SE364510B - - Google Patents
Info
- Publication number
- SE364510B SE364510B SE15867/67A SE1586767A SE364510B SE 364510 B SE364510 B SE 364510B SE 15867/67 A SE15867/67 A SE 15867/67A SE 1586767 A SE1586767 A SE 1586767A SE 364510 B SE364510 B SE 364510B
- Authority
- SE
- Sweden
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Purses, Travelling Bags, Baskets, Or Suitcases (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE15717/66A SE327987B (no) | 1966-11-16 | 1966-11-16 | |
GB03687/67A GB1213162A (en) | 1966-11-16 | 1967-03-23 | Serum lipid lowering pyridine derivatives and their preparation |
GB19174/67A GB1157186A (en) | 1966-11-16 | 1967-04-26 | Serum Lipid Lowering Pyridine Derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE364510B true SE364510B (no) | 1974-02-25 |
Family
ID=27257023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE15867/67A SE364510B (no) | 1966-11-16 | 1967-11-17 |
Country Status (15)
Country | Link |
---|---|
US (2) | US3637714A (no) |
JP (1) | JPS5023030B1 (no) |
AT (2) | AT289113B (no) |
BE (1) | BE706471A (no) |
CH (1) | CH508625A (no) |
DE (3) | DE1670003B2 (no) |
DK (1) | DK125709B (no) |
ES (1) | ES347190A1 (no) |
FI (1) | FI49962C (no) |
FR (3) | FR8017M (no) |
GB (3) | GB1213162A (no) |
IE (1) | IE32127B1 (no) |
NL (2) | NL150440B (no) |
NO (1) | NO124927B (no) |
SE (1) | SE364510B (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3737542A (en) * | 1966-11-16 | 1973-06-05 | Lars Anders Fritz Carlsson | Lowering excessive serum lipid concentrations and preparations containing fluoro-pyridine derivatives |
GB1312775A (en) * | 1969-07-07 | 1973-04-04 | Mar Pha Etu Expl Marques | Aryloxyalkyl nicotinates |
FR2074707B1 (no) * | 1970-01-20 | 1973-01-12 | Centre Etd Ind Pharma | |
US4115393A (en) * | 1974-03-28 | 1978-09-19 | Siegfried Aktiengesellschaft | Pyridyl alkyl esters of substituted phenoxy alkanoic acids having the ability to reduce the level of fatty substances in the blood |
FR2270878B1 (no) * | 1974-05-15 | 1978-02-03 | Fabre Sa Pierre | |
DE2443539C3 (de) * | 1974-09-11 | 1978-11-23 | Karl Dr.Med. 4044 Kaarst Credner | Ester der 5-n-Butyl-pyridin-carbonsäure- (2), Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate |
BE826867A (fr) * | 1974-11-20 | 1975-07-16 | Medicament hypolipidemiant et hydrocholesterolemiant | |
US4058534A (en) * | 1975-03-14 | 1977-11-15 | Solco Basel Ag | Therapeutically effective nicotinates and N-oxide nicotinates of aliphatic amines |
ES438245A1 (es) * | 1975-06-04 | 1977-01-16 | Alter Sa | Procedimiento de purificacion del ester mixto 1-(2-(p-cloro-fenoxi)-2metilpropionato), 2-nicotinato de etilenglicol. |
ES438246A1 (es) * | 1975-06-04 | 1977-01-16 | Alter Sa | Un procedimiento de preparacion del glicol 2-(p-clorofenoci)-2-metilpropinato nicotinato. |
JPS5387531A (en) * | 1977-01-11 | 1978-08-02 | Takenaka Komuten Co | Foldable hanging scaffold for building |
JPS53101827A (en) * | 1977-02-17 | 1978-09-05 | Takenaka Komuten Co | Method of temporarily building scaffold |
JPS5422927A (en) * | 1977-07-22 | 1979-02-21 | Takenaka Komuten Co | Method of tentatively building scaffold* and scaffold for effecting said method |
DE2962915D1 (en) * | 1979-11-02 | 1982-07-08 | Stauffer Chemical Co | Pyridylalkyl esters, insect repellent compositions and method of repelling insects |
IT1168389B (it) * | 1981-05-06 | 1987-05-20 | Alfa Farmaceutici Spa | Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono |
DE3315877A1 (de) * | 1983-05-02 | 1984-11-08 | Merz + Co GmbH & Co, 6000 Frankfurt | N-oxide von pyridyl-carbonsaeureestern, ein verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten |
