SE445352B - Forfarande for framstellning av dipeptider, vilka inhiberar overforing av angiotensin i till angiotensin ii - Google Patents
Forfarande for framstellning av dipeptider, vilka inhiberar overforing av angiotensin i till angiotensin iiInfo
- Publication number
- SE445352B SE445352B SE7800503A SE7800503A SE445352B SE 445352 B SE445352 B SE 445352B SE 7800503 A SE7800503 A SE 7800503A SE 7800503 A SE7800503 A SE 7800503A SE 445352 B SE445352 B SE 445352B
- Authority
- SE
- Sweden
- Prior art keywords
- angiotensin
- acid
- formula
- preparation
- cysteinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/759,685 US4113715A (en) | 1977-01-17 | 1977-01-17 | Amino acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7800503L SE7800503L (sv) | 1978-07-18 |
SE445352B true SE445352B (sv) | 1986-06-16 |
Family
ID=25056579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7800503A SE445352B (sv) | 1977-01-17 | 1978-01-16 | Forfarande for framstellning av dipeptider, vilka inhiberar overforing av angiotensin i till angiotensin ii |
Country Status (15)
Country | Link |
---|---|
US (6) | US4113715A (fr) |
JP (1) | JPS5390218A (fr) |
AU (1) | AU518282B2 (fr) |
BE (1) | BE862944A (fr) |
CA (1) | CA1132136A (fr) |
CH (1) | CH632991A5 (fr) |
DE (1) | DE2801911A1 (fr) |
DK (1) | DK149594C (fr) |
FR (1) | FR2377374A1 (fr) |
GB (1) | GB1600461A (fr) |
HU (1) | HU180529B (fr) |
IE (1) | IE46364B1 (fr) |
NL (1) | NL7800536A (fr) |
NO (1) | NO150397C (fr) |
SE (1) | SE445352B (fr) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4198517A (en) * | 1976-12-03 | 1980-04-15 | E. R. Squibb & Sons, Inc. | Histidine derivatives |
LU78804A1 (de) * | 1977-12-30 | 1979-07-20 | Byk Gulden Lomberg Chem Fab | N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
US4241076A (en) * | 1978-02-21 | 1980-12-23 | E. R. Squibb & Sons, Inc. | Halogenated substituted mercaptoacylamino acids |
US4179568A (en) * | 1978-07-31 | 1979-12-18 | E. R. Squibb & Sons, Inc. | (N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds |
CA1144930A (fr) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Derives mercaptoacyles de prolines substituees |
US4698356A (en) * | 1979-08-14 | 1987-10-06 | University Of Miami | Anti-hypertensive agents |
US4695577A (en) * | 1979-08-14 | 1987-09-22 | University Of Miami | Anti-hypertensive agents |
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
US4690937A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4690940A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4690939A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4698355A (en) * | 1979-08-14 | 1987-10-06 | University Of Miami | Anti-hypertensive agents |
US4690938A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
GR73585B (fr) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
US4198515A (en) * | 1978-12-08 | 1980-04-15 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids |
US4217359A (en) * | 1979-01-15 | 1980-08-12 | E. R. Squibb & Sons, Inc. | Carbamate derivatives of mercaptoacyl hydroxy prolines |
US4181663A (en) * | 1979-01-29 | 1980-01-01 | E. R. Squibb & Sons, Inc. | Selenium containing derivatives of proline and pipecolic acid |
ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
US4329473A (en) * | 1979-06-01 | 1982-05-11 | Almquist Ronald G | Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme |
US4297275A (en) * | 1979-06-25 | 1981-10-27 | E. R. Squibb & Sons, Inc. | Inhibitors of mammalian collagenase |
JPS5629403U (fr) * | 1979-08-13 | 1981-03-20 | ||
PT70158A1 (en) * | 1980-03-03 | 1982-03-01 | Univ Miami | Process for preparing anti-hypertensive agents |
US4690936A (en) * | 1980-03-05 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
US4734420A (en) * | 1980-03-05 | 1988-03-29 | University Of Miami | Anti-hypertensive agents |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
US4342690A (en) * | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
US4299769A (en) * | 1980-04-28 | 1981-11-10 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
US4342689A (en) * | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
US4342691A (en) * | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
