SA90100152B1 - مستحضر سائل يؤخذ عن طريق الفم يحتوي على ثنائي كلوفيناك - Google Patents
مستحضر سائل يؤخذ عن طريق الفم يحتوي على ثنائي كلوفيناك Download PDFInfo
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- SA90100152B1 SA90100152B1 SA90100152A SA90100152A SA90100152B1 SA 90100152 B1 SA90100152 B1 SA 90100152B1 SA 90100152 A SA90100152 A SA 90100152A SA 90100152 A SA90100152 A SA 90100152A SA 90100152 B1 SA90100152 B1 SA 90100152B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- acid
- cellulose
- diclofenac
- suspension
- preparation according
- Prior art date
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- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 229960001259 diclofenac Drugs 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000007788 liquid Substances 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 53
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 16
- -1 ammonium halides Chemical class 0.000 claims description 16
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 15
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 15
- 235000010199 sorbic acid Nutrition 0.000 claims description 15
- 239000004334 sorbic acid Substances 0.000 claims description 15
- 229940075582 sorbic acid Drugs 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 13
- 235000010980 cellulose Nutrition 0.000 claims description 13
- 239000001913 cellulose Substances 0.000 claims description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 10
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 8
- 235000003599 food sweetener Nutrition 0.000 claims description 8
- 239000003381 stabilizer Substances 0.000 claims description 8
- 239000003765 sweetening agent Substances 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 6
- 235000010323 ascorbic acid Nutrition 0.000 claims description 6
- 239000011668 ascorbic acid Substances 0.000 claims description 6
- 229960005070 ascorbic acid Drugs 0.000 claims description 6
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 6
- 235000019204 saccharin Nutrition 0.000 claims description 6
- 229940081974 saccharin Drugs 0.000 claims description 6
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
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- 150000002772 monosaccharides Chemical class 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
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- 238000000034 method Methods 0.000 claims description 3
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- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000008119 colloidal silica Substances 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
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- 150000002989 phenols Chemical class 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
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- 230000000996 additive effect Effects 0.000 claims 3
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- 239000007800 oxidant agent Substances 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 1
- 239000000451 gelidium spp. gum Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
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- 238000009472 formulation Methods 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000008203 oral pharmaceutical composition Substances 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 description 16
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 9
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH416788 | 1988-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA90100152B1 true SA90100152B1 (ar) | 2001-04-14 |
Family
ID=4271057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA90100152A SA90100152B1 (ar) | 1988-11-10 | 1990-04-04 | مستحضر سائل يؤخذ عن طريق الفم يحتوي على ثنائي كلوفيناك |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0373103B1 (enExample) |
