SE420199B - Forfarande for framstellning av 16-oxiderade prostansyraderivat - Google Patents
Forfarande for framstellning av 16-oxiderade prostansyraderivatInfo
- Publication number
- SE420199B SE420199B SE7503431A SE7503431A SE420199B SE 420199 B SE420199 B SE 420199B SE 7503431 A SE7503431 A SE 7503431A SE 7503431 A SE7503431 A SE 7503431A SE 420199 B SE420199 B SE 420199B
- Authority
- SE
- Sweden
- Prior art keywords
- oxidated
- preparing
- procedure
- acid derivatives
- prostanic acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/454,913 US3965143A (en) | 1974-03-26 | 1974-03-26 | 16-Oxygenated prostanoic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7503431L SE7503431L (de) | 1975-09-27 |
SE420199B true SE420199B (sv) | 1981-09-21 |
Family
ID=23806587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7503431A SE420199B (sv) | 1974-03-26 | 1975-03-25 | Forfarande for framstellning av 16-oxiderade prostansyraderivat |
Country Status (25)
Country | Link |
---|---|
US (1) | US3965143A (de) |
JP (1) | JPS5855142B2 (de) |
AR (1) | AR207355A1 (de) |
AT (1) | AT351684B (de) |
BE (1) | BE827127A (de) |
CA (1) | CA1040197A (de) |
CH (1) | CH613443A5 (de) |
DE (1) | DE2513212C2 (de) |
DK (1) | DK128075A (de) |
EG (1) | EG12063A (de) |
ES (1) | ES436043A1 (de) |
FI (1) | FI63747C (de) |
FR (1) | FR2274289A1 (de) |
GB (1) | GB1492426A (de) |
HU (1) | HU174973B (de) |
IE (1) | IE41328B1 (de) |
IL (1) | IL46919A (de) |
NL (2) | NL183294B (de) |
NO (1) | NO146200C (de) |
OA (1) | OA04910A (de) |
PH (1) | PH16276A (de) |
PL (1) | PL100838B1 (de) |
SE (1) | SE420199B (de) |
YU (1) | YU39735B (de) |
ZA (1) | ZA751391B (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4113723A (en) * | 1972-07-13 | 1978-09-12 | Pfizer Inc. | 15-Substituted-ω-pentanorprostaglandins |
US4293704A (en) * | 1975-09-25 | 1981-10-06 | American Cyanamid Company | Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones |
US4107441A (en) * | 1973-06-15 | 1978-08-15 | American Cyanamid Company | Novel 16 hydroxy 15-deoxy-5-cis-prostenoic acids and esters |
US4060691A (en) * | 1974-03-26 | 1977-11-29 | G. D. Searle & Co. | 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl}heptanoic acids and esters |
US4191699A (en) * | 1976-07-19 | 1980-03-04 | American Cyanamid Company | Various- 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins |
US4190596A (en) * | 1976-07-19 | 1980-02-26 | American Cyanamid Company | Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins |
US4328358A (en) * | 1976-07-19 | 1982-05-04 | American Cyanamid Company | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
US4429148A (en) | 1976-07-19 | 1984-01-31 | American Cyanamid Company | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
US4730065A (en) * | 1976-07-19 | 1988-03-08 | American Cyanamid Company | 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
US4192950A (en) * | 1976-07-19 | 1980-03-11 | American Cyanamid Company | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
US4061670A (en) * | 1976-07-19 | 1977-12-06 | American Cyanamid Company | 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners |
AU3437478A (en) * | 1977-03-30 | 1979-09-27 | American Cyanamid Co | Prostanoic acids and congeners |
US4281153A (en) * | 1977-08-01 | 1981-07-28 | American Cyanamid | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
GB2006186A (en) * | 1977-08-29 | 1979-05-02 | American Cyanamid Co | 15-Deoxy-16-substituted prostanoic acids |
GB2009162A (en) * | 1977-12-05 | 1979-06-13 | American Cyanamid Co | Prostanoic acids and congeners |
AU529836B2 (en) * | 1977-12-05 | 1983-06-23 | American Cyanamid Company | Prostaglandin analog |
US4132738A (en) * | 1978-02-23 | 1979-01-02 | Miles Laboratories, Inc. | Preparation of 15-deoxy-16-hydroxyprostaglandins |
US4742080A (en) * | 1978-02-23 | 1988-05-03 | Miles Laboratories, Inc. | Therapeutic method for producing bronchodilation by administration of 15-deoxy-16-hydroxy prostaglandin esters |