US4284624A (en) * | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
GB2076809B (en) * | 1980-05-30 | 1984-03-14 | Squibb & Sons Inc | N-substituted mercapto propionamides |
US4629787A (en) * | 1980-08-18 | 1986-12-16 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
US4587050A (en) * | 1980-08-18 | 1986-05-06 | Merck & Co., Inc. | Substituted enantholactam derivatives as antihypertensives |
US4313948A (en) * | 1980-11-20 | 1982-02-02 | E. R. Squibb & Sons, Inc. | Hypotensive imidazole substituted mercapto-1-oxopropyl-L-prolines |
US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
US4402969A (en) * | 1981-03-23 | 1983-09-06 | Merck & Co., Inc. | Antihypertensive proline derivatives |
US4356118A (en) * | 1981-06-02 | 1982-10-26 | G. D. Searle & Co. | Tryptophan derivatives |
US4587238A (en) * | 1981-07-06 | 1986-05-06 | Merck & Co., Inc. | Substituted caprylolactam derivatives as anti-hypertensives |
US4377701A (en) * | 1981-09-21 | 1983-03-22 | E. R. Squibb & Sons, Inc. | 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid |
US4435329A (en) | 1981-10-16 | 1984-03-06 | American Cyanamid Company | Substituted N-(ω-aroylpropionyl) derivatives of α-amino acids and esters thereof |
IT1140394B (it) * | 1981-12-23 | 1986-09-24 | Maggioni Farma | Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice |
US4866087A (en) * | 1982-01-21 | 1989-09-12 | Merck & Co., Inc. | Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives |
US4555503A (en) * | 1982-05-05 | 1985-11-26 | Merck & Co., Inc. | N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents |
US4483850A (en) * | 1982-05-10 | 1984-11-20 | Merck & Co., Inc. | N-Terminal substituted oligopeptide converting enzyme inhibitors |
US4442038A (en) * | 1982-09-17 | 1984-04-10 | Norwich Eaton Pharmaceuticals, Inc. | Converting enzyme inhibitors |
US4634716A (en) * | 1982-09-30 | 1987-01-06 | Merck & Co., Inc. | Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents |
US4472384A (en) * | 1983-06-15 | 1984-09-18 | Merck & Co., Inc. | Antihypertensive composition |
US4617301A (en) * | 1983-06-22 | 1986-10-14 | Merck & Co., Inc. | Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives |
US4558037A (en) * | 1984-06-04 | 1985-12-10 | Merck & Co., Inc. | Cardiovascular composition |
US4585757A (en) * | 1984-07-27 | 1986-04-29 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
US4626545A (en) * | 1984-08-27 | 1986-12-02 | Merck & Co., Inc. | Amino acid derivatives as enzyme inhibitors |
US4827016A (en) * | 1985-09-16 | 1989-05-02 | Morgan Lee R | Method and compounds for reducing dermal inflammations |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
US4765980A (en) * | 1986-04-28 | 1988-08-23 | International Minerals & Chemical Corp. | Stabilized porcine growth hormone |
US5686422A (en) * | 1987-03-17 | 1997-11-11 | Research Corporation Technologies, Inc. | Synthetic inhibitors of mammalian collagenase |
DE3889726T2 (de) * | 1987-03-17 | 1994-10-13 | Res Corp Technologies Inc | Synthetische inhibitoren von säugetier-collagenase. |
US5401880A (en) * | 1987-06-04 | 1995-03-28 | Oculon Corporation | Chemical prevention or reversal of cataract by phase separation inhibitors |
US5002964A (en) * | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
US5187183A (en) * | 1988-06-15 | 1993-02-16 | Brigham & Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
FR2664269B1 (fr) * | 1990-07-05 | 1992-10-02 | Roussel Uclaf | Nouveaux derives n-substitues d'alpha-mercapto alkylamines, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant. |
TW197945B (fr) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
US5106982A (en) * | 1990-12-10 | 1992-04-21 | E. R. Squibb & Sons, Inc. | Piperidinyl carbonyl derivatives |
DK0784629T3 (da) | 1994-10-05 | 1999-10-25 | Darwin Discovery Ltd | Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser |
US5662991A (en) † | 1994-12-23 | 1997-09-02 | Gentex Corporation | Laminated biocidal fabric |
SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
AR023819A1 (es) | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
