SE460667B - Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning - Google Patents
Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendningInfo
- Publication number
- SE460667B SE460667B SE8006365A SE8006365A SE460667B SE 460667 B SE460667 B SE 460667B SE 8006365 A SE8006365 A SE 8006365A SE 8006365 A SE8006365 A SE 8006365A SE 460667 B SE460667 B SE 460667B
- Authority
- SE
- Sweden
- Prior art keywords
- trans
- compound
- hydrochloride
- group
- acid
- Prior art date
Links
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- 239000002253 acid Substances 0.000 title claims description 13
- 230000001225 therapeutic effect Effects 0.000 title claims description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000005079 alkoxycarbonylmethyl group Chemical group 0.000 claims description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- NRDQFWXVTPZZAZ-UHFFFAOYSA-N butyl carbonochloridate Chemical compound CCCCOC(Cl)=O NRDQFWXVTPZZAZ-UHFFFAOYSA-N 0.000 description 1
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- 150000001718 carbodiimides Chemical class 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
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- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- YKWNUSJLICDQEO-UHFFFAOYSA-N ethoxyethane;propan-2-ol Chemical compound CC(C)O.CCOCC YKWNUSJLICDQEO-UHFFFAOYSA-N 0.000 description 1
- MCTRPSAWYSXUSZ-UHFFFAOYSA-N ethyl 2-(4-hydroxyphenyl)propanoate Chemical compound CCOC(=O)C(C)C1=CC=C(O)C=C1 MCTRPSAWYSXUSZ-UHFFFAOYSA-N 0.000 description 1
- SKAWDTAMLOJQNK-LBPRGKRZSA-N ethyl N-acetyl-L-tyrosinate Chemical compound CCOC(=O)[C@@H](NC(C)=O)CC1=CC=C(O)C=C1 SKAWDTAMLOJQNK-LBPRGKRZSA-N 0.000 description 1
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- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
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- 150000002430 hydrocarbons Chemical class 0.000 description 1
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- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 1
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 229940120152 methyl 3-hydroxybenzoate Drugs 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- SAALQYKUFCIMHR-UHFFFAOYSA-N propan-2-ol;2-propan-2-yloxypropane Chemical compound CC(C)O.CC(C)OC(C)C SAALQYKUFCIMHR-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002151 serous membrane Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12014279A JPS5645454A (en) | 1979-09-20 | 1979-09-20 | Cyclohexanecarboxylic acid derivative and its preparation |
| JP16827179A JPS5692260A (en) | 1979-12-26 | 1979-12-26 | Cyclohexanecarboxylic ester and its preparation |
| JP16827279A JPS5692261A (en) | 1979-12-26 | 1979-12-26 | Novel cyclohexanecarboxylic derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8006365L SE8006365L (sv) | 1981-03-21 |
| SE460667B true SE460667B (sv) | 1989-11-06 |
Family
ID=27313978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8006365A SE460667B (sv) | 1979-09-20 | 1980-09-11 | Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4348410A (en, 2012) |
| AR (1) | AR227525A1 (en, 2012) |
| AT (1) | AT375918B (en, 2012) |
| AU (1) | AU541738B2 (en, 2012) |
| BR (1) | BR8006052A (en, 2012) |
| CA (1) | CA1142943A (en, 2012) |
| CH (1) | CH646687A5 (en, 2012) |
| DE (1) | DE3035086A1 (en, 2012) |
| DK (1) | DK163580C (en, 2012) |
| ES (1) | ES495175A0 (en, 2012) |
| FR (1) | FR2472561B1 (en, 2012) |
| GB (1) | GB2058773B (en, 2012) |
| IN (1) | IN151297B (en, 2012) |
| IT (1) | IT1129264B (en, 2012) |
| NL (1) | NL8005238A (en, 2012) |
| PH (1) | PH17322A (en, 2012) |
| SE (1) | SE460667B (en, 2012) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4465851A (en) * | 1981-01-22 | 1984-08-14 | Nippon Chemiphar Co., Ltd. | Guanidinocyclohexanecarboxylic acid derivatives |
