SE445149B - Latexreagens, som innehaller latexpartiklar sensibiliserade med ett steroid-serumalbuminkonjugat, for immunkemisk bestemning av steroid i mensklig kroppsvetska, samt forfarande for framstellning av reagenset - Google Patents
Latexreagens, som innehaller latexpartiklar sensibiliserade med ett steroid-serumalbuminkonjugat, for immunkemisk bestemning av steroid i mensklig kroppsvetska, samt forfarande for framstellning av reagensetInfo
- Publication number
- SE445149B SE445149B SE7806961A SE7806961A SE445149B SE 445149 B SE445149 B SE 445149B SE 7806961 A SE7806961 A SE 7806961A SE 7806961 A SE7806961 A SE 7806961A SE 445149 B SE445149 B SE 445149B
- Authority
- SE
- Sweden
- Prior art keywords
- steroid
- conjugate
- serum albumin
- latex particles
- latex
- Prior art date
Links
- 239000004816 latex Substances 0.000 title claims description 136
- 150000003431 steroids Chemical class 0.000 title claims description 106
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 49
- 238000000034 method Methods 0.000 title claims description 32
- 108010071390 Serum Albumin Proteins 0.000 title claims description 30
- 102000007562 Serum Albumin Human genes 0.000 title claims description 30
- 238000002360 preparation method Methods 0.000 title claims description 14
- 229920000126 latex Polymers 0.000 claims description 134
- 239000002245 particle Substances 0.000 claims description 101
- 230000004520 agglutination Effects 0.000 claims description 39
- 206010070834 Sensitisation Diseases 0.000 claims description 25
- 230000008313 sensitization Effects 0.000 claims description 25
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 239000002207 metabolite Substances 0.000 claims description 15
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 14
- 102000009027 Albumins Human genes 0.000 claims description 12
- 108010088751 Albumins Proteins 0.000 claims description 12
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 11
- 210000001124 body fluid Anatomy 0.000 claims description 9
- 239000010839 body fluid Substances 0.000 claims description 9
- 239000004793 Polystyrene Substances 0.000 claims description 8
- 229920002223 polystyrene Polymers 0.000 claims description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 7
- 239000000186 progesterone Substances 0.000 claims description 7
- 229960003387 progesterone Drugs 0.000 claims description 7
- 229960000890 hydrocortisone Drugs 0.000 claims description 6
- 239000000262 estrogen Substances 0.000 claims description 5
- 229940011871 estrogen Drugs 0.000 claims description 5
- 230000001235 sensitizing effect Effects 0.000 claims description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 3
- 241001494479 Pecora Species 0.000 claims description 3
- 239000005062 Polybutadiene Substances 0.000 claims description 3
- 229940098773 bovine serum albumin Drugs 0.000 claims description 3
- 229920002857 polybutadiene Polymers 0.000 claims description 3
- 229920003048 styrene butadiene rubber Polymers 0.000 claims description 3
- 239000003098 androgen Substances 0.000 claims 4
- 230000000984 immunochemical effect Effects 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 46
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 45
- 230000035945 sensitivity Effects 0.000 description 45
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 39
- 239000000725 suspension Substances 0.000 description 39
- 239000007853 buffer solution Substances 0.000 description 38
- 239000000203 mixture Substances 0.000 description 31
- 239000007788 liquid Substances 0.000 description 30
- 239000002244 precipitate Substances 0.000 description 27
- 238000002474 experimental method Methods 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 20
- 239000008367 deionised water Substances 0.000 description 16