AT383346B (de) * | 1983-05-02 | 1987-06-25 | Merz & Co Gmbh & Co | Verfahren zur herstellung von neuen n-oxiden von pyridylcarbonsaeureestern |
FR2612189B1 (fr) * | 1987-03-13 | 1989-06-23 | Roussel Uclaf | Nouveaux derives de la pyridine, leur procede de preparation et les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant |
LU87821A1 (fr) * | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
US5436344A (en) * | 1990-11-29 | 1995-07-25 | Pfizer Inc. | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones |
WO1993011768A1 (en) * | 1991-12-13 | 1993-06-24 | Smithkline Beecham Corporation | Pyridyl compounds for psoriasis treatment |
ATE429915T1 (de) * | 2002-10-10 | 2009-05-15 | Arena Pharm Inc | 5-substituierte 2h-pyrazon-3-carbonsäure-derivate als antilipolytische mittel zur behandlung von stoffwechselstörungen, wie z.b. dyslipidemie |
AU2004260636A1 (en) * | 2003-06-13 | 2005-02-10 | Arena Pharmaceuticals, Inc. | 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor RUP25 for the treatment of dyslipidemia and related diseases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE322214B (no) * | 1965-06-28 | 1970-04-06 | Bofors Ab | |
FR1498459A (no) * | 1965-07-30 | 1968-01-08 |
-
1967
- 1967-03-23 GB GB03687/67A patent/GB1213162A/en not_active Expired
- 1967-04-26 GB GB19174/67A patent/GB1157186A/en not_active Expired
- 1967-11-13 DE DE1967A0057350 patent/DE1670003B2/de active Granted
- 1967-11-13 DE DE1795792A patent/DE1795792C3/de not_active Expired
- 1967-11-14 CH CH1586267A patent/CH508625A/de not_active IP Right Cessation
- 1967-11-14 NO NO170525A patent/NO124927B/no unknown
- 1967-11-14 BE BE706471D patent/BE706471A/xx unknown
- 1967-11-15 GB GB52041/67A patent/GB1171509A/en not_active Expired
- 1967-11-15 ES ES347190A patent/ES347190A1/es not_active Expired
- 1967-11-15 US US689751A patent/US3637714A/en not_active Expired - Lifetime
- 1967-11-15 AT AT1028267A patent/AT289113B/de not_active IP Right Cessation
- 1967-11-16 NL NL676715616A patent/NL150440B/xx unknown
- 1967-11-16 FR FR128477A patent/FR8017M/fr not_active Expired
- 1967-11-16 DK DK573567AA patent/DK125709B/da unknown
- 1967-11-16 FI FI673086A patent/FI49962C/fi active
- 1967-11-16 FR FR128479A patent/FR1544594A/fr not_active Expired
- 1967-11-17 SE SE15867/67A patent/SE364510B/xx unknown
-
1968
- 1968-04-08 IE IE400/68A patent/IE32127B1/xx unknown
-
1969
- 1969-03-12 DE DE1912352A patent/DE1912352C3/de not_active Expired
- 1969-03-17 US US807948A patent/US3622587A/en not_active Expired - Lifetime
- 1969-03-19 AT AT268069A patent/AT294089B/de active
- 1969-03-24 FR FR6908585A patent/FR2004661A1/fr not_active Withdrawn
- 1969-03-25 NL NL6904594A patent/NL6904594A/xx unknown
-
1971
- 1971-04-09 JP JP46021827A patent/JPS5023030B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IE32127B1 (en) | 1973-04-18 |
FR1544594A (fr) | 1968-10-31 |
BE706471A (no) | 1968-05-14 |
JPS5023030B1 (no) | 1975-08-05 |
CH508625A (de) | 1971-06-15 |
DE1670003A1 (de) | 1971-11-04 |
IE32127L (en) | 1968-10-26 |
US3622587A (en) | 1971-11-23 |
DK125709B (da) | 1973-03-26 |
AT289113B (de) | 1971-04-13 |
DE1912352B2 (de) | 1975-04-17 |
DE1795792B2 (de) | 1979-07-19 |
NL6904594A (no) | 1969-09-29 |
ES347190A1 (es) | 1969-05-01 |
AT294089B (de) | 1971-11-10 |
FI49962B (no) | 1975-07-31 |
FR8017M (no) | 1970-08-03 |
NL150440B (nl) | 1976-08-16 |
GB1213162A (en) | 1970-11-18 |
DE1795792A1 (de) | 1975-06-19 |
DE1670003B2 (de) | 1976-06-16 |
DE1795792C3 (de) | 1980-03-20 |
GB1171509A (en) | 1969-11-19 |
GB1157186A (en) | 1969-07-02 |
FI49962C (fi) | 1975-11-10 |
US3637714A (en) | 1972-01-25 |
DE1912352A1 (de) | 1969-10-09 |
FR2004661A1 (no) | 1969-11-28 |
NO124927B (no) | 1972-06-26 |
DE1912352C3 (de) | 1975-11-27 |
NL6715616A (no) | 1968-05-17 |