| JPS5838250A (ja) * | 1981-09-01 | 1983-03-05 | Teikoku Chem Ind Corp Ltd | 複合体 |
| JPS6254A (ja) * | 1985-03-08 | 1987-01-06 | Kanebo Ltd | 新規グアニジノメチルシクロヘキサンカルボン酸誘導体および該化合物を有効成分とする抗潰瘍薬 |
| JPS6229566A (ja) * | 1985-07-30 | 1987-02-07 | Taiyo Yakuhin Kogyo Kk | 新規グアニジノメチル安息香酸誘導体 |
| KR100404714B1 (ko) * | 1994-08-30 | 2004-05-31 | 데이코쿠 가가꾸 산교 가부시키가이샤 | 구아니디노메틸사이클로헥산카복실산에스테르유도체 |
| JP4191269B2 (ja) | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
| BR9908911A (pt) | 1998-03-19 | 2001-10-02 | Bristol Myers Squibb Co | Sistema bifásico e processo de distribuição por liberação controlada de substâncias farmacêuticas de alta solubilidade |
| ES2219607T3 (es) | 1998-07-20 | 2004-12-01 | Wilex Ag | Nuevo agente inhibidor de la urocinasa. |
| US7342018B2 (en) | 1998-07-20 | 2008-03-11 | Wilex Ag | Urokinase inhibitors and uses thereof |
| CN1203055C (zh) | 2001-09-26 | 2005-05-25 | 朱德煦 | 治疗或预防细菌感染的方法和组合物 |
| US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| KR101942590B1 (ko) | 2010-07-09 | 2019-01-25 | 비에이치브이 파르마, 인크. | 레모글리플로진을 포함하는 짧은 반감기 약제용의 즉시/지연 조합 방출 전달 시스템 |
| GB2541910B (en) | 2015-09-03 | 2021-10-27 | Thermographic Measurements Ltd | Thermochromic composition |
| JP7380693B2 (ja) * | 2018-10-22 | 2023-11-15 | キーケルト アクツィーエンゲゼルシャフト | 自動車用ロック |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913498B2 (ja) * | 1975-07-30 | 1984-03-30 | 第一製薬株式会社 | トランス−４−アミノメチルシクロヘキサンカルボン酸エステルの製法 |
| US4147876A (en) * | 1978-05-01 | 1979-04-03 | Daiichi Seiyaku Co., Ltd. | Easily hydrolyzable esters of 4-(2-carboxyethyl)phenyl trans-4-aminomethylcyclohexanecarboxylate and process of use |
-
1980
- 1980-09-11 AU AU62320/80A patent/AU541738B2/en not_active Ceased
- 1980-09-11 SE SE8006365A patent/SE460667B/sv not_active IP Right Cessation
- 1980-09-15 US US06/186,849 patent/US4348410A/en not_active Expired - Lifetime
- 1980-09-17 DE DE19803035086 patent/DE3035086A1/de active Granted
- 1980-09-18 GB GB8030183A patent/GB2058773B/en not_active Expired
- 1980-09-19 IT IT68457/80A patent/IT1129264B/it active
- 1980-09-19 AR AR282590A patent/AR227525A1/es active
- 1980-09-19 CH CH706480A patent/CH646687A5/fr not_active IP Right Cessation
- 1980-09-19 FR FR8020263A patent/FR2472561B1/fr not_active Expired
- 1980-09-19 AT AT0470680A patent/AT375918B/de not_active IP Right Cessation
- 1980-09-19 DK DK396880A patent/DK163580C/da active
- 1980-09-19 NL NL8005238A patent/NL8005238A/nl not_active Application Discontinuation
- 1980-09-19 PH PH24606A patent/PH17322A/en unknown
- 1980-09-19 ES ES495175A patent/ES495175A0/es active Granted
- 1980-09-19 CA CA000360655A patent/CA1142943A/en not_active Expired
- 1980-09-20 IN IN1071/CAL/80A patent/IN151297B/en unknown
- 1980-09-23 BR BR8006052A patent/BR8006052A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1129264B (it) | 1986-06-04 |
| GB2058773A (en) | 1981-04-15 |
| PH17322A (en) | 1984-07-20 |
| AU6232080A (en) | 1981-03-26 |
| CA1142943A (en) | 1983-03-15 |
| DE3035086A1 (de) | 1981-04-09 |
| ES8200643A1 (es) | 1981-10-16 |
| US4348410A (en) | 1982-09-07 |
| DK396880A (da) | 1981-03-21 |
| FR2472561A1 (fr) | 1981-07-03 |
| IN151297B (en, 2012) | 1983-03-26 |
| ES495175A0 (es) | 1981-10-16 |
| GB2058773B (en) | 1983-03-23 |
| BR8006052A (pt) | 1981-04-07 |
| CH646687A5 (fr) | 1984-12-14 |
| ATA470680A (de) | 1984-02-15 |
| NL8005238A (nl) | 1981-03-24 |
| AR227525A1 (es) | 1982-11-15 |
| IT8068457A0 (it) | 1980-09-19 |
| AT375918B (de) | 1984-09-25 |
| FR2472561B1 (fr) | 1985-05-31 |
| DE3035086C2 (en, 2012) | 1991-01-03 |
| DK163580B (da) | 1992-03-16 |
| DK163580C (da) | 1992-08-03 |
| SE8006365L (sv) | 1981-03-21 |
| AU541738B2 (en) | 1985-01-17 |
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