WO2004050620A2 (fr) * | 2002-12-03 | 2004-06-17 | Enobia Pharma | Derives d'acides succinique et glutarique et leurs analogues utilises comme inhibiteurs de phex |
US7589233B2 (en) * | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
DE102005054700B4 (de) * | 2005-11-16 | 2009-01-08 | Imtm Gmbh | Neue duale Peptidase-Inhibitoren als Prodrugs zur Therapie von entzündlichen und anderen Erkrankungen |
US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
US8455531B2 (en) | 2007-09-18 | 2013-06-04 | Thermolife International, Llc | Amino acid compositions |
US10435356B1 (en) | 2007-09-18 | 2019-10-08 | Thermolife International, Llc | Amino acid compositions |
US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
US10646508B1 (en) | 2007-09-18 | 2020-05-12 | Thermolife International, Llc | Method of safely administering nitrate dietary supplements and compositions |
US10426750B1 (en) | 2007-09-18 | 2019-10-01 | Thermolife International, Llc | Amino acid supplement formulations |
US7777074B2 (en) | 2007-09-18 | 2010-08-17 | Thermolife International, Llc | Amino acid compounds |
US8569368B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
US8569369B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
US8802731B2 (en) | 2011-04-13 | 2014-08-12 | Thermolife International, Llc | N-acetyl beta alanine methods of use |
US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
WO2013009998A2 (fr) | 2011-07-12 | 2013-01-17 | Pursuit Vascular, Inc. | Dispositif de distribution d'agent antimicrobien dans cathéter transdermique |
AU2015252808B2 (en) | 2014-05-02 | 2019-02-21 | Excelsior Medical Corporation | Strip package for antiseptic cap |
WO2016182822A1 (fr) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Raccords médicaux configurés pour recevoir des émetteurs d'agents thérapeutiques |
SI3525865T1 (sl) | 2016-10-14 | 2023-01-31 | Icu Medical, Inc. | Razkuževalni pokrovčki za medicinske konektorje |
WO2018204206A2 (fr) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Raccords de fluide médical et procédés pour fournir des additifs dans des conduites de fluide médical |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
AU2021396147A1 (en) | 2020-12-07 | 2023-06-29 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3799918A (en) * | 1972-04-26 | 1974-03-26 | Searle & Co | Alkyl esters of alpha-aspartyl alpha-alkyl aliphatic amino acid dipeptides |
US3959519A (en) * | 1972-05-09 | 1976-05-25 | E. I. Du Pont De Nemours And Company | Fortification of food materials with a methionine source |
CA1009252A (en) * | 1972-10-03 | 1977-04-26 | Santen Pharmaceutical Co. | N-(mercaptoacyl) aminoacids |
US3857951A (en) * | 1973-09-14 | 1974-12-31 | Cassenne Lab Sa | Use of 2-mercaptopropionylglycine and its alkali metal salts in treating respiratory diseases |
JPS5124490A (en) * | 1974-08-23 | 1976-02-27 | Komatsu Mfg Co Ltd | Shirinda nyoru ichigime sochi |
US3952115A (en) * | 1975-04-02 | 1976-04-20 | The Procter & Gamble Company | Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters |
US4064235A (en) * | 1975-08-21 | 1977-12-20 | Eisai Co., Ltd. | Dopamine derivative compounds, preparation thereof and medicine containing same |
US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
US4024286A (en) * | 1976-05-17 | 1977-05-17 | Miles Laboratories, Inc. | Fortification of foodstuffs with C-terminal amino acid substituted methionine dipeptides |
US4116962A (en) * | 1976-12-03 | 1978-09-26 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
-
1977
- 1977-01-17 US US05/759,685 patent/US4113715A/en not_active Expired - Lifetime
- 1977-10-31 US US05/846,645 patent/US4129571A/en not_active Expired - Lifetime
- 1977-10-31 US US05/846,738 patent/US4146611A/en not_active Expired - Lifetime
-
1978
- 1978-01-13 GB GB1443/78A patent/GB1600461A/en not_active Expired
- 1978-01-13 CA CA294,939A patent/CA1132136A/fr not_active Expired
- 1978-01-13 DK DK16978A patent/DK149594C/da active
- 1978-01-13 FR FR7801000A patent/FR2377374A1/fr active Granted
- 1978-01-16 HU HU78SU964A patent/HU180529B/hu not_active IP Right Cessation
- 1978-01-16 CH CH42078A patent/CH632991A5/de not_active IP Right Cessation
- 1978-01-16 NO NO780151A patent/NO150397C/no unknown