| JP (1) | JP2894744B2 (enExample) |
| KR (1) | KR0152983B1 (enExample) |
| AT (1) | ATE87476T1 (enExample) |
| AU (1) | AU624190B2 (enExample) |
| CA (1) | CA2002472C (enExample) |
| DE (1) | DE58903964D1 (enExample) |
| DK (1) | DK175752B1 (enExample) |
| ES (1) | ES2054089T3 (enExample) |
| GR (1) | GR3007995T3 (enExample) |
| IE (1) | IE63482B1 (enExample) |
| IL (1) | IL92190A (enExample) |
| NZ (1) | NZ231320A (enExample) |
| PT (1) | PT92228B (enExample) |
| SA (1) | SA90100152B1 (enExample) |
| ZA (1) | ZA898554B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011688A (en) * | 1989-02-02 | 1991-04-30 | Calam Henry D | Liquid composition for the relief of premenstrual and menstrual discomforts |
| IT1256616B (it) * | 1992-12-02 | 1995-12-12 | Zambon Spa | Sciroppo contenente n-acetil-cisteina |
| AUPN969796A0 (en) * | 1996-05-07 | 1996-05-30 | F.H. Faulding & Co. Limited | Taste masked liquid suspensions |
| GB9930058D0 (en) * | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
| PL365135A1 (en) * | 2000-08-07 | 2004-12-27 | Ranbaxy Signature Llc | Liquid formulation of metformin |
| ITMI20020986A1 (it) * | 2002-05-10 | 2003-11-10 | Acraf | Composizione a base di diclofenac per il trattamento topico di affezioni del cavo orofaringeo |
| JP2004059488A (ja) * | 2002-07-29 | 2004-02-26 | Asahi Food & Healthcare Ltd | 乳酸菌整腸組成物および食品 |
| JP2006315966A (ja) * | 2005-04-11 | 2006-11-24 | Sanei Gen Ffi Inc | 黒豆抽出物を含有した咽喉頭用液状組成物 |
| GB201006218D0 (en) | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
| WO2013066616A1 (en) | 2011-10-31 | 2013-05-10 | Glaxo Wellcome Manufacturing Pte Ltd | Pazopanib formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| JPS5238030A (en) * | 1975-07-04 | 1977-03-24 | Gaba Ag | Mouth and tooth reparing agent |
| CH655507B (enExample) * | 1983-01-12 | 1986-04-30 |
-
1989
- 1989-11-01 EP EP89810825A patent/EP0373103B1/de not_active Expired - Lifetime
- 1989-11-01 AT AT89810825T patent/ATE87476T1/de not_active IP Right Cessation
- 1989-11-01 DE DE8989810825T patent/DE58903964D1/de not_active Expired - Lifetime
- 1989-11-01 ES ES89810825T patent/ES2054089T3/es not_active Expired - Lifetime
- 1989-11-02 AU AU44343/89A patent/AU624190B2/en not_active Expired
- 1989-11-02 IL IL9219089A patent/IL92190A/en active IP Right Grant
- 1989-11-06 JP JP1287648A patent/JP2894744B2/ja not_active Expired - Lifetime
- 1989-11-08 NZ NZ231320A patent/NZ231320A/xx unknown
- 1989-11-08 CA CA002002472A patent/CA2002472C/en not_active Expired - Lifetime
- 1989-11-08 PT PT92228A patent/PT92228B/pt not_active IP Right Cessation
- 1989-11-08 KR KR1019890016136A patent/KR0152983B1/ko not_active Expired - Lifetime
- 1989-11-09 ZA ZA898554A patent/ZA898554B/xx unknown
- 1989-11-09 DK DK198905615A patent/DK175752B1/da not_active IP Right Cessation
- 1989-11-09 IE IE361189A patent/IE63482B1/en not_active IP Right Cessation
-
1990
- 1990-04-04 SA SA90100152A patent/SA90100152B1/ar unknown
-
1993
- 1993-05-28 GR GR920403069T patent/GR3007995T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK561589D0 (da) | 1989-11-09 |
| DK561589A (da) | 1990-05-11 |
| EP0373103B1 (de) | 1993-03-31 |
| IL92190A0 (en) | 1990-07-26 |
| PT92228B (pt) | 1995-07-06 |
| NZ231320A (en) | 1992-11-25 |
| CA2002472C (en) | 2000-05-30 |
| ES2054089T3 (es) | 1994-08-01 |
| IL92190A (en) | 1996-07-23 |
| ATE87476T1 (de) | 1993-04-15 |
| KR910009253A (ko) | 1991-06-28 |
| PT92228A (pt) | 1990-05-31 |
| CA2002472A1 (en) | 1990-05-10 |
| GR3007995T3 (enExample) | 1993-08-31 |
| IE893611L (en) | 1990-05-10 |
| ZA898554B (en) | 1990-08-29 |
| AU4434389A (en) | 1990-06-07 |
| AU624190B2 (en) | 1992-06-04 |
| KR0152983B1 (ko) | 1998-11-16 |
| EP0373103A1 (de) | 1990-06-13 |
| DE58903964D1 (de) | 1993-05-06 |
| IE63482B1 (en) | 1995-05-03 |
| DK175752B1 (da) | 2005-02-07 |
| JPH02178224A (ja) | 1990-07-11 |
| JP2894744B2 (ja) | 1999-05-24 |
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