SE0401971D0 - Piperidne derivatives - Google Patents

Piperidne derivatives

Info

Publication number
SE0401971D0
SE0401971D0 SE0401971A SE0401971A SE0401971D0 SE 0401971 D0 SE0401971 D0 SE 0401971D0 SE 0401971 A SE0401971 A SE 0401971A SE 0401971 A SE0401971 A SE 0401971A SE 0401971 D0 SE0401971 D0 SE 0401971D0
Authority
SE
Sweden
Prior art keywords
piperidne
derivatives
sup
compounds
enantiomers
Prior art date
Application number
SE0401971A
Other languages
English (en)
Swedish (sv)
Inventor
James Folmer
Fraser Hunt
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0401971A priority Critical patent/SE0401971D0/xx
Publication of SE0401971D0 publication Critical patent/SE0401971D0/xx
Priority to AU2005267932A priority patent/AU2005267932A1/en
Priority to KR1020077002643A priority patent/KR20070043998A/ko
Priority to CA002576112A priority patent/CA2576112A1/en
Priority to BRPI0514035-8A priority patent/BRPI0514035A/pt
Priority to JP2007524768A priority patent/JP2008508353A/ja
Priority to EP05761797A priority patent/EP1781613A1/en
Priority to CNA2005800262732A priority patent/CN1993325A/zh
Priority to MX2007001226A priority patent/MX2007001226A/es
Priority to US11/572,967 priority patent/US20080064706A1/en
Priority to RU2007105970/04A priority patent/RU2007105970A/ru
Priority to PCT/SE2005/001189 priority patent/WO2006014136A1/en
Priority to IL180548A priority patent/IL180548A0/en
Priority to ZA200700683A priority patent/ZA200700683B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE0401971A 2004-08-02 2004-08-02 Piperidne derivatives SE0401971D0 (sv)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SE0401971A SE0401971D0 (sv) 2004-08-02 2004-08-02 Piperidne derivatives
PCT/SE2005/001189 WO2006014136A1 (en) 2004-08-02 2005-07-27 Piperidine derivatives as histamine h3 receptor ligands
EP05761797A EP1781613A1 (en) 2004-08-02 2005-07-27 Piperidine derivatives as histamine h3 receptor ligands
KR1020077002643A KR20070043998A (ko) 2004-08-02 2005-07-27 히스타민 h3 수용체 리간드로서의 피페리딘 유도체
CA002576112A CA2576112A1 (en) 2004-08-02 2005-07-27 Piperidine derivatives as histamine h3 receptor ligands
BRPI0514035-8A BRPI0514035A (pt) 2004-08-02 2005-07-27 composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto
JP2007524768A JP2008508353A (ja) 2004-08-02 2005-07-27 ヒスタミンh3受容体リガンドとしてのピペリジン誘導体
AU2005267932A AU2005267932A1 (en) 2004-08-02 2005-07-27 Piperidine derivatives as histamine H3 receptor ligands
CNA2005800262732A CN1993325A (zh) 2004-08-02 2005-07-27 作为组胺h3受体配体的哌啶衍生物
MX2007001226A MX2007001226A (es) 2004-08-02 2005-07-27 Derivados de piperidina como ligandos del receptor de histamina h3.
US11/572,967 US20080064706A1 (en) 2004-08-02 2005-07-27 Piperidine Derivatives as Histamine H3 Receptor Ligands
RU2007105970/04A RU2007105970A (ru) 2004-08-02 2005-07-27 Пиперидиновые производные в качестве лигандов гистаминового из рецептора
IL180548A IL180548A0 (en) 2004-08-02 2007-01-04 Piperidine derivatives as histamine h3 receptor ligands
ZA200700683A ZA200700683B (en) 2004-08-02 2007-01-24 Piperidine derivatives as histamine H3 receptor ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401971A SE0401971D0 (sv) 2004-08-02 2004-08-02 Piperidne derivatives

Publications (1)

Publication Number Publication Date
SE0401971D0 true SE0401971D0 (sv) 2004-08-02

Family

ID=32906883

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0401971A SE0401971D0 (sv) 2004-08-02 2004-08-02 Piperidne derivatives

Country Status (14)

Country Link
US (1) US20080064706A1 (enExample)
EP (1) EP1781613A1 (enExample)
JP (1) JP2008508353A (enExample)
KR (1) KR20070043998A (enExample)
CN (1) CN1993325A (enExample)
AU (1) AU2005267932A1 (enExample)
BR (1) BRPI0514035A (enExample)
CA (1) CA2576112A1 (enExample)
IL (1) IL180548A0 (enExample)
MX (1) MX2007001226A (enExample)
RU (1) RU2007105970A (enExample)
SE (1) SE0401971D0 (enExample)
WO (1) WO2006014136A1 (enExample)
ZA (1) ZA200700683B (enExample)