- 229910021641 deionized water Inorganic materials 0.000 description 16
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 238000010521 absorption reaction Methods 0.000 description 10
- FQYGGFDZJFIDPU-JRSYHJKYSA-N estriol 16-O-(beta-D-glucuronide) Chemical compound O([C@@H]1C[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]2([C@H]1O)C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O FQYGGFDZJFIDPU-JRSYHJKYSA-N 0.000 description 10
- FQYGGFDZJFIDPU-UHFFFAOYSA-N estriol 16alpha-beta-D-glucuronide Natural products OC1C2(C)CCC(C3=CC=C(O)C=C3CC3)C3C2CC1OC1OC(C(O)=O)C(O)C(O)C1O FQYGGFDZJFIDPU-UHFFFAOYSA-N 0.000 description 10
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 9
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 9
- 229960002847 prasterone Drugs 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 8
- 229960002319 barbital Drugs 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 6
- 101100298295 Drosophila melanogaster flfl gene Proteins 0.000 description 6
- 230000001900 immune effect Effects 0.000 description 6
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- PLOJJUOTOYNIGL-GFCCVEGCSA-N (2r)-6-amino-2-nitro-2-(n-nitroanilino)hexanoic acid Chemical compound NCCCC[C@@]([N+]([O-])=O)(C(O)=O)N([N+]([O-])=O)C1=CC=CC=C1 PLOJJUOTOYNIGL-GFCCVEGCSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 150000002923 oximes Chemical class 0.000 description 3
- 238000004445 quantitative analysis Methods 0.000 description 3
- 239000003270 steroid hormone Substances 0.000 description 3
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- LRCVOOBIVXNBIT-NQUDVWKHSA-N bis[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] butanedioate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]([C@@H](O)C[C@]23C)[C@@H]1[C@@H]3CC[C@]2(O)C(=O)COC(=O)CCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@H](CCC=3[C@@]4(CCC(=O)C=3)C)[C@@H]4[C@@H](O)C[C@@]21C LRCVOOBIVXNBIT-NQUDVWKHSA-N 0.000 description 2
- 230000009260 cross reactivity Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 2
- 229960001348 estriol Drugs 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229930182480 glucuronide Natural products 0.000 description 2
- 239000003163 gonadal steroid hormone Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- -1 steroid glucuronide Chemical class 0.000 description 2
- NQRKYASMKDDGHT-UHFFFAOYSA-N (aminooxy)acetic acid Chemical compound NOCC(O)=O NQRKYASMKDDGHT-UHFFFAOYSA-N 0.000 description 1
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 1
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 1
- GLDQAMYCGOIJDV-UHFFFAOYSA-N 2,3-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- HHZQLQREDATOBM-CODXZCKSSA-M Hydrocortisone Sodium Succinate Chemical compound [Na+].O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COC(=O)CCC([O-])=O)[C@@H]4[C@@H]3CCC2=C1 HHZQLQREDATOBM-CODXZCKSSA-M 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000001780 adrenocortical effect Effects 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000000431 corpus luteum hormone Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- WTDHULULXKLSOZ-UHFFFAOYSA-N hydroxylamine hydrochloride Substances Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 1
- 229960002899 hydroxyprogesterone Drugs 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229950009829 prasterone sulfate Drugs 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000005845 steroid sulfates Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- NIKZPECGCSUSBV-HMAFJQTKSA-N testosterone 17-glucosiduronic acid Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)CC[C@@]21C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O NIKZPECGCSUSBV-HMAFJQTKSA-N 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52072775A JPS5819222B2 (ja) | 1977-06-21 | 1977-06-21 | ステロイド−血清アルブミン複合体感作ラテックス粒子の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7806961L SE7806961L (sv) | 1978-12-22 |