US4833157A (en) * | 1978-02-23 | 1989-05-23 | Miles Inc. | Methods of inhibitng gastric secretion with prostaglandin derivatives |
US4239899A (en) * | 1979-09-13 | 1980-12-16 | American Cyanamid Company | Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins |
US4322543A (en) * | 1979-11-28 | 1982-03-30 | G. D. Searle & Co. | 4,5-Unsaturated prostanoic acid derivatives |
US4271314A (en) * | 1979-11-28 | 1981-06-02 | G. D. Searle & Co. | 4,5-Unsaturated prostanoic acid derivatives |
US4288633A (en) * | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives |
US4310700A (en) * | 1980-04-03 | 1982-01-12 | American Cyanamid Company | 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives |
US4291174A (en) * | 1980-04-03 | 1981-09-22 | American Cyanamid Company | 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives |
US4291175A (en) * | 1980-04-03 | 1981-09-22 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives |
US4288630A (en) * | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives |
US4288632A (en) * | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives |
US4288629A (en) * | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives |
US4289910A (en) * | 1980-04-03 | 1981-09-15 | American Cyanamid Company | 1-Hydroxymethyl-prosten-1-ol derivatives |
US4301146A (en) * | 1980-07-29 | 1981-11-17 | G. D. Searle & Co. | Stabilization of 16-oxygenated prostanoic acid derivatives |
US4399290A (en) * | 1980-09-22 | 1983-08-16 | E. I. Du Pont De Nemours And Company | Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)heptanoates |
US4459310A (en) * | 1983-06-27 | 1984-07-10 | G.D. Searle & Co. | Method for cholesterol lowering |
US4754059A (en) * | 1984-11-07 | 1988-06-28 | G. D. Searle & Co. | Omega cycloalkyl prostaglandins |
US4499296A (en) * | 1983-11-14 | 1985-02-12 | G. D. Searle & Co. | Omega cycloalkyl prostaglandins |
US4683328A (en) * | 1985-11-25 | 1987-07-28 | G. D. Searle & Co. | Tetraenyl prostaglandins |
US4820728A (en) * | 1985-11-25 | 1989-04-11 | G. D. Searle & Co. | Tetraenyl prostaglandins |
US4847293A (en) * | 1985-11-25 | 1989-07-11 | G. D. Searle & Co. | Tetraenyl prostaglandins |
US5011958A (en) * | 1987-06-08 | 1991-04-30 | G. D. Searle & Co. | Process for preparing higher order cuprate complexes |
US4785124A (en) * | 1987-06-08 | 1988-11-15 | G. D. Searle & Co. | Process for preparing higher order cuprate complexes |
US4777275A (en) * | 1987-06-09 | 1988-10-11 | G. D. Searle & Co. | Process of preparing higher order cuprate complexes |
US5252763A (en) * | 1990-04-17 | 1993-10-12 | G. D. Searle & Co. | Process for preparing prostaglandin analogs |
US5055604A (en) * | 1990-04-17 | 1991-10-08 | G. D. Searle & Co. | Process for preparing prostaglandin analogs using organozirconium compounds |
AU7793791A (en) * | 1990-05-03 | 1991-11-27 | G.D. Searle & Co. | Pharmaceutical composition for use in treating pain |
US5232704A (en) * | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
US5218139A (en) * | 1990-12-27 | 1993-06-08 | G. D. Searle & Co. | Method for inhibiting IgE production |
US5157052A (en) * | 1990-12-27 | 1992-10-20 | Monsanto Company | Method for inhibiting ige production |
US5324746A (en) * | 1993-02-12 | 1994-06-28 | Mckee Rex N | Method of treating damaged mucosal and epithelial tissues with misoprostol |
DE69720587D1 (de) * | 1996-05-17 | 2003-05-15 | Torcan Chemical Ltd | Misoprostol, Verfahren zur deren Herstellung mit Verwendung eines Organometall-Kupferkomplexes |
US5684177A (en) * | 1996-05-17 | 1997-11-04 | Torcan Chemical Ltd. | Misoprostol |
WO1997045114A1 (en) * | 1996-05-30 | 1997-12-04 | Lysis Corporation | The treatment of vascular disease with prostaglandins via a sustained-release dermal patch |
US5994399A (en) * | 1997-03-27 | 1999-11-30 | Mckee; Rex N. | Method of regenerating collagen-containing tissues with misoprostol |
US6030959A (en) * | 1997-04-04 | 2000-02-29 | Monsanto Company | Gastro-specific prodrugs |
