A patent/SE461502B/sv not_active IP Right Cessation
- 1984-09-13 IT IT8448836A patent/IT1178430B/it active
- 1984-09-14 CH CH4417/84A patent/CH666415A5/de not_active IP Right Cessation
- 1984-09-14 BE BE0/213653A patent/BE900581A/fr not_active IP Right Cessation
- 1984-09-14 NL NL8402833A patent/NL8402833A/nl not_active Application Discontinuation
- 1984-09-14 CA CA000463168A patent/CA1232201A/en not_active Expired
- 1984-09-14 ES ES535923A patent/ES8607357A1/es not_active Expired
- 1984-09-14 NO NO843650A patent/NO843650L/no unknown
- 1984-09-17 GB GB08423416A patent/GB2147002B/en not_active Expired
-
1986
- 1986-08-19 GB GB08620117A patent/GB2177708A/en not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2062900A1 (es) * | 1991-07-29 | 1994-12-16 | Univ Madrid Nac Educacion | Hidrogeles de polimero heterociclico, su procedimiento de obtencion y su utilizacion como pastillas insolubles reguladoras del ph. |
Also Published As
Publication number | Publication date |
---|---|
PT79192B (en) | 1986-08-14 |
NZ209323A (en) | 1987-04-30 |
GB8620117D0 (en) | 1986-10-01 |
AU3226884A (en) | 1985-03-21 |
CH666415A5 (de) | 1988-07-29 |
US4693887A (en) | 1987-09-15 |
SE461502B (sv) | 1990-02-26 |
FR2551976A1 (fr) | 1985-03-22 |
NL8402833A (nl) | 1985-04-01 |
SE8404568L (sv) | 1985-03-16 |
ATA290884A (de) | 1991-07-15 |
ES535923A0 (es) | 1986-05-16 |
GB2177708A (en) | 1987-01-28 |
PT79192A (en) | 1984-10-01 |
GB2147002A (en) | 1985-05-01 |
IT1178430B (it) | 1987-09-09 |
FR2551976B1 (fr) | 1988-06-10 |
DK410984A (da) | 1985-03-16 |
NO843650L (no) | 1985-03-18 |
SE8404568D0 (sv) | 1984-09-12 |
IT8448836A0 (it) | 1984-09-13 |
AU577056B2 (en) | 1988-09-15 |
DE3432573A1 (de) | 1985-04-18 |
DK410984D0 (da) | 1984-08-28 |
GB8423416D0 (en) | 1984-10-24 |
BE900581A (fr) | 1985-03-14 |
GB2147002B (en) | 1987-11-11 |
IT8448836A1 (it) | 1986-03-13 |
CA1232201A (en) | 1988-02-02 |
BR8404409A (pt) | 1985-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8607357A1 (es) | Un dispositivo para la entrega controlada y uniforme de un farmaco, agente bioactivo, o similar | |
US4140162A (en) | Clear, autoclavable plastic formulation free of liquid plasticizers | |
US4968317B1 (en) | Surgical materials and devices | |
EG20321A (en) | Medical material and process for producing the same | |
CA2203901A1 (en) | Polymeric wound healing accelerators | |
EP0162026A3 (en) | A bacteria adsorbing composition | |
NZ506415A (en) | Liquid polymeric compositions for controlled release of bioactive substances using a polymer to active agent ratio of less than 1:1 | |
DE3071006D1 (en) | Composition for the controlled release of an active substance and process for its preparation | |
PT76576B (en) | Continuous release formulations | |
MX9706626A (es) | Composiciones farmaceuticas para la liberacion controlada de receptores solubles. | |
CA2161903A1 (en) | Polymer Composition, Absorbent Material Composition, Their Production and Use | |
DE3776776D1 (de) | Polymerlatex mit ultrafeinen teilchen und diesen enthaltende zusammensetzungen. | |
WO1995024430A3 (en) | Block and graft copolymers and methods relating thereto | |
GR3036586T3 (en) | Novel hydrogels containing triblock copolymers, and preparation and use thereof | |
IE46085L (en) | Delivery means for bioactive agents | |
GR3017267T3 (en) | Antiacid compositions with prolonged gastric residence time. | |
AU651615B2 (en) | Polymeric blends containing a block poly (ether-co-amide) | |
IL115138A (en) | Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof | |
EP0272562A3 (en) | Basic adhesive polymeric mass transmitting the active ingredient, method for making it and its use | |
AU8452991A (en) | 1-aryl-3-pyridinyl-2-propene-1-ones | |
ES477787A1 (es) | Un procedimiento para preparar materiales termoplasticos. | |
CA2133955A1 (en) | Polyetheramidoamine hydrogels as heparinizable materials | |
AU1008692A (en) | Hydrogel material | |
GR3026551T3 (en) | Composition of polymers for medical applications. | |
JPS53136053A (en) | Rubber composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |