AT294089B - Verfahren zur Herstellung von neuen Pyridinderivaten und therapeutisch verträglicher Salze hievon - Google Patents

Verfahren zur Herstellung von neuen Pyridinderivaten und therapeutisch verträglicher Salze hievon

Info

Publication number
AT294089B
AT294089B AT268069A AT268069A AT294089B AT 294089 B AT294089 B AT 294089B AT 268069 A AT268069 A AT 268069A AT 268069 A AT268069 A AT 268069A AT 294089 B AT294089 B AT 294089B
Authority
AT
Austria
Prior art keywords
preparation
acceptable salts
pyridine derivatives
therapeutically acceptable
new pyridine
Prior art date
Application number
AT268069A
Other languages
English (en)
Inventor
Lars Anders Fritz Carlsson
Berndt Olof Harald Sjoeberg
Nils Erik Stjernstroem
Ake John Erik Helgestrand
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE15717/66A external-priority patent/SE327987B/xx
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of AT294089B publication Critical patent/AT294089B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
AT268069A 1966-11-16 1969-03-19 Verfahren zur Herstellung von neuen Pyridinderivaten und therapeutisch verträglicher Salze hievon AT294089B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE15717/66A SE327987B (de) 1966-11-16 1966-11-16
GB03687/67A GB1213162A (en) 1966-11-16 1967-03-23 Serum lipid lowering pyridine derivatives and their preparation
GB19174/67A GB1157186A (en) 1966-11-16 1967-04-26 Serum Lipid Lowering Pyridine Derivatives

Publications (1)

Publication Number Publication Date
AT294089B true AT294089B (de) 1971-11-10

Family

ID=27257023

Family Applications (2)

Application Number Title Priority Date Filing Date
AT1028267A AT289113B (de) 1966-11-16 1967-11-15 Verfahren zur Herstellung von neuen Pyridinderivaten
AT268069A AT294089B (de) 1966-11-16 1969-03-19 Verfahren zur Herstellung von neuen Pyridinderivaten und therapeutisch verträglicher Salze hievon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT1028267A AT289113B (de) 1966-11-16 1967-11-15 Verfahren zur Herstellung von neuen Pyridinderivaten

Country Status (15)

