SE0401971D0 - Piperidne derivatives - Google Patents
Piperidne derivativesInfo
- Publication number
- SE0401971D0 SE0401971D0 SE0401971A SE0401971A SE0401971D0 SE 0401971 D0 SE0401971 D0 SE 0401971D0 SE 0401971 A SE0401971 A SE 0401971A SE 0401971 A SE0401971 A SE 0401971A SE 0401971 D0 SE0401971 D0 SE 0401971D0
- Authority
- SE
- Sweden
- Prior art keywords
- piperidne
- derivatives
- sup
- compounds
- enantiomers
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401971A SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Piperidne derivatives |
| PCT/SE2005/001189 WO2006014136A1 (en) | 2004-08-02 | 2005-07-27 | Piperidine derivatives as histamine h3 receptor ligands |
| US11/572,967 US20080064706A1 (en) | 2004-08-02 | 2005-07-27 | Piperidine Derivatives as Histamine H3 Receptor Ligands |
| BRPI0514035-8A BRPI0514035A (pt) | 2004-08-02 | 2005-07-27 | composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto |
| EP05761797A EP1781613A1 (en) | 2004-08-02 | 2005-07-27 | Piperidine derivatives as histamine h3 receptor ligands |
| MX2007001226A MX2007001226A (es) | 2004-08-02 | 2005-07-27 | Derivados de piperidina como ligandos del receptor de histamina h3. |
| AU2005267932A AU2005267932A1 (en) | 2004-08-02 | 2005-07-27 | Piperidine derivatives as histamine H3 receptor ligands |
| KR1020077002643A KR20070043998A (ko) | 2004-08-02 | 2005-07-27 | 히스타민 ｈ3 수용체 리간드로서의 피페리딘 유도체 |
| CNA2005800262732A CN1993325A (zh) | 2004-08-02 | 2005-07-27 | 作为组胺h3受体配体的哌啶衍生物 |
| RU2007105970/04A RU2007105970A (ru) | 2004-08-02 | 2005-07-27 | Пиперидиновые производные в качестве лигандов гистаминового из рецептора |
| CA002576112A CA2576112A1 (en) | 2004-08-02 | 2005-07-27 | Piperidine derivatives as histamine h3 receptor ligands |
| JP2007524768A JP2008508353A (ja) | 2004-08-02 | 2005-07-27 | ヒスタミンｈ３受容体リガンドとしてのピペリジン誘導体 |
| IL180548A IL180548A0 (en) | 2004-08-02 | 2007-01-04 | Piperidine derivatives as histamine h3 receptor ligands |
| ZA200700683A ZA200700683B (en) | 2004-08-02 | 2007-01-24 | Piperidine derivatives as histamine H3 receptor ligands |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401971A SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Piperidne derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0401971D0 true SE0401971D0 (sv) | 2004-08-02 |
Family
ID=32906883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0401971A SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Piperidne derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080064706A1 (enExample) |
| EP (1) | EP1781613A1 (enExample) |
| JP (1) | JP2008508353A (enExample) |
| KR (1) | KR20070043998A (enExample) |
| CN (1) | CN1993325A (enExample) |
| AU (1) | AU2005267932A1 (enExample) |
| BR (1) | BRPI0514035A (enExample) |
| CA (1) | CA2576112A1 (enExample) |
| IL (1) | IL180548A0 (enExample) |
| MX (1) | MX2007001226A (enExample) |
| RU (1) | RU2007105970A (enExample) |
| SE (1) | SE0401971D0 (enExample) |
| WO (1) | WO2006014136A1 (enExample) |
| ZA (1) | ZA200700683B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1608319A4 (en) | 2003-04-03 | 2007-02-28 | Univ California | IMPROVED HEMMER FOR SOLUBLE EPOXY HYDROLASE |
| JP2007532484A (ja) | 2004-03-16 | 2007-11-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法 |
| EP1814875A4 (en) | 2004-10-20 | 2010-02-17 | Univ California | IMPROVED INHIBITORS OF SOLUBLE EPOXY HYDROLASE |
| EP1836179B1 (en) | 2004-12-30 | 2015-05-06 | Janssen Pharmaceutica NV | Piperidine- and piperazine-1-carboxylic acid amide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions |
| AU2006275568A1 (en) | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| MX2009013865A (es) * | 2007-06-22 | 2010-01-27 | Hoffmann La Roche | Urea y derivados carbamato como inhibidores no nucleosidicos de la transcriptasa inversa. |
| MX2010005225A (es) | 2007-11-13 | 2010-05-27 | Taisho Pharmaceutical Co Ltd | Derivados de fenilpirazol. |
| US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| TW201039822A (en) | 2009-02-06 | 2010-11-16 | Taisho Pharmaceutical Co Ltd | Dihydroquinolinone derivatives |
| PT3252057T (pt) | 2009-12-04 | 2024-06-04 | Sunovion Pharmaceuticals Inc | Compostos multicíclicos e métodos de utilização dos mesmos |
| WO2012054093A2 (en) | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| US9045445B2 (en) | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| WO2012113103A1 (en) * | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
| TW201321353A (zh) | 2011-10-08 | 2013-06-01 | Novartis Ag | 胺基甲酸酯／尿素衍生物 |
| JP6098892B2 (ja) | 2011-12-08 | 2017-03-22 | 大正製薬株式会社 | フェニルピロール誘導体 |
| WO2013100054A1 (ja) | 2011-12-27 | 2013-07-04 | 大正製薬株式会社 | フェニルトリアゾール誘導体 |
| US9034874B2 (en) | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
