SE448461B - Nya peptidyl-argininaldehydderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem - Google Patents

Nya peptidyl-argininaldehydderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem

Info

Publication number
SE448461B
SE448461B SE8000032A SE8000032A SE448461B SE 448461 B SE448461 B SE 448461B SE 8000032 A SE8000032 A SE 8000032A SE 8000032 A SE8000032 A SE 8000032A SE 448461 B SE448461 B SE 448461B
Authority
SE
Sweden
Prior art keywords
arginine
prolyl
carboxy
argininaldehyde
allo
Prior art date
Application number
SE8000032A
Other languages
English (en)
Swedish (sv)
Other versions
SE8000032L (sv
Inventor
S Bajusz
E Szell
E Barabas
D Bagdy
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8000032L publication Critical patent/SE8000032L/xx
Publication of SE448461B publication Critical patent/SE448461B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE8000032A 1979-01-04 1980-01-02 Nya peptidyl-argininaldehydderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem SE448461B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79GO1435A HU177098B (en) 1979-01-04 1979-01-04 Process for producing new peptidyl-n-carboxy-l-arginin-a

Publications (2)

Publication Number Publication Date
SE8000032L SE8000032L (sv) 1980-07-05
SE448461B true SE448461B (sv) 1987-02-23

Family

ID=10996883

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8000032A SE448461B (sv) 1979-01-04 1980-01-02 Nya peptidyl-argininaldehydderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem

Country Status (20)

Country Link
US (1) US4316889A (es)
JP (1) JPS5951936B2 (es)
AT (1) AT372076B (es)
AU (1) AU533343B2 (es)
BE (1) BE880844A (es)
CA (1) CA1133897A (es)
CH (1) CH643820A5 (es)
DE (1) DE3000225A1 (es)
DK (1) DK149895C (es)
ES (1) ES8100252A1 (es)
FI (1) FI67539C (es)
FR (1) FR2445826A1 (es)
HU (1) HU177098B (es)
IL (1) IL58978A (es)
IT (1) IT1166917B (es)
NL (1) NL191537C (es)
NO (1) NO151085C (es)
SE (1) SE448461B (es)
SU (1) SU1366062A3 (es)
ZA (1) ZA796895B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
JPH0312905Y2 (es) * 1984-12-21 1991-03-26
JPH0536046Y2 (es) * 1987-09-09 1993-09-13
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
JPH0277227U (es) * 1988-11-30 1990-06-13
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
CA2131367A1 (en) * 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
WO1995035280A1 (en) * 1994-06-17 1995-12-28 Corvas International, Inc. Methods of synthesis of peptidyl argininals
US5514777A (en) * 1994-06-17 1996-05-07 Corvas International, Inc. Methods of synthesis of peptidyl argininals
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
JP2000503010A (ja) * 1995-12-29 2000-03-14 スリー―ダイメンショナル・ファーマスーティカルス・インコーポレーテッド アミジノプロテアーゼ阻害剤
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941418A (es) * 1972-08-29 1974-04-18
HU169870B (es) * 1974-06-14 1977-02-28

Also Published As

Publication number Publication date
JPS55122749A (en) 1980-09-20
IL58978A0 (en) 1980-03-31
JPS5951936B2 (ja) 1984-12-17
ATA1280A (de) 1983-01-15
NO794327L (no) 1980-07-07
US4316889A (en) 1982-02-23
DE3000225A1 (de) 1980-07-24
IT7928304A0 (it) 1979-12-21
FI800008A (fi) 1980-07-05
ES487464A0 (es) 1980-11-01
CA1133897A (en) 1982-10-19
NL191537B (nl) 1995-05-01
NO151085B (no) 1984-10-29
AU533343B2 (en) 1983-11-17
ZA796895B (en) 1980-12-31
DK3880A (da) 1980-07-05
NO151085C (no) 1985-02-06
DE3000225C2 (es) 1989-10-19
AT372076B (de) 1983-08-25
FI67539B (fi) 1984-12-31
CH643820A5 (de) 1984-06-29
FR2445826A1 (fr) 1980-08-01
SU1366062A3 (ru) 1988-01-07
FI67539C (fi) 1985-04-10
HU177098B (en) 1981-07-28
DK149895C (da) 1987-04-21
IL58978A (en) 1982-09-30
ES8100252A1 (es) 1980-11-01
FR2445826B1 (es) 1984-11-23
DK149895B (da) 1986-10-20
SE8000032L (sv) 1980-07-05
BE880844A (fr) 1980-06-24
NL8000040A (nl) 1980-07-08
IT1166917B (it) 1987-05-06
NL191537C (nl) 1995-09-04
AU5420779A (en) 1980-07-10

Similar Documents

Publication Publication Date Title
SE448461B (sv) Nya peptidyl-argininaldehydderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem
AU690275B2 (en) Neurokinine (tachykinine) antagonists
US6455671B1 (en) Thrombin inhibitors, the preparation and use thereof
US4996358A (en) Hydroxylamine bearing amino acid derivatives as collagenase inhibitors
NO171788B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivater
KR100312539B1 (ko) 피페라진유도체
CA2146446A1 (en) Arginine keto-amide enzyme inhibitors
SE452326B (sv) Salter av agmatinderivat och farmaceutiska preparat innehallande desamma
CA2338524A1 (en) Inhibitors of urokinase and blood vessel formation
HU184612B (en) Process for preparing new cyclopeptides of somatostatine type
SE447389B (sv) Nya tripeptider, som inverkar pa det centrala nervsystemet
US4623639A (en) Peptide derivatives
HU201961B (en) Process for producing 2,3-disubstituted isoxazolidines and pharmaceutical compositions comprising same
NO177677B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
US4216209A (en) Tripeptide angiotensin converting enzyme inhibitors
US4371466A (en) Mammalian collagenase inhibitors
EP0009898B1 (en) Novel anti-hypertensive mercaptoacylamino acid derivatives, their preparation and use
US5190921A (en) Amino acids and peptides having a modified tyrosine residue, their preparation and their application as medicaments
AU762540B2 (en) Method for producing cyclo-(Asp-DPhe-NMeVal-Arg-Gly)
US7683026B2 (en) Method for synthesizing KPV tripeptide diamide derivatives
JP4050238B2 (ja) Ｋｐｖトリペプチドジアミド誘導体の改良された合成方法
NO831112L (no) Fremgangsmaate for fremstilling av blodtrykkssenkende midler
KR840002357B1 (ko) S-(아실아미도아실)메르캅토아실 프롤린류의 제조방법
AU2004201899A1 (en) Process for the preparation of clyclic peptides
HU201962B (en) Process for producing renin inhibiting dipeptides and pharmaceutical compositions comprising same as active ingredient

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8000032-6

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8000032-6

Format of ref document f/p: F