- 1978-01-16 BE BE184354A patent/BE862944A/fr not_active IP Right Cessation
- 1978-01-16 AU AU32440/78A patent/AU518282B2/en not_active Expired
- 1978-01-16 IE IE94/78A patent/IE46364B1/en not_active IP Right Cessation
- 1978-01-16 SE SE7800503A patent/SE445352B/sv not_active IP Right Cessation
- 1978-01-17 NL NL7800536A patent/NL7800536A/xx not_active Application Discontinuation
- 1978-01-17 JP JP415978A patent/JPS5390218A/ja active Granted
- 1978-01-17 DE DE19782801911 patent/DE2801911A1/de active Granted
- 1978-06-26 US US05/919,201 patent/US4156786A/en not_active Expired - Lifetime
- 1978-06-28 US US05/919,880 patent/US4154946A/en not_active Expired - Lifetime
- 1978-06-29 US US05/920,590 patent/US4154960A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4156786A (en) | 1979-05-29 |
BE862944A (fr) | 1978-05-16 |
FR2377374A1 (fr) | 1978-08-11 |
AU3244078A (en) | 1980-02-21 |
HU180529B (en) | 1983-03-28 |
JPS6126781B2 (fr) | 1986-06-21 |
DE2801911A1 (de) | 1978-07-20 |
GB1600461A (en) | 1981-10-14 |
US4154946A (en) | 1979-05-15 |
DK149594C (da) | 1987-03-16 |
DE2801911C2 (fr) | 1991-03-21 |
AU518282B2 (en) | 1981-09-24 |
JPS5390218A (en) | 1978-08-08 |
US4129571A (en) | 1978-12-12 |
US4113715A (en) | 1978-09-12 |
NO150397B (no) | 1984-07-02 |
SE7800503L (sv) | 1978-07-18 |
IE46364B1 (en) | 1983-05-18 |
NO150397C (no) | 1984-10-10 |
IE780094L (en) | 1978-07-17 |
DK16978A (da) | 1978-07-18 |
NO780151L (no) | 1978-07-18 |
CA1132136A (fr) | 1982-09-21 |
DK149594B (da) | 1986-08-04 |
FR2377374B1 (fr) | 1981-06-19 |
NL7800536A (nl) | 1978-07-19 |
US4146611A (en) | 1979-03-27 |
US4154960A (en) | 1979-05-15 |
CH632991A5 (de) | 1982-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE445352B (sv) | Forfarande for framstellning av dipeptider, vilka inhiberar overforing av angiotensin i till angiotensin ii | |
US4404206A (en) | Substituted iminoacid derivatives, process for preparing them and their use as enzyme inhibitors | |
FI67369B (fi) | Foerfarande foer framstaellning av nya terapeutiskt aktiva derivat av 3,4-dehydroprolin | |
US4052511A (en) | Carboxyacylproline derivatives | |
EP0049658B1 (fr) | Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant | |
HU176021B (en) | Process for producing substituted acylthio-derivatives of proline | |
US4916146A (en) | Amino acid imide derivatives, usage thereof, and medicinal composition containing the same | |
JPS6121226B2 (fr) | ||
JPS604815B2 (ja) | プロリン誘導体 | |
SG187728A1 (en) | Processes for preparing tubulysins | |
AU602546B2 (en) | Pyridazodiazepine derivatives | |
US5750555A (en) | Bis-indolyl maleinimide or indolopyrrolo carbazole containing an amino acid as PKC inhibitors | |
US4154937A (en) | Hydroxycarbamoylalkylacylpipecolic acid compounds | |
IE56520B1 (en) | Disubstituted proline derivatives,a process for their preparation and their use | |
DE69313290T2 (de) | Laktam-dipeptide mit inhibierender wirkung auf die menschliche leukozytenelastase | |
FR2491469A1 (fr) | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme | |
EP0057998B1 (fr) | Composés alicycliques, leur préparation et utilisation | |
HU215436B (hu) | Eljárás N-[(4,5-dihidroxi-9,10-dihidro-9,10-dioxo-2-antracenil)-karbonil]-aminosav-származékok és ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására | |
US4725617A (en) | Alkylamino-furanon-derivatives | |
IE48497B1 (en) | Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor | |
EP0110484B1 (fr) | Dérivés d'acides aminopyridinocarboxyliques, leur procédé de préparation et les compositions pharmaceutiques les contenant | |
DK148902B (da) | Analogifremgangsmaade til fremstilling af trh-analoge derivater af n-substitueret histidylprolinamid eller farmaceutisk anvendelige syreadditionssalte heraf | |
US5183816A (en) | Bicyclic sulfur-containing compounds | |
HU179780B (en) | Process for preparing thiazolidine-carboxylic acid derivatives | |
EP0008657B1 (fr) | Alpha-vinyl-alpha-aminoacides et leurs esters et compositions pharmaceutiques les contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |
Ref document number: 7800503-0 Effective date: 19940810 Format of ref document f/p: F |