Country Link
US (2) US3637714A (de)
JP (1) JPS5023030B1 (de)
AT (2) AT289113B (de)
BE (1) BE706471A (de)
CH (1) CH508625A (de)
DE (3) DE1670003B2 (de)
DK (1) DK125709B (de)
ES (1) ES347190A1 (de)
FI (1) FI49962C (de)
FR (3) FR8017M (de)
GB (3) GB1213162A (de)
IE (1) IE32127B1 (de)
NL (2) NL150440B (de)
NO (1) NO124927B (de)
SE (1) SE364510B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737542A (en) * 1966-11-16 1973-06-05 Lars Anders Fritz Carlsson Lowering excessive serum lipid concentrations and preparations containing fluoro-pyridine derivatives
GB1312775A (en) * 1969-07-07 1973-04-04 Mar Pha Etu Expl Marques Aryloxyalkyl nicotinates
FR2074707B1 (de) * 1970-01-20 1973-01-12 Centre Etd Ind Pharma
US4115393A (en) * 1974-03-28 1978-09-19 Siegfried Aktiengesellschaft Pyridyl alkyl esters of substituted phenoxy alkanoic acids having the ability to reduce the level of fatty substances in the blood
FR2270878B1 (de) * 1974-05-15 1978-02-03 Fabre Sa Pierre
DE2443539C3 (de) * 1974-09-11 1978-11-23 Karl Dr.Med. 4044 Kaarst Credner Ester der 5-n-Butyl-pyridin-carbonsäure- (2), Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate
BE826867A (fr) * 1974-11-20 1975-07-16 Medicament hypolipidemiant et hydrocholesterolemiant
US4058534A (en) * 1975-03-14 1977-11-15 Solco Basel Ag Therapeutically effective nicotinates and N-oxide nicotinates of aliphatic amines
ES438246A1 (es) * 1975-06-04 1977-01-16 Alter Sa Un procedimiento de preparacion del glicol 2-(p-clorofenoci)-2-metilpropinato nicotinato.
ES438245A1 (es) * 1975-06-04 1977-01-16 Alter Sa Procedimiento de purificacion del ester mixto 1-(2-(p-cloro-fenoxi)-2metilpropionato), 2-nicotinato de etilenglicol.
JPS5387531A (en) * 1977-01-11 1978-08-02 Takenaka Komuten Co Foldable hanging scaffold for building
JPS53101827A (en) * 1977-02-17 1978-09-05 Takenaka Komuten Co Method of temporarily building scaffold
JPS5422927A (en) * 1977-07-22 1979-02-21 Takenaka Komuten Co Method of tentatively building scaffold* and scaffold for effecting said method
DE2962915D1 (en) * 1979-11-02 1982-07-08 Stauffer Chemical Co Pyridylalkyl esters, insect repellent compositions and method of repelling insects
IT1168389B (it) * 1981-05-06 1987-05-20 Alfa Farmaceutici Spa Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono
DE3315877A1 (de) * 1983-05-02 1984-11-08 Merz + Co GmbH & Co, 6000 Frankfurt N-oxide von pyridyl-carbonsaeureestern, ein verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
AT383346B (de) * 1983-05-02 1987-06-25 Merz & Co Gmbh & Co Verfahren zur herstellung von neuen n-oxiden von pyridylcarbonsaeureestern
FR2612189B1 (fr) * 1987-03-13 1989-06-23 Roussel Uclaf Nouveaux derives de la pyridine, leur procede de preparation et les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
US5436344A (en) * 1990-11-29 1995-07-25 Pfizer Inc. 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones
WO1993011768A1 (en) * 1991-12-13 1993-06-24 Smithkline Beecham Corporation Pyridyl compounds for psoriasis treatment
CN1720046A (zh) * 2002-10-10 2006-01-11 阿伦纳药品公司 作为抗脂解药用于治疗血脂异常等代谢相关疾病的5－取代的2h－吡唑－3－甲酸衍生物
WO2005011677A1 (en) * 2003-06-13 2005-02-10 Arena Pharmaceuticals, Inc. 5-substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor rup25 for the treatment of dyslipidemia and related diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE322214B (de) * 1965-06-28 1970-04-06 Bofors Ab
FR1498459A (de) * 1965-07-30 1968-01-08

Also Published As

Publication number Publication date
ES347190A1 (es) 1969-05-01
GB1171509A (en) 1969-11-19
DE1795792A1 (de) 1975-06-19
BE706471A (de) 1968-05-14
FR2004661A1 (de) 1969-11-28
FR8017M (de) 1970-08-03
SE364510B (de) 1974-02-25
NL6715616A (de) 1968-05-17
FR1544594A (fr) 1968-10-31
IE32127B1 (en) 1973-04-18
FI49962C (fi) 1975-11-10
NL6904594A (de) 1969-09-29
AT289113B (de) 1971-04-13
DE1912352B2 (de) 1975-04-17
US3637714A (en) 1972-01-25
JPS5023030B1 (de) 1975-08-05
NL150440B (nl) 1976-08-16
DK125709B (da) 1973-03-26
FI49962B (de) 1975-07-31
DE1670003A1 (de) 1971-11-04
DE1912352C3 (de) 1975-11-27
US3622587A (en) 1971-11-23
GB1157186A (en) 1969-07-02
DE1912352A1 (de) 1969-10-09
NO124927B (de) 1972-06-26
GB1213162A (en) 1970-11-18
IE32127L (en) 1968-10-26
CH508625A (de) 1971-06-15
DE1795792B2 (de) 1979-07-19
DE1670003B2 (de) 1976-06-16
DE1795792C3 (de) 1980-03-20

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