SE426169B - Forfarande att framstella nya prolinderivat med terapeutisk verkan - Google Patents

Forfarande att framstella nya prolinderivat med terapeutisk verkan

Info

Publication number
SE426169B
SE426169B SE7701562A SE7701562A SE426169B SE 426169 B SE426169 B SE 426169B SE 7701562 A SE7701562 A SE 7701562A SE 7701562 A SE7701562 A SE 7701562A SE 426169 B SE426169 B SE 426169B
Authority
SE
Sweden
Prior art keywords
procedure
therapeutic effect
make new
proline derivatives
new proline
Prior art date
Application number
SE7701562A
Other languages
English (en)
Swedish (sv)
Other versions
SE7701562L (sv
Inventor
D W Cushman
M A Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE7701562L publication Critical patent/SE7701562L/xx
Publication of SE426169B publication Critical patent/SE426169B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7701562A 1976-02-13 1977-02-11 Forfarande att framstella nya prolinderivat med terapeutisk verkan SE426169B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/657,793 US4052511A (en) 1976-02-13 1976-02-13 Carboxyacylproline derivatives

Publications (2)

Publication Number Publication Date
SE7701562L SE7701562L (sv) 1977-09-23
SE426169B true SE426169B (sv) 1982-12-13

Family

ID=24638684

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7701562A SE426169B (sv) 1976-02-13 1977-02-11 Forfarande att framstella nya prolinderivat med terapeutisk verkan

Country Status (23)

Country Link
US (3) US4052511A (cs)
JP (1) JPS6058751B2 (cs)
AT (1) AT366030B (cs)
BE (1) BE851363A (cs)
CA (1) CA1104059A (cs)
CH (1) CH602633A5 (cs)
CS (1) CS197285B2 (cs)
DD (1) DD129651A5 (cs)
DE (1) DE2704985A1 (cs)
DK (1) DK59077A (cs)
FR (1) FR2340933A1 (cs)
GB (1) GB1570921A (cs)
HU (1) HU177144B (cs)
IE (1) IE45086B1 (cs)
NL (1) NL167688C (cs)
NO (1) NO145915C (cs)
NZ (1) NZ183222A (cs)
PH (1) PH12066A (cs)
PL (1) PL106416B1 (cs)
SE (1) SE426169B (cs)
SU (1) SU694070A3 (cs)
YU (1) YU33277A (cs)
ZA (1) ZA77564B (cs)

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US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
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JPS584711B2 (ja) * 1978-08-02 1983-01-27 参天製薬株式会社 ピロリジン誘導体
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids
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US4226775A (en) * 1979-06-01 1980-10-07 American Cyanamid Company Substituted thio-substituted benzyl-propionyl-L-prolines
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US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
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US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
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US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
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IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
US4587050A (en) * 1980-08-18 1986-05-06 Merck & Co., Inc. Substituted enantholactam derivatives as antihypertensives
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US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
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US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
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US4587238A (en) * 1981-07-06 1986-05-06 Merck & Co., Inc. Substituted caprylolactam derivatives as anti-hypertensives
US4866087A (en) * 1982-01-21 1989-09-12 Merck & Co., Inc. Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
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US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4472384A (en) * 1983-06-15 1984-09-18 Merck & Co., Inc. Antihypertensive composition
US4617301A (en) * 1983-06-22 1986-10-14 Merck & Co., Inc. Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
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Also Published As

Publication number Publication date
AT366030B (de) 1982-03-10
ATA96977A (de) 1981-07-15
NO145915C (no) 1982-06-23
FR2340933B1 (cs) 1980-04-11
PH12066A (en) 1978-10-18
SE7701562L (sv) 1977-09-23
NO770465L (no) 1977-08-16
US4086338A (en) 1978-04-25
US4052511A (en) 1977-10-04
GB1570921A (en) 1980-07-09
NL167688C (nl) 1982-01-18
PL106416B1 (pl) 1979-12-31
JPS52100461A (en) 1977-08-23
CS197285B2 (en) 1980-04-30
DD129651A5 (de) 1978-02-01
IE45086L (en) 1977-08-13
US4128653A (en) 1978-12-05
FR2340933A1 (fr) 1977-09-09
NL7701463A (nl) 1977-08-16
YU33277A (en) 1982-08-31
JPS6058751B2 (ja) 1985-12-21
DE2704985A1 (de) 1977-08-18
HU177144B (en) 1981-07-28
DK59077A (da) 1977-08-14
ZA77564B (en) 1977-12-28
BE851363A (fr) 1977-08-11
NL167688B (nl) 1981-08-17
IE45086B1 (en) 1982-06-16
SU694070A3 (ru) 1979-10-25
NO145915B (no) 1982-03-15
CA1104059A (en) 1981-06-30
CH602633A5 (cs) 1978-07-31
PL195997A1 (pl) 1978-02-27
NZ183222A (en) 1979-07-11
AU2189877A (en) 1978-08-10

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