| TWI703130B (zh) | 2014-03-07 | 2020-09-01 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
| MX375153B (es) | 2014-05-19 | 2025-03-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelminticos. |
| EP3383853B1 (en) | 2015-12-01 | 2020-11-04 | Merck Sharp & Dohme Corp. | Homobispiperidinyl derivatives as liver x receptor (lxr) beta agonists for treating e.g. alzheimer's disease |
| CA3017048C (en) | 2016-03-22 | 2023-11-07 | Helsinn Healthcare Sa | Benzenesulfonyl-asymmetric ureas and medical uses thereof |
| US10774064B2 (en) | 2016-06-02 | 2020-09-15 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| MX2019000982A (es) | 2016-07-29 | 2019-07-04 | Sunovion Pharmaceuticals Inc | Compuestos y composiciones y usos de los mismos. |
| EA201990400A1 (ru) | 2016-07-29 | 2019-07-31 | Суновион Фармасьютикалз, Инк. | Соединения и композиции и их применение |
| BR112019014814B1 (pt) | 2017-01-23 | 2024-03-12 | Novartis Ag | Compostos, composições farmacêuticas dos mesmos e seus usos no tratamento de doenças associadas à disfunção de canais iônicos de potássio |
| CN116808023A (zh) | 2017-02-16 | 2023-09-29 | 桑诺维恩药品公司 | 治疗精神分裂症的方法 |
| JP7191085B2 (ja) | 2017-08-02 | 2022-12-16 | サノビオン ファーマシューティカルズ インク | イソクロマン化合物およびその使用 |
| MX2020008537A (es) | 2018-02-16 | 2021-01-08 | Sunovion Pharmaceuticals Inc | Sales, formas cristalinas y metodos de produccion de las mismas. |
| SG11202009438UA (en) | 2018-04-18 | 2020-11-27 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN112262143A (zh) | 2018-05-21 | 2021-01-22 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| AU2019366312B2 (en) | 2018-10-22 | 2025-04-24 | Novartis Ag | Crystalline forms of potassium channel modulators |
| CN111349609A (zh) * | 2018-12-21 | 2020-06-30 | 泰州医药城国科化物生物医药科技有限公司 | 一种无标记组胺受体h3的细胞筛选模型 |
| CN113784755B (zh) | 2019-03-14 | 2024-05-10 | 赛诺维信制药公司 | 异色满基化合物的盐及其结晶形式、制备方法、治疗用途和药物组合物 |
| EP3969444A4 (en) * | 2019-05-13 | 2023-10-18 | The Regents of the University of California | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS |
| PH12022550188A1 (en) | 2019-07-24 | 2022-11-21 | Constellation Pharmaceuticals Inc | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
| ES2819309B2 (es) * | 2019-10-14 | 2021-11-17 | Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa | Compuestos agonistas nicotínicos y antioxidantes para el tratamiento de enfermedades neurodegenerativas |
| CA3180115A1 (en) | 2020-04-14 | 2021-10-21 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
| CN113549006B (zh) * | 2020-04-26 | 2023-07-21 | 江苏恩华药业股份有限公司 | 一种酰胺衍生物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
| DE19614204A1 (de) * | 1996-04-10 | 1997-10-16 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| ATE450508T1 (de) * | 2001-09-14 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren |
| US6673829B2 (en) * | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| US7064135B2 (en) * | 2001-10-12 | 2006-06-20 | Novo Nordisk Inc. | Substituted piperidines |
| EP1554260A1 (en) * | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivatives as h3 receptor ligands |
| US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
-
2004
- 2004-08-02 SE SE0401971A patent/SE0401971D0/xx unknown
-
2005
- 2005-07-27 AU AU2005267932A patent/AU2005267932A1/en not_active Abandoned
- 2005-07-27 US US11/572,967 patent/US20080064706A1/en not_active Abandoned
- 2005-07-27 KR KR1020077002643A patent/KR20070043998A/ko not_active Withdrawn
- 2005-07-27 JP JP2007524768A patent/JP2008508353A/ja not_active Abandoned
- 2005-07-27 WO PCT/SE2005/001189 patent/WO2006014136A1/en not_active Ceased
- 2005-07-27 MX MX2007001226A patent/MX2007001226A/es not_active Application Discontinuation
- 2005-07-27 CN CNA2005800262732A patent/CN1993325A/zh active Pending
- 2005-07-27 RU RU2007105970/04A patent/RU2007105970A/ru not_active Application Discontinuation
- 2005-07-27 CA CA002576112A patent/CA2576112A1/en not_active Abandoned
- 2005-07-27 BR BRPI0514035-8A patent/BRPI0514035A/pt not_active Application Discontinuation
- 2005-07-27 EP EP05761797A patent/EP1781613A1/en not_active Withdrawn
-
2007
- 2007-01-04 IL IL180548A patent/IL180548A0/en unknown
- 2007-01-24 ZA ZA200700683A patent/ZA200700683B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0514035A (pt) | 2008-05-27 |
| WO2006014136A1 (en) | 2006-02-09 |
| KR20070043998A (ko) | 2007-04-26 |
| ZA200700683B (en) | 2008-08-27 |
| RU2007105970A (ru) | 2008-09-10 |
| CA2576112A1 (en) | 2006-02-09 |
| IL180548A0 (en) | 2007-06-03 |
| US20080064706A1 (en) | 2008-03-13 |
| EP1781613A1 (en) | 2007-05-09 |
| AU2005267932A1 (en) | 2006-02-09 |
| MX2007001226A (es) | 2007-03-23 |
| JP2008508353A (ja) | 2008-03-21 |
| CN1993325A (zh) | 2007-07-04 |
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