| SE445149B true SE445149B (sv) | 1986-06-02 |
Family
ID=13499080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7806961A SE445149B (sv) | 1977-06-21 | 1978-06-16 | Latexreagens, som innehaller latexpartiklar sensibiliserade med ett steroid-serumalbuminkonjugat, for immunkemisk bestemning av steroid i mensklig kroppsvetska, samt forfarande for framstellning av reagenset |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4226847A (ja) |
| JP (1) | JPS5819222B2 (ja) |
| AU (1) | AU522306B2 (ja) |
| CA (1) | CA1107196A (ja) |
| DE (1) | DE2827250C2 (ja) |
| DK (1) | DK151400C (ja) |
| FR (1) | FR2395507A1 (ja) |
| GB (1) | GB2001992B (ja) |
| NL (1) | NL7806681A (ja) |
| SE (1) | SE445149B (ja) |
| SU (1) | SU1213975A3 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331657A (en) * | 1980-02-06 | 1982-05-25 | Commonwealth Scientific And Industrial Research Organization | Fecundity of domestic livestock |
| NZ196126A (en) * | 1980-02-07 | 1985-05-31 | Commw Scient Ind Res Org | Increasing ovulation rate in female cattle |
| US4340564A (en) * | 1980-07-21 | 1982-07-20 | Daryl Laboratories, Inc. | Immunoadsorptive surface coating for solid-phase immunosubstrate and solid-phase immunosubstrate |
| JPS589068A (ja) * | 1981-07-10 | 1983-01-19 | Eiken Kagaku Kk | エストリオ−ル−１６α−グルクロニドの免疫化学的測定法 |
| US4792527A (en) * | 1981-07-17 | 1988-12-20 | Toray Industries, Inc. | Method of assaying biologically active substances and labelling agents therefor |
| US4738932A (en) * | 1985-12-03 | 1988-04-19 | Advanced Polymer Systems, Inc. | Reaginic test for syphilis |
| ES2028124T3 (es) * | 1987-04-22 | 1992-07-01 | Schiapparelli Biosystems, Inc. | Metodo para la determinacion de albumina en fluidos biologicos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125235C (ja) * | 1965-04-15 | |||
| JPS5226644B2 (ja) * | 1972-05-30 | 1977-07-15 | ||
| JPS5513306B2 (ja) * | 1973-11-29 | 1980-04-08 | ||
| JPS5434818B2 (ja) * | 1974-03-14 | 1979-10-29 | ||
| BE821053A (fr) * | 1974-08-01 | 1975-04-14 | Produit pour diagnostic par determination immunochimique | |
| JPS51112513A (en) * | 1975-03-25 | 1976-10-05 | Asahi Chem Ind Co Ltd | A method for determination of dha.sulfate |
-
1977
- 1977-06-21 JP JP52072775A patent/JPS5819222B2/ja not_active Expired
-
1978
- 1978-06-08 AU AU36945/78A patent/AU522306B2/en not_active Expired
- 1978-06-12 CA CA305,252A patent/CA1107196A/en not_active Expired
- 1978-06-16 SE SE7806961A patent/SE445149B/sv not_active IP Right Cessation
- 1978-06-20 US US05/917,254 patent/US4226847A/en not_active Expired - Lifetime
- 1978-06-20 GB GB7827369A patent/GB2001992B/en not_active Expired
- 1978-06-20 DK DK277178A patent/DK151400C/da not_active IP Right Cessation
- 1978-06-21 SU SU782629447A patent/SU1213975A3/ru active
- 1978-06-21 FR FR7818613A patent/FR2395507A1/fr active Granted
- 1978-06-21 NL NL7806681A patent/NL7806681A/xx not_active Application Discontinuation
- 1978-06-21 DE DE2827250A patent/DE2827250C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2827250C2 (de) | 1986-03-06 |
| FR2395507A1 (fr) | 1979-01-19 |
| GB2001992A (en) | 1979-02-14 |
| DK151400C (da) | 1988-05-16 |
| DK277178A (da) | 1978-12-22 |
| SU1213975A3 (ru) | 1986-02-23 |
| DK151400B (da) | 1987-11-30 |
| GB2001992B (en) | 1982-03-24 |
| JPS5819222B2 (ja) | 1983-04-16 |
| NL7806681A (nl) | 1978-12-27 |
| AU3694578A (en) | 1979-12-13 |
| US4226847A (en) | 1980-10-07 |
| FR2395507B1 (ja) | 1984-10-26 |
| CA1107196A (en) | 1981-08-18 |
| JPS548715A (en) | 1979-01-23 |
| AU522306B2 (en) | 1982-05-27 |
| DE2827250A1 (de) | 1979-01-04 |
| SE7806961L (sv) | 1978-12-22 |
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