IT1166917B - Derivati delle aldeidi della peptidil-arginina e procediemento per la loro preparazione - Google Patents

Derivati delle aldeidi della peptidil-arginina e procediemento per la loro preparazione

Info

Publication number
IT1166917B
IT1166917B IT28304/79A IT2830479A IT1166917B IT 1166917 B IT1166917 B IT 1166917B IT 28304/79 A IT28304/79 A IT 28304/79A IT 2830479 A IT2830479 A IT 2830479A IT 1166917 B IT1166917 B IT 1166917B
Authority
IT
Italy
Prior art keywords
peptidyl
procedure
preparation
aldehyde derivatives
arginine aldehyde
Prior art date
Application number
IT28304/79A
Other languages
English (en)
Other versions
IT7928304A0 (it
Inventor
Sandor Bajusz
Hasenohrl Erszebet Szell
Eva Barabas
Daniel Bagdy
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of IT7928304A0 publication Critical patent/IT7928304A0/it
Application granted granted Critical
Publication of IT1166917B publication Critical patent/IT1166917B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT28304/79A 1979-01-04 1979-12-21 Derivati delle aldeidi della peptidil-arginina e procediemento per la loro preparazione IT1166917B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79GO1435A HU177098B (en) 1979-01-04 1979-01-04 Process for producing new peptidyl-n-carboxy-l-arginin-a

Publications (2)

Publication Number Publication Date
IT7928304A0 IT7928304A0 (it) 1979-12-21
IT1166917B true IT1166917B (it) 1987-05-06

Family

ID=10996883

Family Applications (1)

Application Number Title Priority Date Filing Date
IT28304/79A IT1166917B (it) 1979-01-04 1979-12-21 Derivati delle aldeidi della peptidil-arginina e procediemento per la loro preparazione

Country Status (20)

Country Link
US (1) US4316889A (it)
JP (1) JPS5951936B2 (it)
AT (1) AT372076B (it)
AU (1) AU533343B2 (it)
BE (1) BE880844A (it)
CA (1) CA1133897A (it)
CH (1) CH643820A5 (it)
DE (1) DE3000225A1 (it)
DK (1) DK149895C (it)
ES (1) ES8100252A1 (it)
FI (1) FI67539C (it)
FR (1) FR2445826A1 (it)
HU (1) HU177098B (it)
IL (1) IL58978A (it)
IT (1) IT1166917B (it)
NL (1) NL191537C (it)
NO (1) NO151085C (it)
SE (1) SE448461B (it)
SU (1) SU1366062A3 (it)
ZA (1) ZA796895B (it)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
JPH0312905Y2 (it) * 1984-12-21 1991-03-26
JPH0536046Y2 (it) * 1987-09-09 1993-09-13
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
JPH0277227U (it) * 1988-11-30 1990-06-13
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
CA2131367A1 (en) * 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
WO1995035280A1 (en) * 1994-06-17 1995-12-28 Corvas International, Inc. Methods of synthesis of peptidyl argininals
US5514777A (en) * 1994-06-17 1996-05-07 Corvas International, Inc. Methods of synthesis of peptidyl argininals
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
JP2000503010A (ja) * 1995-12-29 2000-03-14 スリー―ダイメンショナル・ファーマスーティカルス・インコーポレーテッド アミジノプロテアーゼ阻害剤
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941418A (it) * 1972-08-29 1974-04-18
HU169870B (it) * 1974-06-14 1977-02-28

Also Published As

Publication number Publication date
JPS55122749A (en) 1980-09-20
IL58978A0 (en) 1980-03-31
JPS5951936B2 (ja) 1984-12-17
ATA1280A (de) 1983-01-15
NO794327L (no) 1980-07-07
US4316889A (en) 1982-02-23
DE3000225A1 (de) 1980-07-24
IT7928304A0 (it) 1979-12-21
FI800008A (fi) 1980-07-05
ES487464A0 (es) 1980-11-01
CA1133897A (en) 1982-10-19
NL191537B (nl) 1995-05-01
NO151085B (no) 1984-10-29
AU533343B2 (en) 1983-11-17
ZA796895B (en) 1980-12-31
DK3880A (da) 1980-07-05
NO151085C (no) 1985-02-06
DE3000225C2 (it) 1989-10-19
AT372076B (de) 1983-08-25
FI67539B (fi) 1984-12-31
CH643820A5 (de) 1984-06-29
FR2445826A1 (fr) 1980-08-01
SU1366062A3 (ru) 1988-01-07
FI67539C (fi) 1985-04-10
HU177098B (en) 1981-07-28
DK149895C (da) 1987-04-21
SE448461B (sv) 1987-02-23
IL58978A (en) 1982-09-30
ES8100252A1 (es) 1980-11-01
FR2445826B1 (it) 1984-11-23
DK149895B (da) 1986-10-20
SE8000032L (sv) 1980-07-05
BE880844A (fr) 1980-06-24
NL8000040A (nl) 1980-07-08
NL191537C (nl) 1995-09-04
AU5420779A (en) 1980-07-10

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961230