KR20010021625A (ko) | 1997-07-09 | 2001-03-15 | 추후보정 | 개선된 남성발기 기능장애 치료방법 및 그 조성물 |
US6103765A (en) * | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
EP0896823B1 (de) * | 1997-07-15 | 2002-09-25 | Development Center For Biotechnology | Verbesserte Stabilisierung von Misoprostol |
EP2316468A1 (de) | 2002-02-22 | 2011-05-04 | Shire LLC | Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin |
JPWO2004032964A1 (ja) * | 2002-10-10 | 2006-02-09 | 国立大学法人京都大学 | アレルギー性疾患治療剤 |
EP1563846B1 (de) | 2002-10-10 | 2012-08-29 | Ono Pharmaceutical Co., Ltd. | Endogene reparaturfaktoren herstellende promoter |
EP2422814A1 (de) | 2003-07-25 | 2012-02-29 | Ono Pharmaceutical Co., Ltd. | Heilmittel für Knorpelerkrankungen |
US7241746B2 (en) * | 2003-08-06 | 2007-07-10 | Regena Therapeutics, Lc | Method and composition for treating periodontal disease |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
WO2007146795A2 (en) * | 2006-06-12 | 2007-12-21 | Ironwood Pharmaceuticals, Inc. | Pharmaceutical formulation for parenteral administration |
EP2913047B1 (de) | 2012-10-29 | 2019-05-08 | Cardio Incorporated | Spezifisches therapeutikum für pulmonale erkrankungen |
JP6449166B2 (ja) | 2013-10-15 | 2019-01-09 | 小野薬品工業株式会社 | 薬剤溶出性ステントグラフト |
HU231185B1 (hu) | 2017-07-11 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Eljárás Misoprostol előállítására és tisztítására |
CN108753898A (zh) * | 2018-04-09 | 2018-11-06 | 深圳市祥根生物科技有限公司 | 一种米索前列醇酸的制备方法及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812172A (en) * | 1970-05-04 | 1974-05-21 | Upjohn Co | 15-methyl and 15-ethyl dihydro-pge1 |
ZA72646B (en) * | 1971-03-11 | 1973-09-26 | Upjohn Co | Prostaglandin analogs |
GB1444971A (en) * | 1972-07-24 | 1976-08-04 | American Cyanamid Co | Derivatives of prostanoic acid |
-
1974
- 1974-03-26 US US05/454,913 patent/US3965143A/en not_active Expired - Lifetime
-
1975
- 1975-01-01 AR AR258109A patent/AR207355A1/es active
- 1975-03-06 ZA ZA00751391A patent/ZA751391B/xx unknown
- 1975-03-25 NL NLAANVRAGE7503553,A patent/NL183294B/xx active Protection Beyond IP Right Term
- 1975-03-25 DK DK128075A patent/DK128075A/da not_active Application Discontinuation
- 1975-03-25 IL IL46919A patent/IL46919A/xx unknown
- 1975-03-25 JP JP50036028A patent/JPS5855142B2/ja not_active Expired
- 1975-03-25 DE DE2513212A patent/DE2513212C2/de not_active Expired
- 1975-03-25 PH PH16968A patent/PH16276A/en unknown
- 1975-03-25 CA CA222,994A patent/CA1040197A/en not_active Expired
- 1975-03-25 FI FI750899A patent/FI63747C/fi not_active IP Right Cessation
- 1975-03-25 BE BE154714A patent/BE827127A/xx active Protection Beyond IP Right Term
- 1975-03-25 AT AT227375A patent/AT351684B/de active Protection Beyond IP Right Term
- 1975-03-25 YU YU735/75A patent/YU39735B/xx unknown
- 1975-03-25 NO NO751039A patent/NO146200C/no unknown
- 1975-03-25 GB GB12367/75A patent/GB1492426A/en not_active Expired
- 1975-03-25 OA OA55451A patent/OA04910A/xx unknown
- 1975-03-25 SE SE7503431A patent/SE420199B/xx not_active IP Right Cessation
- 1975-03-25 HU HU75SE1775A patent/HU174973B/hu unknown
- 1975-03-26 FR FR7509523A patent/FR2274289A1/fr active Granted
- 1975-03-26 EG EG167/75A patent/EG12063A/xx active
- 1975-03-26 ES ES436043A patent/ES436043A1/es not_active Expired
- 1975-03-26 PL PL1975179076A patent/PL100838B1/pl unknown
- 1975-03-26 CH CH392075A patent/CH613443A5/xx active Protection Beyond IP Right Term
- 1975-03-26 IE IE675/75A patent/IE41328B1/xx unknown
-
1993
- 1993-06-11 NL NL930058C patent/NL930058I2/nl unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
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SPCF | Application for supplementary protection certificate filed |
Free format text: 7503431 |
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SPCG | Supplementary protection certificate granted |
Free format text: 7503431, EXPIRES: 20000325 |
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