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WO2005089380A2 (en) 2004-03-16 2005-09-29 The Regents Of The University Of California Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
JP4943837B2 (ja) 2003-04-03 2012-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 可溶性エポキシド加水分解酵素の改良インヒビター
ZA200703613B (en) 2004-10-20 2009-05-27 Univ California Improved inhibitors for the soluble epoxide hydrolase
PL2937341T3 (pl) 2004-12-30 2017-11-30 Janssen Pharmaceutica N.V. Pochodne fenyloamidowe kwasu 4-(benzylo)-piperazyno-1-karboksylowego oraz związki powiązane, jako modulatory hydrolazy amidu kwasu tłuszczowego (FAAH) do leczenia lęku, bólu i innych schorzeń
CA2606004A1 (en) 2005-08-02 2007-02-08 Neurogen Corporation Dipiperazinyl ketones and related analogues
AR059826A1 (es) 2006-03-13 2008-04-30 Univ California Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble
CN101784529A (zh) * 2007-06-22 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的脲和氨基甲酸酯衍生物
DK2221298T3 (da) 2007-11-13 2013-11-18 Taisho Pharmaceutical Co Ltd Phenylpyrazolderivater
WO2010068453A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
WO2010068452A1 (en) * 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
WO2011069063A2 (en) 2009-12-04 2011-06-09 Sunovion Pharmaceuticals, Inc. Multicyclic compounds and methods of use thereof
US9296693B2 (en) 2010-01-29 2016-03-29 The Regents Of The University Of California Acyl piperidine inhibitors of soluble epoxide hydrolase
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CA2801074A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
WO2012113103A1 (en) * 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
AR088256A1 (es) 2011-10-08 2014-05-21 Novartis Ag Derivados de carbamato / urea como antagonistas del receptor h3
RU2618228C2 (ru) 2011-12-08 2017-05-03 Тайсо Фармасьютикал Ко., Лтд. Производное фенилпиррола
EP2799436A4 (en) 2011-12-27 2015-07-01 Taisho Pharmaceutical Co Ltd PHENYLTRIAZOLDERIVAT
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
TWI703130B (zh) * 2014-03-07 2020-09-01 瑞士商赫爾辛保健股份有限公司 對位取代的不對稱脲及其醫療用途
CN106536518B (zh) * 2014-05-19 2020-05-12 勃林格殷格翰动物保健美国公司 驱蠕虫化合物
EP3383853B1 (en) 2015-12-01 2020-11-04 Merck Sharp & Dohme Corp. Homobispiperidinyl derivatives as liver x receptor (lxr) beta agonists for treating e.g. alzheimer's disease
KR102640774B1 (ko) 2016-03-22 2024-02-26 헬신 헬쓰케어 에스.에이. 벤젠술포닐-비대칭 우레아 및 그의 의학적 용도
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
CA3032141A1 (en) 2016-07-29 2018-02-01 Vadim ALEXANDROV Compounds and compositions and uses thereof
AU2017301769B2 (en) 2016-07-29 2022-07-28 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
HUE057710T2 (hu) 2017-01-23 2022-05-28 Cadent Therapeutics Inc Káliumcsatorna modulátorok
WO2018151861A1 (en) 2017-02-16 2018-08-23 Sunovion Pharamaceuticials Inc. Methods of treating schizophrenia
EA202090414A1 (ru) 2017-08-02 2020-05-28 Суновион Фармасьютикалз Инк. Соединения и их применение
CA3091292A1 (en) 2018-02-16 2019-08-22 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
HRP20240793T1 (hr) 2018-04-18 2024-09-13 Constellation Pharmaceuticals, Inc. Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba
CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
JP2022508945A (ja) 2018-10-22 2022-01-19 カデント セラピューティクス,インコーポレーテッド カリウムチャネルモジュレーターの結晶形態
CN111349609A (zh) * 2018-12-21 2020-06-30 泰州医药城国科化物生物医药科技有限公司 一种无标记组胺受体h3的细胞筛选模型
EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
EP3969444A4 (en) * 2019-05-13 2023-10-18 The Regents of the University of California COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS
SI4003532T1 (sl) 2019-07-24 2025-02-28 Constellation Pharmaceuticals, Inc. Kristalinične oblike 7-kloro-2-(4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-N-((6-metil-4-(metilthio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamida
ES2819309B2 (es) * 2019-10-14 2021-11-17 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa Compuestos agonistas nicotínicos y antioxidantes para el tratamiento de enfermedades neurodegenerativas
MX2022012833A (es) 2020-04-14 2022-11-07 Sunovion Pharmaceuticals Inc (s)-(4,5-dihidro-7h-tieno[2,3-c]piran-7-il)-n-metilmetanamina para tratar trastornos neurologicos y psiquiatricos.
CN113549006B (zh) * 2020-04-26 2023-07-21 江苏恩华药业股份有限公司 一种酰胺衍生物及其应用

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DE19614204A1 (de) * 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
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US6673829B2 (en) * 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
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CN1902177A (zh) * 2003-09-22 2007-01-24 万有制药株式会社 新哌啶衍生物

Also Published As

Publication number Publication date
CN1993325A (zh) 2007-07-04
KR20070043998A (ko) 2007-04-26
CA2576112A1 (en) 2006-02-09
US20080064706A1 (en) 2008-03-13
JP2008508353A (ja) 2008-03-21
ZA200700683B (en) 2008-08-27
IL180548A0 (en) 2007-06-03
MX2007001226A (es) 2007-03-23
BRPI0514035A (pt) 2008-05-27
WO2006014136A1 (en) 2006-02-09
AU2005267932A1 (en) 2006-02-09
EP1781613A1 (en) 2007-05-09
RU2007105970A (ru) 2008-09-10

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